L-glutamate and L-lysine: Traditional products with impetuous developments

Applied Microbiology and Biotechnology

Volumn 52, Issue 2, 1999, Pages 146-153

  Eggeling, L ^a   Sahm, H ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; LYSINE;

AMINO ACID SYNTHESIS; BACTERIAL METABOLISM; CORYNEBACTERIUM GLUTAMICUM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SHORT SURVEY;

EID: 0032858977     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530051501     Document Type: Short Survey

References (56)

1. Bathe B, Kalinowski J, Pühler A (1996) A physical and genetic map of the Corynebacterium glutamicum ATCC 13032 chromosome. Mol Gen Genet 252: 255-265
2. Börmann E, Eikmanns BJ, Sahm H (1992) Molecular analysis of the Corynebacterium glutamicum gdh gene encoding glutamate dehydrogenase. Mol Microbiol 6: 317-326
3. Bröer S, Krämer R (1991) Lysine excretion by Corynebacterium glutamicum. 2. Energetics and mechanism of the transport system. Eur J Biochem 202: 137-143
4. Cocaign-Bousquet M, Lindley ND (1995) Pyruvate overflow and carbon flux within the central metabolic pathways of Corynebacterium glutamicum during growth on lactate. Enzyme Microbiol Technol 17: 260-267
5. Cocaign-Bousquet M, Guyonvarch A, Lindley ND (1996) Growth-rate dependent modulation of carbon flux through central metabolism and the kinetic consequences for glucose-limited chemostat cultures of Corynebacterium glutamicum. Appl Environ Microbiol 62: 429-436
6. Cremer J, Eggeling L, Sahm H (1990) Cloning the dapA dapB cluster of the lysine-secreting bacterium Corynebacterium glutamicum. Mol Gen Genet 220: 478-480
7. Cremer J, Eggeling L, Sahm H (1991) Control of the lysine biosynthetic sequence in Corynebacterium glutamicum as analyzed by overexpression of the individual corresponding genes. Appl Environ Microbiol 57: 1746-1752
8. Eggeling L, Oberle S, Sahm H (1998) Improved L-lysine yield with Corynebacterium glutamicum: Use of dapA resulting in increased flux combined with growth limitation. Appl Microbiol Biotechnol 49: 24-30
9. Eggeling L, Sahm H (1999) Amino acid production: principles of metabolic engineering. In: Papoutsakis ET, Lee HF (eds) Metabolic engineering. Dekker, New York Basel (in press)
10. Eggeling L, Sahm H, Graaf AA de (1996) Quantifying and directing metabolite flux: application to amino acid overproduction. Adv Biochem Eng Biotechnol 54: 1-30
11. Eikmanns BJ, Follettie MT, Griot MU, Sinskey AJ (1989) The phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning nucleotide sequence and expression. Mol Gen Genet 218: 330-339
12. Erdmann A, Weil B, Krämer R (1993) Lysine secretion by wild-type Corynebacterium glutamicum triggered by dipeptide uptake. J Gen Microbiol 139: 3115-3122
13. Follettie MT, Peoples OP, Agoropoulou C, Sinskey AJ (1993) Gene structure and expression of the Corynebacterium flavum N13 ask-asd operon. J Bacteriol 175: 4096-4103
14. Gutmann M, Hoischen C, Krämer R (1992) Carrier-mediated glutamate secretion by Corynebacterium glutamicum under biotin limitation. Biochim Biophys Acta 1112: 115-123
15. Hoischen C, Krämer R (1989) Evidence for an efflux carrier system involved in the secretion of glutamate by Corynebacterium glutamicum. Arch Microbiol 151: 342-347
16. Jäger W, Peters-Wendisch PG, Kalinowski J, Pühler A (1996) A Corynebacterium glutamicum gene encoding a two-domain protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins Arch Microbiol 166: 76-82
17. Jakoby M, Tesch M, Sahm H, Krämer R, Burkowski A (1997) Isolation of the Corynebacterium glutamicum glnA gene encoding glutamine synthetase I. FEMS Microbiol Lett 154: 81-88
18. Jetten MSM, Sinskey AJ (1995) Recent advances in the physiology and genetics of amino acid-producing bacteria. Crit Rev Biotechnol 15: 73-103
19. Jetten MSM, Pitoc GA, Follettie MT, Sinskey AJ (1994) Regulation of phospho(enol)-pyruvate-and oxaloacetate-converting enzymes in Corynebacterium glutamicum. Appl Microbiol Biotechnol 41: 47-52
20. Jetten MSM, Follettie MT, Sinskey AJ (1995) Effect of different levels of aspartokinase on the lysine production by Corynebacterium lactofermentum. Appl Microbiol Biotechnol 41: 76-82
21. Kalinowski J, Bachmann B, Thierbach G, Pühler A (1990) Aspartokinase genes lysCα and lysCβ overlap and are adjacent to the aspartate semialdehyde dehydrogenase gene asd in Corynebacterium glutamicum. Mol Gen Genet 224: 317-324
22. Kalinowski J, Cremer J, Bachmann B, Eggeling L, Sahm H, Pühler A (1991) Genetic and biochemical analysis of the aspartokinase from Corynebacterium glutamicum. Mol Microbiol 5: 1197-1204
23. Kawahara Y, Yoshihara Y, Ikeda, Yoshii H, Hirose Y (1990) Stimulatory effect of glycine betaine on L-lysine fermentation. Appl Microbiol Biotechnol 34: 87-90
24. Kawahara Y, Takahasi-Fuke K, Shimizu E, Nakamatsu T, Nakamori S (1997) Relationship between the glutamate production and activity of 2-oxoglutarate dehydrogenase in Brevibacterium lactofermentum. Biosci Biotechnol Biochem 61: 1109-1112
25. Kimura E, Abe C, Kawahara Y, Nakamatsu T (1996) Molecular cloning of a novel gene, dtsR, which rescues the detergent sensitivity of a mutant derived from Brevibacterium lactofermentum. Biosci Biotechnol Biochem 60: 565-1570
26. Kimura E, Abe C, Kawahara Y, Nakamatsu T, Tokuda H (1997) A dtsR gene-disrupted mutant of Brevibacterium lactofermentum requires fatty acids for growth and efficiently produces L-glutamate in the presence of an excess of biotin. Biochem Biophys Res Commun 234: 157-161
27. Kircher M (1998) Amino acids as feed additives. Mag Soc Ind Microbiol 48: 4-11
28. Kiss RD, Stephanopoulos G (1991) Metabolic activity control of the L-lysine fermentation by restrained growth fed-batch strategies. Biotechnol Prog 7: 501-509
29. Krämer R (1994) Secretion of amino acids by bacteria: physiology and mechanism. FEMS Microbiol Rev 13: 75-79
30. Liebl W, Ehrmann M, Ludwig W, Schleifer KH (1991) Transfer of Brevibacterium divaricatum DSM 20297 Brevibacterium flavum DSM 20412 and DSM 1412 and Corynebacterium lilium DSM 20137 to Corynebacterium glutamicum and their distinction by rRNA gene restriction patterns. Int J Syst Bacteriol 41: 225-260
31. Malumbres M, Mateos L, Martin JF (1995) Microorganisms for amino acid production: Escherichia coli and corynebacteria. In: Hui YH, Khachtourians GG (eds) Food biotechnology. Verlag Chemie, Weinheim New York, pp 423-469
32. Marx A, Graaf AA de, Wiechert W, Eggeling L, Sahm H (1996) Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by NMR spectroscopy combined with metabolite balancing. Biotechnol Bioeng 49: 111-129
33. Marx A, Striegel K, Graaf AA de, Sahm H, Eggeling L (1997) Response of the central metabolism of Corynebacterium glutamicum to different flux burdens. Biotechnol Bioeng 6: 168-180
34. Marx A, Eikmanns BJ, Sahm H, Graaf AA de, Eggeling L (1999) Response of the central metabolism of Corynebacterium glutamicum to the use of an NADH-dependent glutamate dehydrogenase. Metabol Eng 1: 35-48
35. O'Regan M, Thierbach G, Bachmann B, Villeval D, Lepage P, Viret F, Lemoine Y (1989) Cloning and nucleotide sequence of the phosphoenolpyruvate carboxylase-coding gene of Corynebacterium glutamicum ATCC13032. Gene 77: 237-251
36. Patek M, Bilic M, Krumbach K, Eikmanns B, Sahm H, Eggeling L (1997) Isolation and transcriptional analysis of the dapB-orf2-dapA-orf4 operon of Corynebacterium glutamicum encoding two enzymes involved in L-lysine synthesis. Biotechnol Lett 19: 1113-1117
37. Peters-Wendisch P, Eikmanns BJ, Thierbach G, Bachmann B, Sahm H (1993) Phosphoenolpyruvate carboxylase in Corynebacterium glutamicum is dispensible for growth and lysine production. FEMS Microbiol Lett 112: 269-274
38. Peters-Wendisch PG, Wendisch VF, Graaf AA de, Eikmanns BJ, Sahm H (1996) C3-carboxylation as an anaplerotic reaction in phosphoenolpyruvate carboxylase-deficient Corynebacterium glutamicum. Arch Microbiol 165: 387-396
39. Peters-Wendisch PG, Wendisch VF, Paul S, Eikmanns BJ, Sahm H (1997) Pyruvate carboxylase as an anaplerotic enzyme in Corynebacterium glutamicum. Microbiology 143: 1095-1103
40. Peters-Wendisch P, Kreutzer C, Kalinowski J, Patek M, Sahm H, Eikmanns BJ (1998) Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene. Microbiology 134: 1095-1103
41. Pisabarro A, Malumbres M, Mateos LM, Oguiza JA, Martin JF (1993) A cluster of three genes (dapA, orf2, and dapB) of Brevibacterium lactofermentum encodes dihydrodipicolinate synthase, dihydrodipicolinate reductase, and a third polypeptide of unknown function. J Bacteriol 175: 2743-2749
42. Schrumpf B, Schwarzer A, Kalinowski J, Pühler A, Eggeling L, Sahm H (1991) A functionally split pathway for lysine synthesis in Corynebacterium glutamicum. J Bacteriol 173: 4510-4516
43. Schwinde J (1995) PhD thesis, University of Düsseldorf, Germany
44. Shiio I, Ujigawa-Takeda K (1980) Presence and regulation of α-ketoglutarate dehydrogenase complex in a glutamate-producing bacterium Brevibacterium flavum. Agric Biol Chem 44: 1897-1904
45. Siewe RM, Weil B, Burkovski A, Eikmanns BJ, Eikmanns M, Krämer R (1996) Functional and genetic characterization of the (methyl)ammonium uptake carrier system of Corynebacterium glutamicum. J Biol Chem 271: 5398-5403
46. 1H-NMR spectroscopy. Eur J Biochem 213: 1325-1331
47. 15N.NMR. Appl Environ Microbiol 65: 1099-1109
48. Tosaka O, Morioka H, Takinami K (1979) The role of biotin-dependent pyruvate carboxylase in L-lysine production. Agric Biol Chem 43: 1513-1519
49. Usuda Y, Tujimoto N, Abe C, Asakura Y, Kimura E, Kawahara Y, Kurahashi O, Matsui H (1996) Molecular cloning of the Corynebacterium glutamicum (Brevibacterium lactofermentum AJ12036) odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase. Microbiology 142: 3347-3354
50. Vertès AA, Asai Y, Inui M, Kobayashi M, Kurusu Y, Yukawa H (1994) Transposon mutagenesis of coryneform bacteria. Mol Gen Genet 245: 397-405
51. Vrljic M, Sahm H, Eggeling L (1996) A new type of transporter with a new type of cellular function: L-lysine export in Corynebacterium glutamicum Mol Microbiol 22: 815-826
52. Vrljic M, Bellmann A, Garg J, Wachi S, Freudl R, Malecki MJ, Sahm H, Kozina VJ, Eggeling L, Saier MH Jr (1999) The LysE superfamily: topology of the lysine exporter LysE of Corynebacterium glutamicum, a paradyme for a novel superfamily of transmembrane solute translocators. J Mol Microbiol Biotechnol (in press)
53. Wehrmann A, Eggeling L, Sahm H (1994) Analysis of different DNA-fragments of Corynebacterium glutamicum complementing dapE of Escherichia coli. Microbiology 140: 3349-3356
54. Wehrmann A, Phillip B, Sahm H, Eggeling L (1998) Different modes of diaminopimelate synthesis and their role in cell wall integrity: a study with Corynebacterium glutamicum. J Bacteriol 177: 3159-3165
55. Wiechert W, Graaf AA de (1997) Bidirectional reaction steps in metabolic engineering: modeling and simulation of carbon isotope labeling experiments. Biotechnol Bioeng 55: 101-117
56. Wohlleben W, Muth G, Kalinowski J (1993) Genetic engineering of gram positive bacteria. In: Pühler (ed) A genetic engineering of microorganisms. VCH, Weinheim New York Basel