Culture and transportation of human islets between centers

Islet Transplantation and Beta Cell Replacement Therapy

Volumn , Issue , 2007, Pages 251-268

  Ichii, Hirohito ^a   Pileggi, Antonello ^a   Khan, Aisha ^a   Fraker, Chris ^a   Ricordi, Camillo ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85122647473     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (96)

1. Ricordi C, Strom TB. Clinical islet transplantation: advances and immunological challenges. Nat Rev Immunol 2004; 4(4):259-68.
2. Pileggi A, Alejandro R, Ricordi C. Islet transplantation: Steady progress and current challenges. Curr Opin Organ Transplant 2006; 11(1):7-13.
3. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343(4):230-8.
4. Hering BJ, Kandaswamy R, Ansite JD, et al. Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA 2005; 293(7):830-5.
5. Markmann JF, Deng S, Huang X, et al. Insulin independence following isolated islet transplantation and single islet infusions. Ann Surg 2003; 237(6): 741-9; 749-50.
6. Froud T, Ricordi C, Baidal DA, et al. Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am J Transplant 2005; 5(8):2037-46.
7. Pileggi A, Ricordi C, Kenyon NS, et al. Twenty years of clinical islet transplantation at the Diabetes Research Institute-University of Miami. Clinical Transplants 2004; 1-28.
8. Ricordi C. Islet transplantation: a brave new world. Diabetes 2003; 52(7): 1595-603.
9. Lee TC, Barshes NR, Brunicardi FC, et al. Procurement of the human pancreas for pancreatic islet transplantation. Transplantation 2004; 78(3):481-3.
10. Kuroda Y, Kawamura T, Suzuki Y, Fujiwara H, Yamamoto K, Saitoh Y. A new, simple method for cold storage of the pancreas using perfluorochemical. Transplantation 1988; 46(3):457-60.
11. Ricordi C, Fraker C, Szust J, et al. Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold-storage solution. Transplantation 2003; 75(9):1524-7.
12. Noguchi H, Ueda M, Nakai Y, et al. Modified two-layer preservation method (M-Kyoto/PFC) improves islet yields in islet isolation. Am J Transplant 2006; 6 (3):496-504.
13. Ricordi C, Lacy PE, Finke EH, Olack BJ, Scharp DW. Automated method for isolation of human pancreatic islets. Diabetes 1988; 37(4):413-20.
14. Linetsky E, Bottino R, Lehmann R, Alejandro R, Inverardi L, Ricordi C. Improved human islet isolation using a new enzyme blend, liberase. Diabetes 1997; 46(7):1120-3.
15. Goto M, Eich TM, Felldin M, et al. Refinement of the automated method for human islet isolation and presentation of a closed system for in vitro islet culture. Transplantation 2004; 78(9):1367-75.
16. Lake SP, Bassett PD, Larkins A, et al. Large-scale purification of human islets utilizing discontinuous albumin gradient on IBM 2991 cell separator. Diabetes 1989; 38(Suppl1):143-5.
17. Alejandro R, Strasser S, Zucker PF, Mintz DH. Isolation of pancreatic islets from dogs. Semiautomated purification on albumin gradients. Transplantation 1990; 50(2):207-10.
18. Ichii H, Pileggi A, Molano RD, et al. Rescue purification maximizes the use of humanisletpreparations fortransplantation. AmJTransplant2005; 5(1):21-30.
19. Ricordi C, Gray DW, Hering BJ, et al. Islet isolation assessment in man and large animals. Acta Diabetol Lat 1990; 27(3):185-95.
20. Ichii H, Inverardi L, Pileggi A, et al. A novel method for the assessment of cellular composition and β-cell viability in human islet preparations. Am J Transplant 2005; 5(7):1635-45.
21. Ichii H, Wang X, Messinger S, et al. Improved human islet isolation using nicotinamide. Am J Transplant 2006; 6(9):2060-8.
22. Thomas F, Wu J, Contreras JL, et al. A tripartite anoikis-like mechanism causes early isolated islet apoptosis. Surgery 2001; 130(2):333-8.
23. Scharp DW, Lacy PE, Santiago JV, et al. Results of our first nine intraportal islet allografts in type 1, insulin-dependent diabetic patients. Transplantation 1991; 51(1):76-85.
24. Alejandro R, Mintz DH. Experimental and clinical methods of islet transplantation. In: Transplantation of the Endocrine Pancreas in Diabetes Mellitus. Elsevier Science 1988; 217-223.
25. Alejandro R, Cutfield RG, Shienvold FL, et al. Natural history of intrahepatic canine islet cell autografts. J Clin Invest 1986; 78(5):1339-48.
26. Tzakis AG, Ricordi C, Alejandro R, et al. Pancreatic islet transplantation after upper abdominal exenteration and liver replacement. Lancet 1990; 336 (8712):402-5.
27. Warnock GL, Kneteman NM, Ryan EA, Rabinovitch A, Rajotte RV. Longterm follow-up after transplantation of insulin-producing pancreatic islets into patients with type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1992; 35(1):89-95.
28. Goss JA, Schock AP, Brunicardi FC, et al. Achievement of insulin independence in three consecutive type-1 diabetic patients via pancreatic islet transplantation using islets isolated at a remote islet isolation center. Transplantation 2002; 74(12):1761-6.
29. Hering BJ, Kandaswamy R, Harmon JV, et al. Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody. Am J Transplant 2004; 4(3):390-401.
30. Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54(7):2060-9.
31. Warnock GL, Meloche RM, Thompson D, et al. Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus. Arch Surg 2005; 140(8): 735-44.
32. Nano R, Clissi B, Melzi R, et al. Islet isolation for allotransplantation: variables associated with successful islet yield and graft function. Diabetologia 2005; 48 (5):906-12.
33. Inverardi L, Linetsky E, Kenyon NS, Socci C, Ricordi C. Human mixed lymphocyte-islet cultures: the influence of heterologous proteins on islet immunogenicity. Transplant Proc 1997; 29(4):2066.
34. Simeonovic CJ, Bowen KM, Kotlarski I, Lafferty KJ. Modulation of tissue immunogenicity by organ culture. Comparison of adult islets and fetal pancreas. Transplantation 1980; 30(3):174-9.
35. Lacy PE, Davie JM, Finke EH. Prolongation of islet allograft survival following in vitro culture (24 degrees C) and a single injection of ALS. Science 1979; 204(4390):312-3.
36. Ricordi C, Lacy PE, Sterbenz K, Davie JM. Low-temperature culture of human islets or in vivo treatment with L3T4 antibody produces a marked prolongation of islet human-to-mouse xenograft survival. Proc Natl Acad Sci USA 1987; 84(22):8080-4.
37. Benhamou PY, Stein E, Hober C, et al. Ultraviolet light irradiation reduces human islet immunogenicity without altering islet function. Horm Metab Res 1995; 27(3):113-20.
38. Moberg L, Olsson A, Berne C, et al. Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation. Transplantation 2003; 76(9):1285-8.
39. Goss JA, Goodpastor SE, Brunicardi FC, et al. Development of a human pancreatic islet-transplant program through a collaborative relationship with a remote islet-isolation center. Transplantation 2004; 77(3):462-6.
40. Kempf MC, Andres A, Morel P, et al. Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantation. Transplantation 2005; 79(9):1200-5.
41. Kessler L, Bucher P, Milliat-Guittard L, et al. Influence of islet transportation on pancreatic islet allotransplantation in type 1 diabetic patients within the Swiss-French GRAGIL network. Transplantation 2004; 77(8):1301-4.
42. Nagata N, Gu Y, Hori H, et al. Evaluation of insulin secretion of isolated rat islets cultured in extracellular matrix. Cell Transplant 2001; 10(4-5): 447-51.
43. Nagata NA, Inoue K, Tabata Y. Co-culture of extracellular matrix suppresses the cell death of rat pancreatic islets. J Biomater Sci Polym Ed 2002; 13(5): 579-90.
44. Pinkse GG, Bouwman WP, Jiawan-Lalai R, Terpstra OT, Bruijn JA, de Heer E. Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans. Diabetes 2006; 55(2): 312-7.
45. van Deijnen JH, Hulstaert CE, Wolters GH, van Schilfgaarde R. Significance of the peri-insular extracellular matrix for islet isolation from the pancreas of rat, dog, pig, and man. Cell Tissue Res 1992; 267(1):139-46.
46. Wang RN, Rosenberg L. Maintenance of β-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J Endocrinol 1999; 163(2):181-90.
47. Carlsson PO, Palm F. Oxygen tension in isolated transplanted rat islets and in islets of rat whole-pancreas transplants. Transpl Int 2002; 15(11):581-5.
48. Sweet IR, Khalil G, Wallen AR, et al. Continuous measurement of oxygen consumption by pancreatic islets. Diabetes Technol Ther 2002; 4(5):661-72.
49. Dionne KE, Colton CK, Yarmush ML. Effect of oxygen on isolated pancreatic tissue. ASAIO Trans 1989; 35(3):739-U.
50. Pileggi A, Ricordi C, Alessiani M, Inverardi L. Factors influencing Islet of Langerhans graft function and monitoring. Clin Chim Acta 2001; 310(1):3-16.
51. Abdelli S, Ansite J, Roduit R, et al. Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes 2004; 53(11):2815-23.
52. Bottino R, Balamurugan AN, Tse H, et al. Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes 2004; 53(10): 2559-68.
53. Matsuda T, Omori K, Vuong T, et al. Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function. Am J Transplant 2005; 5(3):484-93.
54. Noguchi H, Nakai Y, Matsumoto S, et al. Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function. Am J Transplant 2005; 5(8):1848-55.
55. Klein D, Barbe-Tuana F, Pugliese A, et al. A functional CD40 receptor is expressed in pancreatic β-cells. Diabetologia 2005; 48(2):268-76.
56. Pileggi A, Fenjves ES, Klein D, Ricordi C, Pastori RL. Protecting pancreatic β-cells. IUBMB Life 2004; 56(7):387-94.
57. Pileggi A, Cobianchi L, Inverardi L, Ricordi C. Overcoming the challenges now limiting islet transplantation: a sequential, integrated approach. Ann NY Acad Sci 2006; 1079(1):383-398.
58. Brandhorst D, Brandhorst H, Hering BJ, Bretzel RG. Long-term survival, morphology and in vitro function of isolated pig islets under different culture conditions. Transplantation 1999; 67(12):1533-U.
59. Ilieva A, Yuan S, Wang R, Duguid WP, Rosenberg L. The structural integrity of the islet in vitro: the effect of incubation temperature. Pancreas 1999; 19(3): 297-303.
60. Ilieva A, Yuan S, Wang RN, Agapitos D, Hill DJ, Rosenberg L. Pancreatic islet cell survival following islet isolation: the role of cellular interactions in the pancreas. J Endocrinol 1999; 161(3):357-64.
61. Holmes MA, Clayton HA, Chadwick DR, Bell PR, London NJ, James RF. Functional studies of rat, porcine, and human pancreatic islets cultured in ten commercially available media. Transplantation 1995; 60(8):854-60.
62. Murdoch TB, McGhee-Wilson D, Shapiro AM, Lakey JR. Methods ofhuman islet culture for transplantation. Cell Transplant 2004; 13(6):605-17.
63. Bertuzzi F, Saccomanno K, Socci C, et al. Long-term in vitro exposure to high glucose increases proinsulin-like-molecules release by isolated human islets. J Endocrinol 1998; 158(2):205-11.
64. Brendel MD, Kong SS, Alejandro R, Mintz DH. Improved functional survival of human islets of Langerhans in three-dimensional matrix culture. Cell Transplant 1994; 3(5):427-35.
65. Fraga DW, Sabek O, Hathaway DK, Gaber AO. A comparison of media supplement methods for the extended culture of human islet tissue. Transplantation 1998; 65(8):1060-6.
66. Matsumoto S, Goel S, Qualley S, Strong DM, Reems JA. A comparative evaluation of culture conditions for short-term maintenance <(24 hr) of human islets isolated using the Edmonton protocol. Cell Tissue Bank 2003; 4(2/4):85-93.
67. Marzorati S, Melzi R, Nano R, et al. In vitro modulation of monocyte chemoattractant protein-1 release in human pancreatic islets. Transplant Proc 2004; 36(3):607-8.
68. Eizirik DL, Korbutt GS, Hellerstrom C. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function. J Clin Invest 1992; 90(4):1263-8.
69. Straus DS. Growth-stimulatory actions of insulin in vitro and in vivo. Endocr Rev 1984; 5(2):356-69.
70. Clayton H, Turner J, Swift S, James R, Bell P. Supplementation of islet culture medium with insulin may have a beneficial effect on islet secretory function. Pancreas 2001; 22(1):72-4.
71. Clark SA, Chick WL. Islet cell culture in defined serum-free medium. Endocrinology 1990; 126(4):1895-903.
72. Hoorens A, Pipeleers D. Nicotinamide protects human β-cells against chemically-induced necrosis, but not against cytokine-induced apoptosis. Diabetologia 1999; 42(1):55-9.
73. Eizirik DL, Sandler S, Welsh N, Bendtzen K, Hellerstrom C. Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines. Autoimmunity 1994; 19(3):193-8.
74. Andersen HU, Jorgensen KH, Egeberg J, Mandrup-Poulsen T, Nerup J. Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of Langerhans. Diabetes 1994; 43(6):770-7.
75. Aikin R, Rosenberg L, Paraskevas S, Maysinger D. Inhibition of caspase-mediated PARP-1 cleavage results in increased necrosis in isolated islets of Langerhans. J Mol Med 2004; 82(6):389-97.
76. Johansson H, Lukinius A, Moberg L, et al. Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes 2005; 54(6):1755-62.
77. Moberg L, Johansson H, Lukinius A, et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002; 360(9350):2039-45.
78. Piemonti L, Leone BE, Nano R, et al. Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation. Diabetes 2002; 51(1):55-65.
79. Bertuzzi F, Marzorati S, Maffi P, et al. Tissue factor and CCL2/monocyte chemoattractant protein-1 released by human islets affect islet engraftment in type 1 diabetic recipients. J Clin Endocrinol Metab 2004; 89(11):5724-8.
80. Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL. Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 β-exposed human and rat islet cells. Diabetologia 2001; 44(3):325-32.
81. Luca G, Nastruzzi C, Basta G, et al. Effects of anti-oxidizing vitamins on in vitro cultured porcine neonatal pancreatic islet cells. Diabetes Nutr Metab 2000; 13(6):301-7.
82. Burkart V, Gross-Eick A, Bellmann K, Radons J, Kolb H. Suppression of nitric oxide toxicity in islet cells by alpha-tocopherol. FEBS Lett 1995; 364(3): 259-63.
83. Weber DJ. FDA regulation of allogeneic islets as a biological product. Cell Biochem Biophys 2004; 40(3 Suppl):19-22.
84. Weber DJ, McFarland RD, Irony I. Selected Food and Drug Administration review issues for regulation of allogeneic islets of langerhans as somatic cell therapy. Transplantation 2002; 74(12):1816-20.
85. Wonnacott K. Update on regulatory issues in pancreatic islet transplantation. Am J Ther 2005; 12(6):600-4.
86. LatifZA, Noel J, Alejandro R. A simple method ofstaining fresh and cultured islets. Transplantation 1988; 45(4):827-30.
87. Ricordi C. Quantitative and qualitative standards for islet isolation assessment in humans and large mammals. Pancreas 1991; 6(2):242-4.
88. Shapiro AM, Ricordi C. Unraveling the secrets of single donor success in islet transplantation. Am J Transplant 2004; 4(3):295-8.
89. Shapiro AM, Ricordi C, Hering B. Edmonton's islet success has indeed been replicated elsewhere. Lancet 2003; 362(9391):1242.
90. Brunicardi FC, Atiya A, Stock P, et al. Clinical islet transplantation experience of the University of California Islet Transplant Consortium. Surgery 1995; 118(6):967-71; discussion 971-2.
91. Brunicardi FC. Clinical islet transplantation: a consortium model. Transplant Proc 1996; 28(4):2138-40.
92. Rabkin JM, Leone JP, Sutherland DE, et al. Transcontinental shipping of pancreatic islets for autotransplantation after total pancreatectomy. Pancreas 1997; 15(4):416-9.
93. Rabkin JM, Olyaei AJ, Orloff SL, et al. Distant processing of pancreas islets for autotransplantation following total pancreatectomy. Am J Surg 1999; 177 (5):423-7.
94. Goss JA, Soltes G, Goodpastor SE, et al. Pancreatic islet transplantation: the radiographic approach. Transplantation 2003; 76(1):199-203.
95. Lemoli RM, Tafuri A, Strife A, Andreeff M, Clarkson BD, Gulati SC. Proliferation of human hematopoietic progenitors in long-term bone marrow cultures in gas-permeable plastic bags is enhanced by colony-stimulating factors. Exp Hematol 1992; 20(5):569-75.
96. Ichii H, Sakuma Y, Pileggi A, Fraker C, et al. Shipment of human islet for transplantation. Am J Transplantation 2007; 7(4):1010-1020.