Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells

Neuron

Volumn 16, Issue 5, 1996, Pages 941-952

  Kofuji, Paulo ^a   Hofer, Magdalena ^b   Millen, Kathleen J ^b   Millonig, James H ^b   Davidson, Norman ^a   Lester, Henry A ^a   Hatten, Mary E ^b  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIZOCILPINE; LIDOCAINE ETHOBROMIDE; POTASSIUM CHANNEL; VERAPAMIL;

ANIMAL CELL; ARTICLE; CEREBELLUM; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GRANULE CELL; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SODIUM CONDUCTANCE; XENOPUS LAEVIS;

EID: 0029941292     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80117-8     Document Type: Article

References (62)

1. + conductance by QX-314 in the rat hippocampus. Eur. J. Pharmacol. 199, 259-262.
2. Bormann, J. (1992). U-tube drug application. In Practical Electrophysiological Methods: A Guide for in vitro Studies in Vertebrate Neurobiology, H. Kettenman and R. Grantyn, eds. (New York: Wiley-Liss), pp. 136-140.
3. + channel activation as revealed by hydrolysis-resistant GTP analogues. J. Gen. Physiol. 91, 469-494.
4. Chavis, P., Shinozaki, H., Bockaert, J., and Fagni, L. (1994). The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. J. Neurosci. 14, 7067-7076.
5. + channel. J. Biol. Chem. 269, 7839-7842.
6. Clapham, D.E. (1994). Direct G protein activation of ion channels. Annu. Rev. Neurosci. 17, 441-464.
7. + channel: expression cloning and molecular properties. Proc. Natl. Acad. Sci. USA 90, 10235-10239.
8. Dodd, J., Morton, S.B., Karagogeos, D., Yamamoto, M., and Jessel, T.M. (1988). Spatial regulation of axonal glycoprotein expression of subsets of embryonic spinal neurons. Neuron 2, 105-116.
9. Doupnik, C.A., Davidson, N., and Lester, H.A. (1995). The inward rectifier potassium channel family. Curr. Opin. Neurobiol. 5, 268-277.
10. + channels is caused by intracellular spermine. Cell 80, 149-154.
11. Gao, W.-Q., and Hatten, M.E. (1993). Neuronal differentiation rescued by implantation of weaver granule cell precursors into wild-type cerebellar cortex. Science 260, 367-369.
12. Gao, W.-Q., Heintz, N., and Hatten, M.E. (1991). Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro. Neuron 6, 705-715.
13. Gao, W.-Q., Liu, X.-L., and Hatten, M.E. (1992). The weaver gene encodes a nonautonomous signal for CNS neuronal differentiation. Cell 68, 841-854.
14. Goldowitz, D. (1989). The weaver granuloprival phenotype is due to intrinsic action of the mutant locus in granule cells: evidence from homozygous weaver chimeras. Neuron 2, 1565-1575.
15. Goldowitz, D., and Mullen, R.J. (1982). Granule cell as a site of gene action in the weaver cerebellum: evidence from heterozygous mutant chimeras. J. Neurosci. 2, 1474-1485.
16. Graybiel, A.M., Ohta, K., and Roffler-Tarlov, S. (1990). Patterns of cell and fiber vulnerability in the mesostriatal system of the mutant mouse weaver. I. Gradients and compartments. J. Neurosci. 10, 720-733.
17. Gupta, M., Felten, D.L., and Ghetti, B. (1987). Selective loss of monoaminergic neurons in weaver mutant mice: an immunocytochemical study. Brain Res. 402, 379-382.
18. Hamill, O.P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F.J. (1981). Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391, 85-100.
19. Hatten, M.E. (1985). Neuronal regulation of astroglial morphology and proliferation in vitro. J. Cell Biol. 100, 384-396.
20. Hatten, M.E., and Francois, A.M. (1981). Cell assembly patterns of embryonic and early postnatal mouse cerebellar cells in lectin-derivatized cultured substrata. Dev. Biol. 87, 102-113.
21. Hatten, M.E., Liem, R.K.H., and Mason, C.A. (1986). Weaver mouse cerebellar granule neurons fail to migrate on wild type astroglial processes in vitro. J. Neurosci. 6, 2676-2683.
22. KACh currents in oocytes. Neuron 16, 423-429
23. + channel signature sequence. Biophys. J. 66, 1061-1067.
24. Herrup, K., 61nd Trenkner, E. (1987). Regional differences in cytoarchitecture of the weaver cerebellum suggest a new model for weaver gene action. Neuroscience 23, 871-885.
25. Hille, B. (1992). Ionic Channels in Excitable Membranes, Second Edition (Sunderland, Massachusetts: Sinauer).
26. Ho, S.N., Hunt, H.D., Horton, R.M., Pullen, J.K., and Pease, L.R. (1989). Site-directed mutagenesis by overlap extension using the polymerase chain rection. Gene 77, 51-59.
27. + channel is important for channel activation. Neuron 15, 1133-1143.
28. + channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain. Biochem. Biophys. Res. Commun. 208, 1166-1173.
29. + channels are activated by Gβγ subunits and function as heteromultimers. Proc. Natl. Acad. Sci. USA 92, 6542-6546.
30. +-channel proteins. Nature 374, 135-141.
31. Kubo, Y., Reuveny, E., Slesinger, P.A., Jan, Y.N., and Jan, L.Y. (1993). Primary structure and functional expression of a rat G protein-coupled muscarinic potassium channel. Nature 364, 802-806.
32. Kuhar, S.G., Feng, L., Vidan, S., Ross, M.E., Hatten, M.E., and Heintz, N. (1993). Changing patterns of gene-expression define 4 stages of cerebellar granule neuron differentiation. Development 117, 97-104.
33. Kunkel, M.T., and Peralta, E.G. (1995). Identification of domains conferring protein regulation on inward rectifier potassium channels. Cell 83, 443-449.
34. Kurachi, Y. (1995). G protein regulation of cardiac muscarinic potassium channel. Am. J. Physiol. 38, C821-C830.
35. + channels in the brain. FEBS Lett. 353, 37-42.
36. + channels. J. Biol. Chem. 48, 28660-28667.
37. Lim, N.F., Dascal, N., Labarca, C., Davidson, N., and Lester, H.A. (1995). A G protein-gated K channel is activated via β2-adrenergic receptors and Gβγ subunits in Xenopus oocytes. J. Gen. Physiol. 105, 421-439.
38. Lopatin, A.N., Makhina, E.N., and Nichols, C.G. (1994). Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 372, 366-369.
39. Millen, K.J., and Hui, C.-C. (1996). Radioactive in situ hybridization of tissue sections. In A Laboratory Guide to RNA: Isolation, Analysis and Synthesis, P. Krieg, ed. (New York: John Wiley and Sons, Incorporated), pp. 339-355.
40. Millen, K.J., Hui, C.-C., and Joyner, A.L. (1995). A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum. Development 121, 3935-3945.
41. Millonig, J.H., Millen, K.J., and Hatten, M.E. (1996). A high-density molecular genetic map around the weaver locus. Mammalian Genome, in press.
42. Mjaatvedt, A.E., Cabin, D.E., Cole, S.E., Long, L.J., Breitwieser, G.E., and Reeves, R.H. (1995). Assessment of a mutation in the H5 domain of GIRK2 as a candidate for the weaver mutation. Genome Res. 5, 453-463.
43. + channels. Trends Pharmacol. Sci. 9, 320-323.
44. North, R.A. (1989). Drug receptors and the inhibition of nerve cells. Br. J. Pharmacol. 98, 13-28.
45. Patil, N., Cox, D.R., Bhat, D., Faham, M., Myers, R.M., and Peterson, A.S. (1995). A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nature Genet. 11, 126-129.
46. Quick, M.W., and Lester, H.A. (1994). Methods for expression of excitability proteins in Xenopus oocytes. In Ion Channels of Excitable Cells, T. Narahashi, ed. (San Diego, California: Academic Press), pp. 261-279.
47. Rakic, P., and Sidman, R.L. (1973). Weaver mutant mouse cerebellum: defective neuronal migration secondary to abnormality of Bergmann glia. Proc. Natl. Acad. Sci. USA 70, 240-244.
48. 2+ channel currents in rat cerebellar granule neurons. J. Neurosci. 15, 2995-3012.
49. Reeves, R.H., Crowley, M.R., Lorenzon, N., Pavan, W.J., Smeyne, R.J., and Goldowitz, D. (1989). The mouse neurological mutant weaver maps within the region of chromosome-16 that is homologous to human chromosome-21. Genomics 5, 522-526.
50. Reuveny, E., Slesinger, P.A., Inglese, J., Morales, J.M., Iniguez-Lluhi, J.A., Lefkowitz, R.J., Bourne, H.R., Jan, Y.N., and Jan, L.Y. (1994). Activation of the cloned muscarinic potassium channel by G protein βγ subunits. Nature 370, 143-146.
51. Rezai, Z., and Yoon, H. (1972). Abnormal rate of granule cell migration in the cerebellum of "weaver" mutant mice. Dev. Biol. 29, 17-26.
52. Roffler-Tarlov, S., Martin, B., Graybiel, A.M., and Kauer, J.S. (1996). Cell death in the midbrain of the murine mutation weaver. J. Neurosci. 16, 1819-1826.
53. Schaeren-Wiemers, N., and Gerfin-Moser, A. (1993). A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labeled cDNA probes. Histochemistry 100, 431-440.
54. Sekiguchi, M., Nowakowski, R.S., Nagato, Y., Tanaka, O., Guo, H., Madoka, M., and Abe, H. (1995). Morphological abnormalities in the hippocampus of the weaver mutant mouse. Brain Res. 696, 262-267.
55. + channels. Neuron 16, 321-331.
56. Sotelo, C., and Changeux, J.P. (1974). Bergmann fibers and granular cell migration in the cerebellum of homozygous weaver mutant mouse. Brain Res. 77, 484-491.
57. Steward, R.R., Bossu, J.-L., Muzet, M., Dupont, J.-L., and Feltz, A. (1995). Voltage-activated ionic currents in differentiating rat cerebellar granule neurons cultured from the external germinal layer. J. Neurobiol. 28, 419-432.
58. Takano, K., Stanfield, P.R., Nakajima, S., and Nakajima, Y. (1995). Protein kinase C-mediated inhibition of an inward rectifier potassium channel by substance P in nucleus basalis neurons. Neuron 14, 999-1008.
59. Triarhou, L.C., Norton, J., and Ghetti, B. (1988). Mesencephalic dopamine cell deficit involves areas A8, A9, and A10 in weaver mutant mice. Exp. Brain Res. 70: 256-265.
60. + channel. FEBS Lett. 379, 31-37.
61. Willinger, M., and Margolis, D.M. (1985). Effect of the weaver (wv) mutation on cerebellar neuron differentiation. I. Qualitative observations of neuron behavior in culture. Dev. Biol. 107, 156-172.
62. B receptor coupling diversity in isolated granule cells of rat cerebellum. J. Physiol. 459, 281P.