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Volumn 52, Issue 6, 2004, Pages 389-393

Molecular mechanisms of increased glucose production: Identifying potential therapeutic targets

Author keywords

Endogenous glucose production; Gluconeogenesis; Glycogenolysis

Indexed keywords

11BETA HYDROXYDEHYDROGENASE 1 INHIBITOR; ADENOSINE A2B RECEPTOR; ADENOSINE A2B RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR BLOCKING AGENT; BVT 3498; C ENHANCER BINDING PROTEIN BETA INHIBITOR; CARNITINE PALMITOYLTRANSFERASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT ACTIVITY MODULATOR; DICHLOROACETIC ACID; ENZYME INHIBITOR; FRUCTOSE BISPHOSPHATASE; GENE EXPRESSION MODULATOR; GLUCAGON; GLUCAGON RECEPTOR; GLUCAGON RECEPTOR ANTAGONIST; GLUCOCORTICOID RECEPTOR ANTAGONIST; GLUCOSE 6 PHOSPHATASE; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE KINASE 3; HORMONE; HORMONE RECEPTOR AFFECTING AGENT; LIVER X RECEPTOR; NUCLEOTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA AGONIST; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 9244241518     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.1136/jim-52-06-33     Document Type: Conference Paper
Times cited : (9)

References (29)
  • 1
    • 0035656128 scopus 로고    scopus 로고
    • Plasma glucose levels throughout the day and HbA(1c) interrelationships in type 2 diabetes: Implications for treatment: And monitoring of metabolic control
    • Bonora E, Calcaterra F, Lombardi S, et al. Plasma glucose levels throughout the day and HbA(1c) interrelationships in type 2 diabetes: implications for treatment: and monitoring of metabolic control. Diabetes Care 2001;24:2023-9.
    • (2001) Diabetes Care , vol.24 , pp. 2023-2029
    • Bonora, E.1    Calcaterra, F.2    Lombardi, S.3
  • 2
    • 0030851974 scopus 로고    scopus 로고
    • Renal glucose production and utilization: New aspects in humans
    • Stumvoll M, Meyer C, Mitrakou A, et al. Renal glucose production and utilization: new aspects in humans. Diabetologia 1997;40:749-57.
    • (1997) Diabetologia , vol.40 , pp. 749-757
    • Stumvoll, M.1    Meyer, C.2    Mitrakou, A.3
  • 3
    • 0032520870 scopus 로고    scopus 로고
    • Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans
    • Petersen KF, Laurent D, Rothman DL, et al. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest 1998;101:1203-9.
    • (1998) J Clin Invest , vol.101 , pp. 1203-1209
    • Petersen, K.F.1    Laurent, D.2    Rothman, D.L.3
  • 4
    • 9244220626 scopus 로고    scopus 로고
    • Gluconeogenesis and glycogenolysis in health and diabetes
    • Boden G. Gluconeogenesis and glycogenolysis in health and diabetes. J Invest Med 2004;52:311-313.
    • (2004) J Invest Med , vol.52 , pp. 311-313
    • Boden, G.1
  • 5
    • 0025630056 scopus 로고
    • Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism
    • Consoli A, Nurjhan N, Reilly JJ Jr, et al. Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism. J Clin Invest 1990;86:2038-45.
    • (1990) J Clin Invest , vol.86 , pp. 2038-2045
    • Consoli, A.1    Nurjhan, N.2    Reilly Jr., J.J.3
  • 6
    • 0026646940 scopus 로고
    • Lipolysis and gluconeogenesis from glycerol are increased in patients with noninsulin-dependent diabetes mellitus
    • Puhakainen I, Koivisto VA, Yki-Jarvinen H. Lipolysis and gluconeogenesis from glycerol are increased in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1992;75:789-94.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 789-794
    • Puhakainen, I.1    Koivisto, V.A.2    Yki-Jarvinen, H.3
  • 7
    • 0026518355 scopus 로고
    • Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus
    • Nurjhan N, Consoli A, Gerich J. Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus. J Clin Invest 1992;89:169-75.
    • (1992) J Clin Invest , vol.89 , pp. 169-175
    • Nurjhan, N.1    Consoli, A.2    Gerich, J.3
  • 8
    • 0026006690 scopus 로고
    • Evolution of insulin resistance in New Zealand obese mice
    • Veroni MC, Proietto J, Larkins RG. Evolution of insulin resistance in New Zealand obese mice. Diabetes 1991;40:1480-7.
    • (1991) Diabetes , vol.40 , pp. 1480-1487
    • Veroni, M.C.1    Proietto, J.2    Larkins, R.G.3
  • 9
    • 0028856933 scopus 로고
    • The biochemical basis of increased hepatic glucose production in a mouse model of type 2 (non-insulin-dependent) diabetes mellitus
    • Andrikopoulos S, Proietto J. The biochemical basis of increased hepatic glucose production in a mouse model of type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1995;38:1389-96.
    • (1995) Diabetologia , vol.38 , pp. 1389-1396
    • Andrikopoulos, S.1    Proietto, J.2
  • 10
    • 0027489148 scopus 로고
    • Impaired regulation of hepatic fructose-1,6-bisphosphatase in the New Zealand obese mouse model of NIDDM
    • Andrikopoulos S, Rosella G, Gaskin E, et al. Impaired regulation of hepatic fructose-1,6-bisphosphatase in the New Zealand obese mouse model of NIDDM. Diabetes 1993;42:1731-6.
    • (1993) Diabetes , vol.42 , pp. 1731-1736
    • Andrikopoulos, S.1    Rosella, G.2    Gaskin, E.3
  • 11
    • 0029915937 scopus 로고    scopus 로고
    • Impaired regulation of hepatic fructose-1,6-biphosphatase in the New Zealand obese mouse: An acquired defect
    • Andrikopoulos S, Rosella G, Kaczmarczyk SJ, et al. Impaired regulation of hepatic fructose-1,6-biphosphatase in the New Zealand obese mouse: an acquired defect. Metabolism 1996;45:622-6.
    • (1996) Metabolism , vol.45 , pp. 622-626
    • Andrikopoulos, S.1    Rosella, G.2    Kaczmarczyk, S.J.3
  • 13
    • 0037247641 scopus 로고    scopus 로고
    • Prospects for pharmacologic inhibition of hepatic glucose production
    • Kurukulasuriya R, Link JT, Madar DJ, et al. Prospects for pharmacologic inhibition of hepatic glucose production. Curr Med Chem 2003;10:99-121.
    • (2003) Curr Med Chem , vol.10 , pp. 99-121
    • Kurukulasuriya, R.1    Link, J.T.2    Madar, D.J.3
  • 14
    • 0032539696 scopus 로고    scopus 로고
    • Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo
    • Martin WH, Hoover DJ, Armento SJ, et al. Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo. Proc Natl Acad Sci U S A 1998;95:1776-81.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 1776-1781
    • Martin, W.H.1    Hoover, D.J.2    Armento, S.J.3
  • 15
    • 0036789185 scopus 로고    scopus 로고
    • Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats
    • Cline GW, Johnson K, Regittnig W, et al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes 2002;51:2903-10.
    • (2002) Diabetes , vol.51 , pp. 2903-2910
    • Cline, G.W.1    Johnson, K.2    Regittnig, W.3
  • 16
    • 0036273020 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
    • Martinez A, Castro A, Dorronsoro I, Alonso M. Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Med Res Rev 2002;22:373-84.
    • (2002) Med Res Rev , vol.22 , pp. 373-384
    • Martinez, A.1    Castro, A.2    Dorronsoro, I.3    Alonso, M.4
  • 17
    • 0029098648 scopus 로고
    • Impaired glucose tolerance and increased weight gain in transgenic rats overexpressing a non-insulin-responsive phosphoenolpyruvate carboxykinase gene
    • Rosella G, Zajac JD, Baker L, et al. Impaired glucose tolerance and increased weight gain in transgenic rats overexpressing a non-insulin-responsive phosphoenolpyruvate carboxykinase gene. Mol Endocrinol 1995;9:1396-404.
    • (1995) Mol Endocrinol , vol.9 , pp. 1396-1404
    • Rosella, G.1    Zajac, J.D.2    Baker, L.3
  • 18
    • 0033015491 scopus 로고    scopus 로고
    • Features of syndrome X develop in transgenic rats expressing a non-insulin responsive phosphoenolpyruvate carboxykinase gene
    • Thorburn AW, Baldwin ME, Rosella G, et al. Features of syndrome X develop in transgenic rats expressing a non-insulin responsive phosphoenolpyruvate carboxykinase gene. Diabetologia 1999;42:419-26.
    • (1999) Diabetologia , vol.42 , pp. 419-426
    • Thorburn, A.W.1    Baldwin, M.E.2    Rosella, G.3
  • 19
    • 0142125212 scopus 로고    scopus 로고
    • Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney
    • Lamont BJ, Andrikopoulos S, Funkat A, et al. Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney. Diabetologia 2003;46:1338-47.
    • (2003) Diabetologia , vol.46 , pp. 1338-1347
    • Lamont, B.J.1    Andrikopoulos, S.2    Funkat, A.3
  • 20
    • 0026063181 scopus 로고
    • Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes
    • Vincent MF, Marangos PJ, Gruber HE, Van den Berghe G. Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes. Diabetes 1991;40:1259-66.
    • (1991) Diabetes , vol.40 , pp. 1259-1266
    • Vincent, M.F.1    Marangos, P.J.2    Gruber, H.E.3    Van Den Berghe, G.4
  • 21
    • 0035155821 scopus 로고    scopus 로고
    • Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D- ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner
    • Buhl ES, Jessen N, Schmitz O, et al. Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner. Diabetes 2001;50:12-7.
    • (2001) Diabetes , vol.50 , pp. 12-17
    • Buhl, E.S.1    Jessen, N.2    Schmitz, O.3
  • 22
    • 0033458088 scopus 로고    scopus 로고
    • Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats
    • Herling AW, Burger H, Schubert G, et al. Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats. Eur J Pharmacol 1999;386:75-82.
    • (1999) Eur J Pharmacol , vol.386 , pp. 75-82
    • Herling, A.W.1    Burger, H.2    Schubert, G.3
  • 23
    • 0029760864 scopus 로고    scopus 로고
    • Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits
    • Brand CL, Jorgensen PN, Svendsen I, Holst JJ. Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits. Diabetes 1996;45:1076-83.
    • (1996) Diabetes , vol.45 , pp. 1076-1083
    • Brand, C.L.1    Jorgensen, P.N.2    Svendsen, I.3    Holst, J.J.4
  • 24
    • 0034856974 scopus 로고    scopus 로고
    • Pharmacological approaches to inhibit endogenous glucose production as a means of anti-diabetic therapy
    • McCormack JG, Westergaard N, Kristiansen M, et al. Pharmacological approaches to inhibit endogenous glucose production as a means of anti-diabetic therapy. Curr Pharm Des 2001;7:1451-74.
    • (2001) Curr Pharm Des , vol.7 , pp. 1451-1474
    • McCormack, J.G.1    Westergaard, N.2    Kristiansen, M.3
  • 25
    • 0031438356 scopus 로고    scopus 로고
    • Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice
    • Friedman JE, Sun Y, Ishizuka T, et al. Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice. J Biol Chem 1997;272:31475-81.
    • (1997) J Biol Chem , vol.272 , pp. 31475-31481
    • Friedman, J.E.1    Sun, Y.2    Ishizuka, T.3
  • 26
    • 0037449472 scopus 로고    scopus 로고
    • Functional characterization of the adenosine receptor contributing to glycogenolysis and gluconeogenesis in rat hepatocytes
    • Yasuda N, Inoue T, Horizoe T, et al. Functional characterization of the adenosine receptor contributing to glycogenolysis and gluconeogenesis in rat hepatocytes. Eur J Pharmacol 2003;459:159-66.
    • (2003) Eur J Pharmacol , vol.459 , pp. 159-166
    • Yasuda, N.1    Inoue, T.2    Horizoe, T.3
  • 27
    • 0035905833 scopus 로고    scopus 로고
    • 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: Their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor
    • Harada H, Asano O, Hoshino Y, et al. 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. J Med Chem 2001;44:170-9.
    • (2001) J Med Chem , vol.44 , pp. 170-179
    • Harada, H.1    Asano, O.2    Hoshino, Y.3
  • 28
    • 0018263913 scopus 로고
    • Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia
    • Stacpoole PW, Moore GW, Kornhauser DM. Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia. N Engl J Med 1978;298:526-30.
    • (1978) N Engl J Med , vol.298 , pp. 526-530
    • Stacpoole, P.W.1    Moore, G.W.2    Kornhauser, D.M.3
  • 29
    • 0029131453 scopus 로고
    • Antidiabetic agents: A new class of reversible carnitine palmitoyltransferase I inhibitors
    • Anderson RC, Balestra M, Bell PA, et al. Antidiabetic agents: a new class of reversible carnitine palmitoyltransferase I inhibitors. J Med Chem 1995;38:3448-50.
    • (1995) J Med Chem , vol.38 , pp. 3448-3450
    • Anderson, R.C.1    Balestra, M.2    Bell, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.