메뉴 건너뛰기




Volumn , Issue , 2016, Pages 149-184

Multidose general toxicology studies

Author keywords

[No Author keywords available]

Indexed keywords


EID: 85123327147     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (14)

References (81)
  • 1
    • 0011223898 scopus 로고    scopus 로고
    • International conference on harmonization: Guidance on preclinical safety evaluation of biotechnology-derived pharmaceuticals
    • Food and Drug Administration. International conference on harmonization: guidance on preclinical safety evaluation of biotechnology-derived pharmaceuticals. Fed Regist 1997; 62:61515.
    • (1997) Fed Regist , vol.62 , pp. 61515
  • 2
    • 0033024643 scopus 로고    scopus 로고
    • Safety assessment of biotechnology-derived pharmaceuticals: ICH and beyond
    • Serabian MA, Pilaro AM. Safety assessment of biotechnology-derived pharmaceuticals: ICH and beyond. Toxicol Pathol 1999; 27:27.
    • (1999) Toxicol Pathol , vol.27 , pp. 27
    • Serabian, M.A.1    Pilaro, A.M.2
  • 3
    • 0033012742 scopus 로고    scopus 로고
    • Preclinical development strategies for novel gene therapeutic products
    • Pilaro AM, Serbian MA. Preclinical development strategies for novel gene therapeutic products. Toxicol Pathol 1999; 27:4.
    • (1999) Toxicol Pathol , vol.27 , pp. 4
    • Pilaro, A.M.1    Serbian, M.A.2
  • 4
    • 0030138572 scopus 로고    scopus 로고
    • The uncontrolled variable in risk assessment: Ad libitum overfed rodents-fat, facts and fiction
    • Keenan KP. The uncontrolled variable in risk assessment: ad libitum overfed rodents-fat, facts and fiction. Toxicol Pathol 1996; 24:376.
    • (1996) Toxicol Pathol , vol.24 , pp. 376
    • Keenan, K.P.1
  • 5
    • 0031829801 scopus 로고    scopus 로고
    • Nutrition and toxicity modulation: The impact of animal body weight on study outcome
    • Allaben WT, Hart RW. Nutrition and toxicity modulation: the impact of animal body weight on study outcome. Int J Toxicol 1998; 17:1.
    • (1998) Int J Toxicol , vol.17 , pp. 1
    • Allaben, W.T.1    Hart, R.W.2
  • 7
    • 1642422357 scopus 로고    scopus 로고
    • Blood coagulation test in toxicological studies-review of methods and their significance for drug safety assessment
    • Kurata M, Horii I. Blood coagulation test in toxicological studies-review of methods and their significance for drug safety assessment. J Toxicol Sci 2004; 29:13.
    • (2004) J Toxicol Sci , vol.29 , pp. 13
    • Kurata, M.1    Horii, I.2
  • 8
    • 0019823046 scopus 로고
    • Target organ toxicity
    • Heywood R. Target organ toxicity. Toxicol Lett 1981; 8:349.
    • (1981) Toxicol Lett , vol.8 , pp. 349
    • Heywood, R.1
  • 9
    • 0031955222 scopus 로고    scopus 로고
    • Precision in data acquisition and reporting of organ weights in rats and mice
    • Long GG, Symanowski JT, Roback K. Precision in data acquisition and reporting of organ weights in rats and mice. Toxicol Pathol 1998; 26:316.
    • (1998) Toxicol Pathol , vol.26 , pp. 316
    • Long, G.G.1    Symanowski, J.T.2    Roback, K.3
  • 10
    • 85123327759 scopus 로고    scopus 로고
    • Invited commentary. Precision of organ and body weight data: Additional perspective
    • Carr GJ, Maurer JK. Invited commentary. Precision of organ and body weight data: additional perspective. Toxicol Pathol 1998; 26:321.
    • (1998) Toxicol Pathol , vol.26 , pp. 321
    • Carr, G.J.1    Maurer, J.K.2
  • 12
    • 0035985137 scopus 로고    scopus 로고
    • Integration of safety pharmacology endpoints into toxicology studies
    • Luft J, Bode G. Integration of safety pharmacology endpoints into toxicology studies. Fundam Clin Pharmacol 2002; 16:91.
    • (2002) Fundam Clin Pharmacol , vol.16 , pp. 91
    • Luft, J.1    Bode, G.2
  • 13
    • 0242270844 scopus 로고    scopus 로고
    • A flow-cytometric NK-cytotoxicity assay adapted for use in rat repeated dose toxicity studies
    • Marcusson-Stahl M, Cererbrant K. A flow-cytometric NK-cytotoxicity assay adapted for use in rat repeated dose toxicity studies. Toxciology 2003; 193:269.
    • (2003) Toxciology , vol.193 , pp. 269
    • Marcusson-Stahl, M.1    Cererbrant, K.2
  • 15
    • 0036186764 scopus 로고    scopus 로고
    • Distinguishing adverse from non-adverse effects in drug development
    • Williams GM, Iatropoulos MJ. Distinguishing adverse from non-adverse effects in drug development. Toxicol Pathol 2002; 30:41.
    • (2002) Toxicol Pathol , vol.30 , pp. 41
    • Williams, G.M.1    Iatropoulos, M.J.2
  • 16
    • 84976597244 scopus 로고
    • Extracting "more" from cardio pulmonary studies on beagle dogs
    • Gilman MR, ed. Bethesda, MD: American College of Toxicology and LRE
    • Hamlin R. Extracting "more" from cardio pulmonary studies on beagle dogs. In: Gilman MR, ed. The Canine as a Biomedical Model. Bethesda, MD: American College of Toxicology and LRE, 1985:9.
    • (1985) The Canine as a Biomedical Model , pp. 9
    • Hamlin, R.1
  • 17
    • 85047676448 scopus 로고
    • Electrophysiological changes in animal model of chronic cardiac failure
    • Doherty JD, Cobbe SM. Electrophysiological changes in animal model of chronic cardiac failure. Cardiovas Res 1990; 24:309.
    • (1990) Cardiovas Res , vol.24 , pp. 309
    • Doherty, J.D.1    Cobbe, S.M.2
  • 18
    • 0035110216 scopus 로고    scopus 로고
    • Methods of collecting and evaluating non-clinical electrophysiology data in the pharmaceutical industry: Results of an international survey
    • Hammond TG, Carlsson L, Davis AS, et al. Methods of collecting and evaluating non-clinical electrophysiology data in the pharmaceutical industry: results of an international survey. Cardiovasc Res 2001; 49:741.
    • (2001) Cardiovasc Res , vol.49 , pp. 741
    • Hammond, T.G.1    Carlsson, L.2    Davis, A.S.3
  • 19
    • 0019176687 scopus 로고
    • Clinical chemistry values for some common laboratory animals
    • Caisey JD, King DJ. Clinical chemistry values for some common laboratory animals. Clin Chem 1980; 26:1877.
    • (1980) Clin Chem , vol.26 , pp. 1877
    • Caisey, J.D.1    King, D.J.2
  • 21
    • 0027620863 scopus 로고
    • Clinical pathology reference ranges of laboratory animals
    • Matsuzawa T, Nomura M, Unno T. Clinical pathology reference ranges of laboratory animals. J Vet Med Sci 1993; 55:351.
    • (1993) J Vet Med Sci , vol.55 , pp. 351
    • Matsuzawa, T.1    Nomura, M.2    Unno, T.3
  • 22
    • 0017607209 scopus 로고
    • Variations of sodium, potassium and chloride plasma levels in the rat with age and sex
    • Nachbaur J, Clarke MR, Provost JP, Dancia JL. Variations of sodium, potassium and chloride plasma levels in the rat with age and sex. Lab Anim Sci 1977; 27:972.
    • (1977) Lab Anim Sci , vol.27 , pp. 972
    • Nachbaur, J.1    Clarke, M.R.2    Provost, J.P.3    Dancia, J.L.4
  • 23
    • 0022143263 scopus 로고
    • Successive changes in the blood composition of the experimental normal beagle dogs accompanied with age
    • Uchiyama T, Tokoi K, Deki T. Successive changes in the blood composition of the experimental normal beagle dogs accompanied with age. Exp Anim 1985; 34:367.
    • (1985) Exp Anim , vol.34 , pp. 367
    • Uchiyama, T.1    Tokoi, K.2    Deki, T.3
  • 24
    • 0028040499 scopus 로고
    • Effect of fasting on haematology and clinical chemistry values in the rat and dog
    • Matsuzawa T, Sakazume S. Effect of fasting on haematology and clinical chemistry values in the rat and dog. Comp Haematol Int 1994; 4:152.
    • (1994) Comp Haematol Int , vol.4 , pp. 152
    • Matsuzawa, T.1    Sakazume, S.2
  • 25
    • 0022360517 scopus 로고
    • Effect of sampling site and collection method on variations in baseline clinical pathology parameters in fischer 344 rats
    • Neptun DA, Smith CN, Irons R. Effect of sampling site and collection method on variations in baseline clinical pathology parameters in fischer 344 rats. Fund Appl Toxicol 1985; 5:1180.
    • (1985) Fund Appl Toxicol , vol.5 , pp. 1180
    • Neptun, D.A.1    Smith, C.N.2    Irons, R.3
  • 26
    • 0032934342 scopus 로고    scopus 로고
    • Effects of carbon dioxide inhalation on hematology, coagulation, and serum clinical chemistry values in rats
    • Walter GL. Effects of carbon dioxide inhalation on hematology, coagulation, and serum clinical chemistry values in rats. Toxicol Pathol 1999; 27:217.
    • (1999) Toxicol Pathol , vol.27 , pp. 217
    • Walter, G.L.1
  • 28
    • 84988135980 scopus 로고
    • Animal models for cholesterol metabolism
    • Beynon AC, Solleveld HA, eds. Dordrecht: Martinus Nijoff
    • Beynon AC. Animal models for cholesterol metabolism. In: Beynon AC, Solleveld HA, eds. Biosciences. Dordrecht: Martinus Nijoff, 1988:279.
    • (1988) Biosciences , pp. 279
    • Beynon, A.C.1
  • 29
    • 0033000396 scopus 로고    scopus 로고
    • Species differences in the proportion of plasma lipoprotein lipid carried by high-density lipoproteins influence the distribution of free and liposomal nystatin in human, dog, and rat plasma
    • Ramaswamy M, Wallace TL, Cossum PA, Wasan KM. Species differences in the proportion of plasma lipoprotein lipid carried by high-density lipoproteins influence the distribution of free and liposomal nystatin in human, dog, and rat plasma. Antimicrob Agents Chemother 1999; 43:1424.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1424
    • Ramaswamy, M.1    Wallace, T.L.2    Cossum, P.A.3    Wasan, K.M.4
  • 30
    • 0025081996 scopus 로고
    • Assessment of renal function and damage in animal species. A review of the current approach of the academic, governmental and industrial institutions represented by the animal clinical chemistry association
    • Stonard. Assessment of renal function and damage in animal species. A review of the current approach of the academic, governmental and industrial institutions represented by the animal clinical chemistry association. J Appl Toxicol 1990; 10:267.
    • (1990) J Appl Toxicol , vol.10 , pp. 267
  • 32
    • 0017457490 scopus 로고
    • The effect of chronic underfeeding on organ weights of rats
    • Scharer K. The effect of chronic underfeeding on organ weights of rats. Toxicology 1977; 7:45.
    • (1977) Toxicology , vol.7 , pp. 45
    • Scharer, K.1
  • 33
    • 85123327120 scopus 로고
    • Unique aspects of GLP pathology
    • Farrow MG. Unique aspects of GLP pathology. J Am Coll Toxicol 1987; 6:389.
    • (1987) J Am Coll Toxicol , vol.6 , pp. 389
    • Farrow, M.G.1
  • 34
    • 84973850981 scopus 로고
    • Toxicity testing: Some principles and some pitfalls in histopathologic evaluation
    • Roe FJC. Toxicity testing: some principles and some pitfalls in histopathologic evaluation. Human Toxicol 1988; 7:405.
    • (1988) Human Toxicol , vol.7 , pp. 405
    • Roe, F.J.C.1
  • 35
    • 0024529904 scopus 로고
    • Correlations between morphologic and functional changes induced by xenobiotics: Is every induced change a sign of toxicity
    • Ruben Z, Wagner BM. Correlations between morphologic and functional changes induced by xenobiotics: is every induced change a sign of toxicity. Toxicol Appl Pharmacol 1989; 97:4.
    • (1989) Toxicol Appl Pharmacol , vol.97 , pp. 4
    • Ruben, Z.1    Wagner, B.M.2
  • 38
    • 0023111258 scopus 로고
    • Extrapolation from animals to man: Predictions, pitfalls and perspectives
    • Ruelius HW. Extrapolation from animals to man: predictions, pitfalls and perspectives. Xenobiotic 1987; 17:255.
    • (1987) Xenobiotic , vol.17 , pp. 255
    • Ruelius, H.W.1
  • 41
    • 0030174250 scopus 로고    scopus 로고
    • Conversion factors estimating indicative chronic no-observed-adverse-effect levels from short-term toxicity data
    • Kramer HJ, Van Der Ham WA, Slob W, Pieters MN. Conversion factors estimating indicative chronic no-observed-adverse-effect levels from short-term toxicity data. Regul Toxicol Pharmacol 1996; 23:249.
    • (1996) Regul Toxicol Pharmacol , vol.23 , pp. 249
    • Kramer, H.J.1    van der Ham, W.A.2    Slob, W.3    Pieters, M.N.4
  • 42
    • 0021883160 scopus 로고
    • A critical review of time-weighted average as an index of exposure and dose of its key elements
    • Atherley G. A critical review of time-weighted average as an index of exposure and dose of its key elements. Am Ind Hyg Assoc J 1985; 46:481.
    • (1985) Am Ind Hyg Assoc J , vol.46 , pp. 481
    • Atherley, G.1
  • 43
    • 0024263189 scopus 로고
    • Assessing risk from data on other exposure routes
    • Sharratt M. Assessing risk from data on other exposure routes. Regul Toxicol Pharmacol 1988; 8:399.
    • (1988) Regul Toxicol Pharmacol , vol.8 , pp. 399
    • Sharratt, M.1
  • 44
    • 0029021743 scopus 로고
    • A review of the acceptable daily intakes of pesticides assessed by WHO
    • Lu FC. A review of the acceptable daily intakes of pesticides assessed by WHO. Regul Toxicol Pharmacol 1995; 21:352.
    • (1995) Regul Toxicol Pharmacol , vol.21 , pp. 352
    • Lu, F.C.1
  • 45
    • 0042882184 scopus 로고    scopus 로고
    • Hazard and risk assessment of industrial chemicals in the occupational context in Europe: Some current issues
    • Fairhurst S. Hazard and risk assessment of industrial chemicals in the occupational context in Europe: some current issues. Food Chem Toxicol 2003; 41:1453.
    • (2003) Food Chem Toxicol , vol.41 , pp. 1453
    • Fairhurst, S.1
  • 47
    • 0036386331 scopus 로고    scopus 로고
    • A straw man proposal for a quantitative definition of the RfD
    • Hattis D, Baird S, Goble R. A straw man proposal for a quantitative definition of the RfD. Drug Chem Toxicol 2002; 25:403.
    • (2002) Drug Chem Toxicol , vol.25 , pp. 403
    • Hattis, D.1    Baird, S.2    Goble, R.3
  • 49
    • 0023751374 scopus 로고
    • Assessment of hepatic function and damage in animal species
    • Woodman DD. Assessment of hepatic function and damage in animal species. J Appl Toxicol 1988; 8:249.
    • (1988) J Appl Toxicol , vol.8 , pp. 249
    • Woodman, D.D.1
  • 50
    • 0035990394 scopus 로고    scopus 로고
    • A toxicologist's guide to biomarkers of hepatic response
    • Amacher DE. A toxicologist's guide to biomarkers of hepatic response. Human Exp Toxicol 2002; 21:253.
    • (2002) Human Exp Toxicol , vol.21 , pp. 253
    • Amacher, D.E.1
  • 51
    • 0027161423 scopus 로고
    • Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats
    • Waterfield CJ, Turton JA, Scales MDC, Timbrell JA. Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats. Arch Toxciol 1993; 67:244.
    • (1993) Arch Toxciol , vol.67 , pp. 244
    • Waterfield, C.J.1    Turton, J.A.2    Scales, M.D.C.3    Timbrell, J.A.4
  • 52
    • 0027508182 scopus 로고
    • Effects of various non-hepatotoxic compounds on urinary and liver taurine levels in rats
    • Waterfield CJ, Turton JA, Scales MDC, Timbrell JA. Effects of various non-hepatotoxic compounds on urinary and liver taurine levels in rats. Arch Toxicol 1993; 67:538.
    • (1993) Arch Toxicol , vol.67 , pp. 538
    • Waterfield, C.J.1    Turton, J.A.2    Scales, M.D.C.3    Timbrell, J.A.4
  • 53
    • 0036066905 scopus 로고    scopus 로고
    • Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats
    • O'Brien PJ, Slaughter MR, Polley SR, Kramer K. Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats. Lab Anim 2002; 36:313.
    • (2002) Lab Anim , vol.36 , pp. 313
    • O'Brien, P.J.1    Slaughter, M.R.2    Polley, S.R.3    Kramer, K.4
  • 54
    • 0036186764 scopus 로고    scopus 로고
    • Alteration of liver cell function and proliferation: Differentiation between adaptation and toxicity
    • Willimas GM, Iatropoulos MJ. Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity. Toxicol Pathol 2002; 30:41.
    • (2002) Toxicol Pathol , vol.30 , pp. 41
    • Willimas, G.M.1    Iatropoulos, M.J.2
  • 56
    • 0346037254 scopus 로고    scopus 로고
    • Isolated hemoperfused slaughterhouse livers as a valid model to study hepatotoxicity
    • Grosse-Siestrup C, Pfeffere J, Unger V, et al. Isolated hemoperfused slaughterhouse livers as a valid model to study hepatotoxicity. Toxicol Pathol 2002; 30:749.
    • (2002) Toxicol Pathol , vol.30 , pp. 749
    • Grosse-Siestrup, C.1    Pfeffere, J.2    Unger, V.3
  • 58
    • 0025187994 scopus 로고
    • Molecular and biochemical mechanisms of chemically induced nephrotoxicity: A review
    • Commandeur JNM, Vermeulen NPE. Molecular and biochemical mechanisms of chemically induced nephrotoxicity: a review. Chem Res Toxicol 1990; 3:171.
    • (1990) Chem Res Toxicol , vol.3 , pp. 171
    • Commandeur, J.N.M.1    Vermeulen, N.P.E.2
  • 59
    • 84914313847 scopus 로고
    • Comparative pharmacology of the kidney: Implications for drug-induced renal failure
    • Bach PH et al. Chichester: Wiley
    • Mudge GH. Comparative pharmacology of the kidney: implications for drug-induced renal failure. In: Bach PH et al. ed. Nephrotoxicity: Assessment and Pathogenesis. Chichester: Wiley, 1982:504.
    • (1982) Nephrotoxicity: Assessment and Pathogenesis , pp. 504
    • Mudge, G.H.1
  • 60
    • 0022483594 scopus 로고
    • Renal function and laboratory evaluation
    • Bovee KC. Renal function and laboratory evaluation. Toxicol Pathol 1986; 14:26.
    • (1986) Toxicol Pathol , vol.14 , pp. 26
    • Bovee, K.C.1
  • 61
    • 0022497923 scopus 로고
    • Functional-morphologic correlations in assessing renal toxicity
    • Hottendorf GH. Functional-morphologic correlations in assessing renal toxicity. Toxicol Pathol 1986; 14:123.
    • (1986) Toxicol Pathol , vol.14 , pp. 123
    • Hottendorf, G.H.1
  • 62
    • 0023907865 scopus 로고
    • Nephrotoxicity screening in rats: A validation study
    • Fent K, Mayer E, Zbinden G. Nephrotoxicity screening in rats: a validation study. Arch Toxicol 1988; 61:349.
    • (1988) Arch Toxicol , vol.61 , pp. 349
    • Fent, K.1    Mayer, E.2    Zbinden, G.3
  • 64
    • 0027848920 scopus 로고
    • Α2u-Globulin nephropathy: Review of the cellular and molecular mechanisms involved and their implications for human risk assessment
    • Swenberg JA. α2u-Globulin nephropathy: review of the cellular and molecular mechanisms involved and their implications for human risk assessment. Environ Health Perspect 1993;101:39.
    • (1993) Environ Health Perspect , vol.101 , pp. 39
    • Swenberg, J.A.1
  • 66
    • 0035165794 scopus 로고    scopus 로고
    • Pathology and pathophysiology of drug-induced arterial injury in laboratory animals and its implications on the evaluation of novel chemical entities for human clinical trials
    • Louden C, Morgan DG. Pathology and pathophysiology of drug-induced arterial injury in laboratory animals and its implications on the evaluation of novel chemical entities for human clinical trials. Pharmacol Toxicol 2001; 89:158.
    • (2001) Pharmacol Toxicol , vol.89 , pp. 158
    • Louden, C.1    Morgan, D.G.2
  • 70
    • 0342908315 scopus 로고
    • Slit-lamp examination of experimental animal eyes. Grading scales and photographic evaluation of induced pathological conditions
    • Balwin HA, McDonald TO, Beasley CH. Slit-lamp examination of experimental animal eyes. Grading scales and photographic evaluation of induced pathological conditions. J Soc Cosmet Chem 1973; 24:181.
    • (1973) J Soc Cosmet Chem , vol.24 , pp. 181
    • Balwin, H.A.1    McDonald, T.O.2    Beasley, C.H.3
  • 72
    • 0021358141 scopus 로고
    • Effects of drugs and chemicals upon the structure of the adrenal gland
    • Ribelin ES, Mosley MT. Effects of drugs and chemicals upon the structure of the adrenal gland. Fund Appl Toxicol 1984; 4:105.
    • (1984) Fund Appl Toxicol , vol.4 , pp. 105
    • Ribelin, E.S.1    Mosley, M.T.2
  • 73
    • 0023883706 scopus 로고
    • Adrenal gland toxicity: Chemically induced dysfunction
    • Colby HD. Adrenal gland toxicity: chemically induced dysfunction. J Am Coll Toxicol 1988; 7:45.
    • (1988) J Am Coll Toxicol , vol.7 , pp. 45
    • Colby, H.D.1
  • 74
    • 0032422631 scopus 로고    scopus 로고
    • Correlation of mechanistic data and histopathology in the evaluation of selected toxic endpoints of the endocrine system
    • Capen CC. Correlation of mechanistic data and histopathology in the evaluation of selected toxic endpoints of the endocrine system. Toxicol Lett 1998; 102-103:405.
    • (1998) Toxicol Lett , vol.102-103 , pp. 405
    • Capen, C.C.1
  • 75
    • 0023930549 scopus 로고
    • Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 4. Tests involving measurements of pancreatic enzymes in body fluid
    • Boyd EJS, Rinderknecht H, Wormsley KG. Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 4. Tests involving measurements of pancreatic enzymes in body fluid. Int J Pancreatol 1988; 3:1.
    • (1988) Int J Pancreatol , vol.3 , pp. 1
    • Boyd, E.J.S.1    Rinderknecht, H.2    Wormsley, K.G.3
  • 76
    • 0030013720 scopus 로고    scopus 로고
    • Drug-induced pancreatitis
    • Wilmink T, Frick TW. Drug-induced pancreatitis. Drug Saf 1996; 14:406.
    • (1996) Drug Saf , vol.14 , pp. 406
    • Wilmink, T.1    Frick, T.W.2
  • 79
    • 0036859006 scopus 로고    scopus 로고
    • Protein expression analysis of drug-mediated hepatoxicity in the Sprague-Dawley rat
    • Man WJ, White IR, Bryant D, et al. Protein expression analysis of drug-mediated hepatoxicity in the Sprague-Dawley rat. Proteomics 2002; 2:1577.
    • (2002) Proteomics , vol.2 , pp. 1577
    • Man, W.J.1    White, I.R.2    Bryant, D.3
  • 80
    • 0142244529 scopus 로고    scopus 로고
    • Toward the identification of liver toxicity markers: A proteome study in human cell culture and rats
    • Thome-Kromer B, Bonk I, Klatt M, et al. Toward the identification of liver toxicity markers: a proteome study in human cell culture and rats. Proteomics 2003; 3:1835.
    • (2003) Proteomics , vol.3 , pp. 1835
    • Thome-Kromer, B.1    Bonk, I.2    Klatt, M.3
  • 81
    • 12144290763 scopus 로고    scopus 로고
    • Identification of putative gene based markers of renal toxicity
    • Amin RP, Vickers AE, Sistare F, et al. Identification of putative gene based markers of renal toxicity. Environ Health Perspect 2004; 112:465.
    • (2004) Environ Health Perspect , vol.112 , pp. 465
    • Amin, R.P.1    Vickers, A.E.2    Sistare, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.