Power of regression and maximum likelihood methods to map QTL from sib-pair and DZ twin data

Annals of Human Genetics

Volumn 65, Issue 6, 2001, Pages 583-601

  Visscher, P M ^a,b   Hopper, J L ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DIZYGOTIC TWINS; GENE LOCATION; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC MODEL; GENOTYPE; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; LINKAGE ANALYSIS; MARKER GENE; MAXIMUM LIKELIHOOD METHOD; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; QUANTITATIVE TRAIT LOCUS MAPPING; REGRESSION ANALYSIS; SIBLING; STATISTICAL ANALYSIS;

EID: 0035714498     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1469-1809.2001.6560583.x     Document Type: Article

References (17)

1. Allison, D. B., Neale, M. C., Zannolli, R., Schork, N. J., Amos, C. I. & Blangero, J. (1999). Testing tile robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure. Am. J. Hum. Genet. 65, 531-544.
2. Allison, D. B., Fermandex, J. R., Heo, M. & Beasley, T. M. (2000). Testing the robustness of the new Haseman-Elston quantitative-trait loci-mapping procedure. Am. J. Hum. Genet. 67, 249-252.
3. Almasy, L. & Blangero, J. (1998). Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 62, 1198-1211.
4. Amos, C. I. (1994). Robust variance-components approach for assessing genetic linkage in pedigrees. Am. J. Hum. Genet. 54, 535-543.
5. Amos, C. I., Krushkal, J., Thiel, T. J., Young, A., Zhu, D. K., Boerwinkle, E. & de Andrade M. (1997). Comparison of model-free linkage mapping strategies for the study of a complex trait. Genet. Epidemiol. 14, 743-748.
6. Amos, C. I. & de Andrade M. (2001). Genetic linkage methods for quantitative traits. Stat. Meth. Med. Res. 10, 3-25.
7. Baret, P. V., Knott, S. A., & Visscher, P. M. (1998). On the use of regression and maximum likelihood for QTL mapping in halfsib designs. Genet. Res. 72, 149-158.
8. Churchill, G. A. & Doerge, R. W. (1994). Empirical threshold values for quantitative trait mapping. Genetics 138, 963-971.
9. Drigalenko, E. (1998). How sib pairs reveal linkage. Am. J. Hum. Genet. 63, 1242-1245.
10. Duggirala, R., Stern, M. P., Mitchell, B. D., Reinhart, L. J., Shipman, P. A., Uresandi, O. C., Chung, W. K., Leibel, R. L., Hales, C. N., O'Connell, P. & Blangero, J. (1996). Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. Am. J. Hum. Genet. 59, 694-703.
11. Elston, R. C., Buxbaum, S., Jacobs, K. B. & Olson, J. M. (2000). Haseman & Elston revisited. Genet. Epidemiol. 19, 1-17.
12. Fisher, R. A. (1918). The correlation between relatives on tile supposition of Mendelian inheritance. Trans. Royal Soc. Edin. 52, 399-433.
13. Forrest, W. F. (2001). Weighting improves the 'New Haseman-Elston' method. Hum. Hered. 52, 47-54.
14. Fulker, D. W. & Cherny, S. S. (1996). An improved multipoint sib-pair analysis of quantitative trait loci. Behav. Genet. 26, 527-532.
15. Gessler, D. G. & Xu, S. (1996). Using the expectation or the distribution of the identity by descent for mapping quantitative trait loci under the random model. Am. J. Hum. Genet. 59, 1382-1390.
16. Wright, F. A. (1997). The phenotypic difference discards sib-pair QTL linkage information. Am. J. Hum. Genet. 60, 740-742.
17. Xu, X., Weiss, S., Xu, X.-P. & Wei, L. J. (2000). A unified Haseman-Elston method for testing linkage with quantitative traits. Am. J. Hum. Genet. 67, 1025-1028.