Randomized Controlled Trial of Hyalobarrier® Versus No Hyalobarrier® on the Ovulatory Status of Women with Periovarian Adhesions: A Pilot Study

Advances in Therapy

Volumn 34, Issue 1, 2017, Pages 199-206

  Cheong, Ying ^a,b   Bailey, Sarah ^a,c   Forbes, Jane ^a  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Adhesiolysis; Adhesion prevention; Fertility; Hyalobarrier; Ovary

Indexed keywords

FOLLITROPIN; LUTEINIZING HORMONE; PROGESTERONE; HYALURONIC ACID;

ADHESION BARRIER GEL; ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENDOMETRIAL THICKNESS; FEMALE; FEMALE SUBFERTILITY; FOLLITROPIN BLOOD LEVEL; HUMAN; IN VITRO FERTILIZATION; LAPAROSCOPY; LUTEINIZING HORMONE BLOOD LEVEL; OVARY DISEASE; OVARY FOLLICLE; OVULATION; PERIOVARIAN ADHESION; PILOT STUDY; POSTOPERATIVE PERIOD; PREGNANCY RATE; PROGESTERONE BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; ADMINISTRATION AND DOSAGE; ADNEXA DISEASE; GEL; PREGNANCY; TISSUE ADHESION;

ADNEXAL DISEASES; ADULT; FEMALE; GELS; HUMANS; HYALURONIC ACID; LAPAROSCOPY; OVULATION; PILOT PROJECTS; PREGNANCY; TISSUE ADHESIONS;

EID: 85000774322     PISSN: 0741238X     EISSN: 18658652     Source Type: Journal    
DOI: 10.1007/s12325-016-0453-z     Document Type: Article

References (16)

1. Caspi E, Halperin Y. Surgical management of periadnexal adhesions. Int J Fertil. 1981;26(1):49–52.
2. Mahadevan MM, et al. The effects of ovarian adhesive disease upon follicular development in cycles of controlled stimulation for in vitro fertilization. Fertil Steril. 1985;44(4):489–92.
3. Bowman MC, Cooke ID, Lenton EA. Investigation of impaired ovarian function as a contributing factor to infertility in women with pelvic adhesions. Hum Reprod. 1993;8(10):1654–6.
4. Nagata Y, et al. Peri-ovarian adhesions interfere with the diffusion of gonadotrophin into the follicular fluid. Hum Reprod. 1998;13(8):2072–6.
5. Hamilton CJ, Evers JL, Hoogland HJ. Ovulatory disorders and inflammatory adnexal damage: a neglected cause of the failure of fertility microsurgery. Br J Obstet Gynaecol. 1986;93(3):282–4.
6. Alborzi S, Motazedian S, Parsanezhad ME. Chance of adhesion formation after laparoscopic salpingo-ovariolysis: is there a place for second-look laparoscopy? J Am Assoc Gynecol Laparosc. 2003;10(2):172–6.
7. Carpenter TT, Kent A. Ovaries do not float. Gynecol Surg. 2004;1(4):263–4.
8. Hooker A, et al. Prevention of adhesions post (spontaneous) abortion (PAPA study); a randomized controlled trial evaluating application of hyaluronic acid (HA). Hum Reprod. 2016;31(Supp 1):39.
9. Cheong YC, et al. Should women with chronic pelvic pain have adhesiolysis? BMC Womens Health. 2014;14(1):36.
10. Tulandi T, Falcone T, Kafka I. Second-look operative laparoscopy 1 year following reproductive surgery. Fertil Steril. 1989;52(3):421–4.
11. Gomel V. Salpingo-ovariolysis by laparoscopy in infertility. Fertil Steril. 1983;40(5):607–11.
12. Bosteels J, et al. Anti-adhesion barrier gels following operative hysteroscopy for treating female infertility: a systematic review and meta-analysis. Gynecol Surg. 2014;11:113–27.
13. Ahmad G, et al. Barrier agents for adhesion prevention after gynaecological surgery. Cochrane Database Syst Rev. 2015(4):CD000475.
14. Metwally M, Cheong Y, Li TC. A review of techniques for adhesion prevention after gynaecological surgery. Curr Opin Obstet Gynecol. 2008;20(4):345–52.
15. De Wilde RL, et al. Adhesions and endometriosis: challenges in subfertility management: (an expert opinion of the ANGEL-The ANti-Adhesions in Gynaecology Expert PaneL-group). Arch Gynecol Obstet. 2016;294(2):299–301.
16. RCOG. The use of adhesion prevention agents in obstetrics and gynaecology (Scientific Impact Paper no. 39). London: Royal College of Obstetricians & Gynaecologists; 2013.