메뉴 건너뛰기




Volumn 79, Issue 12, 2004, Pages 1321-1330

Mechanistic understanding of the fermentative L-glutamic acid overproduction by Corynebacterium glutamicum through combined metabolic flux profiling and transmembrane transport characteristics

Author keywords

Biosynthetic pathways; Corynebacterium glutamicum; L glutamic acid; Metabolic flux analysis; Transport mechanisms

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; FERMENTATION; METABOLISM; OPTIMIZATION;

EID: 9444248631     PISSN: 02682575     EISSN: None     Source Type: Journal    
DOI: 10.1002/jctb.1133     Document Type: Review
Times cited : (8)

References (72)
  • 1
    • 0032858977 scopus 로고    scopus 로고
    • L-Glutamate and L-lysine: Traditional products with impetuous developments
    • Eggeling L and Sahm H, L-Glutamate and L-lysine: traditional products with impetuous developments. Applied Microbiology and Biotechnology 52:146-153 (1999).
    • (1999) Applied Microbiology and Biotechnology , vol.52 , pp. 146-153
    • Eggeling, L.1    Sahm, H.2
  • 2
    • 0001595180 scopus 로고    scopus 로고
    • Amino acids - Technical production and use
    • in ed by Roehr M. VCH, Weinheim
    • Leuchtenberger W, Amino acids - technical production and use, in Biotechnology, ed by Roehr M. VCH, Weinheim, pp 455-502 (1996).
    • (1996) Biotechnology , pp. 455-502
    • Leuchtenberger, W.1
  • 4
    • 0022210884 scopus 로고
    • L-Glutamic acid fermentation
    • in ed by Moo-Young M. Pergamon Press Inc, Oxford
    • Hirose Y, Enei H and Shibai H, L-Glutamic acid fermentation, in Comprehensive Biotechnology, ed by Moo-Young M. Pergamon Press Inc, Oxford, pp 593-600 (1985).
    • (1985) Comprehensive Biotechnology , pp. 593-600
    • Hirose, Y.1    Enei, H.2    Shibai, H.3
  • 5
    • 85008095806 scopus 로고
    • Studies on the amino acid fermentation Part I. Production of L-glutamic acid by various microorganisms
    • Kinoshita S, Udaka S and Shimono M, Studies on the amino acid fermentation Part I. Production of L-glutamic acid by various microorganisms. Journal of General Microbiology 3:193-205 (1957).
    • (1957) Journal of General Microbiology , vol.3 , pp. 193-205
    • Kinoshita, S.1    Udaka, S.2    Shimono, M.3
  • 8
    • 0017132770 scopus 로고
    • Thin-layer chromatographic analysis of mycolic acid and other long-chain components in whole-organism methanolysates of and related taxa
    • Goodfellow M and Collins MD, Thin-layer chromatographic analysis of mycolic acid and other long-chain components in whole-organism methanolysates of and related taxa. Journal of General Microbiology 96:351-358 (1976).
    • (1976) Journal of General Microbiology , vol.96 , pp. 351-358
    • Goodfellow, M.1    Collins, M.D.2
  • 9
    • 0025744542 scopus 로고
    • Discrimination of Corynebacterium glutamicum, Brevibacterium flavum and Brevibacterium lactofermentum by restriction pattern analysis of DNA adjacent to the hom gene
    • Eikmanns B, Kricher M and Reinscheid D, Discrimination of Corynebacterium glutamicum, Brevibacterium flavum and Brevibacterium lactofermentum by restriction pattern analysis of DNA adjacent to the hom gene. FEMS Microbiology Letters 82 203-208 (1991).
    • (1991) FEMS Microbiology Letters , vol.82 , pp. 203-208
    • Eikmanns, B.1    Kricher, M.2    Reinscheid, D.3
  • 11
    • 0042932755 scopus 로고    scopus 로고
    • Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics
    • Tauch A, Puhler A, Kalinowski J and Thierbach G, Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics. Journal of Biotechnology 104:27-40 (2003).
    • (2003) Journal of Biotechnology , vol.104 , pp. 27-40
    • Tauch, A.1    Puhler, A.2    Kalinowski, J.3    Thierbach, G.4
  • 12
    • 0029838470 scopus 로고    scopus 로고
    • A physical and genetic map of the Corynebacterium glutamicum ATCC 13032 chromosome
    • Bathe B, Kalinowski J and Pühler A, A physical and genetic map of the Corynebacterium glutamicum ATCC 13032 chromosome. Molecular Genetics and Genomics 252:255-265 (1996).
    • (1996) Molecular Genetics and Genomics , vol.252 , pp. 255-265
    • Bathe, B.1    Kalinowski, J.2    Pühler, A.3
  • 16
    • 0008163710 scopus 로고
    • Amino acids, in Economic Microbiology
    • ed by Rose AH. Elsevier Science, Amsterdam
    • Kinoshita S and Nakayama K, Amino acids, in Economic Microbiology, Primary Products of Metabolism, ed by Rose AH. Elsevier Science, Amsterdam, pp 209-261 (1978).
    • (1978) Primary Products of Metabolism , pp. 209-261
    • Kinoshita, S.1    Nakayama, K.2
  • 18
    • 0032987442 scopus 로고    scopus 로고
    • In vivo fluxes in the ammonium-assimilatory pathways in Corynebacterium glutamicum studied by 15N nuclear magnetic resonance
    • Tesch M, de Graaf AA and Sahm H, In vivo fluxes in the ammonium-assimilatory pathways in Corynebacterium glutamicum studied by 15N nuclear magnetic resonance. Applied and Environmental Microbiology 65:1099-1109 (1999).
    • (1999) Applied and Environmental Microbiology , vol.65 , pp. 1099-1109
    • Tesch, M.1    de Graaf, A.A.2    Sahm, H.3
  • 19
    • 0035910193 scopus 로고    scopus 로고
    • Nitrogen and carbon regulation of glutamine synthetase and glutamine synthase in Corynebacterium glutamicum ATCC 13032
    • Schulz AA, Collet HJ and Reid SJ, Nitrogen and carbon regulation of glutamine synthetase and glutamine synthase in Corynebacterium glutamicum ATCC 13032. FEMS Microbiology Letters 205:361-367 (2001).
    • (2001) FEMS Microbiology Letters , vol.205 , pp. 361-367
    • Schulz, A.A.1    Collet, H.J.2    Reid, S.J.3
  • 20
    • 0035159923 scopus 로고    scopus 로고
    • Glutamate synthase of Corynebacterium glutamicum is not essential for glutamate synthesis and is regulated by the nitrogen status
    • Beckers G, Nolden L and Burkovski A, Glutamate synthase of Corynebacterium glutamicum is not essential for glutamate synthesis and is regulated by the nitrogen status. Microbiology 147 2961-2970 (2001).
    • (2001) Microbiology , vol.147 , pp. 2961-2970
    • Beckers, G.1    Nolden, L.2    Burkovski, A.3
  • 21
    • 0035838555 scopus 로고    scopus 로고
    • Glutamine synthases, of Corynebacterium glutamicum: Transcriptional control and regulation of activity
    • Nolden L, Farwick M, Krämer R and Burkovski A, Glutamine synthases, of Corynebacterium glutamicum: transcriptional control and regulation of activity. FEMS Microbiology Letters 201 91-98 (2001).
    • (2001) FEMS Microbiology Letters , vol.201 , pp. 91-98
    • Nolden, L.1    Farwick, M.2    Krämer, R.3    Burkovski, A.4
  • 22
    • 0022228535 scopus 로고
    • Lysine
    • in ed by Moo-Young M. Pergamon press Inc, Oxford
    • Nakayama K, Lysine, in Comprehensive Biotechnology, ed by Moo-Young M. Pergamon press Inc, Oxford, pp 607-620 (1985).
    • (1985) Comprehensive Biotechnology , pp. 607-620
    • Nakayama, K.1
  • 24
    • 0002640894 scopus 로고
    • Effect of biotin on the bacterial formation of glutamic acid I. Glutamate formation and cellular permeability of amino acids
    • Shiio I, Otsuka SI and Takahashi M, Effect of biotin on the bacterial formation of glutamic acid I. Glutamate formation and cellular permeability of amino acids. Journal of Biochemistry 51:56-62 (1962).
    • (1962) Journal of Biochemistry , vol.51 , pp. 56-62
    • Shiio, I.1    Otsuka, S.I.2    Takahashi, M.3
  • 25
    • 0022634014 scopus 로고
    • Glutamate excretion mechanism in Corynebacterium glutamicum: Triggering by biotin starvation or by surfactant addition
    • Clement Y and Laneelle G, Glutamate excretion mechanism in Corynebacterium glutamicum: triggering by biotin starvation or by surfactant addition. Journal of General Microbiology 132 925-929 (1986).
    • (1986) Journal of General Microbiology , vol.132 , pp. 925-929
    • Clement, Y.1    Laneelle, G.2
  • 26
    • 85011221776 scopus 로고
    • Microbial production of glutamic acid by glycerol auxotrophs. I. Induction of glycerol auxotrophs and production of L-glutamic acid from n-paraffins
    • Nakao Y, Kikuchi M, Suzuki M and Doi M, Microbial production of glutamic acid by glycerol auxotrophs. I. Induction of glycerol auxotrophs and production of L-glutamic acid from n-paraffins. Agricultural Biology and Chemistry 36:490-496 (1972).
    • (1972) Agricultural Biology and Chemistry , vol.36 , pp. 490-496
    • Nakao, Y.1    Kikuchi, M.2    Suzuki, M.3    Doi, M.4
  • 27
    • 0343230743 scopus 로고
    • L-Glutamate fermentation with acetic acid by an oleic requiring mutant. II. Inhibitory factors against the extracellular accumulation of L-glutamate
    • Kitano K, Sugiyama Y and Kanzaki T, L-Glutamate fermentation with acetic acid by an oleic requiring mutant. II. Inhibitory factors against the extracellular accumulation of L-glutamate. Journal of Fermentation Technology 50:182-191 (1972).
    • (1972) Journal of Fermentation Technology , vol.50 , pp. 182-191
    • Kitano, K.1    Sugiyama, Y.2    Kanzaki, T.3
  • 28
    • 0041429588 scopus 로고    scopus 로고
    • Mycomembrane and S-layer: Two important structures of Corynebacterium glutamicum cell envelope with promising biotechnology applications
    • Bayan N, Houssin C, Chami M and Leblon G, Mycomembrane and S-layer: two important structures of Corynebacterium glutamicum cell envelope with promising biotechnology applications. Journal of Biotechnology 104:55-67 (2003).
    • (2003) Journal of Biotechnology , vol.104 , pp. 55-67
    • Bayan, N.1    Houssin, C.2    Chami, M.3    Leblon, G.4
  • 29
    • 0034996154 scopus 로고    scopus 로고
    • Structure of the cell envelope of Corynebacteria: Importance of the non-covalently bound lipids in the formation of the cell wall permeability barrier and fracture plane
    • Puech V, Chami M, Lemassu A, Laneelle MA, Schiffler B, Gounon P, Bayan N, Benz R and Daffe M, Structure of the cell envelope of Corynebacteria: importance of the non-covalently bound lipids in the formation of the cell wall permeability barrier and fracture plane. Microbiology 147:1365-1382 (2001).
    • (2001) Microbiology , vol.147 , pp. 1365-1382
    • Puech, V.1    Chami, M.2    Lemassu, A.3    Laneelle, M.A.4    Schiffler, B.5    Gounon, P.6    Bayan, N.7    Benz, R.8    Daffe, M.9
  • 30
    • 0034776319 scopus 로고    scopus 로고
    • The cell wall barrier of Corynebacterium glutamicum and amino acid efflux
    • Eggeling L and Sahm H, The cell wall barrier of Corynebacterium glutamicum and amino acid efflux. Journal of Bioscience and Bioengineering 92:201-231 (2001).
    • (2001) Journal of Bioscience and Bioengineering , vol.92 , pp. 201-231
    • Eggeling, L.1    Sahm, H.2
  • 31
    • 0342699701 scopus 로고    scopus 로고
    • Structure of surfactants and glutamate efflux by Corynebacterium glutamicum
    • Naji B, Gehin G and Bonaly R, Structure of surfactants and glutamate efflux by Corynebacterium glutamicum. Process Biochemistry 35:759-764 (2000).
    • (2000) Process Biochemistry , vol.35 , pp. 759-764
    • Naji, B.1    Gehin, G.2    Bonaly, R.3
  • 33
    • 0021134980 scopus 로고
    • Is glutamate excreted by its uptake system in Corynebacterium glutamicum? A working hypothesis
    • Clement Y, Escoffier B, Trombe MC and Laneelle G, Is glutamate excreted by its uptake system in Corynebacterium glutamicum A working hypothesis. Journal of General Microbiology 130 2589-2594 (1984).
    • (1984) Journal of General Microbiology , vol.130 , pp. 2589-2594
    • Clement, Y.1    Escoffier, B.2    Trombe, M.C.3    Laneelle, G.4
  • 34
    • 0000482285 scopus 로고
    • Evidence for an efflux carrier system involved in the secretion of glutamate by Corynebacterium glutamicum
    • Hoischen C and Krämer R, Evidence for an efflux carrier system involved in the secretion of glutamate by Corynebacterium glutamicum. Archives in Microbiology 151:342-347 (1989).
    • (1989) Archives in Microbiology , vol.151 , pp. 342-347
    • Hoischen, C.1    Krämer, R.2
  • 35
    • 0025300483 scopus 로고
    • Membrane alteration is necessary but not sufficient for effective glutamate secretion in Corynebacterium glutamicum
    • Hoischen C and Krämer R, Membrane alteration is necessary but not sufficient for effective glutamate secretion in Corynebacterium glutamicum. Journal of Bacteriology 172 3409-3416 (1990).
    • (1990) Journal of Bacteriology , vol.172 , pp. 3409-3416
    • Hoischen, C.1    Krämer, R.2
  • 36
    • 0027121369 scopus 로고
    • Physiological and energetic aspects of bacterial metabolite overproduction
    • Tempest DW and Neijssel OM, Physiological and energetic aspects of bacterial metabolite overproduction. FEMS Microbiology Letters 100:169-176 (1992).
    • (1992) FEMS Microbiology Letters , vol.100 , pp. 169-176
    • Tempest, D.W.1    Neijssel, O.M.2
  • 37
    • 0028944577 scopus 로고
    • Structure of the gluABCD cluster encoding the glutamate uptake system of Corynebacterium glutamicum
    • Kronemeyer W, Peekhaus N, Krämer R, Sahm H and Eggeling L, Structure of the gluABCD cluster encoding the glutamate uptake system of Corynebacterium glutamicum. Journal of Bacteriology 177 1152-1158 (1995).
    • (1995) Journal of Bacteriology , vol.177 , pp. 1152-1158
    • Kronemeyer, W.1    Peekhaus, N.2    Krämer, R.3    Sahm, H.4    Eggeling, L.5
  • 38
    • 0025637263 scopus 로고
    • Uptake of glutamate in Corynebacterium glutamicum 1. Kinetic properties and regulation by internal pH and potassium
    • Krämer R, Lambert C, Hoischen C and Ebbighausen H, Uptake of glutamate in Corynebacterium glutamicum 1. Kinetic properties and regulation by internal pH and potassium. European Journal of Biochemistry 194:929-935 (1990).
    • (1990) European Journal of Biochemistry , vol.194 , pp. 929-935
    • Krämer, R.1    Lambert, C.2    Hoischen, C.3    Ebbighausen, H.4
  • 39
    • 0025672777 scopus 로고
    • Uptake of glutamate in Corynebacterium glutamicum 2. Evidence for a primary active transport system
    • Krämer R and Lambert C, Uptake of glutamate in Corynebacterium glutamicum 2. Evidence for a primary active transport system. European Journal of Biochemistry 194:937-944 (1990).
    • (1990) European Journal of Biochemistry , vol.194 , pp. 937-944
    • Krämer, R.1    Lambert, C.2
  • 40
    • 0025885045 scopus 로고
    • Cloning and characterization of a glutamine transport operon of Bacillus stearothermophilus NUB36: Effect of temperature on regulation of transcription
    • Wu L and Welker NE, Cloning and characterization of a glutamine transport operon of Bacillus stearothermophilus NUB36: effect of temperature on regulation of transcription. Journal of Bacteriology 173:4877-4888 (1991).
    • (1991) Journal of Bacteriology , vol.173 , pp. 4877-4888
    • Wu, L.1    Welker, N.E.2
  • 42
    • 0025327409 scopus 로고
    • The ami locus of the Gram-positive bacterium Streptococcus pneumoniae is similar to binding protein-dependent transport operons of Gram-negative bacteria
    • Alloing G, Trombe M and Claverys J, The ami locus of the Gram-positive bacterium Streptococcus pneumoniae is similar to binding protein-dependent transport operons of Gram-negative bacteria. Molecular Microbiology 4:633-634 (1990).
    • (1990) Molecular Microbiology , vol.4 , pp. 633-634
    • Alloing, G.1    Trombe, M.2    Claverys, J.3
  • 44
    • 0030010445 scopus 로고    scopus 로고
    • Characterization of secondary uptake system for L-glutamate in Corynebacterium glutamicum
    • Burkovski A, Weil B and Krämer R, Characterization of secondary uptake system for L-glutamate in Corynebacterium glutamicum. FEMS Microbiology Letters 136:169-173 (1996).
    • (1996) FEMS Microbiology Letters , vol.136 , pp. 169-173
    • Burkovski, A.1    Weil, B.2    Krämer, R.3
  • 45
    • 0037294258 scopus 로고    scopus 로고
    • Glts, the sodium-coupled L-glutamate uptake system of Corynebacterium glutamicum: Identification of the corresponding gene and impact on L-glutamate production
    • Trötschel C, Kandirali S, Diaz-Achirica P, Meinhardt A, Morbach S, Krämer R and Burkovski A, Glts, the sodium-coupled L-glutamate uptake system of Corynebacterium glutamicum: identification of the corresponding gene and impact on L-glutamate production. Applied Microbiology and Biotechnology 60:738-742 (2003).
    • (2003) Applied Microbiology and Biotechnology , vol.60 , pp. 738-742
    • Trötschel, C.1    Kandirali, S.2    Diaz-Achirica, P.3    Meinhardt, A.4    Morbach, S.5    Krämer, R.6    Burkovski, A.7
  • 46
    • 0027572102 scopus 로고
    • Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction
    • Vallino J and Stephanopoulos G, Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction. Biotechnology and Bioengineering 41:633-646 (1993).
    • (1993) Biotechnology and Bioengineering , vol.41 , pp. 633-646
    • Vallino, J.1    Stephanopoulos, G.2
  • 47
    • 0027305845 scopus 로고
    • Phosphoenolpruvate carboxylase in Corynebacterium glutamicum is dispensable for growth and lysine production
    • Peters-Wendisch PG, Eikmanns BJ, Thierbach G, Bachmann B and Sahm H, Phosphoenolpruvate carboxylase in Corynebacterium glutamicum is dispensable for growth and lysine production. FEMS Microbiology Letters 112:269-274 (1993).
    • (1993) FEMS Microbiology Letters , vol.112 , pp. 269-274
    • Peters-Wendisch, P.G.1    Eikmanns, B.J.2    Thierbach, G.3    Bachmann, B.4    Sahm, H.5
  • 48
    • 0028329083 scopus 로고
    • Effects of phosphoenol pyruvate carboxylase deficiency on metabolism and lysine production in Corynebacterium glutamicum
    • Gubler M, Park SM, Jetten M, Stephanopoulos G and Sinskey AJ, Effects of phosphoenol pyruvate carboxylase deficiency on metabolism and lysine production in Corynebacterium glutamicum. Applied Microbiology and Biotechnology 40:857-863 (1994).
    • (1994) Applied Microbiology and Biotechnology , vol.40 , pp. 857-863
    • Gubler, M.1    Park, S.M.2    Jetten, M.3    Stephanopoulos, G.4    Sinskey, A.J.5
  • 49
    • 0033205652 scopus 로고    scopus 로고
    • Importance of phosphoenolpyruvate carboxylase of Corynebacterium glutamicum during the temperature triggered glutamic acid fermentation
    • Delaunay S, Uy D, Baucher MF, Endasser JM, Guyonvarch A and Goergen JL, Importance of phosphoenolpyruvate carboxylase of Corynebacterium glutamicum during the temperature triggered glutamic acid fermentation. Metabolic Engineering 1:334-343 (1999).
    • (1999) Metabolic Engineering , vol.1 , pp. 334-343
    • Delaunay, S.1    Uy, D.2    Baucher, M.F.3    Endasser, J.M.4    Guyonvarch, A.5    Goergen, J.L.6
  • 50
    • 0028152391 scopus 로고
    • Secretion of amino acids by bacteria. Physiology and mechanism
    • Krämer R, Secretion of amino acids by bacteria. Physiology and mechanism. FEMS Microbiology Reviews 13:75-94 (1994).
    • (1994) FEMS Microbiology Reviews , vol.13 , pp. 75-94
    • Krämer, R.1
  • 51
    • 0001632941 scopus 로고
    • Glutamic acid production in biotin-rich media by temperature-sensitive mutants of Brevibacterium lactofermentum, a novel fermentation process
    • Momose H and Takagi T, Glutamic acid production in biotin-rich media by temperature-sensitive mutants of Brevibacterium lactofermentum, a novel fermentation process. Agricultural Biology and Chemistry 42:1911-1917 (1978).
    • (1978) Agricultural Biology and Chemistry , vol.42 , pp. 1911-1917
    • Momose, H.1    Takagi, T.2
  • 52
    • 0032005841 scopus 로고    scopus 로고
    • Genetic tuning of bacteria for the overproduction of amino acids
    • Nampoothiri M and Pandey A, Genetic tuning of bacteria for the overproduction of amino acids. Process Biochemistry 33 147-161 (1998).
    • (1998) Process Biochemistry , vol.33 , pp. 147-161
    • Nampoothiri, M.1    Pandey, A.2
  • 53
    • 0015949374 scopus 로고
    • A linear steady state treatment of enzymatic chains. Critique of the crossover theorem and a general procedure to identify interaction sites with an effector
    • Heinrich R and Rapoport T, A linear steady state treatment of enzymatic chains. Critique of the crossover theorem and a general procedure to identify interaction sites with an effector. European Journal of Biochemistry 42:97-105 (1974).
    • (1974) European Journal of Biochemistry , vol.42 , pp. 97-105
    • Heinrich, R.1    Rapoport, T.2
  • 54
    • 45949117248 scopus 로고
    • Biochemical systems theory and metabolic control theory: I. Fundamental similarities and differences
    • Savageau MA, Voit EO and Irvine DH, Biochemical systems theory and metabolic control theory: I. Fundamental similarities and differences. Mathematical Bioscience 86:127-145 (1987).
    • (1987) Mathematical Bioscience , vol.86 , pp. 127-145
    • Savageau, M.A.1    Voit, E.O.2    Irvine, D.H.3
  • 55
    • 0025866296 scopus 로고
    • Network rigidity and metabolic engineering in metabolite overproduction
    • Stephanopoulos G and Vallino J, Network rigidity and metabolic engineering in metabolite overproduction. Science 252 1675-1681 (1991).
    • (1991) Science , vol.252 , pp. 1675-1681
    • Stephanopoulos, G.1    Vallino, J.2
  • 57
    • 0026000556 scopus 로고
    • C-13 nuclear-magnetic-resonance studies of glucose-metabolism in L-glutamic acid and L-lysine fermentation by Corynebacterium glutamicum
    • Ishino S, Shimomuranishimuta J, Yamaguchi K, Shirahata K and Araki K, C-13 nuclear-magnetic-resonance studies of glucose-metabolism in L-glutamic acid and L-lysine fermentation by Corynebacterium glutamicum. Journal of General and Applied Microbiology 72 157-165 (1991).
    • (1991) Journal of General and Applied Microbiology , vol.72 , pp. 157-165
    • Ishino, S.1    Shimomuranishimuta, J.2    Yamaguchi, K.3    Shirahata, K.4    Araki, K.5
  • 60
    • 0029617755 scopus 로고
    • 13C NMR studies of the fluxes in the central metabolism of Corynebacterium glutamicum during growth and overproduction of amino acids in batch cultures
    • Sonntag K, Schwinde J, de Graaf AA, Marx A, Eikmanns BJ, Wiechert W and Sahm H, 13C NMR studies of the fluxes in the central metabolism of Corynebacterium glutamicum during growth and overproduction of amino acids in batch cultures. Applied Microbiology and Biotechnology 44:489-495 (1995).
    • (1995) Applied Microbiology and Biotechnology , vol.44 , pp. 489-495
    • Sonntag, K.1    Schwinde, J.2    de Graaf, A.A.3    Marx, A.4    Eikmanns, B.J.5    Wiechert, W.6    Sahm, H.7
  • 61
    • 0036148326 scopus 로고    scopus 로고
    • Flux distribution and partitioning in Corynebacterium glutamicum grown at different specific growth rates
    • Zhao Y and Lin YH, Flux distribution and partitioning in Corynebacterium glutamicum grown at different specific growth rates. Process Biochemistry 37:775-785 (2002).
    • (2002) Process Biochemistry , vol.37 , pp. 775-785
    • Zhao, Y.1    Lin, Y.H.2
  • 64
    • 0035852624 scopus 로고    scopus 로고
    • Progress in monitoring, modeling and control of bioprocess during the last 20 years
    • Schügerl K, Progress in monitoring, modeling and control of bioprocess during the last 20 years. Journal of Biotechnology 85:149-173 (2001).
    • (2001) Journal of Biotechnology , vol.85 , pp. 149-173
    • Schügerl, K.1
  • 65
    • 9444267467 scopus 로고
    • Amino acid fermentation
    • Paper presented at Singapore International Congress for Microbiology, Singapore, Oct 31-Nov 3
    • Kinoshita S, Amino acid fermentation. Paper presented at Singapore International Congress for Microbiology, Singapore, Oct 31-Nov 3 (1989).
    • (1989)
    • Kinoshita, S.1
  • 66
    • 0033782932 scopus 로고    scopus 로고
    • Pathway analysis and metabolic engineering in Corynebacterium glutamicum
    • Sahm H, Eggeling L and de Graaf AA, Pathway analysis and metabolic engineering in Corynebacterium glutamicum. Biological Chemistry 381:899-910 (2000).
    • (2000) Biological Chemistry , vol.381 , pp. 899-910
    • Sahm, H.1    Eggeling, L.2    de Graaf, A.A.3
  • 69
    • 0019869334 scopus 로고
    • The molecular basis of dominance
    • Kacser H and Burns JA, The molecular basis of dominance. Genetics 97:639-666 (1981).
    • (1981) Genetics , vol.97 , pp. 639-666
    • Kacser, H.1    Burns, J.A.2
  • 70
    • 0030050268 scopus 로고    scopus 로고
    • Determination of fluxes in the central metabolism of Corynebacterium glutamicum by NMR spectroscopy combined with metabolite balancing
    • Marx A, De Graaf AA, Wiechert W, Eggeling L and Sahm H, Determination of fluxes in the central metabolism of Corynebacterium glutamicum by NMR spectroscopy combined with metabolite balancing. Biotechnology and Bioengineering 49:111-129 (1996).
    • (1996) Biotechnology and Bioengineering , vol.49 , pp. 111-129
    • Marx, A.1    De Graaf, A.A.2    Wiechert, W.3    Eggeling, L.4    Sahm, H.5
  • 72
    • 0031554635 scopus 로고    scopus 로고
    • Bidirectional reaction steps in metabolic networks. Part I: Modelling and simulation of carbon isotope labelling experiments
    • Wiechert W and de Graaf AA, Bidirectional reaction steps in metabolic networks. Part I: Modelling and simulation of carbon isotope labelling experiments. Biotechnology and Bioengineering 55 101-117 (1997).
    • (1997) Biotechnology and Bioengineering , vol.55 , pp. 101-117
    • Wiechert, W.1    de Graaf, A.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.