Inhibition of caspase-mediated PARP-1 cleavage results in increased necrosis in isolated islets of Langerhans

Journal of Molecular Medicine

Volumn 82, Issue 6, 2004, Pages 389-397

  Aikin, Reid ^a,b   Rosenberg, Lawrence ^a   Paraskevas, Steven ^a   Maysinger, Dusica ^b,c  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Apoptosis; Caspase; Diabetes mellitus; Islet transplantation; Islets of Langerhans; Necrosis

Indexed keywords

CASPASE 3; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P50;

APOPTOSIS; ARTICLE; BIOAVAILABILITY; CELL DAMAGE; CELL DEATH; CELL ISOLATION; CELL LOSS; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; LANGERHANS CELL; MITOCHONDRION; NECROSIS; NONHUMAN; PANCREAS; PANCREAS ISLET CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSPLANTATION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; CASPASES; CELL DEATH; CELLS, CULTURED; DOGS; ENZYME INHIBITORS; HUMANS; ISLETS OF LANGERHANS; NECROSIS; NIACINAMIDE; PROTEINS;

EID: 3042796160     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-004-0540-5     Document Type: Article

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