메뉴 건너뛰기




Volumn 145, Issue 12, 2004, Pages 5417-5419

Nonsteroidal selective androgen receptors modulators (SARMs): Designer androgens with flexible structures provide clinical promise

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANTIANDROGEN; BICALUTAMIDE; CYPROTERONE ACETATE; FLUTAMIDE; MEGESTROL ACETATE; NILUTAMIDE; RALOXIFENE; SELECTIVE ANDROGEN RECEPTOR MODULATOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 9444285918     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-1207     Document Type: Short Survey
Times cited : (25)

References (33)
  • 3
    • 0023929785 scopus 로고
    • Molecular cloning of human and rat complementary DNA encoding androgen receptors
    • Chang C, Kokontis J, Liao S 1988 Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science 240:324-326
    • (1988) Science , vol.240 , pp. 324-326
    • Chang, C.1    Kokontis, J.2    Liao, S.3
  • 5
    • 0029875771 scopus 로고    scopus 로고
    • Androgens in men - Uses and abuses
    • Bagatell CJ, Bremner WJ 1996 Androgens in men - uses and abuses. N Engl J Med 334:707-714
    • (1996) N Engl J Med , vol.334 , pp. 707-714
    • Bagatell, C.J.1    Bremner, W.J.2
  • 6
    • 0001920080 scopus 로고    scopus 로고
    • Pharmacology and clinical uses of testosterone
    • Nieschlag E, Behre H, eds. Berlin: Springler-Verlag
    • Nieschlag E, Behre H 1998 Pharmacology and clinical uses of testosterone. In: Nieschlag E, Behre H, eds. Testosterone: action, deficiency, substitution. Berlin: Springler-Verlag; 293-328
    • (1998) Testosterone: Action, Deficiency, Substitution , pp. 293-328
    • Nieschlag, E.1    Behre, H.2
  • 7
    • 0022818061 scopus 로고
    • Pharmacology of antiandrogens
    • Neumann F, Topert M 1986 Pharmacology of antiandrogens. J Steroid Biochem 25:885-895
    • (1986) J Steroid Biochem , vol.25 , pp. 885-895
    • Neumann, F.1    Topert, M.2
  • 8
    • 1642544604 scopus 로고    scopus 로고
    • Selective estrogen receptor modulation: Concept and consequences in cancer
    • Jordan VC 2004 Selective estrogen receptor modulation: concept and consequences in cancer. Cancer Cell 5:207-213
    • (2004) Cancer Cell , vol.5 , pp. 207-213
    • Jordan, V.C.1
  • 9
    • 9444244523 scopus 로고    scopus 로고
    • Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: New approach for benign prostate hyperplasia
    • Gao W, Kearbey JD, Nair VA, Chung K, Parlow AF, Miller DD, Dalton JT 2004 Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology 145:5420-5428
    • (2004) Endocrinology , vol.145 , pp. 5420-5428
    • Gao, W.1    Kearbey, J.D.2    Nair, V.A.3    Chung, K.4    Parlow, A.F.5    Miller, D.D.6    Dalton, J.T.7
  • 13
    • 0842325914 scopus 로고    scopus 로고
    • Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators
    • Marhefka CA, Gao W, Chung K, Kim J, He Y, Yin D, Bohl C, Dalton JT, Miller DD 2004 Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators. J Med Chem 47:993-998
    • (2004) J Med Chem , vol.47 , pp. 993-998
    • Marhefka, C.A.1    Gao, W.2    Chung, K.3    Kim, J.4    He, Y.5    Yin, D.6    Bohl, C.7    Dalton, J.T.8    Miller, D.D.9
  • 14
    • 0001418652 scopus 로고    scopus 로고
    • Selective androgen receptor modulators (SARMs)
    • Zhi L, Martinborough E 2001 Selective androgen receptor modulators (SARMs). Annu Rep Med Chem 36:169-180
    • (2001) Annu Rep Med Chem , vol.36 , pp. 169-180
    • Zhi, L.1    Martinborough, E.2
  • 15
    • 0033526095 scopus 로고    scopus 로고
    • Switching androgen receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2-g] quinolinone
    • Zhi L, Tegley CM, Marschke KB, Jones TK 1999 Switching androgen receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2-g] quinolinone. Bioorg Med Chem Lett 9:1009-1012
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 1009-1012
    • Zhi, L.1    Tegley, C.M.2    Marschke, K.B.3    Jones, T.K.4
  • 16
    • 0034611134 scopus 로고    scopus 로고
    • Effects of isoteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl- trifluoromethyl-8-pyridono[5,6-g]quinolines
    • Kong JW, Hamann LG, Ruppar DA, Edwards JP, Marschke KB, Jones TK 2000 Effects of isoteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-trifluoromethyl-8- pyridono[5,6-g]quinolines. Bioorg Med Chem Lett 10:411-414
    • (2000) Bioorg Med Chem Lett , vol.10 , pp. 411-414
    • Kong, J.W.1    Hamann, L.G.2    Ruppar, D.A.3    Edwards, J.P.4    Marschke, K.B.5    Jones, T.K.6
  • 18
    • 0033304913 scopus 로고    scopus 로고
    • Selective androgen receptor modulators (SARMs): A novel approach to androgen therapy for the new millennium
    • Negro-Vilar A 1999 Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium. J Clin Endocrinol Metab 84:3459-3462
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3459-3462
    • Negro-Vilar, A.1
  • 19
    • 9444286210 scopus 로고    scopus 로고
    • Therapeutic androgen receptor ligands
    • ID# 3.09172003.09172001
    • Allan GF, Sui Z 2003 Therapeutic androgen receptor ligands. NURSA e-Journal 1:ID# 3.09172003.09172001
    • (2003) NURSA E-Journal , vol.1
    • Allan, G.F.1    Sui, Z.2
  • 21
    • 0023893448 scopus 로고
    • Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides
    • Tucker H, Crook JW, Chesterson GJ 1988 Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides. J Med Chem 31:954-959
    • (1988) J Med Chem , vol.31 , pp. 954-959
    • Tucker, H.1    Crook, J.W.2    Chesterson, G.J.3
  • 22
    • 0037373345 scopus 로고    scopus 로고
    • Pharmacology, pharmacokinetics, and metabolism of acetothiolutamide, a novel nonsteroidal agonist for the androgen receptor
    • Yin D, Xu H, Kirkovsky LI, Miller DD, Dalton JT 2003 Pharmacology, pharmacokinetics, and metabolism of acetothiolutamide, a novel nonsteroidal agonist for the androgen receptor. J Pharmacol Exp Ther 304:1323-1333
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1323-1333
    • Yin, D.1    Xu, H.2    Kirkovsky, L.I.3    Miller, D.D.4    Dalton, J.T.5
  • 23
    • 0028181765 scopus 로고
    • Agonists, but not antagonists, alter the conformation of the hormone-binding domain of androgen receptor
    • Kallio PJ, Janne OA, Palvimo JJ 1994 Agonists, but not antagonists, alter the conformation of the hormone-binding domain of androgen receptor. Endocrinology 134:998-1001
    • (1994) Endocrinology , vol.134 , pp. 998-1001
    • Kallio, P.J.1    Janne, O.A.2    Palvimo, J.J.3
  • 24
    • 0028891989 scopus 로고
    • Ligand-induced conformational alterations of the androgen receptor analyzed by limited trypsinization - Studies on the mechanism of antiandrogen action
    • Kuil CW, Berrevoets CA, Mulder E 1995 Ligand-induced conformational alterations of the androgen receptor analyzed by limited trypsinization - studies on the mechanism of antiandrogen action. J Biol Chem 270:27569-27576
    • (1995) J Biol Chem , vol.270 , pp. 27569-27576
    • Kuil, C.W.1    Berrevoets, C.A.2    Mulder, E.3
  • 27
    • 0028904382 scopus 로고
    • Identification of two transcription activation units in the N-terminal domain of the human androgen receptor
    • Jenster G, van der Korput JAGM, Trapman J, Brinkmann AO 1995 Identification of two transcription activation units in the N-terminal domain of the human androgen receptor. J Biol Chem 270:7341-7346
    • (1995) J Biol Chem , vol.270 , pp. 7341-7346
    • Jenster, G.1    Van Der Korput, J.A.G.M.2    Trapman, J.3    Brinkmann, A.O.4
  • 28
    • 0031039480 scopus 로고    scopus 로고
    • Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor
    • Doesburg P, Kuil CW, Berrovoets CA, Steketee K, Faber PW, Mulder E, Brinkmann AO, Trapman J 1997 Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor. Biochemistry 36:1052-1064
    • (1997) Biochemistry , vol.36 , pp. 1052-1064
    • Doesburg, P.1    Kuil, C.W.2    Berrovoets, C.A.3    Steketee, K.4    Faber, P.W.5    Mulder, E.6    Brinkmann, A.O.7    Trapman, J.8
  • 29
    • 0033601249 scopus 로고    scopus 로고
    • Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH(2)-terminal domain
    • He B, Kemppainen JA, Voegel JJ, Gronemeyer H, Wilson EM 1999 Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH(2)-terminal domain. J Biol Chem 274:37219-37225
    • (1999) J Biol Chem , vol.274 , pp. 37219-37225
    • He, B.1    Kemppainen, J.A.2    Voegel, J.J.3    Gronemeyer, H.4    Wilson, E.M.5
  • 30
    • 0034725648 scopus 로고    scopus 로고
    • FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor
    • He B, Kemppainen JA, Wilson EM 2000 FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor. J Biol Chem 275:22986-22994
    • (2000) J Biol Chem , vol.275 , pp. 22986-22994
    • He, B.1    Kemppainen, J.A.2    Wilson, E.M.3
  • 31
    • 0032230283 scopus 로고    scopus 로고
    • Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor 2)
    • Berrevoets CA, Doesburg P, Steketee K, Trapman J, Brinkmann AO 1998 Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor 2). Mol Endocrinol 12:1172-1183
    • (1998) Mol Endocrinol , vol.12 , pp. 1172-1183
    • Berrevoets, C.A.1    Doesburg, P.2    Steketee, K.3    Trapman, J.4    Brinkmann, A.O.5
  • 32
    • 0032935119 scopus 로고    scopus 로고
    • Distinguishing androgen receptor agonists and antagonists: Distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone
    • Kemppainen JA, Langley E, Wong CI, Bobseine K, Kelce WR, Wilson EM 1999 Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone. Mol Endocrinol 13:440-454
    • (1999) Mol Endocrinol , vol.13 , pp. 440-454
    • Kemppainen, J.A.1    Langley, E.2    Wong, C.I.3    Bobseine, K.4    Kelce, W.R.5    Wilson, E.M.6
  • 33
    • 0035834722 scopus 로고    scopus 로고
    • Androgen-induced NH2- and COOH-terminal interaction inhibits p160 coactivator recruitment by activation function 2
    • He B, Bowen NT, Minges JT, Wilson EM 2001 Androgen-induced NH2- and COOH-terminal interaction inhibits p160 coactivator recruitment by activation function 2. J Biol Chem 276:42293-42301
    • (2001) J Biol Chem , vol.276 , pp. 42293-42301
    • He, B.1    Bowen, N.T.2    Minges, J.T.3    Wilson, E.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.