HIV fusion inhibitor peptide T-1249 is able to insert or adsorb to lipidic bilayers. Putative correlation with improved efficiency

Journal of the American Chemical Society

Volumn 126, Issue 45, 2004, Pages 14758-14763

  Veiga, A Salomé ^a   Santos, Nuno C ^b   Loura, Luís M S ^c,d   Fedorov, Aleksandre ^c   Castanho, Miguel A R B ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^c INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^d UNIVERSITY OF ÉVORA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CHOLESTEROL; COMPOSITION; ENERGY TRANSFER; ENZYME INHIBITION; FLUORESCENCE; HYDROPHOBICITY; INTERFACES (MATERIALS); LIQUID CRYSTALS; MATHEMATICAL MODELS; MEDICAL IMAGING; SPECTROSCOPIC ANALYSIS;

FLUORESCENCE SPECTROSCOPY; HIV FUSION INHIBITOR PEPTIDES; HYDROPHOBIC TERMINALS; LIPIDIC BILAYERS;

AMINO ACIDS;

1 PALMITOYL 2 OLEYLGLYCERO 3 [PHOSPHO (1 GLYCEROL)]; 2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; ANTIVIRUS AGENT; CHOLESTEROL; DIPALMITOYLPHOSPHATIDYLCHOLINE; ENFUVIRTIDE; GLYCOPROTEIN GP 41; HIV VIRUS FUSION INHIBITOR PEPTIDE; INHIBITOR PROTEIN; T 1249; UNCLASSIFIED DRUG;

ADSORPTION; ALPHA HELIX; ARTICLE; BINDING SITE; CELL SURFACE; CONCENTRATION RESPONSE; CONFORMATION; CORRELATION ANALYSIS; FLUORESCENCE SPECTROSCOPY; HUMAN IMMUNODEFICIENCY VIRUS; LIPID BILAYER; LIPID COMPOSITION; MEMBRANE BINDING; MEMBRANE MODEL; NONHUMAN; PARTITION COEFFICIENT; PEPTIDE ANALYSIS; RECEPTOR DENSITY;

AMINO ACID SEQUENCE; CHOLESTEROL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIV ENVELOPE PROTEIN GP41; KINETICS; LIPID BILAYERS; MEMBRANES, ARTIFICIAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHOSPHATIDYLCHOLINES; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS;

EID: 8844228894     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0459882     Document Type: Article

References (34)

1. Lasky, L. A.; Nakamura, G.; Smith, D. H.; Fennie, C.; Shimasaki, C.; Patzer, E.; Berman, P.; Gregory, T.; Capon, D. J. Cell 1987, 50, 975-985.
2. Dragic, T.; Litwin, V.; Allaway, G. P.; Martin, S. R.; Huang, Y.; Nagashima, K. A. Cayanan, C.; Maddon, P. J.; Koup, R. A.; Moore, J. P.; Paxton, W. A. Nature 1996, 381, 667-673.
3. Feng, Y.; Broder, C. C.; Kennedy, P. E.; Berger, E. A. Science 1996, 272, 872-877.
4. Kliger, Y.; Aharoni, A.; Rapaport, D.; Jones, P.; Blumenthal, R.; Shai, Y. J. Biol. Chem. 1997, 272, 13496-13505.
5. Trivedi, V. D.; Cheng, S.; Wu, C.; Karthikeyan, R.; Chen, C.; Chang, D. Protein Eng. 2003, 16, 311-317.
6. Baldwin, C. E.; Sanders, R. W.; Berkhout, B. Curr. Med. Chem. 2003, 10, 1633-1642.
7. Cooley, L. A.; Lewin, S. R. J. Clin. Virol. 2003, 26, 121-132.
8. Kilby, J. M.; Eron, J. J. N. Engl. J. Med. 2003, 348, 2228-2238.
9. Eron, J. J.; Gulick, R. M.; Bartlett, J. A.; Merigan, T.; Arduino, R.; Kilby, J. M.; Yangco, B.; Diers, A.; Drobnes, C; DeMasi, R.; Greenberg, M.; Melby, T.; Raskino, C.; Rusnak, P.; Zhang, Y.; Spence, R.; Miralles, G. D. J. Infect. Dis. 2004, 189, 1075-1083.
10. Gulick, R. M. Clin. Microbiol. Infect. 2003, 9, 186-193.
11. White, S. H.; Wimley, W. C. Annu. Rev. Biophys. Biomol. Struct. 1999, 28, 319-365.
12. Jayasinghe, S.; Hristova, K.; White, S. H. J. Mol Biol. 2001, 312, 927-934.
13. Loura, L. M.; Fedorov, A.; Prieto, M. Biophys. J. 1996, 71, 1823-1836.
14. Mayer, L. D.; Hope, M. J.; Cullis, P. R. Biophys. Biochim. Acta 1986, 858, 161-168.
15. Santos, N. C.; Prieto, M.; Castanho, M. A. R. B. Biochemistry 1998, 37, 8674-8682.
16. Berberan-Santos, M. N.; Prieto, M. J. Chem, Soc., Faraday Trans. 1987, 83, 1391-1407.
17. Davenport, L.; Dale, R. E.; Bisby, R. H.; Cundall, R. B. Biochemistry 1985, 24, 4097-4108.
18. Coutinho, A.; Prieto, M. J. Chem. Educ. 1993, 70, 425-428.
19. Santos, N. C.; Prieto, M.; Castanho, M. A. R. B. Biochim. Biophys. Acta 2003, 1612, 123-135.
20. Chiu, S. W.; Jakobsson, E.; Subramaniam, S.; Scott, H. L. Biophys. J. 1999, 77, 2462-2469.
21. Veiga, S.; Henriques, S.; Santos, N. C.; Castanho, M. Biochem. J. 2004, 377, 107-110.
22. Campbell, S. M.; Crowe, S. M.; Mak, J. J. Clin. Virol. 2001, 22, 217-227.
23. Silvius, J. R. Biochim. Biophys. Acta 2003, 1610, 174-183.
24. Alonso, M. A.; Millán, J. J. Cell Sci. 2001, 114, 3957-3965.
25. Simons, K.; Ehehalt, R. J. Clin. Invest. 2002, 110, 597-603.
26. Guyader, M.; Kiyokawa, E.: Abrami, L.; Turelli, P.; Trono, D. J. Virol. 2002, 76, 100356-10364.
27. Tauc, P.; Mateo, C. R.; Brochon, J.-C. Biophys. J. 1998, 74, 1864-1870.
28. Fernandes, M. X.; de la Torre, J. G.; Castanho, M. A. R. B. Anal. Biochem. 2002, 307, 1-12.
29. Kliger, Y.; Shai, Y. J. Mol. Biol. 2000, 295, 163-168.
30. Mobley, P. W.; Pilpa, R.; Brown, C.; Waring, A. J.; Gordon, L. M. AIDS Res. Hum. Retroviruses 2001, 17, 311-327.
31. Campbell, S. M.; Crowe, S. M.; Mak, J. AIDS 2002, 16, 2253-2261.
32. Bär, S.; Alizon, M. J. Virol. 2004, 78, 811-820.
33. Hildinger, M.; Dittmar, M. T.; Schult-Dietrich, P.; Fehse, B.; Schnierle, B. S.; Thaler, S.; Stiegler, G.; Welker, R.; von Laer, D. J. Virol. 2001, 75, 3038-3042.
34. Egelhofer, M.; Brandenburg, G.; Martinius, H.; Schult-Dietrich, P.; Melikyan, G.; Kunert, R.; Baum, C.; Choi, I.; Alexandrov, A.; von Laer; D. J. Virol. 2004, 78, 568-575.