Multi-mycotoxin analysis by LC-MS/MS in a single sample extract

Mycotoxins and phycotoxins: Advances in determination, toxicology and exposure management

Volumn , Issue , 2023, Pages 117-124

  Spanjer, M ^a   Rensen, P ^a   Scholten, J ^a  

^a National Reference Laboratory   (Netherlands)

Author keywords

Baby food; Electrospray ionization; Ergot; Ion suppression; LC MS MS; Matrix effect; Multi mycotoxin; Multiple reaction monitoring

Indexed keywords

EID: 85200302227     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.3920/9789086865857_012     Document Type: Chapter

References (21)

1. Berger, U., Oehme, M., and Kuhn, F., 1999. Quantitative determination and structure elucidation of type A-and B-trichothecenes by HPLC/Ion trap multiple mass spectrometry. Journal of Agricultural and Food Chemistry 47: 4240-4245.
2. Commission Regulation (European Commission 472/2002) of March 12th 2002, amending Regulation EC 466/2001, setting maximum levels for certain contaminants in foodstuffs.
3. Entwisle, A.C., Williams, A.C., Mann, P.J., Slack, P.T., and Gilbert, J., 2000. Liquid Chromatographic Method with Immunoaffinity Column Cleanup for Determination of Ochratoxin A in Barley: Collaborative Study. Journal of AOAC International 83: 1377-1383.
4. European Union, Scientific Committee of Food, 2000. Brussels, http://europa.eu.int/comm/food/fs/sc/scf/opinions.
5. Holcomb, M., Sutherland, J.B., Chiarelli, M.P., Korfmacher, W.A., Thompson, Jr., H.C., Lay, Jr. J.O., Hankins, L.J. and Cerniglia, C.E., 1993. HPLC and FAB Mass spectrometry analysis of fumonisins B1 and B2 produced by Fusarium moniliforme on food substrates. Journal of Agricultural and Food Chemistry 41: 357-360.
6. Hurst, W.J., Martin, R.A., and Vestal, C.H., 1991. The use of HPLC/thermospray MS for the confirmation of aflatoxins in peanuts. Journal of liquid chromatography 14: 2541-2550.
7. Kussak, A., Nilsson, C.-A., Andersson, B. and Langridge, J., 1995. Determination of aflatoxins in dust and urine by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 9: 1234-1237.
8. Lagana, A., Curini, R., Dáscenzo, G., De Leva, I., Faberi, A., and Pastorini, E., 2003. Liquid chromatography/tandem mass spectrometry for the identification and determination of trichothecenes in maize. Rapid Communications in Mass Spectrometry 17: 1037-1043.
9. Lukacs, Z., Schaper, S., Herderich, M. Schreier, P., and Humpf, H.-U., 1996. Identfication and determination of fumonisin FB1 and FB2 in corn and corn products by high-performance liquid chromatography-electrosprayionization tandem mass spectrometry (HPLC-ESI-MS-MS). Chromatographia 43: 124-128.
10. Nielsen, K.F., and Smedsgaard, J., 2003. Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardized liquid chromatography-UV-mass spectrometry methodology. Journal of Chromatography A 1002: 111-136.
11. Park, J.W., Kim, E.K., Shon, D.H., and Kim, Y.B., 2002. Natural co-occurrence of aflatoxin B1, fumonisin B1 and ochratoxin A in barley and corn foods from Korea. Food Additives and Contaminants 19: 1073-1080.
12. Razzazi-Fazeli, E., Böhm, J., and Luf, W., 1999. Determination of nivalenol and deoxynivalenol in wheat using liquid chromatography-mass spectrometry with negative ion atmospheric pressure chemical ionisation. Journal of Chromatography A 854: 45-55.
13. Razzazi-Fazeli, E., Rabus, B., Cecon, B., and Böhm, J., 2002. Simultaneous quantification of A-trichothecene mycotoxins in grains using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Journal of Chromatography A 968: 129-142.
14. Rundberget, T., and Wilkins, A.L., 2002. Determination of Penicillium mycotoxins in foods and feds using liquid chromatography-mass spectrometry. Journal of Chromatography A 964: 189-197.
15. Smedsgaard, J., and Frisvad, J.C., 1996. Using direct electrospray mass spectrometry in taxonomy and secondary metabolite profiling of crude fungal extracts. Journal of Microbiological Methods 25: 5-17.
16. Spanjer, M.C., Scholten, J.M., Rensen, P.M., 2003. Single run LC-MS/MS analysis of mycotoxins subject to actual and upcoming EU legislation in one sample extract. Poster presentation at the Second World Mycotoxin Forum, 17-18 february 2003, Noordwijk, The Netherlands.
17. Stroka, J., Anklam, E., Jörissen, U., and Gilbert, J., 2000. Immunoaffinity Column Cleanup with Liquid Chromatography Using Post-Column Bromination for Determination of Aflatoxins in Peanut Butter, Pistachio Paste, Fig Paste, and Paprika Powder: Collaborative Study. Journal of AOAC International 83: 320-340.
18. Tuomi, T., Saarinen, L., and Reijula, K., 1998. Detection of polar and macrocyclic trichothecene mycotoxins from indoor environments. The Analyst 123: 1835-1841.
19. van Bennekom, E.O., Brouwer, L., Laurant, E.H.M., Hooijerink, H., and Nielen, M.W.F., 2002. Confirmatory analysis method for zeranol, its metabolites and related mycotoxins in urine by liquid chromatography-negative ion electrospray tandem mass spectrometry. Analytica Chimica Acta 473: 151-160.
20. Visconti, A., Solfrizzo, M., and De Girolamo, A., 2001. Determination of Fumonisins B1 and B2 in Corn and Corn Flakes by Liquid Chromatography with Immunoaffinity Column Cleanup: Collaborative Study. Journal of AOAC International 84: 1828-1837.
21. Xiao, H., Marquardt, R.R., Frohlich, A.A., and Ling, Y.Z. 1995. Synthesis and structural elucidation of analogs of Ochratoxin A. Journal of Agricultural and Food Chemistry 43: 524-530.