2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells

Molecular Pharmacology

Volumn 66, Issue 6, 2004, Pages 1662-1670

  Boverhof, Darrell R ^a,c   Tam, Elaine ^a   Harney, Allison S ^a   Crawford, Robert B ^b,c   Kaminski, Norbert E ^b,c   Zacharewski, Timothy R ^a,c  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3,3',4,4',5 PENTACHLOROBIPHENYL; AROMATIC HYDROCARBON RECEPTOR; BETA NAPHTHOFLAVONE; CARBAZOLE DERIVATIVE; CYCLOHEXIMIDE; CYTOCHROME P450 1A1; DIOXIN; INDOLO[3,2 B]CARBAZOLE; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CYTOKINE PRODUCTION; DNA MICROARRAY; DNA RESPONSIVE ELEMENT; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOTOXICITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; DNA PRIMERS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; LYMPHOMA, B-CELL; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TETRACHLORODIBENZODIOXIN; TRANS-ACTIVATORS;

EID: 9444236827     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.002915     Document Type: Article

References (40)

1. Alexander WS (2002) Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol 2:410-416.
2. Bishop GA and Haughton G (1986) Induced differentiation of a transformed clone of Ly-1+ B cells by clonal T cells and antigen. Proc Natl Acad Sci USA 83:7410-7414.
3. Bunger MK, Moran SM, Glover E, Thomae TL, Lahvis GP, Lin BC, and Bradfield CA (2003) Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem 278:17767-17774.
4. Chen XP, Losman JA, and Rothman P (2000) SOCS proteins, regulators of intracellular signaling. Immunity 13:287-290.
5. Denison MS and Heath-Pagliuso S (1998) The Ah receptor: a regulator of the biochemical and lexicological actions of structurally diverse chemicals. Bull Environ Contam Toxicol 61:557-568.
6. Denison MS and Nagy SR (2003) Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43:309-334.
7. Denison MS, Pandini A, Nagy SR, Baldwin EP, and Bonati L (2002) Ligand binding and activation of the Ah receptor. Chem Biol Interact 141:3-24.
8. Dey BR, Spence SL, Nissley P, and Furlanetto RW (1998) Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. J Biol Chem 273:24095-24101.
9. Dooley RK and Holsapple MP (1988) Elucidation of cellular targets responsible for tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of antibody responses: I. The role of the B lymphocyte. Immunopharmacology 16:167-180.
10. Eltom SE, Zhang L, and Jefcoate CR (1999) Regulation of cytochrome P-450 (CYP) 1B1 in mouse Hepa-1 variant cell lines: a possible role for aryl hydrocarbon receptor nuclear translocate (ARNT) as a suppressor of CYP1B1 gene expression. Mol Pharmacol 55:594-604.
11. Eyckerman S, Verhee A, der Heyden JV, Lemmens I, Ostade XV, Vandekerckhove J, and Tavernier J (2001) Design and application of a cytokine-receptor-based interaction trap. Nat Cell Biol 3:1114-1119.
12. Fielden MR, Halgren RG, Dere E, and Zacharewski TR (2002) GP3: GenePix post-processing program for automated analysis of raw microarray data. Bioinformatics 18:771-773.
13. Greenhalgh CJ and Hilton DJ (2001) Negative regulation of cytokine signaling. J Leukoc Biol 70:348-356.
14. Greenhalgh CJ, Metcalf D, Thaus AL, Corbin JE, Uren R, Morgan PO, Fabri LJ, Zhang JG, Martin HM, Willson TA, et al. (2002) Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling. J Biol Chem 277:40181-40184.
15. Hankinson O (1995) The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35:307-340.
16. Hestermann EV, Stegeman JJ, and Hahn ME (2000) Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency. Toxicol Appl Pharmacol 168:160-172.
17. Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K, Nakajima K, Pyun KH, and Kishimoto T (1985) Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci USA 82:5490-5494.
18. Karras JG and Holsapple MP (1994) Mechanisms of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)-induced disruption of B-lymphocyte signaling in the mouse: a current perspective. Exp Clin Immunogenet 11:110-118.
19. Krebs DL and Hilton DJ (2000) SOCS: physiological suppressors of cytokine signaling. J Cell Sci 113:2813-2819.
20. La Flamme AC and Pearce EJ (1999) The absence of IL-6 does not affect Th2 cell development in vivo, but does lead to impaired proliferation, IL-2 receptor expression and B cell responses. J Immunol 162:5829-5837.
21. Leung KC, Doyle N, Ballesteros M, Sjogren K, Watts CK, Low TH, Leong GM, Ross RJ, and Ho KK (2003) Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Proc Natl Acad Sci USA 100:1016-1021.
22. Ma Q, Renzelli AJ, Baldwin KT, and Antonini JM (2000) Superinduction of CYP1A1 gene expression. Regulation of 2,3,7, 8-tetrachlorodibenzo-p-dioxin- induced degradation of Ah receptor by cycloheximide. J Biol Chem 275:12676-12683.
23. Martinez JM, Afshari CA, Bushel PR, Masuda A, Takahashi T, and Walker NJ (2002) Differential toxicogenomic responses to 2,3,7,8-tetrachlorodibenzo-p- dioxin in malignant and nonmalignant human airway epithelial cells. Toxicol Sci 69: 409-423.
24. Metcalf D, Greenhalgh CJ, Viney E, Willson TA, Starr R, Nicola NA, Hilton DJ, and Alexander WS (2000) Gigantism in mice lacking suppressor of cytokine signalling-2. Nature (Lond) 405:1069-1073.
25. Miraura J and Fujii-Kuriyama Y (2003) Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 1619:263-268.
26. Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, and Kishimoto T (1997) Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem Biophys Res Commun 237:79-83.
27. Nicholsou SE, Willson TA, Farley A, Starr R, Zhang JG, Baca M, Alexander WS, Metcalf D, Hilton DJ, and Nicola NA (1999) Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO (Eur Mol Biol Organ) J 18:375-385.
28. Poland A and Knutson JC (1982) 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of tosicity. Annu Rev Pharmacol Toxicol 22:517-554.
29. Rozen S and Skaletsky HJ (2000) Primer3 on the WWW for general users and for biologist programmers, in Bioinformatics Methods and Protocols: Methods in Molecular Biology (Krawetz S MS ed) pp 365-386, Humana Press, Totowa, NJ.
30. Schmidt JV and Bradfield CA (1996) Ah receptor signaling pathways. Annu Rev Cell Dev Biol 12:55-89.
31. Schultheis B, Carapeti-Marootian M, Hochhaus A, Weisser A, Goldman JM, and Melo JV (2002) Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism. Blood 99:1766-1775.
32. Shehin SE, Stephenson RO, and Greenlee WF (2000) Transcriptional regulation of the human CYP1B1 gene. Evidence for involvement of an aryl hydrocarbon receptor response element in constitutive expression. J Biol Chem 275:6770-6776.
33. Siewert E, Muller-Esterl W, Starr R, Heinrich PC, and Schaper F (1999) Different protein turnover of interleukin-6-type cytokine signalling components. Eur J Biochem 265:251-257.
34. Sulentic CE, Holsapple MP, and Kaminski NE (1998) Aryl hydrocarbon receptor-dependent suppression by 2,3,7, 8-tetrachlorodibenzo-p-dioxin of IgM secretion in activated B cells. Mol Pharmacol 53:623-629.
35. Sulentic CE, Holsapple MP, and Kaminski NE (2000) Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p- dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway. J Pharmacol Exp Ther 295:705-716.
36. Turnley AM, Faux CH, Rietze RL, Coonan JR, and Bartlett PF (2002) Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling. Nat Neurosci 5:1155-1162.
37. Vorderstrasse BA, Steppan LB, Silverstone AE, and Kerkvliet NI (2001) Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression. Toxicol Appl Pharmacol 171:157-164.
38. Williams CE, Crawford RB, Holsapple MP, and Kaminski NE (1996) Identification of functional aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator in murine splenocytes. Biochem Pharmacol 52:771-780.
39. Yuen T, Wurmbach E, Pfeffer RL, Ebersole BJ, and Sealfou SC (2002) Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays. Nucleic Acids Res 30:e48.
40. Zhang JG, Parley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, et al. (1999) The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci USA 98:2071-2076.