New synthetic flavonoids as potent protectors against doxorubicin-induced cardiotoxicity

Free Radical Biology and Medicine

Volumn 31, Issue 1, 2001, Pages 31-37

  Van Acker, Frédérique A A ^a,b   Hulshof, Janneke W ^c   Haenen, Guido R M M ^b   Menge, Wiro M P B ^c   Van der Vijgh, Wim J F ^a   Bast, Aalt ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Cardiotoxicity; Doxorubicin; Flavonoids; Free radicals; Hepatocytes; Left atrium; Lipid peroxidation

Indexed keywords

3 HYDROXYETHOXY 7,3',4' TRIHYDROXYFLAVONE; 3',4' DIHYDROXY 3 GLUCOSYLFLAVONE; ASCORBIC ACID; DOXORUBICIN; FERROUS ION; FLAVANOID; GLUTATHIONE; LACTATE DEHYDROGENASE; MONOXERUTIN; N [3 (3',4' DIHYDROXYFLAVON 7 YL)OXYPROPYL] N,N,N TRIMETHYLAMMONIUM CHLORIDE; N [3 (7,3',4' TRIHYDROXYFLAVON 3 YL)OXYPROPYL] N,N,N TRIMETHYLAMMONIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOTOXICITY; CELL LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; HEART LEFT ATRIUM; HEART PROTECTION; IC 50; INOTROPISM; LIPID PEROXIDATION; LIVER CELL; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; DOXORUBICIN; DRUG THERAPY, COMBINATION; FLAVONOIDS; GLUTATHIONE; HEART ATRIA; HEART DISEASES; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED BALB C; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PROTECTIVE AGENTS; RATS; RATS, WISTAR;

EID: 0035399633     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00546-9     Document Type: Article

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