In vivo reduction of erythrocyte oxidant stress in a murine model of β-thalassemia

Haematologica

Volumn 89, Issue 11, 2004, Pages 1287-1298

  De Franceschi, Lucia ^a   Turrini, Franco ^b   Honczarenko, Marek ^c   Ayi, Kojio ^a   Rivera, Alicia ^c   Fleming, Mark D ^c   Law, Terry ^c   Mannu, Franca ^d   Kuypers, Frans A ^e   Bast, Aalt ^f   Van Der Vijgh, Wim J F ^g   Brugnara, Carlo ^c  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d Nurex Bioresearch   (Italy)

^e CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^f MAASTRICHT UNIVERSITY   (Netherlands)

^g VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Erythrocyte; K cl co transport; MonoHER; Phosphatidylserine; Vitamin E

Indexed keywords

7 MONOHYDROXYETHYLRUTOSIDE; ALPHA TOCOPHEROL; ANTIOXIDANT; BILIRUBIN; FLAVONOID; IMMUNOGLOBULIN G; LACTATE DEHYDROGENASE; PHOSPHATIDYLSERINE; POTASSIUM CHLORIDE; RUTOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA THALASSEMIA; CELL DAMAGE; CELL SURVIVAL; CIRCULATION; CONTROLLED STUDY; DEHYDRATION; ERYTHROCYTE LEVEL; ERYTHROPOIESIS; FEMALE; ION TRANSPORT; IRON BLOOD LEVEL; KILLER CELL; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARAMETER; RETICULOCYTE COUNT; UPREGULATION; VITAMIN BLOOD LEVEL;

ANIMALS; ANNEXINS; ANTIOXIDANTS; BETA-THALASSEMIA; CHLORIDES; DISEASE MODELS, ANIMAL; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; FEMALE; HYDROXYETHYLRUTOSIDE; IMMUNOGLOBULIN G; ION TRANSPORT; MALE; MICE; OXIDATIVE STRESS; POTASSIUM; VITAMIN E;

EID: 9144261634     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Orkin SH, Nathan DG. The thalassemias. In: Nathan DG, Orkin SH, Ginsburg D, Look TA, editors. Hematology of infancy and childhood. Philadelphia, PA: Saunders; 2003. p. 842-99.
2. Shinar E, Rachmilewitz EA. Oxidative denaturation of red blood cells in thalassemia. Semin Hematol 1990;27:70-82.
3. Rachmilewitz EA, Lubin BH, Shohet S. Lipid membrane oxidation in β thal major. Blood 1976;47:495-505.
4. Rouyer-Fessard P, Leroy-Viard K, Domenget C, Mrad A, Beuzard Y. Mouse beta thalassemia, a model for the membrane defects of erythrocytes in the human disease. J Biol Chem 1990;265:20247-51.
5. Advani R, Sorenson S, Shinar E, Londe W, Rachmilewitz E, Schrier SL. Characterization and comparison of the red blood cell membrane damage in severe human α and β thalassemia. Blood 1992;79:1058-63.
6. Schrier SL, Mohandas N. Globin-chain specificity of oxidation-induced changes in red blood cell membrane properties. Blood 1992; 79:1586-92.
7. Kuypers FA, Yuan J, Lewis RA, Snyder LM, Kiefer CR, Bunyaratvej A, et al. Membrane phospholipid asymmetry in human thalassemia. Blood 1998;91:3044-51.
8. Yuan J, Kannan R, Shinar E, Rachmilewitz EA, Low PS. Isolation, characterization, and immunoprecipitation studies of immune complexes from membranes of β-thalassemic erythrocytes. Blood 1992;79:3007-13.
9. Mannu F, Arese P, Cappellini MD, Fiorelli G, Cappadoro M, Giribaldi G, et al. Role of hemichrome binding to erythrocyte membrane in the generation of band-3 alterations in beta-thalassemia intermedia erythrocytes. Blood 1995;86:2014-20.
10. Zwaal RFA, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997;89:1121-32.
11. de Jong K, Larkin SK, Styles LA, Bookchin RM, Kuypers FA. Characterization of the phosphatidylserine-exposing subpopulation of sickle cells. Blood 2001;98:860-7.
12. de Jong K, Emerson RK, Butler J, Bastacky J, Mohandas N, Kuypers FA. Short survival of phosphatidylserine-exposing red blood cells in murine sickle cell anemia. Blood 2001;98:1577-84.
13. +/Cl-cotransport in human erythrocytes exposed to oxidative agents. Biochim Biophys Acta 1993;1176:37-42.0
14. Olivieri O, De Franceschi L, Capellini MD, Girelli D, Corrocher R, Brugnara C. Oxidative damage and erythrocyte membrane transport abnormalities in thalassemias. Blood 1994;84:315-20.
15. De Franceschi L, Shalev O, Piga A, Collel M, Olivieri O, Corrocher R, et al. Deferiprone (L1) treatment removes erythrocyte membrane free iron and affects K-Cl cotransport activity in homozygous β thalassemia. Blood 1996;88:24b (abstr).
16. Rachmilewitz EA, Shifter A, Kahane I. Vitamin E deficiency in beta-thalassemia major: changes in hematological and biochemical parameters after a therapeutic trial with α-tocopherol. Am J Clin Nutr 1979;32:1850-8.
17. Grinberg LN, Rachmilewitz EA, Newmark H. Protective effects of rutin against hemoglobin oxidation. Biochem Pharmacol 1994;48:643-9.
18. Grinberg LN, Newmark H, Kitrossky N, Rahamim E, Chevion M, Rachmilewitz EA. Protective effects of tea polyphenols against oxidative damage to red blood cells. Biochem Pharmacol 1997;54:973-8.
19. van Acker FA, Schouten O, Haenen GR, van der Vijgh WJ, Bast A. Flavonoids can replace α-tocopherol as an antioxidant. FEBS Letters 2000;473:145-8.
20. van Acker SA, Boven E, Kuiper K, van den Berg DJ, Grimbergen JA, Kramer K, et al. Monohydroxyethylrutoside, a dose-dependent cardioprotective agent, does not affect the antitumor activity of doxorubicin. Clin Cancer Res 1997;3:1747-54.
21. van Acker FA, van Acker SA, Kramer K, Haenen GR, Bast A, van der Vijgh WJ. 7-monohydroxyethylrutoside protects against chronic doxorubicin-induced cardiotoxicity when administered only once per week. Clin Cancer Res 2000;6:1337-41.
22. Yang B, Kirby S, Lewis J, Detloff PJ, Maeda N, Smithies O. A mouse model for β°-thalassemia. Proc Natl Acad Sci USA 1995;92:11608-12.
23. Danon D, Marikovsky Y. Determination of density distribution of red cell population. J Lab Clin Med 1964;64:668-73.
24. +)-Cl- cotransport in regulatory volume decrease. Am J Physiol 1995;268:C894-902.
25. Armsby CC, Stuart-Tilley AK, Alper SL, Brugnara C. Resistance to osmotic lysis in BXD-31 mouse erythrocytes: association with upregulated K-Cl cotransport. Am J Physiol 1996;270:C866-77.
26. Kina T, Ikuta K, Takayama E, Wada K, Majumdar AS, Weissman IL, et al. The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stage of murine erythroid lineage. Br J Haematol 2000;109:280-7.
27. Auffray I, Marfatia SM, de Jong K, Lee G, Huang CH, Paszty C, et al. Glycophorin A dimerization and band 3 interaction during erythroid membrane biogenesis: in vivo studies in human glycophorin A transgenic mice. Blood 2001;97:2872-8.
28. Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood 2001;98:3261-73.
29. Huang ML, Burckart GJ, Venkataramanan R. Sensitive high performance liquid chromatographic analysis of plasma vitamin A using amperometric and ultraviolet detection. J Chromatogr 1986; 380:331-8.
30. Bieri JG, Farrell PM, Tolliver TJ, Catignani GL. Simultaneous determination of α-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography. Am J Clin Nutr 1979;32:2143-9.
31. Catignani GL. An HPLC method for the simultaneous determination of retinol and α-tocopherol in plasma or serum. Method Enzymol 1986;123:215-9.
32. Turrini F, Mannu F, Cappadoro M, Ulliers D, Giribaldi G, Arese P. Binding of naturally occurring antibodies to oxidatively and non oxidatively modified erythrocyte band 3. Biochim Biophys Acta 1994; 1190:297-303.
33. Friedman JS, Rebel VI, Derby R, Bell K, Huang TT, Kuypers F, et al. Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant. J Exp Med 2001;193:925-34.
34. Desaulniers JAH, Sturgeon RE, Berman SS. Atomic absorption determination of trace metals in marine sediments and biological tissues using a stabilized temperature platform furnace. Atomic Spectroscopy 1985;6:125-7.
35. Miller-Ihli NJ. Graphite furnace atomic absorption spectrometry for the analysis of biological materials. Spectrochimica Acta 1989;44b:1221-7.
36. Haas M, Harrison JH Jr. Stimulation of K-C1 cotransport in rat red cells by a hemolytic anemia-producing metabolite of dapsone. Am J Physiol 1989;256:C265-72.
37. Lauf PK. Thiol-dependent passive K:Cl Cotransport in sheep red blood cells: X. ahydroxylamine-oxidation induced K:Cl flux blocked by diethylpyrocarbonate. J Membr Biol 1990;118:153-9.
38. Bize I, Munoz P, Canessa M, Dunham PB. Stimulation of membrane serine threonine phosphatase in erythrocytes by hydrogen peroxide and staurosporine. Am J Physiol 1998;274:C440-6.
39. Lauf PK, Adragna NC. K-Cl cotransport: properties and molecular mechanism. Cell Physiol Biochem 2000;10:341-54.
40. De Franceschi L, Fattovich G, Turrini F, Ayi K, Brugnara C, Manzato F, et al. Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: role of membrane oxidative damage. Hepatology 2000; 31:997-1004.
41. Livrea MA, Tesoriere L, Pintaudi AM, Calabrese R, Maggio A, Freisleben HJ, et al. Oxidative stress and antioxidant status in β-thalassemia major; iron overload and depletion of lipid-soluble antioxidant. Blood 1996;88:3608-14.
42. Tesoriere L, D'Arpa D, Maggio A, Giaccone V, Pedone E, Livrea MA. Oxidation resistance of LDL is correlated with vitamin E status in β-thalassemia intermedia. Atherosclerosis 1998;137:429-35.
43. Kannan R, Labotka R, Low PS. Isolation and characterization of the hemichrome stabilized membrane protein aggregates from sickle erythrocytes. Major site of autologous antibody binding. J Biol Chem 1988;263:13766-73.
44. Cappellini MD, Tavazzi D, Duca L, Graziadei G, Mannu F, Turrini F, et al. Metabolic indicators of oxidative stress correlate with haemichrome attachment to membrane, band 3 aggregation and erythrophagocytosis in β-thalassaemia intermedia. Br J Haematol 1999;104:504-12.
45. Scott MD, van den Berg JJ, Repka T, Rouyer-Fessard P, Hebbel RP, Beuzard Y, et al. Effect of excess α-hemoglobin chains on cellular and membrane oxidation in model β-thalassemic erythrocytes. J Clin Invest 1993;91:1706-12.
46. Scott MD, Eaton JW. Thalassaemic erythrocytes: cellular suicide arising from iron and glutathione-dependent oxidation reactions? Br J Haematol 1995;91:811-9.
47. Grinberg LN, Shalev O, Tonnesen H, Rachmilewitz E. Studies on curcumin and curcuminoids: XXVI. Antioxidant effects of curcumin on the red blood cell membrane. Int J Pharmacol 1996;32:251-7.
48. Teng CM, Hsiao G, Ko FN, Lin DT, Lee SS. N-allylsecoboldine as a novel antioxidant against peroxidative damage. Eur J Pharmacol 1996;303.
49. van Acker FA, Hulshof JW, Haenen GR, Menge WM, van der Vijgh WJ, Bast A.New synthetic flavonoids as potent protectors against doxorubicin-induced cardiotoxicity. Free Rad Biol Med 2001;31:31-7.
50. Heijnen CG, Haenen GR, van Acker FA, van der Vijgh WJ, Bast A. Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. Toxicol Vitro 2001;15:3-6.
51. van Acker FA, Hageman JA, Haenen GR, van Der Vijgh WJ, Bast A, Menge WM. Synthesis of novel 3,7-substituted-2-(3′,4′-dihydroxyphenyl) flavones with improved anti oxidant activity. J Med Chem 2000;43:3752-60.
52. van Acker SA, van Balen GP, van den Berg DJ, Bast A, van der Vijgh WJ. Influence of iron chelation on the antioxidant activity of flavonoids. Biochem Pharmacol 1998;56:935-43.
53. + loss and lipid peroxidation induced by oxygen-free radicals in human red cells. Pharmacol Res Comm 1986;18:61-72.
54. Kean LS, Brown LE, Nichols JW, Mohandas N, Archer DR, Hsu LL. Comparison of mechanisms of anemia in mice with sickle cell disease and β-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase mediated phosphatidylserine exposure. Exp Hematol 2002;30:394-402.
55. Eldor A, Durst R, Hy-Am E, Goldfarb A, Gillis S, Rachmilewitz EA, et al. A chronic hypercoagulable state in patients with β-thalassaemia major is already present in childhood. Br J Haematol 1999;107:739-46.
56. Cappellini MD, Robbiolo L, Bottasso BM, Coppola R, Fiorelli G, Mannucci AP. Venous thromboembolism and hypercoagulability in splenectomized patients with thalassaemia intermedia. Br J Haematol 2000;111:467-73.
57. Hebbel RP. The sickle erythrocyte in double jeopardy: autoxidation and iron decompartmentalization. Semin Hematol 1990;27:51-69.
58. Natta CL, Tatum VL, Chow CK. Antioxidant status and free radical-induced oxidative damage of sickle erythrocytes. Ann N Y Acad Sci 1992;669:365-7.
59. Chiu D, Vichinsky E, Ho SL, Liu T, Lubin BH. Vitamin C deficiency in patients with sickle cell anemia. Am J Pediatr Hematol Oncol 1990;12:262-7.
60. Adelekan DA, Thurnham DI, Adekile AD. Reduced antioxidant capacity in paediatric patients with homozygous sickle cell disease. Eur J Clin Nutr 1989;43:609-14.
61. Shi ZT, Afzal V, Coller B, Patel D, Chasis JA, Parra M, et al. Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities. J Clin Invest 1999;103:331-40.