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Multiple Mizoroki-Heck reaction: (a) Bräse, S.; de Meijere, A. In Handbook of Organopalladium Chemistry for Organic Synthesis; Negishi, E., Ed.; Wiley-Interscience: New York, 2002; p 1179. (b) Nilsson, P.; Larhed, M.; Hallberg, A. J. Am. Chem. Soc. 2003, 125, 3430. (c) Reference 8. (d) Reference 10b.
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2 catalyst are used in combination with amines. As for the low-yielding examples in Figure 1, the mono-MHR products were formed in reasonable yields.
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