Globoidnan A: A lignan from Eucalyptus globoidea inhibits HIV integrase

Phytochemistry

Volumn 65, Issue 24, 2004, Pages 3255-3259

  Ovenden, Simon P B ^a   Yu, Jin ^a   San Wan, Soo ^a   Sberna, Gian ^a   Murray Tait, R ^a   Rhodes, David ^b   Cox, Susan ^b   Coates, Jonathan ^b   Walsh, Neville G ^c   Meurer Grimes, Barbara M ^a  

^a Richmond Vic 3121 Australia   (Australia)

^b Amrad Corporation Limited   (Australia)

^c ROYAL BOTANIC GARDENS VICTORIA   (Australia)

Author keywords

3 (3,4 dihydroxyphenyl) lactic acid; 4 (3,4 Dihydroxyphenyl) 6,7 dihydroxy 2 naphthalene carboxylic acid; Cyclolignan; Eucalyptus globoidea; Globoidnan A; HIV integrase; Lignan; Phenylpropanoid

Indexed keywords

EUCALYPTUS EXTRACT; GLOBOIDAN A; INTEGRASE; INTEGRASE INHIBITOR; LIGNAN; METHANOL; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; BUD; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG PURIFICATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EUCALYPTUS; EUCALYPTUS GLOBOIDEA; FRACTIONATION; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT;

EUCALYPTUS; FLOWERS; HIV INTEGRASE INHIBITORS; HIV-1; LIGNANS; MOLECULAR STRUCTURE;

EUCALYPTUS; EUCALYPTUS GLOBOIDEA;

EID: 9244252539     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2004.10.006     Document Type: Article

References (19)

1. T.K. Au, T.L. Lam, T.B. Ng, W.P. Fong, and D.C.C. Wan A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs Life Sci. 68 2001 1687 1694
2. S.A. Chow In vitro assays for activities of retroviral integrase Methods 12 1997 306 317
3. F. Cullmann, A. Schmidt, F. Schuld, M.L. Trennheuser, and H. Becker Lignans from the liverworts Lepidozia incurvata, Chiloscyphus polyanthos and Jungermannia exsertifolia ssp. cordifolia Phytochemistry 52 1999 1647 1650
4. R. Dupont, L. Jeanson, J.-F. Mouscadet, and P. Cotelle Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives Bioorg. Med. Chem. Lett. 11 2001 3175 3178
5. K.B. Herath, H. Jayasuriya, G.F. Bills, J.D. Polishook, A.W. Dombrowski, Z. Guan, P.J. Felock, D.J. Hazuda, and S.B. Singh Isolation, structure, absolute stereochemistry, and HIV-1 integrase inhibitory activity of integrasone, a novel fungal polyketide J. Nat. Prod. 67 2004 872 874
6. Y. Hwang, D. Rhodes, and F. Bushman Rapid microtitre assays for poxvirus topoisomerase, mammalian type IB topoisomerase and HIV-1 integrase: application to inhibitor isolation Nucl. Acid Res. 28 2000 4884 4892
7. H.J. Kim, E.R. Woo, C.G. Shin, and H. Park A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase J. Nat. Prod. 61 1998 145 148
8. Z. Lin, N. Neamati, H. Zhao, Y. Kiryu, J.A. Turpin, C. Aberham, K. Strebel, K. Kohn, M. Witvrouw, C. Pannecouque, Z. Debyser, E. De Clercq, W.G. Rice, Y. Pommier, and T.R. Burke Jr. Chicoric acid analogues as HIV-1 integrase inhibitors J. Med. Chem. 42 1999 1401 1414
9. Y.Q. Long, X.H. Jiang, R. Dayam, T. Sanchez, R. Shoemaker, S. Sei, and N. Neamati Rotational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implications for binding to two metal ions on the active site of integrase J. Med. Chem. 47 2004 2561 2573
10. N. Neamati, H. Hong, A. Mazumder, S. Wang, S. Sunder, M.C. Nicklaus, G.W.A. Milne, B. Proksa, and Y. Pommier Despides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching J. Med. Chem. 40 1997 942 951
11. N. Neamati Patented small molecules inhibitors of HIV-1 integrase: a 10-year saga Expert Opin. Ther. Patents 12 2002 709 724
12. G.C.G. Pais, X. Zhang, C. Marchand, N. Neamati, K. Cowansage, E.S. Svarovskaia, V.K. Pathak, Y. Tang, M. Nicklaus, Y. Pommier, and T.R. Burke Jr. Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors J. Med. Chem. 45 2002 3184 3194
13. R.J. Pomerantz, and D.L. Horn Twenty years of therapy for HIV-1 infection Nat. Med. 9 2003 867 873
14. M. Rischmann, R. Mues, H. Geiger, H.J. Laas, and T. Eicher Isolation and synthesis of 6,7-dihydroxy-4-(3,4-dihydroxyphenyl)naphthalene-2-carboxylic acid from Pellia epiphylla Phytochemistry 28 1989 867 869
15. S.B. Singh, D.L. Zink, M.A. Goetz, A.W. Dombrowski, J.D. Polishook, and D.J. Hazuda Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase Tetrahedron Lett. 39 1998 2243 2246
16. S.B. Singh, D.L. Zink, G.F. Bills, F. Pelaez, A. Teran, J. Collado, K.C. Silverman, R.B. Lingham, P. Felock, and D.J. Hazuda Discovery, structure and HIV-1 integrase inhibitory activities of integracins, novel dimeric alkyl aromatics from Cytonaema sp Tetrahedron Lett. 43 2002 1617 1620
17. S.B. Singh, D.L. Zink, D.S. Quamina, F. Pelaez, A. Teran, P. Felock, and D.J. Hazuda Integrastatins: structure and HIV-1 integrase inhibitory activities of two novel racemic tetracyclic aromatic heterocycles produced by two fungal species Tetrahedron Lett. 43 2002 2351 2354
18. H. Tazaki, K.P. Adam, and H. Becker Five lignan derivatives from in vitro cultures of the liverwort Jamesoniella autumnalis Phytochemistry 40 1995 1671 1675
19. World Health Organisation, 2004. "AIDS and Sexually Transmitted Diseases: World AIDS Campaign 2003 Fact Sheets". Accessed 30/06/2004. Available from: 〈 http://www.emro.who.int/ASD/wac2003-FactSheet-Statistics. htm 〉