A modeling approach to the impact of HIV mutations on the immune system

Computers in Biology and Medicine

Volumn 35, Issue 1, 2005, Pages 1-24

  Vergu, Elisabeta ^a,b   Mallet, Alain ^a   Golmard, Jean Louis ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSERM   (France)

Author keywords

HIV dynamics; Immune response; Immunological recognition efficacy index; Point process; Steady state analysis; Viral mutants

Indexed keywords

DISEASE CONTROL; LARGE SCALE SYSTEMS; MATHEMATICAL MODELS; VIRUSES;

DYNAMICAL SYSTEMS; IMMUNOLOGICAL RECOGNITION EFFICACY (IRE); MUTATION;

IMMUNOLOGY;

ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOLOGY; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MODEL; PRIORITY JOURNAL; SIMULATION; STEADY STATE; STOCHASTIC MODEL; VIRUS MUTANT; VIRUS MUTATION;

CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; HIV; HIV INFECTIONS; HUMANS; MODELS, IMMUNOLOGICAL; MUTATION; NONLINEAR DYNAMICS; STOCHASTIC PROCESSES; VARIATION (GENETICS); VIRAL LOAD;

EID: 9344228985     PISSN: 00104825     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compbiomed.2004.01.001     Document Type: Article

References (25)

1. Ho D.D., Neumann A.U., Perelson A.S., Chen W., Leonard J.M., Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature. 373:1995;123-126
2. Kirschner D., Webb G.F., Cloyd M. Model of HIV-1 disease progression based on virus-induced lymph node homing and homing-induced apoptosis of CD4+ lymphocytes. JAIDS. 24:2000;352-362
3. Krakauer D.C., Nowak M. T-cell induced pathogenesis in HIV. bystander effects and latent infection Proc. R. Soc. Lond. B Biol. Sci. 266:1999;1069-1075
4. Nowak M.A., May R.M., Anderson R.M. The evolutionary dynamics of HIV-1 quasispecies and the development of immunodeficiency disease. AIDS. 4:1990;1095-1103
5. Nowak M.A., May R.M. Mathematical biology of HIV infections. antigenic variation and diversity threshold Math. Biosci. 106:1991;1-21
6. Wodarz D., Klenerman P., Nowak M.A. Dynamics of cytotoxic T-lymphocyte exhaustion. Proc. R. Soc. Lond. B Biol. Sci. 265:1998;191-203
7. Wodarz D., Lloyd A.L., Jansen V.A., Nowak M.A. Dynamics of macrophage and T cell infection by HIV. J. Theor. Biol. 196:1999;101-113
8. Nowak M.A., May R.M. Virus Dynamics: Mathematical Principles of Immunology and Virology. 2000;Oxford University Press, Oxford
9. Wu H., Kuritzkes D.R., McClernon D.R., Kessler H., Connick E., Landay A., Spear G., Heath-Chiozzi M., Rousseau F., Fox L., Spritzler J., Leonard J.M., Lederman M.M. Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy. relationships to host factors, cellular restoration and virological endpoints J. Infect. Dis. 179:1999;799-807
10. Visco-Comandini U., Aleman S., Yun Z., Sonnerborg A. Human immunodeficiency virus type 1 variability and long-term non-progression. J. Biol. Regul. Homeost. Agents. 15:2001;299-303
11. Mansky L.M., Temin H.M. Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase. J. Virol. 69:1995;5087-5094
12. Mansky L.M. Forward mutation rate of human immunodeficiency virus type 1 in a T lymphoid cell line. AIDS Res. Hum. Retroviruses. 12:1996;307-314
13. Nowak M.A., May R.M., Philips R.E., Rowland-Jones S., Lalloo D.G., McAdam S., Klenerman P., Koppe B., Sigmund K., Bangham C.R., et al. Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature. 375:1995;6532-6534
14. Nowak M.A., Bangham C.R.M. Population dynamics of immune responses to persistent viruses. Science. 272:1996;74-79
15. Perelson A.S., Kirschner D.E., De Boer R. Dynamics of HIV infection of CD4+ T cells. Math. Biosci. 114:1993;81-125
16. Callaway D.S., Perelson A.S. HIV-1 Infection and low steady state viral loads. Bull. Math. Biol. 64:2002;29-64
17. Perelson A.S., Neumann A.U., Markowitz M., Leonard J.M., Ho D.D. HIV-1 dynamics in vivo. virion clearance rate, infected cell life-span, and viral generation time Science. 271:1996;1582-1586
18. Mohri H., Bonhoeffer S., Monard S., Perelson A.S., Ho D.D. Rapid turnover of T lymphocytes in SIV-infected rhesus macaques. Science. 279:1998;1223-1227
19. Ferguson N.M., de Wolf F., Ghani A.C., Fraser C., Donnelly C.A., Reiss P., Lange J.M.A., Danner S.A., Garnett G.P., Goudsmit J., Anderson R.M. Antigen-driven CD4+ T cell and HIV-1 dynamics. residual viral replication under highly active antiretroviral therapy Proc. Natl. Acad. Sci. USA. 96:1999;15167-15172
20. Mittler J.E., Markowitz M., Ho D.D., Perelson A.S. Improved estimates for HIV-1 clearance rate and intracellular delay. AIDS. 13:1999;1415-1417
21. Ramratnam B., Bonhoeffer S., Binley J., Hurley A., Zhang L., Mittler J.E., Markowitz M., Moore J.P., Perelson A.S., Ho D.D. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet. 354:1999;1782-1785
22. Ogg G.S., Jin X., Bonhoeffer S., Moss P., Nowak M.A., Monard S., Segal J.P., Cao Y., Rowland-Jones D.L., Hurley A., Markowitz M., Ho D.D., McMichael A.J., Nixon D.F. Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy. J. Virol. 73:1999;797-800
23. Haase A.T., Henry K., Zupancic M., Sedgewick G., Faust R.A., Melroe H., Cavert W., Gebhard K., Staskus K., Zhang Z.Q., Dailey P.J., Balfour H.H. Jr., Erice A., Perelson A.S. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science. 274:1996;985-989
24. Willems J.L. Stability Theory of Dynamical Systems. 1970;Nelson, London
25. Verhulst F. Nonlinear Differential Equations and Dynamical Systems. 1990;Springer, London