Fluid and pharmacological agents for adhesion prevention after gynaecological surgery

Cochrane Database of Systematic Reviews

Volumn 2020, Issue 7, 2020, Pages

  Ahmad, Gaity ^a   Thompson, Matthew ^a   Kim, Kyungmin ^a   Agarwal, Priya ^a   Mackie, Fiona L ^a   Dias, Sofia ^b   Metwally, Mostafa ^c   Watson, Andrew ^d  

^a PENNINE ACUTE HOSPITALS NHS TRUST   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^d Tameside Glossop Integrated Care NHS Foundation Trust   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; ANTICOAGULANT AGENT; DIALYSIS FLUID; GLUCOCORTICOID; ICODEXTRIN; ORAL REHYDRATION SOLUTION; PLASMA SUBSTITUTE;

ADVERSE OUTCOME; BIRTH RATE; CLINICAL EFFECTIVENESS; DRUG EFFICACY; DRUG USE; ECTOPIC PREGNANCY; EVIDENCE BASED MEDICINE; FLUID THERAPY; GYNECOLOGIC SURGERY; HUMAN; INCIDENCE; LAPAROSCOPY; LIVE BIRTH; PAIN ASSESSMENT; PATIENT SAFETY; PELVIC PAIN; PREGNANCY; PREGNANCY RATE; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW; ADVERSE EVENT; DRUG THERAPY; FEMALE; FEMALE INFERTILITY; GEL; META ANALYSIS; POSTOPERATIVE COMPLICATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SECOND LOOK SURGERY; TISSUE ADHESION;

ANTICOAGULANTS; BIRTH RATE; DIALYSIS SOLUTIONS; FEMALE; GELS; GLUCOCORTICOIDS; GYNECOLOGIC SURGICAL PROCEDURES; HUMANS; ICODEXTRIN; INFERTILITY, FEMALE; PELVIC PAIN; PLASMA SUBSTITUTES; POSTOPERATIVE COMPLICATIONS; PREGNANCY; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REHYDRATION SOLUTIONS; SECOND-LOOK SURGERY; TISSUE ADHESIONS;

EID: 85088252403     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD001298.pub5     Document Type: Review

References (75)

1. Brown CB, Luciano AA, Martin D, Peers E, Scrimgeour A, diZerega GS. Adept (icodextrin 4% solution) reduces adhesions after laparoscopic surgery for adhesiolysis: a double-blind, randomised, controlled study. Fertility and Sterility 2007;88(5):1413-26. x-wiley/crsRef/3118746
2. Peers EM, Brown CB, Adept Adhesion Study Group. American Fertility Society score as a measure of effectiveness of 4% icodextrin in a pivotal adhesion reduction trial in the USA. Fertility and Sterility 2005;84(Suppl 1):S160. x-wiley/crsRef/3118747
3. Buttram V, Malinak R, Cleary R, Cohen S, Cowan B, Daniell J, et al, Adhesion Study Group. Reduction of postoperative pelvic adhesions with intraperitoneal 32% dextran 70: a prospective, randomized clinical trial. Fertility and Sterility 1983;40:612-9. x-wiley/crsRef/14135660
4. Cheong Y, Bailey S, Forbes J. Randomized Controlled Trial of Hyalobarrier Versus No Hyalobarrier on the Ovulatory Status of Women with Periovarian Adhesions: A Pilot Study. Advances in Therapy 2017;34(1):199-206. x-wiley/crsRef/14135662 [PMID: 27900662]
5. Coddington C, Grow D, Ahmed M, Toner J, Cook E, Diamond M. Gonadotropin-releasing hormone agonist pretreatment did not decrease postoperative adhesion formation after abdominal myomectomy in a randomized control trial. Fertility and Sterility 2009;91:1909-13. x-wiley/crsRef/3118749
6. Diamond MP. Reduction of de novo postsurgical adhesions by intraoperative pre coating with Sepracoat (HAL-C) solution: a prospective, randomized, blinded, placebo-controlled multicenter study. The Sepracoat Adhesion Study Group. Fertility and Sterility 1998;69(6):1067-74. x-wiley/crsRef/3118751
7. Diamon MP, Luciano A, Johns A, Dunn R, Young P, Bieber E. Reduction of postoperative adhesions by N, O-carboxymethylchitosan: a pilot study. Fertility and Sterility 2003;80(3):631-6. x-wiley/crsRef/3118753
8. diZerega GS, Verco SJ, Young P, Kettel M, Kobak W, Martin D, et al. A randomized, controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgery. Human Reproduction 2002;17(4):1031-8. x-wiley/crsRef/3118755
9. Fossum GT, Silverberg KM, Miller CE, Diamond MP, Holmdahl L. Gynecologic use of SepraSpray Adhesion Barrier for reduction of adhesion development after laparoscopic myomectomy: a pilot study. Fertility and Sterility 2011;96:487-91. x-wiley/crsRef/3118759
10. Hellebrekers BWJ, Trimbos-Kemper TCM, Boesten L, Jansen FW, Kolkman W, Trimbos JB, et al. Preoperative predictors of postsurgical adhesion formation and the prevention of adhesions with plasminogen activator (PAPA-study): results of a clinical pilot study. Fertility and Sterility 2009;91(4):1204-14. x-wiley/crsRef/3118761
11. Jansen RPS. Failure of intraperitoneal adjuncts to improve the outcome of pelvic operations in young women. American Journal of Obstetrics and Gynecology 1985;153:363-71. x-wiley/crsRef/3118763
12. Jansen RPS. Failure of peritoneal irrigation with heparin during pelvic operations upon young women to reduce adhesions. Surgery, Gynecology & Obstetrics 1988;166:154-60. x-wiley/crsRef/3118765
13. Jansen RPS. Controlled clinical approaches to investigating the prevention of peritoneal adhesions. In: Treatment of Postsurgical Adhesions. Vol. 358. New York: Wiley-Liss Inc, 1990:177-92. x-wiley/crsRef/3118767
14. Johns BD, Keyport GM, Hoehler F, diZerega G. Reduction of postsurgical adhesions with Intergel adhesion prevention solution: a multicenter study of safety and efficacy after conservative gynecologic surgery. Fertility and Sterility 2001;76(3):595-604. x-wiley/crsRef/3118769
15. Larsson B, Lalos O, Marsk L, Tronstad S-E, Bygdeman M, Pehrson S, Joelsson I. Effect of intraperitoneal instillation of 32% dextran 70 on postoperative adhesion formation after tubal surgery. Acta Obstetricia et Gynecologia Scandinavica 1985;64:437-41. x-wiley/crsRef/3118771
16. Liu C, Lu Q, Zhang Z, Xue M, Zhang Y, Zhang Y, et al. A randomized controlled trial on the efficacy and safety of a new crosslinked hyaluronan gel in reducing adhesions after gynecologic laparoscopic surgeries. The Journal of Minimally Invasive Gynaecology 2015;22(5):853-63. x-wiley/crsRef/14135664
17. Liu C, Zhang Z, Lu Q, Zhang Z. The efficacy and safety of a new cross-linked hyaluronan hydrogel in the reduction of postsurgical adhesions after laparoscopic gynecological surgery: a randomized controlled trial. The Journal of Minimally Invasive Gynaecology 2014;21:S59-60. x-wiley/crsRef/14135665
18. Lundorff P, Geldorp H, Tronstad SE, Lalos O, Larsson B, Johns DB, et al. Reduction of postsurgical adhesions with ferric hyaluronate gel: a European study. Human Reproduction 2001;16(9):1982-8. x-wiley/crsRef/3118773
19. Lundorff P, Donnez J, Korell M, Audebert AJM, Block K, diZerega GS. Clinical evaluation of a viscoelastic gel for reduction of adhesions following gynaecological surgery by laparoscopy in Europe. Human Reproduction 2004;20(2):514-20. x-wiley/crsRef/3118775
20. Mais V, Bracco GI, Litta P, Gargiulo, Melis GB. Reduction of postoperative adhesions with an auto-crosslinked hyaluronan gel in gynaecological laparoscopic surgery: a blinded, controlled, randomised, multicentre study. Human Reproduction 2006;21(5):1248-54. x-wiley/crsRef/3118777
21. Mettler L, Audebert A, Lehmann-Willenbrock E, Schive K, Jacobs VR. Prospective clinical trial of SprayGel as a barrier to adhesion formation: an interim analysis. Journal of American Association of Gynecologic Laparoscopists 2003;10(3):339-44. x-wiley/crsRef/14135666
22. Mettler L, Audebert A, Lehmann-Willenbrock E, Schive-Peterhansi K, Jacobs V. A randomized prospective, controlled, multicenter clinical trial of a sprayable, site specific adhesion barrier system in patients undergoing myomectomy. Fertility and Sterility 2004;82(2):398-404. x-wiley/crsRef/14135667
23. Mettler L. Pelvic adhesions: laparoscopic approach. Annals of the New York Academy of Sciences 2003;997:255-68. x-wiley/crsRef/14135668
24. Mettler L, Hucke J, Bojahr B, Tinneberg HR, Leyland N, Avelar R. A safety and efficacy study of a resorbable hydrogel for reduction of post-operative adhesions following myomectomy. Human Reproduction 2008;23(5):1093-100. x-wiley/crsRef/3118781
25. Pellicano M, Bramante S, Cirillo D, Palomba S, Bifulco G, Zullo F, et al. Effectiveness of autocrosslinked hyaluronic acid gel after laparoscopic myomectomy in infertile patients: a prospective, randomized, controlled study. Fertility and Sterility 2003;80(2):441-4. x-wiley/crsRef/3118783
26. Querleu D, Vankeerberghen-Deffense F, Bouteville C. The effect of noxytioline and systemic corticosteroids in infertility surgery. A prospective randomized study [Traitement adjuvant des plasties tubaires. Etude prospective randomisee des corticoides par voie generale et de la noxytioline]. Journal de Gynecologie Obstetrique et Biologie de la Reproduction 1989;18(7):935-40. x-wiley/crsRef/3118785
27. Rock JA, Siegler AM, Boer Miesel M, Haney AF, Rosenwaks Z, Pardo-Vargas F, et al. The efficacy of postoperative hydrotubation: a randomized prospective multicenter clinical trial. Fertility and Sterility 1984;42:373-6. x-wiley/crsRef/3118787
28. Rose B, MacNeill C, Larrain R, Kopreski M. Abdominal instillation of high-molecular-weight dextran or lactated Ringer's solution after laparoscopic surgery. Journal of Reproductive Medicine 1991;36:537-9. x-wiley/crsRef/3118789
29. Rosenberg SM, Board JA. High-molecular weight dextran in human infertility surgery. American Journal of Obstetrics and Gynecology 1984;148:380-5. x-wiley/crsRef/3118791
30. Sites CK, Jensen BA, Glock JL, Blackman JA, Badger GJ, Joh JV, et al. Transvaginal ultrasonographic assessment of Hyskon and lactated Ringer's solution instillation after laparoscopy. A randomized, controlled trial. Journal of Ultrasound Medicine 1997;16(3):195-9. x-wiley/crsRef/3118793 [MEDLINE: 9166816]
31. Tchartchian G, Hackethal A, Herrmann A, Bojahr B, Wallwiener C, Ohlinger R, et al. Evaluation of SprayShieldTM Adhesion Barrier in a single center: randomized controlled study in 15 women undergoing reconstructive surgery after laparoscopic myomectomy. Archives of Gynecology and Obstetrics 2014;290(4):697-704. x-wiley/crsRef/14135670 [PMID: 24781718]
32. Ten Broek RPG, Kok-Krant N, Verhoeve HR, van Goor H, Bakkum EA. Efficacy of polyethylene glycol adhesion barrier after gynaecological laparoscopic surgery. Gynecological Surgery 2012;9:29-35. x-wiley/crsRef/3118795
33. Thornton MH, Johns DB, Campeau JD, Hoehler F, DiZerega GS. Clinical evaluation of 0.5% ferric hyaluronate adhesion prevention gel for the reduction of adhesions following peritoneal cavity surgery: open label pilot study. Human Reproduction 1998;13(6):1480-5. x-wiley/crsRef/3118797
34. Trew G, Pistofidis G, Pados G, Lower A, Mettler L, Wallweiner D, et al. Gynaecological endoscopic evaluation of 4% icodextrin solution: a European, multicentre, double-blind, randomised study of the efficacy and safety in the reduction of de novo adhesions after laparoscopic gynaecological surgery. Human Reproduction 2011;26(8):2015-27. x-wiley/crsRef/3118799
35. Trew G, Pistofidis G, Ziegler N, Korrell M, Brucker S, Ritter H, et al. A first-in-human, randomized, controlled, subject- and reviewer-blinded study of a degradable hydrogel adhesion barrier spray applied laparoscopically to all sites of surgical trauma following gynecologic laparoscopic surgery. Journal of Minimally Invasive Gynaecology 2014;21:S90. x-wiley/crsRef/14135672
36. Trew GH, Pistofidis GA, Brucker SY, Krämer B, Ziegler NM, Korell M, et al. A first-in-human, randomized, controlled, subject- and reviewer-blinded multicenter study of ActamaxTM Adhesion Barrier. Archives of Gynecology and Obstetrics 2017;295:383-95. x-wiley/crsRef/14135673
37. Trew GH, Pistofidis GA, Brucker SY, Kraemer B, Ziegler NM, Korell M, et al. Twelve month follow-up of a first-In-human (FIH), randomized, controlled, subject- and reviewer-blinded study of a degradable hydrogel adhesion barrier spray (Actamax Adhesion Barrier) applied to all sites of surgical trauma following gynecologic laparoscopic surgery. Journal of Minimally Invasive Gynaecology 2016;23:S203. x-wiley/crsRef/14135674
38. Young P, Johns A, Templeman C, Witz C, Webster B, Ferland R, et al. Reduction of postoperative adhesions for laparoscopic gynaecological surgery with Oxiplex/AP gel: a pilot study. Fertility and Sterility 2005;84(5):1450-6. x-wiley/crsRef/3118801
39. Abu-Elhasan AM, Abdellah MS, Hamed HO. Safety and efficacy of postoperative continuous intra-peritoneal wash with lactated Ringer's for minimizing post-myomectomy pelvic adhesions: a pilot clinical trial. European Journal of Obstetrics, Gynecology, and Reproductive Biology 2014 Dec;183:78-82. x-wiley/crsRef/14135676
40. Diamond MP, Korell M, Martinez S, Kurman E, Kamar M, Adhexil Adhesion Study Group. A prospective, controlled, randomized, multicenter, exploratory pilot study evaluating the safety and potential trends in efficacy of Adhexil. Fertility and Sterility 2011;95:1086-90. x-wiley/crsRef/3118803
41. DiZerega GS, Coad J, Donnez J. Clinical evaluation of endometriosis and differential response to surgical therapy with and without application of Oxiplex/AP* adhesion barrier gel. Fertility and Sterility 2007;87:485-9. x-wiley/crsRef/3118757
42. Imai A, Sugiyama T, Furui A, Takahashi S, Tamaya T. Gonadotrophin-releasing hormones agonist therapy increases peritoneal fibrinolytic activity and prevents adhesion formation after myomectomy. Journal of Obstetrics and Gynaecology 2003;23(6):660-3. x-wiley/crsRef/3118805
43. Johns DA, Ferland R, Dunn R. Initial feasibility study of a sprayable hydrogel adhesion barrier system in patients undergoing laparoscopic ovarian surgery. Journal of the American Association of Gynecologic Laparoscopists 2003;10(3):334-8. x-wiley/crsRef/3118807
44. Pellicano M, Guida M, Bramante S, Acunzo G, Di Spiezio Sardo A, Tommaselli G, et al. Reproductive outcome after autocrosslinked hyaluronic acid gel application in infertile patients who underwent laparoscopic myomectomy. Fertility and Sterility 2005;83:498-500. x-wiley/crsRef/3118813
45. Swolin K. The effect of a massive Intraperitoneal dose of a glucocorticoid on the formation of postoperative adhesions. Clinical studies using laparoscopy in patients operated on for extrauterine pregnancy [Die einwirkung von grossen intraperitonealen dosen glukokortikoid auf die bildung von postoperativen adhasionen]. Acta Obstetricia et Gynaecologica Scandinavica 1967;46(2):204-10. x-wiley/crsRef/3118815
46. Tsuji S, Takahashi K, Yomo H, Fujiwara M, Kita N, Takebayashi K, et al. Effectiveness of antiadhesion barriers in preventing adhesion after myomectomy in patients with uterine leiomyoma. European Journal of Obstetrics and Gynecology 2005;123:244-8. x-wiley/crsRef/3118817
47. Tulandi T. Effect of intraperitoneal 32% dextran 70 on blood coagulation and serum electrolytes. Journal of Reproductive Medicine 1985;30:431-4. x-wiley/crsRef/3118819
48. Tulandi T. Effects of fibrin sealant on tubal anastomosis and adhesion formation. Fertility and Sterility 1991;56:136-8. x-wiley/crsRef/3118821
49. Hudecek R, Ivanova Z, Smerdova M, Pankova S, Krajcovicova R. Effect of GnRH analogues pre-treatment on myomectomy outcomes in reproductive age women. Ceska Gynekologie / Ceska Lekarska Spolecnost J. Ev. Purkyne 2009;77(2):109-17. x-wiley/crsRef/3118823
50. Litta P, Pluchino N, Freschi L, Borgato S, Angioni S. Evaluation of adhesions after laparoscopic myomectomy using the Harmonic Ace and the auto-crosslinked hyaluronan gel vs Ringer's lactate solution. Clinical and Experimental Obstetrics and Gynecology 2013;2:210-4. x-wiley/crsRef/3118825
51. Robertson LM, Rislund DC, Lim, HJ, Pierson RA, Tulandi T, Gargiulo AR, et al. A novel therapeutic approach to prevent adhesion: a double blind randomized study (DBRCT) of intraperitoneal L-Alanyl-L-Glutamine (A-G or EvitarTM) for the prevention of adhesion in laparoscopic myomectomies. The Journal of Minimally Invasive Gynaecology 2018;25(7):S158. x-wiley/crsRef/14135678
52. Ahmad G, Kim K, Thompson M, Agarwal P, O'Flynn H, Hindocha A, Watson A. Barrier agents for adhesion prevention after gynaecological surgery. Cochrane Database of Systematic Reviews 2020, Issue 3. [DOI: 10.1002/14651858.CD000475.pub4]
53. Practice Committee of American Society for Reproductive Medicine in collaboration with Society of Reproductive Surgeons. Pathogenesis, consequences, and control of peritoneal adhesions in gynecologic surgery: a committee opinion. Fertility and Sterility 2013;99(6):1550-5.
54. Cheong Y, Sadek K, Watson A, Metwally M, Li TC. Adhesion reduction agents in gynaecological procedures: can NHS afford it? Journal of Obstetrics and Gynaecology 2011;31:631-5.
55. De Wilde RL, Trew G. Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position. Part 2—steps to reduce adhesions. Gynaecological Surgery 2007;4(4):243-53.
56. De Wilde RL, Brölmann H, Koninckx PR, Lundorff P, Lower AM, Wattiez A, et al, the Anti-Adhesions in Gynecology Expert Panel (ANGEL). Prevention of adhesions in gynaecological surgery: the 2012 European field guideline. Gynecological Surgery 2012;9(4):365-8.
57. Diamond MP, Freeman ML. Clinical implications of postsurgical adhesions. Human Reproduction Update 2001;7:567-76.
58. McMaster University (developed by Evidence Prime, Inc.) GRADEpro GDT. Version accessed 4 May 2020. Hamilton (ON): McMaster University (developed by Evidence Prime, Inc.).Available at gradepro.org.
59. Hammoud A, Gago LA, Diamond MP. Adhesions in patients with chronic pelvic pain: a role for adhesiolysis? Fertility and Sterility 2004;82:1483-91.
60. Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
61. Hosie K, Gilbert JA, Kerr D, Brown CB, Peers EM. Fluid dynamics in man of an intraperitoneal drug delivery solution: 4% icodextrin. Drug Delivery 2001;8:9-12.
62. Kumar S, Wong PF, Leaper DJ. Intra-peritoneal prophylactic agents for preventing adhesions and adhesive intestinal obstruction after non-gynaecological abdominal surgery. Cochrane Database of Systematic Reviews 2009, Issue 21. [DOI: 10.1002/14651858.CD005080.pub2]
63. Lower AM, Hawthorn RJ, Ellis H, O'Brien F, Buchan S, Crowe AM. The impact of adhesions on hospital readmissions over ten years after 8849 open gynaecological operations: an assessment from the Surgical and Clinical Adhesions Research Study. BJOG 2000;107:855-62.
64. Lower AM, Hawthorn RJ, Clark D, Boyd JH, Finlayson AR, Knight AD, et al. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Human Reproduction 2004;19:1877-85.
65. Mais V, Cirronis MG, Peiretti M, Ferrucci G, Cossu E, Melis GB. Efficacy of auto-crosslinked hyaluronan gel for adhesion prevention in laparoscopy and hysteroscopy: a systematic review and meta-analysis of randomized controlled trials. European Journal of Obstetrics, Gynecology, and Reproductive Biology 2012 January;160(1):1-5.
66. Okabayashi K, Ashrafian H, Zacharakis E, Hasegawa H, Kitagawa Y, Athanasiou T, et al. Adhesions after abdominal surgery: a systematic review of the incidence, distribution and severity. Surgery Today 2014;44(3):405-20.
67. Robertson D, Lefebvre G, Leyland N, Wolfman W, Allaire C, Awadalla A, et al, Society of Obstetricians and Gynaecologists of Canada. SOGC clinical practice guidelines: adhesion prevention in gynaecological surgery. International Journal of Gynaecology and Obstetrics 2010;111(2):193-7.
68. Tang CL, Jayne DG, Seow-Choen F, Ng YY, Eu KW, Mustapha N. A randomized controlled trial of 0.5% ferric hyaluronate gel (Intergel) in the prevention of adhesions following abdominal surgery. Annals of Surgery 2006r;243(4):449-55.
69. US Food and Drug Administration. MedWatch: Managing Risks at the FDA. https://www.fda.gov/drugs/drug-information-consumers/medwatch-managing-risks-fda [Accessed 23.06.2020].
70. Van den Beukel BA, de Ree R, van Leuven S, Bakkum EA, Strik C, van Goor H, et al. Surgical treatment of adhesion-related chronic abdominal and pelvic pain after gynaecological and general surgery: a systematic review and meta-analysis. Human Reproduction Update 2017;23(3):276-88. [DOI: https://doi.org/10.1093/humupd/dmx004]
71. Wilson MS, Menzies D, Knight AD, Crowe AM. Demonstrating the clinical and cost effectiveness of adhesion reduction strategies. Colorectal Disease 2002;4:355-60.
72. Wiseman DM. Possible Intergel Reaction Syndrome (pIRS). Annals of Surgery 2006;244(4):630-632.
73. Ahmad G, Mackie FL, Iles DA, O'Flynn H, Dias S, Metwally M, et al. Fluid and pharmacological agents for adhesion prevention after gynaecological surgery. Cochrane Database of Systematic Reviews 2014, Issue 7. [DOI: 10.1002/14651858.CD001298.pub4]
74. Metwally M, Watson A, Lilford R, Vandekerckhove P. Fluid and pharmacological agents for adhesion prevention after gynaecological surgery. Cochrane Database of Systematic Reviews 2006, Issue 4. [DOI: 10.1002/14651858.CD001298.pub3]
75. Watson A, Vandekerckhove, Lilford R. Subfertility: Pelvic surgery: Pharmacological and liquid adjuncts to prevent adhesions. Cochrane Database of Systematic Reviews 2000, Issue 4. [DOI: 10.1002/14651858.CD001298]