Biosynthesis of Indole Diterpene Lolitrems: Radical-Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton

Angewandte Chemie - International Edition

Volumn 59, Issue 41, 2020, Pages 17996-18002

  Jiang, Yulu ^a   Ozaki, Taro ^a   Harada, Mei ^b,c   Miyasaka, Tadachika ^d   Sato, Hajime ^b,c   Miyamoto, Kazunori ^b   Kanazawa, Junichiro ^b   Liu, Chengwei ^a,g   Maruyama, Jun ichi ^e   Adachi, Masaatsu ^f   Nakazaki, Atsuo ^d   Nishikawa, Toshio ^d   Uchiyama, Masanobu ^b,c   Minami, Atsushi ^a   Oikawa, Hideaki ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Japan   (Japan)

^d NAGOYA UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f TOHOKU UNIVERSITY   (Japan)

^g NORTHEAST FORESTRY UNIVERSITY   (China)

Author keywords

cyclization; cytochrome P450; lolitrem; natural products; radical reactions

Indexed keywords

ASPERGILLUS; BIOCHEMISTRY; BIOSYNTHESIS; DENSITY FUNCTIONAL THEORY; POLYCYCLIC AROMATIC HYDROCARBONS; REACTION INTERMEDIATES;

ASPERGILLUS ORYZAE; BICYCLIC SYSTEMS; BIOSYNTHETIC PATHWAY; HETEROLOGOUS EXPRESSION; MODEL EXPERIMENTS; MULTISTEP OXIDATION; PRENYLTRANSFERASE; SYNTHETIC ANALOGUES;

CYCLIZATION;

ALCOHOL DERIVATIVE; DITERPENOID; INDOLE ALKALOID; INDOLE DERIVATIVE;

CHEMISTRY; CYCLIZATION; SYNTHESIS;

ALCOHOLS; CYCLIZATION; DITERPENES; INDOLE ALKALOIDS; INDOLES;

EID: 85089492186     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.202007280     Document Type: Article

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