Conversion factors estimating indicative chronic no-observed-adverse-effect levels from short-term toxicity data

Regulatory Toxicology and Pharmacology

Volumn 23, Issue 3, 1996, Pages 249-255

  Kramer, H J ^a   Van Den Ham, W A ^a   Slob, W ^a   Pieters, M N ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL AGENT;

ARTICLE; CHRONIC TOXICITY; LD 50; MULTIPLE REGRESSION; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING;

EID: 0030174250     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1996.0050     Document Type: Article

References (7)

1. Layton, D. W., Mallon, B. J., Rosenblatt, D. H., and Small, M. J. (1987). Deriving allowable daily intakes for systemic toxicants lacking chronic toxicity data. Regul. Toxicol. Pharmacol. 7, 96-112.
2. McNamara, B. P. (1976). Concepts in health evaluation of commercial and industrial chemicals. In Advances in Modern Technology, 1: Part 1, New Concepts in Safety Evaluation (M. A. Mehlman, R. E. Shapiro, and H. Blumenthal, Eds.), pp. 61-140. Hemisphere, Washington, DC.
3. Owen, D. B. (1962). Handbook of Statistical Tables. Pergamon, London.
4. Owen, D. B. (1968). A survey of properties and applications of the non-central t-distribution. Technometrics 10, 445-478.
5. Venman, B. C., and Flaga, C. (1985). Development of an acceptable factor to estimate chronic end points from acute toxicity data. Toxicol. Ind. Health 1, 261-269.
6. Wagner, C., and Løkke, H. (1991). Estimations of ecotoxicological protection levels from NOEC toxicity data. Water Res. 14, 141-150.
7. Weil, C. S., and McCollister, D. D. (1963). Relationship between short-and long-term feeding studies in designing an effective toxicity test. J. Agric. Food Chem. 11, 486-491.