Voltage-gated calcium channels mediate intracellular calcium increase in weaver dopaminergic neurons during stimulation of D2 and GABA B receptors

Journal of Neurophysiology

Volumn 92, Issue 6, 2004, Pages 3368-3374

  Guatteo, Ezia ^a   Bengtson, C Peter ^a,c   Bernardi, Giorgio ^a,b   Mercuri, Nicola B ^a,b  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; CALCIUM ION; DOPAMINE 2 RECEPTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CEREBELLUM; DISEASE MODEL; DOPAMINERGIC NERVE CELL; DYNAMICS; GRANULE CELL; HOMOZYGOTE; HYPERPOLARIZATION; MESENCEPHALON; MICROFLUOROMETRY; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRIATONIGRAL DEGENERATION; VOLTAGE CLAMP;

ANIMALS; BACLOFEN; CALCIUM; CALCIUM CHANNELS; DOPAMINE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GABA AGONISTS; HOMOZYGOTE; MESENCEPHALON; MICE; MICE, NEUROLOGIC MUTANTS; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, DOPAMINE D2; RECEPTORS, GABA-B;

EID: 8644245826     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00602.2004     Document Type: Article

References (36)

1. Bonci A, Grillner P, Mercuri NB, and Bernardi G. L-Type calcium channels mediate a slow excitatory synaptic transmission in rat midbrain dopaminergic neurons. J Neurosci 18: 6693-6703, 1998.
2. Chesnoy-Marchais D and Cathala L. Modulation of glycine responses by dihydropyridines and verapamil in rat spinal neurons. Eur J Neurosci 13: 2195-2204, 2001.
3. Das P, Bell-Horner CL, Huang RQ, Raut A, Gonzales EB, Chen ZL, Covey DF, and Dillon GH. Inhibition of type A GABA receptors by L-type calcium channel blockers. Neuroscience 124: 195-206, 2004.
4. Davila V, Van Z, Craciun LC, Logothetis D, and Sulzer D. D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons. J Neurosci 23: 5693-5697, 2003.
5. Durante P, Cardenas CG, Whittaker JA, Kitai ST, and Scroggs RS. Low-threshold L-type calcium channels in rat dopamine neurons. J Neurophysiol 91: 1450-1454, 2004.
6. Fox AP, Dlouhy S, Ghetti B, Hurley JH, Nucifora PGP, Nelson DJ, Won L, and Heller A. Altered responses to potassium in cerebellar neurons from weaver heterozygote mice. Exp Brain Res 123: 298-306, 1998.
7. Grynkiewicz G, Poenie M, and Tsien RY. A new generation of calcium indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
8. Guatteo E, Fusco FR, Giacomini P, Bernardi G, and Mercuri NB. The weaver mutation reverses the function of dopamine and GABA in mouse dopaminergic neurons. J Neurosci 20: 6013-6020, 2000.
9. Guatteo E, Mercuri NB, Bernardi G, and Knopfel T. Intracellular sodium and calcium homeostasis during hypoxia in dopamine neurons of rat substantia nigra pars compacta. J Neurophysiol 80: 2237-2243, 1998.
10. Gupta AM, Felten DL, and Ghetti B. Selective loss of monoaminergic neurons in the weaver mutant mice: an immunocytochemical study. Brain Res 402: 379-382, 1987.
11. Harkins AB, Dlouhy S, Ghetti B, Cahill AL, Won L, Heller B, Heller A, and Fox AP. Evidence for elevated intracellular calcium levels in weaver homozygote mice. J Physiol 524: 447-455, 2000.
12. Hirasawa M, and Pittman QJ. Nifedipine facilitates neurotransmitter release independently of calcium channels. Proc Natl Acad Sci USA 100: 6139-6144, 2003.
13. Hou P, Di A, Huang P, Hansen CB, and Nelson DJ. Impermeability of the GIRK2 weaver channel to divalent cations. Am J Physiol Cell Physiol 278: C1038-C1046, 2000.
14. +-dependent inhibition in weaver hippocampus. J Neurosci 18: 4001-4007, 1998.
15. + channel and rescue of weaver granule cells. Neuron 16: 941-952, 1996
16. Lacey MG, Mercuri NB, and North RA. Dopamine acts on D2 receptors to increase potassium conductance in neurons of the rat substantia nigra zona compacta. J Physiol 392: 397-416, 1987.
17. Liesi P and Wright JM. Weaver granule neurons are rescued by calcium channel antagonists and antibodies against a neurite outgrowth domain of the B2 chain of laminin. J Cell Biol 134: 477-486, 1996.
18. + channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain. J Neurosci 16: 7137-7150, 1996.
19. Liss B, Neu A, and Roeper J. The weaver mouse gain-of-function phenotype of dopaminergic neurons is determined by coactivation of wvGIRK2 and K-ATP channels. J Neurosci 19: 8839-8848, 1999.
20. Mercuri NB, Bonci A, Calabresi P, Stratta F, Stefani A, and Bernardi G. Effects of dihydropyridine calcium antagonists on rat midbrain dopaminergic neurones. Br J Pharmacol 113: 831-838, 1994.
21. + channels. Science 272: 1950-1953, 1996.
22. 2+ conductances in guinea pig substantia nigra pars compacta neurones. J Physiol 466: 727-747, 1993.
23. Patil N, Cox DR, Bhat D, Faham M, Myers RM, and Peterson AS. A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nat Genet 11: 126-129, 1995.
24. 2+-dependent slow afterdepolarization in nigral dopamine neurons. J Neurophysiol 81: 977-984, 1999.
25. Radnikow G, Titz S, Mades S, Baurle J, and Misgeld U. Gamma-aminobutyric acid(B) autoreceptors in substantia nigra and neostriatum of the weaver mutant mouse. Neurosci Lett 299: 81-84, 2001.
26. Rakic P and Sidman RL. Sequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice. J Comp Neurol 152: 103-132, 1973.
27. Rossi P, De Filippi G, Armano S, Taglietti V, and D'Angelo E. The weaver mutation causes a loss of inward rectifier current regulation in premigratory granule cells of the mouse cerebellum. J Neurosci 18: 3537-3547, 1998.
28. Schmidt MJ, Sawyer BD, Perry KW, Foreman MM, and Ghetti B. Dopamine deficiency in the weaver mutant mouse. J Neurosci 2: 376-380, 1982.
29. Shepard PD and Stump D. Nifedipine blocks apamin-induced bursting activity in nigral dopamine-containing neurons. Brain Res 817: 104-109, 1999.
30. Silverman SK, Kofuji P, Dougherty DA, Davidson N, and Lester HA. A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation. Proc Natl Acad Sci USA 93: 15429-15434, 1996.
31. Simon JR and Ghetti B. The weaver mutant mouse as a model of nigrostriatal dysfunction. Mol Neurobiol 9: 183-189, 1994.
32. + currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice. Proc Natl Acad Sci USA 94: 12210-12217, 1997.
33. Smith MW III, Cooper TR, Joh TH, and Smith DE. Cell loss and class distribution of TH-1 cells in the substantia nigra of the neurological mutant, weaver. Brain Res 510: 242-250, 1990.
34. + current in cerebellar granule cells. Proc Natl Acad Sci USA 93: 11191-11195, 1996.
35. Triarhou LC, Norton J, and Ghetti B. Mesencephalic dopamine cell deficit involves areas A8, A9 and A10 in weaver mice. Exp Brain Res 70: 256-265, 1988.
36. Yang J, Jan YN, and Jan LY. Determination of the subunit stoichiometry of an inwardly rectifying potassium channel. Neuron 14: 1047-1054, 1995.