Diabetic LDL triggers apoptosis in vascular endothelial cells

Diabetes

Volumn 52, Issue 5, 2003, Pages 1240-1247

  Artwohl, Michaela ^a   Graier, Wolfgang F ^b   Roden, Michael ^a   Bischof, Martin ^a   Freudenthaler, Angelika ^a   Waldhäus, Werner ^a   Baumgartner Parzer, Sabina M ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE INHIBITOR; CYCLIN D3; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN; NITRIC OXIDE SYNTHASE; RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL TRANSPORT; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; ENDOTHELIUM CELL; GLYCATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

APOPTOSIS; CELL LINE; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DNA; ENDOTHELIUM, VASCULAR; FEMALE; GLUCOSE; GLYCOSYLATION; HUMANS; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; REFERENCE VALUES; UMBILICAL VEINS;

EID: 0242684704     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.5.1240     Document Type: Article

References (48)

1. Tames FJ, Mackness MI, Arrol S, Laing I, Durrington PN: Non-enzymatic glycation of apolipoprotein B in the sera of diabetic and non-diabetic subjects. Atherosclerosis 93:237-244, 1992
2. Schleicher E, Deufel T, Wieland OH: Non-enzymatic glycosylation of human serum lipoproteins: elevated ε-lysine glycosylated low density lipoprotein in diabetic patients. FEBS Lett 129:1-4, 1981
3. Klein RL, Laimins M, Lopes-Virella MF: Isolation, characterization, and metabolism of the glycated and nonglycated subfractions of low-density lipoproteins isolated from type I diabetic patients and nondiabetic subjects. Diabetes 44:1093-1098, 1995
4. Lyons TJ, Baynes JW, Patrick JS, Colwell JA, Lopes-Virella MF: Glycosylation of low density lipoprotein in patients with type 1 (insulin-dependent) diabetes: correlations with other parameters of glycaemic control. Diabetologia 29:685-689, 1986
5. Jack CM, Sheridan B, Kennedy L, Stout RW: Non-enzymatic glycosylation of low-density lipoprotein: results of an affinity chromatography method. Diabetologia 31:126-127, 1988
6. Cohen MP, Lautenslager G, Shea E: Glycated LDL concentrations in non-diabetic and diabetic subjects measured with monoclonal antibodies reactive with glycated apolipoprotein B epitopes. Eur J Clin Chem Clin Biochem 31:707-713, 1993
7. Lyons TJ, Li W, Wells-Knecht MC, Jokl R: Toxicity of mildly modified low-density lipoproteins to cultured retinal capillary endothelial cells and pericytes. Diabetes 43:1090-1095, 1994
8. Steinbrecher UP, Witztum JL: Glucosylation of low-density lipoproteins to an extent comparable to that seen in diabetes slows their catabolism. Diabetes 33:130-134, 1984
9. Lorenzi M, Cagliero E, Markey B, Henriksen T, Witztum JL, Sampietro T: Interaction of human endothelial cells with elevated glucose concentrations and native and glycosylated low density lipoproteins. Diabetologia 26:218-222, 1984
10. Zimmermann R, Panzenböck U, Wintersperger A, Levak-Frank S, Graier W, Glatter O, Fritz G, Kostner GM, Zechner R: Lipoprotein lipase mediates the uptake of glycated LDL in fibroblasts, endothelial cells, and macrophages. Diabetes 50:1643-1653, 2001
11. Khan BV, Parthasarathy SS, Alexander RW, Medford RM: Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J Clin Invest 95:1262-1270, 1995
12. Posch K, Simecek S, Wascher TC, Jürgens G, Baumgartner-Parzer S, Kostner GM, Graier WF: Glycated low-density lipoprotein attenuates shear stress-induced nitric oxide synthesis by inhibition of shear stress-activated L-arginine uptake in endothelial cells. Diabetes 48:1331-1337, 1999
13. King GL: The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes. Ann Med 28:427-432, 1996
14. Baumgartner SM, Waldhäusl WK: The endothelium as a metabolic and endocrine organ: its relation with insulin resistance. Exp Clin Endocrinol Diabetes 109 (Suppl. 2):S166-S179, 2001
15. Mizutani M, Kern TS, Lorenzi M: Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest 97:2883-2890, 1996
16. Boeri D, Maiello M, Lorenzi M: Increased prevalence of microthromboses in retinal capillaries of diabetic individuals. Diabetes 50:1432-1439, 2001
17. Ross R: Atherosclerosis: an inflammatory disease. N Engl J Med 340:115-126, 1999
18. Dimmeler S, Zeiher AM: Endothelial cell apoptosis in angiogenesis and vessel regression. Circ Res 87:434-439, 2000
19. Baumgartner-Parzer SM, Wagner L, Pettermann M, Grillari J, Gessl A, Waldhäusl W: High-glucose-triggered apoptosis in cultured endothelial cells. Diabetes 44:1323-1327, 1995
20. Kern TS, Tang J, Mizutani M, Kowluru RA, Nagaraj RH, Romeo G, Podesta F, Lorenzi M: Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Invest Ophthalmol Vis Sci 41:3972-3978, 2000
21. Mercie P, Garnier O, Lascoste L, Renard M, Closse C, Durrieu F, Marit G, Boisseau RM, Belloc F: Homocysteine-thiolactone induces caspase-independent vascular endothelial cell death with apoptotic features. Apoptosis 5:403-411, 2000
22. Herbst U, Toborek M, Kaiser S, Mattson MP, Hennig B: 4-Hydroxynonenal induces dysfunction and apoptosis of cultured endothelial cells. J Cell Physiol 181:295-303, 1999
23. Graier WF, Kostner GM: Glycated low-density lipoprotein and atherogenesis: the missing link between diabetes mellitus and hypercholesterolaemia? Eur J Clin Invest 27:457-459, 1997
24. Havel RJ, Eder HA, Bragdon JH: The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34:1345-1353, 1955
25. Habeeb AFSA: Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. Analytical Biochem 14:328-336, 1966
26. Baumgartner-Parzer SM, Wagner L, Pettermann M, Gessl A, Waldhäusl W: Modulation by high glucose of adhesion molecule expression in cultured endothelial cells. Diabetologia 38:1367-1370, 1995
27. Artwohl M, Hölzenbein T, Wagner L, Freudenthaler A, Waldhäusl W, Baumgartner-Parzer SM: Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol 131:1577-1583, 2000
28. Artwohl M, Roden M, Hölzenbein T, Freudenthaler A, Waldhäusl W, Baumgartner-Parzer SM: Modulation by leptin of proliferation and apoptosis in vascular endothelial cells. Int J Obesity Relat Metab Disord 26:577-580, 2002
29. Ramachandra S, Studzinski GP: Morphological and biochemical criteria of apoptosis. In Cell Growth and Apoptosis: A Practical Approach. Studzinski GP, Ed. Oxford, UK, IRL Press, 1995, p. 119-142
30. Dimmeler S, Haendeler J, Galle J, Zeiher AM: Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases: a mechanistic clue to the "response to injury" hypothesis. Circulation 95:1760-1763, 1997
31. Sata M, Walsh K: Oxidized LDL activates Fas-mediated endothelial cell apoptosis. J Clin Invest 102:1682-1689, 1998
32. Rössig L, Dimmeler S, Zeiher AM: Apoptosis in the vascular wall and atherosclerosis. Basic Res Cardiol 96:11-22, 2001
33. Korpinen E, Akerblom HK, Groop P-H, Vaarala O: Immune response to glycated and oxidized LDL in IDDM patients with and without renal disease. Diabetes Care 20:1168-1171, 1997
34. Jenkins AJ, Velarde V, Klein RL, Joyce KC, Phillips KD, Mayfield RK, Lyons TJ, Jaffa AA: Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells. Diabetes 49:2160-2169, 2000
35. Nishi K, Itabe H, Uno M, Kitazato KT, Horiguchi H, Shinno K, Nagahiro S: Oxidized LDL in carotid plaques and plasma associates with plaque instability. Arterioscler Thromb Vasc Biol 22:1649-1654, 2002
36. Stroh C, Schulze-Osthoff K: Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ 5:997-1000, 1998
37. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT: Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278:294-298, 1997
38. 1/S phase transition in fibroblasts. J Biol Chem 273:14958-14961, 1998
39. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81:323-330, 1995
40. 1/S-regulatory genes. Mol Cell Biol 15:4215-4224, 1995
41. Weinberg RA: E2F and cell proliferation: a world turned upside down. Cell 85:457-459, 1996
42. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304-6311, 1991
43. Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK: Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A 98:2604-2609, 2001
44. Liao JK, Shin WS, Lee WY, Clark SL: Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem 270:319-324, 1995
45. Chakravarthy U, Hayes RG, Stitt AW, McAuley E, Archer DB: Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products. Diabetes 47:945-952, 1998
46. Angulo J, Sanchez-Ferrer CF, Peiro C, Marin J, Rodriguez-Manas L: Impairment of endothelium-dependent relaxation by increasing percentages of glycosylated hemoglobin: possible mechanisms involved. Hypertension 28:583-592, 1996
47. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA: Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 320:1025-1030, 1989
48. Obunike JC, Edwards LJ, Rumsey SC, Curtiss LK, Wagner WD, Deckelbaum RJ, Goldberg IJ: Cellular differences in lipoprotein lipase-mediated uptake of low density lipoproteins. J Biol Chem 269:13129-13135, 1994