Erythropoietin in the clinical trials of the cardiac disease, what is and what is not

Journal of Cellular and Molecular Anesthesia

Volumn 4, Issue 4, 2019, Pages 136-144

  Tehrani, Mohammad Masoud Majidi ^a   Foroughi, Mahnoosh ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute myocardial infarction; Cardioprotection; Cardiovascular outcomes; Erythropoietin; Heart failure; Reperfusion injury

Indexed keywords

EID: 85087619518     PISSN: 25382462     EISSN: 24765120     Source Type: Journal    
DOI: 10.22037/jcma.v4i4.29156     Document Type: Review

References (62)

1. Mastromarino V, Volpe M, Musumeci MB, Autore C, Conti E. Erythropoietin and the heart: facts and perspectives. Clin Sci (Lond). 2011;120(2):51-63.
2. Tanaka T, Nangaku M. Recent advances and clinical application of erythropoietin and erythropoiesis-stimulating agents. Exp Cell Res. 2012;318(9):1068-73.
3. Mastromarino V, Musumeci MB, Conti E, Tocci G, Volpe M. Erythropoietin in cardiac disease: effective or harmful? J Cardiovasc Med (Hagerstown). 2013;14(12):870-8.
4. Kimáková P, Solár P, Solárová Z, Komel R, Debeljak N. Erythropoietin and its angiogenic activity. Int J Mol Sci. 2017;18(7).
5. Nekoui A, Blaise G. Erythropoietin and nonhematopoietic effects. Am J Med Sci. 2017;353(1):76-81.
6. Zahidova KK. Indexes of the erythropoietin level in the blood plasma of chronic heart failure patients with anemia. J Basic Clin Physiol Pharmacol. 2018;29(1):11-17.
7. Sîrbu O, Floria M, Dascalita P, Stoica A, Adascalitei P, Sorodoc V, Sorodoc L. Anemia in heart failure-from guidelines to controversies and challenges. Anatol J Cardiol. 2018;20(1):52-59.
8. Zhang Y, Wang L, Dey S, Alnaeeli M, Suresh S, Rogers H, Teng R, Noguchi CT. Erythropoietin action in stress response, tissue maintenance and metabolism. Int J Mol Sci. 2014;15(6):10296-333.
9. Grote Beverborg N, van der Wal HH, Klip IT, Voors AA, de Boer RA, van Gilst WH, van Veldhuisen DJ, Gansevoort RT, Hillege HL, van der Harst P, Bakker SJ, van der Meer P. High serum erythropoietin levels are related to heart failure development in subjects from the general population with albuminuria: data from PREVEND. Eur J Heart Fail. 2016;18(7):814-21.
10. Spahn DR, Schoenrath F, Spahn GH, Seifert B, Stein P, Theusinger OM, Kaserer A, Hegemann I, Hofmann A, Maisano F, Falk V. Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial. Lancet. 2019;393(10187):2201-12.
11. Ali-Hassan-Sayegh S, Mirhosseini SJ, Tahernejad M, Mahdavi P, Haddad F, Shahidzadeh A, Lotfaliani MR, Sedaghat-Hamedani F, Kayvanpour E, Weymann A, Sabashnikov A, Popov AF. Administration of erythropoietin in patients with myocardial infarction: does it make sense? An updated and comprehensive meta-analysis and systematic review. Cardiovasc Revasc Med. 2015;16(3):179-89.
12. Penny-Dimri JC, Cochrane AD, Perry LA, Smith JA. Characterising the role of perioperative erythropoietin for preventing acute kidney injury after cardiac surgery: systematic review and meta-analysis. Heart Lung Circ. 2016;25(11):1067-1076.
13. Rivera-Cervantes MC, Jarero-Basulto JJ, Murguía-Castillo J, Marín-López AG, Gasca-Martínez Y, Cornelio-Martínez S, Beas-Zárate C. The recombinant human erythropoietin administered in neonatal rats after excitotoxic damage, induces molecular changes in the hippocampus. Front Neurosci. 2019;13:118.
14. Brines M. The therapeutic potential of erythropoiesis-stimulating agents for tissue protection: a tale of two receptors. Blood Purif. 2010;29(2):86-92.
15. Yang HT, Xiu WJ, Zheng YY, Ma YT, Xie X. Effects of erythropoietin on the clinical outcomes of patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention: A meta-analysis. Int J Clin Pharmacol Ther. 2018;56(6):277-279.
16. Rymer JA, Rao SV. Anemia and coronary artery disease: pathophysiology, prognosis, and treatment. Coron Artery Dis. 2018;29(2):161-167.
17. Seo WW, Suh JW, Oh IY, Yoon CH, Cho YS, Youn TJ, Chae IH, Choi DJ. Efficacy of IntraCoronary Erythropoietin Delivery BEfore Reperfusion-Gauging Infarct Size in Patients with Acute ST-segment Elevation Myocardial Infarction (ICEBERG). Int Heart J. 2019;60(2):255-263
18. Satoh K, Fukumoto Y, Nakano M, Kagaya Y, Shimokawa H. Emergence of the erythropoietin/erythropoietin receptor system as a novel cardiovascular therapeutic target. J Cardiovasc Pharmacol. 2011;58(6):570-4.
19. Garimella PS, Katz R, Patel KV, Kritchevsky SB, Parikh CR, Ix JH, Fried LF, Newman AB, Shlipak MG, Harris TB, Sarnak MJ; Health ABC Study. Association of serum erythropoietin with cardiovascular events, kidney function decline, and mortality: the Health Aging and Body Composition Study. Circ Heart Fail. 2016;9(1):e002124.
20. Nagai T, Nishimura K, Honma T, Higashiyama A, Sugano Y, Nakai M, Honda S, Iwakami N, Okada A, Kawakami S, Kanaya T, Asaumi Y, Aiba T, Nishida Y, Kubota Y, Sugiyama D, Okamura T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T; NaDEF investigators. Prognostic significance of endogenous erythropoietin in long-term outcome of patients with acute decompensated heart failure. Eur J Heart Fail. 2016;18(7):803-13.
21. Oba T, Yasukawa H, Nagata T, Kyogoku S, Minami T, Nishihara M, Ohshima H, Mawatari K, Nohara S, Takahashi J, Sugi Y, Igata S, Iwamoto Y, Kai H, Matsuoka H, Takano M, Aoki H, Fukumoto Y, Imaizumi T. Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning. Circ J. 2015;79(7):1557-67.
22. Ferrario M, Massa M, Rosti V, Campanelli R, Ferlini M, Marinoni B, De Ferrari GM, Meli V, De Amici M, Repetto A, Verri A, Bramucci E, Tavazzi L. Early haemoglobin-independent increase of plasma erythropoietin levels in patients with acute myocardial infarction. Eur Heart J. 2007;28(15):1805-13.
23. Namiuchi S, Kagaya Y, Ohta J, Shiba N, Sugi M, Oikawa M, Kunii H, Yamao H, Komatsu N, Yui M, Tada H, Sakuma M, Watanabe J, Ichihara T, Shirato K. High serum erythropoietin level is associated with smaller infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention. J Am Coll Cardiol. 2005;45(9):1406-12.
24. Yuksel IO, Cagirci G, Koklu E, Yilmaz A, Kucukseymen S, Ellidag HY, Cay S, Yilmaz N, Arslan S. Erythropoietin stimulates the coronary collateral development in patients with coronary chronic total occlusion. Neth Heart J. 2016;24(10):609-16.
25. Li YM, Xiang L, Zhao Q, Zhao J, Xu XX, Lin QQ, Zhang C, Xiao Q. Correlation between endogenous EPO levels and electrocardiogram scatter plot changes in patients with coronary heart disease and autonomic nerve function injury. Zhonghua Yi Xue Za Zhi. 2019;99(18):1412-1417.
26. Özyüncü N, Güleç S, Özdöl Ç, Candemir B, Ongun A, Tulunay Kaya C, Erol Ç. Impact of serum erythropoietin level on collateral vessel development in patients with coronary artery disease. Anatol J Cardiol. 2017;17(5):386-391.
27. Menzorov MV, Shutov AM, Larionova NV, Strakhov AA, Serova DV. Prognostic Significance of Erythropoietin in Patients With Acute Coronary Syndrome. Kardiologiia. 2016;56(9):15-20.
28. Li Y, Li M, Teng Y, Zhang C, Liu Q, Hou H. The association between red cell distribution width, erythropoietin levels, and coronary artery disease. Coron Artery Dis. 2018;29(1):74-80.
29. Roubille F, Prunier F, Barrère-Lemaire S, Leclercq F, Piot C, Kritikou EA, Rhéaume E, Busseuil D, Tardif JC. What is the role of erythropoietin in acute myocardial infarct? Bridging the gap between experimental models and clinical trials. Cardiovasc Drugs Ther. 2013;27(4):315-31.
30. Minamino T, Higo S, Araki R, Hikoso S, Nakatani D, Suzuki H, Yamada T, Okutsu M, Yamamoto K, Fujio Y, Ishida Y, Ozawa T, Kato K, Toba K, Aizawa Y, Komuro I; EPO-AMI-II Investigators. Low-Dose Erythropoietin in Patients With ST-Segment Elevation Myocardial Infarction (EPO-AMI-II)- A Randomized Controlled Clinical Trial. Circ J. 2018;82(4):1083-1091.
31. Steppich B, Groha P, Ibrahim T, Schunkert H, Laugwitz KL, Hadamitzky M, Kastrati A, Ott I; Regeneration of Vital Myocardium in ST-Segment Elevation Myocardial Infarction by Erythropoietin (REVIVAL-3) Study Investigators. Effect of Erythropoietin in patients with acute myocardial infarction: five-year results of the REVIVAL-3 trial. BMC Cardiovasc Disord. 2017;17(1):38.
32. Talan MI, Latini R. Myocardial infarction: cardioprotection by erythropoietin. Methods Mol Biol. 2013;982:265-302.
33. Mueller C, Wodack K, Twelker K, Werner N, Custodis F, Nickenig G. Darbepoetin improves endothelial function and increases circulating endothelial progenitor cell number in patients with coronary artery disease. Heart. 2011;97(18):1474-8.
34. Schneider MD. EPO and super-EPO: erythropoietins direct neoangiogenesis by cardiac progenitor cells. Cell Stem Cell. 2011;9(2):95-6.
35. Sanada D, Honda H, Kato N, Yokochi A, Michihata T, Akizawa T. Associations among Darbepoetin-α, CD34+ Cells and Cardiovascular Disease Events in Patients on Hemodialysis. Nephron Extra. 2012;2(1):233-46.
36. Bartnicki P, Rysz J, Franczyk B, Baj Z, Majewska E. Impact of Continuous Erythropoietin Receptor Activator on Selected Biomarkers of Cardiovascular Disease and Left Ventricle Structure and Function in Chronic Kidney Disease. Oxid Med Cell Longev. 2016;2016:9879615.
37. Xanthos T, Vasileiou P, Kakavas S, Syggelou A, Iacovidou N. The potential role of erythropoietin as a pleiotropic agent in post-cardiac arrest syndrome. Curr Pharm Des. 2011;17(15):1517-29.
38. Gholamzadeh A, Amini S, Mohammadpour AH, Vahabzadeh M, Fazelifar AF, Fazlinezhad A, Dehghani M, Moohebati M, Dastani M, Malaekeh-Nikouie B, Falsoleiman H. Erythropoietin reduces post-PCI arrhythmias in patients with ST-elevation myocardial infarction. J Cardiovasc Pharmacol. 2015;65(6):555-61.
39. Patel NS, Nandra KK, Thiemermann C. Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care. Crit Care. 2012;16(4):229.
40. Anand IS, Gupta P. Anemia and iron deficiency in heart failure: current concepts and emerging therapies. Circulation. 2018;138(1):80-98.
41. Vatutin NT, Taradin GG, Kanisheva IV, Venzheha VV. Anaemia and iron deficiency in chronic heart failure patients. Kardiologiia. 2019;59(4S):4-20.
42. Swedberg K, Young JB, Anand IS, Cheng S, Desai AS, Diaz R, Maggioni AP, McMurray JJ, O'Connor C, Pfeffer MA, Solomon SD, Sun Y, Tendera M, van Veldhuisen DJ; RED-HF Committees; RED-HF Investigators. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med. 2013 Mar 28;368(13):1210-9.
43. Urena M, Del Trigo M, Altisent OA, Campelo-Prada F, Regueiro A, DeLarochellière R, Doyle D, Mohammadi S, Paradis JM, Dagenais F, Dumont E, Puri R, Laroche V, Rodés-Cabau J. Combined erythropoietin and iron therapy for anaemic patients undergoing transcatheter aortic valve implantation: the EPICURE randomised clinical trial. EuroIntervention: journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the EuroIntervention. 2017 May 15;13(1):44-52.
44. Green P, Babu BA, Teruya S, Helmke S, Prince M, Maurer MS. Impact of epoetin alfa on left ventricular structure, function, and pressure volume relations as assessed by cardiac magnetic resonance: the heart failure preserved ejection fraction (HFPEF) anemia trial. Congest Heart Fail. 2013;19(4):172-9.
45. Grote Beverborg N, van Veldhuisen DJ, van der Meer P. Anemia in heart failure: still relevant? JACC Heart Fail. 2018;6(3):201-8.
46. van der Meer P, Grote Beverborg N, Pfeffer MA, Olson K, Anand IS, Westenbrink BD, McMurray JJV, Swedberg K, Young JB, Solomon SD, van Veldhuisen DJ. Hyporesponsiveness to Darbepoetin Alfa in Patients With Heart Failure and Anemia in the RED-HF Study (Reduction of Events by Darbepoetin Alfa in Heart Failure) Clinical and Prognostic Associations. Circ Heart Fail. 2018;11(2):e004431.
47. Bozkurt B. What is new in heart failure management in 2017? Update on ACC/AHA heart failure guidelines. Curr Cardiol Rep. 2018;20(6):39.
48. Jackevicius CA, Fan CS, Warner A. Clinical outcomes of erythropoietin use in heart failure patients with anemia of chronic kidney disease. J Card Fail. 2014;20(5):327-33.
49. Blaudszun G, Butchart A, Klein AA. Blood conservation in cardiac surgery. Transfus Med. 2018;28(2):168-80.
50. Pagano D, Milojevic M, Meesters MI, Benedetto U, Bolliger D, von Heymann C, Jeppsson A, Koster A, Osnabrugge RL, Ranucci M, Ravn HB, Vonk ABA, Wahba A, Boer C. 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery. Eur J Cardiothorac Surg. 2018;53(1):79-111.
51. Cladellas M, Farré N, Comín-Colet J, Gómez M, Meroño O, Bosch MA, Vila J, Molera R, Segovia A, Bruguera J. Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement. Am J Cardiol. 2012;110(7):1021-6.
52. Yoo YC, Shim JK, Kim JC, Jo YY, Lee JH, Kwak YL. Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery. Anesthesiology. 2011;115(5):929-37.
53. Weltert L, Rondinelli B, Bello R, Falco M, Bellisario A, Maselli D, Turani F, De Paulis R, Pierelli L. A single dose of erythropoietin reduces perioperative transfusions in cardiac surgery: results of a prospective single‐ blind randomized controlled trial. Transfusion. 2015;55(7):1644-54.
54. Cho BC, Serini J, Zorrilla-Vaca A, Scott MJ, Gehrie EA, Frank SM, Grant MC. Impact of preoperative erythropoietin on allogeneic blood transfusions in surgical patients: results from a systematic review and meta-analysis. Anesth Analg. 2019;128(5):981-92.
55. Tie HT, Luo MZ, Lin D, Zhang M, Wan JY, Wu QC. Erythropoietin administration for prevention of cardiac surgery-associated acute kidney injury: a meta-analysis of randomized controlled trials. Eur J Cardiothorac Surg. 2015;48(1):32-9.
56. de Seigneux S, Ponte B, Weiss L, Pugin J, Romand JA, Martin P-Y, Martin PY, Saudan P. Epoetin administrated after cardiac surgery: effects on renal function and inflammation in a randomized controlled study. BMC nephrol. 2012;13(1):132.
57. Kim JH, Shim JK, Song JW, Song Y, Kim HB, Kwak YL. Effect of erythropoietin on the incidence of acute kidney injury following complex valvular heart surgery: a double blind, randomized clinical trial of efficacy and safety. Crit Care. 2013;17(5):R254.
58. Tasanarong A, Duangchana S, Sumransurp S, Homvises B, Satdhabudha O. Prophylaxis with erythropoietin versus placebo reduces acute kidney injury and neutrophil gelatinase-associated lipocalin in patients undergoing cardiac surgery: a randomized, double-blind controlled trial. BMC Nephrol. 2013;14:136.
59. Lakič N, Mrak M, Šušteršič M, Rakovec P, Bunc M. Perioperative erythropoietin protects the CNS against ischemic lesions in patients after open heart surgery. Wien Klin Wochenschr. 2016;128(23-24):875-81.
60. Maiese K, Li F, Chong ZZ. New avenues of exploration for erythropoietin. JAMA. 2005;293(1):90-5.
61. McCullough PA, Barnhart HX, Inrig JK, Reddan D, Sapp S, Patel UD, Singh AK, Szczech LA, Califf RM. Cardiovascular toxicity of epoetin-alfa in patients with chronic kidney disease. Am J Nephrol. 2013;37(6):549-58.
62. Nassif ME, Patel JS, Shuster JE, Raymer DS, Jackups R, Novak E, Gage BF, Prasad S, Silvestry SC, Ewald GA, LaRue SJ. Clinical outcomes with use of erythropoiesis stimulating agents in patients with the HeartMate II left ventricular assist device. JACC Heart Fail. 2015;3(2):146-53.