Genome-wide scan for blood pressure suggests linkage to chromosome 11, and replication of loci on 16, 17, and 22

Hypertension

Volumn 44, Issue 6, 2004, Pages 872-877

  De Lange, Marlies ^a,b   Spector, Tim D ^a   Andrew, Toby ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Blood pressure; Genetics; Linkage analysis; Twins

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD PRESSURE MONITORING; CHROMOSOME 11; CHROMOSOME 16; CHROMOSOME 17; CHROMOSOME 22; CHROMOSOME REPLICATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIZYGOTIC TWINS; FEMALE; GENE LOCATION; GENE LOCUS; GENETIC LINKAGE; GENOME ANALYSIS; HUMAN; HYPERTENSION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK FACTOR; SEX ROLE; STATISTICAL ANALYSIS; SYSTOLIC BLOOD PRESSURE; UNITED KINGDOM;

ADULT; AGED; BLOOD PRESSURE; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 22; DISEASES IN TWINS; FEMALE; HUMANS; HYPERTENSION; LINKAGE (GENETICS); MIDDLE AGED; TWINS, DIZYGOTIC;

EID: 9644258901     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000148994.89903.fa     Document Type: Article

References (34)

1. Altmuller J, Palmer LJ, Fischer G, Scherb H, Wjst M. Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet. 2001;69:936-950.
2. Evans A, Van Baal GC, McCarron P, de Lange M, Soerensen TI, De Geus EJ, Kyvik K, Pedersen NL, Spector TD, Andrew T, Patterson C, Whitfield JB, Zhu G, Martin NG, Kaprio J, Boomsma DI. The genetics of coronary heart disease: the contribution of twin studies. Twin Res. 2003;6:432-441.
3. Angius A, Petretto E, Maestrale GB, Forabosco P, Casu G, Piras D, Fanciulli M, Falchi M, Melis PM, Palermo M, Pirastu M. A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search. Am J Hum Genet. 2002;71:893-905.
4. Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D, Lathrop GM, Farrall M, Connell J. Genome-wide mapping of human loci for essential hypertension. Lancet. 2003;361:2118-2123.
5. Perola M, Kainulainen K, Pajukanta P, Terwilliger JD, Hiekkalinna T, Ellonen P, Kaprio J, Koskenvuo M, Kontula K, Peltonen L. Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings. J Hypertens. 2000;18:1579-1585.
6. Hsueh WC, Mitchell BD, Schneider JL, Wagner MJ, Bell CJ, Nanthakumar E, Shuldiner AR. QTL influencing blood pressure maps to the region of PPH1 on chromosome 2q31-34 in Old Order Amish. Circulation. 2000;101:2810-2816.
7. Atwood LD, Samollow PB, Hixson JE, Stern MP, MacCluer JW. Genome-wide linkage analysis of blood pressure in Mexican Americans. Genet Epidemiol. 2001;20:373-382.
8. Levy D, DeStefano AL, Larson MG, O'Donnell CJ, Lifton RP, Gavras H, Cupples LA, Myers RH. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham Heart Study. Hypertension. 2000;36:477-483.
9. Rice T, Rankinen T, Province MA, Chagnon YC, Perusse L, Borecki IB, Bouchard C, Rao DC. Genome-wide linkage analysis of systolic and diastolic blood pressure: the Quebec Family Study. Circulation. 2000;102:1956-1963.
10. Rice T, Rankinen T, Chagnon YC, Province MA, Perusse L, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Genomewide linkage scan of resting blood pressure: HERITAGE Family Study. Health, Risk Factors, Exercise Training, and Genetics. Hypertension. 2002;39:1037-1043.
11. Krushkal J, Ferrell R, Mockrin SC, Turner ST, Sing CF, Boerwinkle E. Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings. Circulation. 1999;99:1407-1410.
12. Xu X, Rogus JJ, Terwedow HA, Yang J, Wang Z, Chen C, Niu T, Wang B, Xu H, Weiss S, Schork NJ, Fang Z. An extreme-sib-pair genome scan for genes regulating blood pressure. Am J Hum Genet. 1999;64:1694-1701.
13. Thiel BA, Chakravarti A, Cooper RS, Luke A, Lewis S, Lynn A, Tiwari H, Schork NJ, Weder AB. A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans. Am J Hypertens. 2003;16:151-153.
14. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995;11:241-247.
15. Easterbrook PJ, Berlin JA, Gopalan R, Matthews DR. Publication bias in clinical research. Lancet. 1991;337:867-872.
16. Göring HH, Terwilliger JD, Blangero J. Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Gen. 2001;69:1357-1369.
17. Chiodini BD, Lewis CM. Meta-analysis of 4 coronary heart disease genome-wide linkage studies confirms a susceptibility locus on chromosome 3q. Arterioscler Thromb Vasc Biol. 2003;23:1863-1868.
18. Poulter NR, Chang CL, MacGregor AJ, Snieder H, Spector TD. Association between birth weight and adult blood pressure in twins: historical cohort study. BMJ. 1999;319:1330-1333.
19. Spector TD, MacGregor AJ. The St Thomas' UK adult twin registry. Twin Res. 2002;5:440-443.
20. Cui JS, Hopper JL, Harrap SB. Antihypertensive treatments obscure familial contributions to blood pressure variation. Hypertension. 2003;41:207-210.
21. Palmer LJ. Loosening the cuff: important new advances in modeling antihypertensive treatment effects in genetic studies of hypertension. Hypertension. 2003;41:197-198.
22. Reed PW, Davies JL, Copeman JB, Bennett ST, Palmer SM, Pritchard LE, Gough SC, Kawaguchi Y, Cordell HJ, Balfour KM. Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping. Nat Genet. 1994;7:390-395.
23. Pritchard LE, Kawaguchi Y, Reed PW, Copeman JB, Davies JL, Barnett AH, Bain SC, Todd JA. Analysis of the CD3 gene region and type 1 diabetes: application of fluorescence-based technology to linkage disequilibrium mapping. Hum Mol Genet. 1995;4:197-202.
24. Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J. A comprehensive genetic map of the human genome based on 5264 microsatellites. Nature. 1996;380:152-154.
25. Wilson SG, Reed PW, Bansal A, Chiano M, Lindersson M, Langdown M, Prince RL, Thompson D, Thompson E, Bailey M, Kleyn PW, Sambrook P, Shi MM, Spector TD. Comparison of genome screens for two independent cohorts provides replication of suggestive linkage of bone mineral density to 3p21 and 1p36. Am J Hum Genet. 2003;72:144-155.
26. Barber MJ, Cordell HJ, MacGregor AJ, Andrew T. Gamma regression improves Haseman-Elston and variance components linkage analysis for sib-pairs. Genet Epidemiol. 2004;26:97-107.
27. Pratt SC, Daly MJ, Kruglyak L. Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. Am J Hum Genet. 2000;66:1153-1157.
28. McCullagh P, Nelder JA. Generalized Linear Models. 2nd ed. Monographs on Statistics and Applied Probability 37. London, UK: Chapman and Hall; 1989.
29. Camp NJ, Farnham JM. Correcting for multiple analyses in genomewide linkage studies. Ann Hum Genet. 2001;65:577-582.
30. Colhoun H. Confirmation needed for genes for hypertension. Lancet. 1999;353:1200-1201.
31. Rao DC, Province MA. The future of path analysis, segregation analysis, and combined models for genetic dissection of complex traits. Hum Hered. 2000;50:34-42.
32. Visscher PM, Hopper JL. Power of regression and maximum likelihood methods to map QTL from sib-pair and DZ twin data. Ann Hum Genet. 2001;65:583-601.
33. Andrew T, Hart DJ, Snieder H, de Lange M, Spector TD, MacGregor AJ. Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res. 2001;4:464-477.
34. Hong Y, Pedersen NL, Brismar K, de Faire U. Genetic and environmental architecture of the features of the insulin-resistance syndrome. Am J Hum Gen. 1997;60:143-152.