The weaver mutation causes a loss of inward rectifier current regulation in premigratory granule cells of the mouse cerebellum

Journal of Neuroscience

Volumn 18, Issue 10, 1998, Pages 3537-3547

  Rossi, Paola ^a,b   De Filippi, Giovanna ^a,b   Armano, Simona ^a,b   Taglietti, Vanni ^a,b   D'Angelo, Egidio ^a,b,c  

^a Istituto di Fisiologia Generale   (Italy)

^b INFM   (Italy)

^c Istituto di Fisiologia Generale   (Italy)

Author keywords

Cerebellum; Channel opathy; Granule cell; Inward rectifier; Mouse; Weaver

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; ION CHANNEL;

ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; GENE MUTATION; GRANULE CELL; ION CURRENT; MOTOR DYSFUNCTION; MOUSE; NERVE CELL DEGENERATION; NERVE CELL DIFFERENTIATION; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; WEAVER MUTATION;

EID: 0032525098     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-10-03537.1998     Document Type: Article

References (36)

1. A receptors. J Physiol (Lond) 497:753-759.
2. Choi DW (1995) Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 18:58-60.
3. Crepel F, Penit-Soria J (1986) Inward rectification and low threshold calcium conductance in rat cerebellar Purkinje cells. An in vitro study. J Physiol (Lond) 372:1-23.
4. D'Angelo E, Rossi P, De Filippi G, Magistretti J, Taglietti V (1994) The relationship between synaptogenesis and expression of voltage-dependent currents in cerebellar granule cells in situ. J Physiol (Paris) 88:197-207.
5. D'Angelo E, De Filippi G, Rossi P, Taglietti V (1995) Synaptic excitation of individual rat cerebellar granule cells in situ: evidence for the role of NMDA receptors. J Physiol (Lond) 484:397-413.
6. 2+ action potentials in immature rat cerebellar granule cells in situ. J Neurophysiol 78:1631-1642.
7. + channel. J Gen Physiol 106:1-23.
8. + channel activity of neuronal and cardiac G-protein-activated inward rectifiers. Biochem Biophys Res Commun 212:657-663.
9. Edwards FA, Konnerth A, Sakmann B, Takahashi T (1989) A thin slice preparation for patch-clamp recordings from neurons of the mammalian central nervous system. Pflügers Arch 414:600-612.
10. Gao WQ, Hatten ME (1993) Neuronal differentiation rescued by implantation of weaver granule cell precursors into wild-type cerebellar cortex. Science 260:367-369.
11. Gao WQ, Liu X-L, Hatten ME (1992) The weaver gene encodes a nonautonomous signal for CNS neuronal differentiation. Cell 68:841-854.
12. Garthwaite J (1994) NMDA receptors, neuronal development, and neurodegeneration. In: The NMDA receptor (Collingridge GL, Watkins JC, eds), pp 428-456. Oxford: Oxford UP.
13. Hatten ME, Heintz N (1995) Mechanisms of neural patterning and specification in the developing cerebellum. Annu Rev Neurosci 18:385-408.
14. Hess EJ (1996) Identification of the weaver mouse mutation: the end of the beginning. Neuron 16:1073-1076.
15. Hille B, Schwarz W (1978) Potassium channels as multi-ion single-file pores. J Gen Physiol 72:409-442.
16. + channels are activated by Gβγ subunits and function as heteromultimers. Proc Natl Acad Sci USA 92:6542-6546.
17. + channel and rescue of weaver granule cells. Neuron 16:941-952.
18. Komuro H, Rakic P (1993a) Selective role of N-type calcium channels in neuronal migration. Science 257:806-809.
19. Komuro H, Rakic P (1993b) Modulation of neuronal migration by NMDA receptors. Science 260:95-97.
20. + channel proteins. Nature 374:135-141.
21. Marchetti C, Amico C, Usai C (1995) Functional characterization of the effect of nimodipine on the calcium current in rat cerebellar granule cells. J Neurophysiol 73:1169-1180.
22. + channels. Science 272:1950-1953.
23. Patil N, Cox DR, Bhat D, Faham M, Myers RM, Peterson AS (1995) A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nat Genet 11:126-129.
24. Perkins KL, Wong RKS (1995) Intracellular QX-314 blocks the hyperpolarization-activated inward current Iq in hippocampal CA1 pyramidal cells. J Neurophysiol 73:911-915.
25. Pitzer KS, Mayorga G (1973) Thermodynamics of electrolytes. II. Activity and osmotic coefficients for strong electrolytes with one or both ions univalent. J Physical Chem 77:2300-2308.
26. Rakic P, Sidman RL (1973a) Sequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice. J Comp Neurol 152:103-132.
27. Rakic P, Sidman RL (1973b) Organization of cerebellar cortex secondary to deficit of granule cells in wearer mutant mice. J Comp Neurol 152:133-162.
28. Silverman SK, Kofuji P, Dougherty DA, Davidson N, Lester HA (1996) A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation. Proc Natl Acad Sci USA 93:15429-15434.
29. Slater NT, Rossi DJ (1996) Functional expression of NMDA receptors in developing neurons. In: Excitatory amino acids and the cerebral cortex (Conti F, Hicks TP, eds), pp 215-226. Cambridge, MA; MIT.
30. + channels. Neuron 16:321-331.
31. Smeyne RJ, Goldowitz D (1989) Development and death of external granular layer cells in the weaver mouse cerebellum: a quantitative study. J Neurosci 9:1608-1620.
32. SoteloC, Changeux JP (1974) Bergmann fibers and granular cell migration in the cerebellum of homozygous weaver mutant mouse. Brain Res 77:484-491.
33. Spitzer NC (1991) A developmental handshake: neuronal control of ionic currents and their control of neuronal differentiation. J Neurobiol 22:659-673.
34. + current in cerebellar granule cells. Proc Natl Acad Sci USA 93:11191-11195.
35. + current sensitive to musearinic receptor activation in rat cultured cerebellar granule neurons. J Physiol (Lond) 491:401-412.
36. Wickman KD, Clapham DE (1995) G-protein regulation of ion channels. Curr Opin Neurobiol 5:278-285.