메뉴 건너뛰기




Volumn 6, Issue 3, 2018, Pages 201-208

Anemia in Heart Failure: Still Relevant?

Author keywords

anemia; erythropoiesis stimulating agents; heart failure; iron

Indexed keywords

ANTIANEMIC AGENT; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; FERRIC CARBOXYMALTOSE; HEMOGLOBIN; HEPCIDIN; IRON; IRON POLYSACCHARIDE; IRON SACCHARATE; LEXAPTEPID PEGOL; LY 2787106; PLACEBO; RECOMBINANT ERYTHROPOIETIN; ROXADUSTAT; SPIEGELMER; UNCLASSIFIED DRUG; FERRITIN;

EID: 85033394211     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2017.08.023     Document Type: Review
Times cited : (74)

References (49)
  • 1
    • 80052102921 scopus 로고    scopus 로고
    • Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches
    • van Veldhuisen, D.J., Anker, S.D., Ponikowski, P., Macdougall, I.C., Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches. Nat Rev Cardiol 8 (2011), 485–493.
    • (2011) Nat Rev Cardiol , vol.8 , pp. 485-493
    • van Veldhuisen, D.J.1    Anker, S.D.2    Ponikowski, P.3    Macdougall, I.C.4
  • 2
    • 53249107656 scopus 로고    scopus 로고
    • Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume
    • Adlbrecht, C., Kommata, S., Hülsmann, M., et al. Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume. Eur Heart J 29 (2008), 2343–2350.
    • (2008) Eur Heart J , vol.29 , pp. 2343-2350
    • Adlbrecht, C.1    Kommata, S.2    Hülsmann, M.3
  • 3
    • 84928630976 scopus 로고    scopus 로고
    • Erythropoietin in the general population: reference ranges and clinical, biochemical and genetic correlates
    • Grote Beverborg, N., Verweij, N., Klip, I.T., et al. Erythropoietin in the general population: reference ranges and clinical, biochemical and genetic correlates. PLoS One, 10, 2015, e0125215.
    • (2015) PLoS One , vol.10 , pp. e0125215
    • Grote Beverborg, N.1    Verweij, N.2    Klip, I.T.3
  • 4
    • 49849088979 scopus 로고    scopus 로고
    • Anemia and mortality in heart failure patients. a systematic review and meta-analysis
    • Groenveld, H.F., Januzzi, J.L., Damman, K., et al. Anemia and mortality in heart failure patients. a systematic review and meta-analysis. J Am Coll Cardiol 52 (2008), 818–827.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 818-827
    • Groenveld, H.F.1    Januzzi, J.L.2    Damman, K.3
  • 5
    • 38349101846 scopus 로고    scopus 로고
    • Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure
    • Tang, W.H., Tong, W., Jain, A., Francis, G.S., Harris, C.M., Young, J.B., Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure. J Am Coll Cardiol 51 (2008), 569–576.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 569-576
    • Tang, W.H.1    Tong, W.2    Jain, A.3    Francis, G.S.4    Harris, C.M.5    Young, J.B.6
  • 6
    • 84855969520 scopus 로고    scopus 로고
    • Baseline anemia is not a predictor of all-cause mortality in outpatients with advanced heart failure or severe renal dysfunction. Results from the Norwegian Heart Failure Registry
    • Waldum, B., Westheim, A.S., Sandvik, L., et al. Baseline anemia is not a predictor of all-cause mortality in outpatients with advanced heart failure or severe renal dysfunction. Results from the Norwegian Heart Failure Registry. J Am Coll Cardiol 59 (2012), 371–378.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 371-378
    • Waldum, B.1    Westheim, A.S.2    Sandvik, L.3
  • 7
    • 84875474830 scopus 로고    scopus 로고
    • Iron deficiency in chronic heart failure: an international pooled analysis
    • Klip, I.T., Comin-Colet, J., Voors, A.A., et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J 165 (2013), 575–582.e3.
    • (2013) Am Heart J , vol.165 , pp. 575-582.e3
    • Klip, I.T.1    Comin-Colet, J.2    Voors, A.A.3
  • 8
    • 80052862992 scopus 로고    scopus 로고
    • Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival
    • Okonko, D.O., Mandal, A.K., Missouris, C.G., Poole-Wilson, P.A., Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival. J Am Coll Cardiol 58 (2011), 1241–1251.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 1241-1251
    • Okonko, D.O.1    Mandal, A.K.2    Missouris, C.G.3    Poole-Wilson, P.A.4
  • 9
    • 33845299533 scopus 로고    scopus 로고
    • Etiology of anemia in patients with advanced heart failure
    • Nanas, J.N., Matsouka, C., Karageorgopoulos, D., et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 48 (2006), 2485–2489.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 2485-2489
    • Nanas, J.N.1    Matsouka, C.2    Karageorgopoulos, D.3
  • 10
    • 45849129725 scopus 로고    scopus 로고
    • Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients
    • van der Meer, P., Lok, D.J., Januzzi, J.L., et al. Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients. Eur Heart J 29 (2008), 1510–1515.
    • (2008) Eur Heart J , vol.29 , pp. 1510-1515
    • van der Meer, P.1    Lok, D.J.2    Januzzi, J.L.3
  • 11
    • 33847053226 scopus 로고    scopus 로고
    • Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well
    • Westenbrink, B.D., Visser, F.W., Voors, A.A., et al. Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well. Eur Heart J 28 (2007), 166–171.
    • (2007) Eur Heart J , vol.28 , pp. 166-171
    • Westenbrink, B.D.1    Visser, F.W.2    Voors, A.A.3
  • 12
    • 77954932493 scopus 로고    scopus 로고
    • Bone marrow dysfunction in chronic heart failure patients
    • Westenbrink, B.D., Voors, A.A., De Boer, R.A., et al. Bone marrow dysfunction in chronic heart failure patients. Eur J Heart Fail 12 (2010), 676–684.
    • (2010) Eur J Heart Fail , vol.12 , pp. 676-684
    • Westenbrink, B.D.1    Voors, A.A.2    De Boer, R.A.3
  • 14
    • 84978982838 scopus 로고    scopus 로고
    • High serum erythropoietin levels are related to heart failure development in subjects from the general population with albuminuria: data from PREVEND
    • Grote Beverborg, N., van der Wal, H.H., Klip, I.T., et al. High serum erythropoietin levels are related to heart failure development in subjects from the general population with albuminuria: data from PREVEND. Eur J Heart Fail 18 (2016), 814–821.
    • (2016) Eur J Heart Fail , vol.18 , pp. 814-821
    • Grote Beverborg, N.1    van der Wal, H.H.2    Klip, I.T.3
  • 15
    • 25444450031 scopus 로고    scopus 로고
    • Levels of hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline partially explain the occurrence of anemia in heart failure
    • van der Meer, P., Lipsic, E., Westenbrink, B.D., et al. Levels of hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline partially explain the occurrence of anemia in heart failure. Circulation 112 (2005), 1743–1747.
    • (2005) Circulation , vol.112 , pp. 1743-1747
    • van der Meer, P.1    Lipsic, E.2    Westenbrink, B.D.3
  • 16
    • 13244268473 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction
    • Ishani, A., Weinhandl, E., Zhao, Z., et al. Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 45 (2005), 391–399.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 391-399
    • Ishani, A.1    Weinhandl, E.2    Zhao, Z.3
  • 17
    • 33745697922 scopus 로고    scopus 로고
    • The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET
    • Komajda, M., Anker, S.D., Charlesworth, A., et al. The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET. Eur Heart J 27 (2006), 1440–1446.
    • (2006) Eur Heart J , vol.27 , pp. 1440-1446
    • Komajda, M.1    Anker, S.D.2    Charlesworth, A.3
  • 18
    • 0032554096 scopus 로고    scopus 로고
    • Human cardiovascular and metabolic response to acute, severe isovolemic anemia
    • Weiskopf, R.B., Viele, M.K., Feiner, J., et al. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA 279 (1998), 217–221.
    • (1998) JAMA , vol.279 , pp. 217-221
    • Weiskopf, R.B.1    Viele, M.K.2    Feiner, J.3
  • 19
    • 84955449424 scopus 로고    scopus 로고
    • The impact of iron deficiency and anaemia on exercise capacity and outcomes in patients with chronic heart failure. Results from the studies investigating co-morbidities aggravating heart failure
    • Ebner, N., Jankowska, E.A., Ponikowski, P., et al. The impact of iron deficiency and anaemia on exercise capacity and outcomes in patients with chronic heart failure. Results from the studies investigating co-morbidities aggravating heart failure. Int J Cardiol 205 (2016), 6–12.
    • (2016) Int J Cardiol , vol.205 , pp. 6-12
    • Ebner, N.1    Jankowska, E.A.2    Ponikowski, P.3
  • 20
    • 84901986431 scopus 로고    scopus 로고
    • The additive burden of iron deficiency in the cardiorenal-anaemia axis: scope of a problem and its consequences
    • Klip, I.T., Jankowska, E.A., Enjuanes, C., et al. The additive burden of iron deficiency in the cardiorenal-anaemia axis: scope of a problem and its consequences. Eur J Heart Fail 16 (2014), 655–662.
    • (2014) Eur J Heart Fail , vol.16 , pp. 655-662
    • Klip, I.T.1    Jankowska, E.A.2    Enjuanes, C.3
  • 21
    • 70349223838 scopus 로고    scopus 로고
    • Blood transfusion for acute decompensated heart failure—friend or foe?
    • Garty, M., Cohen, E., Zuchenko, A., et al. Blood transfusion for acute decompensated heart failure—friend or foe?. Am Heart J 158 (2009), 653–658.
    • (2009) Am Heart J , vol.158 , pp. 653-658
    • Garty, M.1    Cohen, E.2    Zuchenko, A.3
  • 22
    • 78650138371 scopus 로고    scopus 로고
    • Characteristics and outcomes among heart failure patients with anemia and renal insufficiency with and without blood transfusions (public discharge data from California 2000-2006)
    • Kao, D.P., Kreso, E., Fonarow, G.C., Krantz, M.J., Characteristics and outcomes among heart failure patients with anemia and renal insufficiency with and without blood transfusions (public discharge data from California 2000-2006). Am J Cardiol 107 (2011), 69–73.
    • (2011) Am J Cardiol , vol.107 , pp. 69-73
    • Kao, D.P.1    Kreso, E.2    Fonarow, G.C.3    Krantz, M.J.4
  • 23
    • 84890306496 scopus 로고    scopus 로고
    • Treatment of anemia in patients with heart disease: a clinical practice guideline from the American College of Physicians
    • Qaseem, A., Humphrey, L.L., Fitterman, N., Starkey, M., Shekelle, P., Clinical Guidelines Committee of the American College of Physicians. Treatment of anemia in patients with heart disease: a clinical practice guideline from the American College of Physicians. Ann Intern Med 159 (2013), 770–779.
    • (2013) Ann Intern Med , vol.159 , pp. 770-779
    • Qaseem, A.1    Humphrey, L.L.2    Fitterman, N.3    Starkey, M.4    Shekelle, P.5
  • 24
    • 84875500204 scopus 로고    scopus 로고
    • Treatment of anemia with darbepoetin alfa in systolic heart failure
    • Swedberg, K., Young, J.B., Anand, I.S., et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med 368 (2013), 1210–1219.
    • (2013) N Engl J Med , vol.368 , pp. 1210-1219
    • Swedberg, K.1    Young, J.B.2    Anand, I.S.3
  • 25
    • 84955191367 scopus 로고    scopus 로고
    • Increased risk of stroke with darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease
    • Bello, N.A., Lewis, E.F., Desai, A.S., et al. Increased risk of stroke with darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease. Eur J Heart Fail 17 (2015), 1201–1207.
    • (2015) Eur J Heart Fail , vol.17 , pp. 1201-1207
    • Bello, N.A.1    Lewis, E.F.2    Desai, A.S.3
  • 26
    • 40349103260 scopus 로고    scopus 로고
    • Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia
    • Bennett, C.L., Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. JAMA, 299, 2008, 914.
    • (2008) JAMA , vol.299 , pp. 914
    • Bennett, C.L.1
  • 27
    • 33750983605 scopus 로고    scopus 로고
    • Correction of anemia with epoetin alfa in chronic kidney disease
    • Singh, A.K., Szczech, L., Tang, K.L., et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 355 (2006), 2085–2098.
    • (2006) N Engl J Med , vol.355 , pp. 2085-2098
    • Singh, A.K.1    Szczech, L.2    Tang, K.L.3
  • 28
    • 84864352214 scopus 로고    scopus 로고
    • Inflammation and anaemia in a broad spectrum of patients with heart failure
    • Kleijn, L., Belonje, A.M., Voors, A.A., et al. Inflammation and anaemia in a broad spectrum of patients with heart failure. Heart 98 (2012), 1237–1241.
    • (2012) Heart , vol.98 , pp. 1237-1241
    • Kleijn, L.1    Belonje, A.M.2    Voors, A.A.3
  • 29
    • 84885933575 scopus 로고    scopus 로고
    • Differences in blood volume components between hyporesponders and responders to erythropoietin alfa: the Heart Failure With Preserved Ejection Fraction (HFPEF) anemia trial
    • Borovka, M., Teruya, S., Alvarez, J., Helmke, S., Maurer, M.S., Differences in blood volume components between hyporesponders and responders to erythropoietin alfa: the Heart Failure With Preserved Ejection Fraction (HFPEF) anemia trial. J Card Fail 19 (2013), 685–691.
    • (2013) J Card Fail , vol.19 , pp. 685-691
    • Borovka, M.1    Teruya, S.2    Alvarez, J.3    Helmke, S.4    Maurer, M.S.5
  • 30
    • 85042482009 scopus 로고    scopus 로고
    • Abstract 1293: hyporesponsiveness to darbepoetin alfa in patients with heart failure and anemia in the RED-HF study: clinical and prognostic associations
    • van Veldhuisen, D.J., Pfeffer, M.A., van der Meer, P., Olson, K., Solomon, S.D., Abstract 1293: hyporesponsiveness to darbepoetin alfa in patients with heart failure and anemia in the RED-HF study: clinical and prognostic associations. Eur J Heart Fail, 17, 2015, 269.
    • (2015) Eur J Heart Fail , vol.17 , pp. 269
    • van Veldhuisen, D.J.1    Pfeffer, M.A.2    van der Meer, P.3    Olson, K.4    Solomon, S.D.5
  • 31
    • 84969188133 scopus 로고    scopus 로고
    • Oral iron therapy for heart failure with reduced ejection fraction: design and rationale for oral iron repletion effects on oxygen uptake in heart failure
    • Lewis, G.D., Semigran, M.J., Givertz, M.M., et al. Oral iron therapy for heart failure with reduced ejection fraction: design and rationale for oral iron repletion effects on oxygen uptake in heart failure. Circ Heart Fail, 9, 2016, e000345.
    • (2016) Circ Heart Fail , vol.9 , pp. e000345
    • Lewis, G.D.1    Semigran, M.J.2    Givertz, M.M.3
  • 32
    • 35248870765 scopus 로고    scopus 로고
    • Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency
    • Toblli, J.E., Lombraña, A., Duarte, P., Di Gennaro, F., Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol 50 (2007), 1657–1665.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1657-1665
    • Toblli, J.E.1    Lombraña, A.2    Duarte, P.3    Di Gennaro, F.4
  • 33
    • 37849053243 scopus 로고    scopus 로고
    • Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial
    • Okonko, D.O., Grzeslo, A., Witkowski, T., et al. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial. J Am Coll Cardiol 51 (2008), 103–112.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 103-112
    • Okonko, D.O.1    Grzeslo, A.2    Witkowski, T.3
  • 34
    • 72449156527 scopus 로고    scopus 로고
    • Ferric carboxymaltose in patients with heart failure and iron deficiency
    • Anker, S.D., Comin Colet, J., Filippatos, G., et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 361 (2009), 2436–2448.
    • (2009) N Engl J Med , vol.361 , pp. 2436-2448
    • Anker, S.D.1    Comin Colet, J.2    Filippatos, G.3
  • 35
    • 84925275800 scopus 로고    scopus 로고
    • Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency
    • Ponikowski, P., Van Veldhuisen, D.J., Comin-Colet, J., et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J 36 (2015), 657–668.
    • (2015) Eur Heart J , vol.36 , pp. 657-668
    • Ponikowski, P.1    Van Veldhuisen, D.J.2    Comin-Colet, J.3
  • 36
    • 85024483330 scopus 로고    scopus 로고
    • Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency
    • van Veldhuisen, D.J., Ponikowski, P., van der Meer, P., et al. Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency. Circulation 136 (2017), 1374–1383.
    • (2017) Circulation , vol.136 , pp. 1374-1383
    • van Veldhuisen, D.J.1    Ponikowski, P.2    van der Meer, P.3
  • 37
    • 85042475152 scopus 로고    scopus 로고
    • Definition of iron deficiency based on the gold standard of bone marrow iron staining and treatment effect of ferric carboxymaltose in heart failure patients
    • (abstr)
    • Grote Beverborg, N., van der Meer, P., Definition of iron deficiency based on the gold standard of bone marrow iron staining and treatment effect of ferric carboxymaltose in heart failure patients. (abstr) Eur J Heart Fail 19 (2017), 20–21.
    • (2017) Eur J Heart Fail , vol.19 , pp. 20-21
    • Grote Beverborg, N.1    van der Meer, P.2
  • 38
    • 85018909285 scopus 로고    scopus 로고
    • Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis
    • Anker, S.D., Kirwan, B.A., van Veldhuisen, D.J., et al. Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis. Eur J Heart Fail 20 (2018), 125–133.
    • (2018) Eur J Heart Fail , vol.20 , pp. 125-133
    • Anker, S.D.1    Kirwan, B.A.2    van Veldhuisen, D.J.3
  • 39
    • 84980396108 scopus 로고    scopus 로고
    • 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure
    • Ponikowski, P., Voors, A.A., Anker, S.D., et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 37 (2016), 2129–2200.
    • (2016) Eur Heart J , vol.37 , pp. 2129-2200
    • Ponikowski, P.1    Voors, A.A.2    Anker, S.D.3
  • 40
    • 84884294190 scopus 로고    scopus 로고
    • 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • Yancy, C.W., Jessup, M., Bozkurt, B., et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 62 (2013), e147–e239.
    • (2013) J Am Coll Cardiol , vol.62 , pp. e147-e239
    • Yancy, C.W.1    Jessup, M.2    Bozkurt, B.3
  • 41
    • 85016048184 scopus 로고    scopus 로고
    • A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia
    • Vadhan-Raj, S., Abonour, R., Goldman, J.W., et al. A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia. J Hematol Oncol, 10, 2017, 73.
    • (2017) J Hematol Oncol , vol.10 , pp. 73
    • Vadhan-Raj, S.1    Abonour, R.2    Goldman, J.W.3
  • 42
    • 84908233244 scopus 로고    scopus 로고
    • Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans
    • van Eijk, L.T., John, A.S., Schwoebel, F., et al. Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans. Blood 124 (2014), 2643–2646.
    • (2014) Blood , vol.124 , pp. 2643-2646
    • van Eijk, L.T.1    John, A.S.2    Schwoebel, F.3
  • 43
    • 65549147617 scopus 로고    scopus 로고
    • Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women
    • Ruckle, J., Jacobs, M., Kramer, W., et al. Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women. J Bone Miner Res 24 (2009), 744–752.
    • (2009) J Bone Miner Res , vol.24 , pp. 744-752
    • Ruckle, J.1    Jacobs, M.2    Kramer, W.3
  • 44
    • 85042483117 scopus 로고    scopus 로고
    • Sotatercept improves anemia, vascular calcification, and bone loss in patients with end-stage kidney disease on hemodialysis
    • (Abstr. TH-PO038)
    • Havill, J., Kopyt, N., Coyne, D., Weiswasser, M., Smith, W., Sotatercept improves anemia, vascular calcification, and bone loss in patients with end-stage kidney disease on hemodialysis. (Abstr. TH-PO038) J Am Soc Nephrol 26 (2015), 310A–311A.
    • (2015) J Am Soc Nephrol , vol.26 , pp. 310A-311A
    • Havill, J.1    Kopyt, N.2    Coyne, D.3    Weiswasser, M.4    Smith, W.5
  • 45
    • 84898023608 scopus 로고    scopus 로고
    • Targeting a new regulator of erythropoiesis to alleviate anemia
    • Paulson, R.F., Targeting a new regulator of erythropoiesis to alleviate anemia. Nat Med 20 (2014), 334–335.
    • (2014) Nat Med , vol.20 , pp. 334-335
    • Paulson, R.F.1
  • 46
    • 84873505981 scopus 로고    scopus 로고
    • Stromal cell-mediated inhibition of erythropoiesis can be attenuated by Sotatercept (ACE-011), an activin receptor type II ligand trap
    • Iancu-Rubin, C., Mosoyan, G., Wang, J., Kraus, T., Sung, V., Hoffman, R., Stromal cell-mediated inhibition of erythropoiesis can be attenuated by Sotatercept (ACE-011), an activin receptor type II ligand trap. Exp Hematol 41 (2013), 155–166.e17.
    • (2013) Exp Hematol , vol.41 , pp. 155-166.e17
    • Iancu-Rubin, C.1    Mosoyan, G.2    Wang, J.3    Kraus, T.4    Sung, V.5    Hoffman, R.6
  • 47
    • 0032190614 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: master regulator of O2 homeostasis
    • Semenza, G.L., Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev 8 (1998), 588–594.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 588-594
    • Semenza, G.L.1
  • 49
    • 85018412680 scopus 로고    scopus 로고
    • Phase 2 studies of oral hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 for treatment of anemia in China
    • Chen, N., Qian, J., Chen, J., et al. Phase 2 studies of oral hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 for treatment of anemia in China. Nephrol Dial Transplant 32 (2017), 1373–1386.
    • (2017) Nephrol Dial Transplant , vol.32 , pp. 1373-1386
    • Chen, N.1    Qian, J.2    Chen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.