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Volumn 16, Issue 4, 2012, Pages

Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; PLACEBO;

EID: 84864350546     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11315     Document Type: Review
Times cited : (16)

References (63)
  • 1
    • 0037300439 scopus 로고    scopus 로고
    • Pleiotropic functions of erythropoietin
    • 10.2169/internalmedicine.42.142, 12636232
    • Sasaki R. Pleiotropic functions of erythropoietin. Intern Med 2003, 42:142-149. 10.2169/internalmedicine.42.142, 12636232.
    • (2003) Intern Med , vol.42 , pp. 142-149
    • Sasaki, R.1
  • 2
    • 0032516086 scopus 로고    scopus 로고
    • In vivo evidence that erythropoietin protects neurons from ischemic damage
    • 10.1073/pnas.95.8.4635, 22542, 9539790
    • Sakanaka M, Wen TC, Matsuda S, Masuda S, Morishita E, Nagao M, Sasaki R. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 1998, 95:4635-4640. 10.1073/pnas.95.8.4635, 22542, 9539790.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4635-4640
    • Sakanaka, M.1    Wen, T.C.2    Matsuda, S.3    Masuda, S.4    Morishita, E.5    Nagao, M.6    Sasaki, R.7
  • 3
    • 9644297877 scopus 로고    scopus 로고
    • Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia
    • 10.1097/01.shk.00001276869.21260.9d, 15201704
    • Abdelrahman M, Sharples EJ, McDonald MC, Collin M, Patel NS, Yaqoob MM, Thiemermann C. Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia. Shock 2004, 22:63-69. 10.1097/01.shk.00001276869.21260.9d, 15201704.
    • (2004) Shock , vol.22 , pp. 63-69
    • Abdelrahman, M.1    Sharples, E.J.2    McDonald, M.C.3    Collin, M.4    Patel, N.S.5    Yaqoob, M.M.6    Thiemermann, C.7
  • 4
    • 10744224449 scopus 로고    scopus 로고
    • Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma
    • 10.1002/art.11351, 14674008
    • Cuzzocrea S, Mazzon E, Dugo L, Patel NS, Serraino I, Di Paola R, Genovese T, Britti D, De Maio M, Caputi AP, Thiemermann C. Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma. Arthritis Rheum 2003, 48:3544-3556. 10.1002/art.11351, 14674008.
    • (2003) Arthritis Rheum , vol.48 , pp. 3544-3556
    • Cuzzocrea, S.1    Mazzon, E.2    Dugo, L.3    Patel, N.S.4    Serraino, I.5    Di Paola, R.6    Genovese, T.7    Britti, D.8    De Maio, M.9    Caputi, A.P.10    Thiemermann, C.11
  • 6
    • 4344675279 scopus 로고    scopus 로고
    • Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo
    • 10.1111/j.1523-1755.2004.00847.x, 15327391
    • Patel NS, Sharples EJ, Cuzzocrea S, Chatterjee PK, Britti D, Yaqoob MM, Thiemermann C. Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo. Kidney Int 2004, 66:983-989. 10.1111/j.1523-1755.2004.00847.x, 15327391.
    • (2004) Kidney Int , vol.66 , pp. 983-989
    • Patel, N.S.1    Sharples, E.J.2    Cuzzocrea, S.3    Chatterjee, P.K.4    Britti, D.5    Yaqoob, M.M.6    Thiemermann, C.7
  • 12
    • 84862588012 scopus 로고    scopus 로고
    • Erythropoietin in the intensive care unit: beyond treatment of anemia
    • 10.1186/2110-5820-1-40, 3224459, 21943500
    • Patel NS, Collino M, Yaqoob MM, Thiemermann C. Erythropoietin in the intensive care unit: beyond treatment of anemia. Ann Intensive Care 2011, 1:40. 10.1186/2110-5820-1-40, 3224459, 21943500.
    • (2011) Ann Intensive Care , vol.1 , pp. 40
    • Patel, N.S.1    Collino, M.2    Yaqoob, M.M.3    Thiemermann, C.4
  • 15
    • 67649236523 scopus 로고    scopus 로고
    • Improved survival of critically ill trauma patients treated with recombinant human erythropoietin
    • discussion 297-289, 10.1097/TA.0b013e31817f2c6e, 18695463
    • Napolitano LM, Fabian TC, Kelly KM, Bailey JA, Block EF, Langholff W, Enny C, Corwin HL. Improved survival of critically ill trauma patients treated with recombinant human erythropoietin. J Trauma 2008, 65:285-297. discussion 297-289, 10.1097/TA.0b013e31817f2c6e, 18695463.
    • (2008) J Trauma , vol.65 , pp. 285-297
    • Napolitano, L.M.1    Fabian, T.C.2    Kelly, K.M.3    Bailey, J.A.4    Block, E.F.5    Langholff, W.6    Enny, C.7    Corwin, H.L.8
  • 17
    • 0016175381 scopus 로고
    • On the mechanism of erythropoietin-induced differentiation. 13. The role of sialic acid in erythropoietin action
    • Goldwasser E, Kung CK, Eliason J. On the mechanism of erythropoietin-induced differentiation. 13. The role of sialic acid in erythropoietin action. J Biol Chem 1974, 249:4202-4206.
    • (1974) J Biol Chem , vol.249 , pp. 4202-4206
    • Goldwasser, E.1    Kung, C.K.2    Eliason, J.3
  • 18
    • 0024497455 scopus 로고
    • Survival of recombinant erythropoietin in the circulation: the role of carbohydrates
    • Fukuda MN, Sasaki H, Lopez L, Fukuda M. Survival of recombinant erythropoietin in the circulation: the role of carbohydrates. Blood 1989, 73:84-89.
    • (1989) Blood , vol.73 , pp. 84-89
    • Fukuda, M.N.1    Sasaki, H.2    Lopez, L.3    Fukuda, M.4
  • 19
    • 0026554053 scopus 로고
    • Receptor binding of asialoerythropoietin
    • 10.1002/jcb.240480307, 1400613
    • Dong YJ, Kung C, Goldwasser E. Receptor binding of asialoerythropoietin. J Cell Biochem 1992, 48:269-276. 10.1002/jcb.240480307, 1400613.
    • (1992) J Cell Biochem , vol.48 , pp. 269-276
    • Dong, Y.J.1    Kung, C.2    Goldwasser, E.3
  • 21
    • 34548155283 scopus 로고    scopus 로고
    • Asialoerythropoietin has strong renoprotective effects against ischemia-reperfusion injury in a murine model
    • 10.1097/01.tp.0000277672.02783.33, 17713435
    • Okada T, Sawada T, Kubota K. Asialoerythropoietin has strong renoprotective effects against ischemia-reperfusion injury in a murine model. Transplantation 2007, 84:504-510. 10.1097/01.tp.0000277672.02783.33, 17713435.
    • (2007) Transplantation , vol.84 , pp. 504-510
    • Okada, T.1    Sawada, T.2    Kubota, K.3
  • 22
    • 40949144537 scopus 로고    scopus 로고
    • Erythropoietin and its derivative protect the intestine from severe ischemia/reperfusion injury in the rat
    • 10.1016/j.surg.2007.12.013, 18374054
    • Mori S, Sawada T, Okada T, Kubota K. Erythropoietin and its derivative protect the intestine from severe ischemia/reperfusion injury in the rat. Surgery 2008, 143:556-565. 10.1016/j.surg.2007.12.013, 18374054.
    • (2008) Surgery , vol.143 , pp. 556-565
    • Mori, S.1    Sawada, T.2    Okada, T.3    Kubota, K.4
  • 23
    • 79958182363 scopus 로고    scopus 로고
    • Erythropoietin (EPO) affords more potent cardioprotection by activation of distinct signaling to mitochondrial kinases compared with carbamylated EPO
    • 10.1007/s10557-010-6265-5, 20953685
    • Sato T, Tanno M, Miki T, Yano T, Shimamoto K, Miura T. Erythropoietin (EPO) affords more potent cardioprotection by activation of distinct signaling to mitochondrial kinases compared with carbamylated EPO. Cardiovasc Drugs Ther 2010, 24:401-408. 10.1007/s10557-010-6265-5, 20953685.
    • (2010) Cardiovasc Drugs Ther , vol.24 , pp. 401-408
    • Sato, T.1    Tanno, M.2    Miki, T.3    Yano, T.4    Shimamoto, K.5    Miura, T.6
  • 24
    • 0033982372 scopus 로고    scopus 로고
    • Impaired biological activity of erythropoietin by cyanate carbamylation
    • 10.1159/000014403, 10686438
    • Mun KC, Golper TA. Impaired biological activity of erythropoietin by cyanate carbamylation. Blood Purification 2000, 18:13-17. 10.1159/000014403, 10686438.
    • (2000) Blood Purification , vol.18 , pp. 13-17
    • Mun, K.C.1    Golper, T.A.2
  • 25
    • 0027302375 scopus 로고
    • Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells
    • Masuda S, Nagao M, Takahata K, Konishi Y, Gallyas F, Tabira T, Sasaki R. Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells. J Biol Chem 1993, 268:11208-11216.
    • (1993) J Biol Chem , vol.268 , pp. 11208-11216
    • Masuda, S.1    Nagao, M.2    Takahata, K.3    Konishi, Y.4    Gallyas, F.5    Tabira, T.6    Sasaki, R.7
  • 26
    • 0027133568 scopus 로고
    • Alanine scanning mutagenesis of human erythropoietin identifies four amino acids which are critical for biological activity
    • 10.1111/j.1432-1033.1993.tb18413.x, 8269950
    • Grodberg J, Davis KL, Sykowski AJ. Alanine scanning mutagenesis of human erythropoietin identifies four amino acids which are critical for biological activity. Eur J Biochem 1993, 218:597-601. 10.1111/j.1432-1033.1993.tb18413.x, 8269950.
    • (1993) Eur J Biochem , vol.218 , pp. 597-601
    • Grodberg, J.1    Davis, K.L.2    Sykowski, A.J.3
  • 27
    • 0025253474 scopus 로고
    • Chemical modification of erythropoietin: an increase in in vitro activity by guanidination
    • 10.1016/0167-4838(90)90020-G, 2107876
    • Satake R, Kozutsumi H, Takeuchi M, Asano K. Chemical modification of erythropoietin: an increase in in vitro activity by guanidination. Biochim Biophys Acta 1990, 1038:125-129. 10.1016/0167-4838(90)90020-G, 2107876.
    • (1990) Biochim Biophys Acta , vol.1038 , pp. 125-129
    • Satake, R.1    Kozutsumi, H.2    Takeuchi, M.3    Asano, K.4
  • 29
    • 33845979434 scopus 로고    scopus 로고
    • Carbamylated erythropoietin protects the kidneys from ischemia-reperfusion injury without stimulating erythropoiesis
    • 10.1016/j.bbrc.2006.12.099, 17196938
    • Imamura R, Isaka Y, Ichimaru N, Takahara S, Okuyama A. Carbamylated erythropoietin protects the kidneys from ischemia-reperfusion injury without stimulating erythropoiesis. Biochem Biophys Res Commun 2007, 353:786-792. 10.1016/j.bbrc.2006.12.099, 17196938.
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 786-792
    • Imamura, R.1    Isaka, Y.2    Ichimaru, N.3    Takahara, S.4    Okuyama, A.5
  • 31
    • 17744386517 scopus 로고    scopus 로고
    • Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration
    • 10.1016/S0092-8674(01)00213-6, 11207369
    • Carr PD, Gustin SE, Church AP, Murphy JM, Ford SC, Mann DA, Woltring DM, Walker I, Ollis DL, Young IG. Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration. Cell 2001, 104:291-300. 10.1016/S0092-8674(01)00213-6, 11207369.
    • (2001) Cell , vol.104 , pp. 291-300
    • Carr, P.D.1    Gustin, S.E.2    Church, A.P.3    Murphy, J.M.4    Ford, S.C.5    Mann, D.A.6    Woltring, D.M.7    Walker, I.8    Ollis, D.L.9    Young, I.G.10
  • 32
    • 0031974879 scopus 로고    scopus 로고
    • Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors
    • 10.1074/jbc.273.2.1192, 9422786
    • Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF. Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors. J Biol Chem 1998, 273:1192-1199. 10.1074/jbc.273.2.1192, 9422786.
    • (1998) J Biol Chem , vol.273 , pp. 1192-1199
    • Stomski, F.C.1    Woodcock, J.M.2    Zacharakis, B.3    Bagley, C.J.4    Sun, Q.5    Lopez, A.F.6
  • 33
    • 0028937977 scopus 로고
    • Erythropoietin induces tyrosine phosphorylation of the beta chain of the GM-CSF receptor
    • 10.1006/bbrc.1995.1442, 7535525
    • Hanazono Y, Sasaki K, Nitta H, Yazaki Y, Hirai H. Erythropoietin induces tyrosine phosphorylation of the beta chain of the GM-CSF receptor. Biochem Biophys Res Commun 1995, 208:1060-1066. 10.1006/bbrc.1995.1442, 7535525.
    • (1995) Biochem Biophys Res Commun , vol.208 , pp. 1060-1066
    • Hanazono, Y.1    Sasaki, K.2    Nitta, H.3    Yazaki, Y.4    Hirai, H.5
  • 34
    • 0030884016 scopus 로고    scopus 로고
    • The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor
    • Jubinsky PT, Krijanovski OI, Nathan DG, Tavernier J, Sieff CA. The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Blood 1997, 90:1867-1873.
    • (1997) Blood , vol.90 , pp. 1867-1873
    • Jubinsky, P.T.1    Krijanovski, O.I.2    Nathan, D.G.3    Tavernier, J.4    Sieff, C.A.5
  • 35
    • 0031598397 scopus 로고    scopus 로고
    • Identification of a neurotrophic sequence in erythropoietin
    • Campana WM, Misasi R, O'Brien JS. Identification of a neurotrophic sequence in erythropoietin. Int J Mol Med 1998, 1:235-241.
    • (1998) Int J Mol Med , vol.1 , pp. 235-241
    • Campana, W.M.1    Misasi, R.2    O'Brien, J.S.3
  • 36
    • 33846390316 scopus 로고    scopus 로고
    • Dimerization of the erythropoietin receptor transmembrane domain in micelles
    • 10.1016/j.jmb.2006.11.035, 17173930
    • Ebie AZ, Fleming KG. Dimerization of the erythropoietin receptor transmembrane domain in micelles. J Mol Biol 2007, 366:517-524. 10.1016/j.jmb.2006.11.035, 17173930.
    • (2007) J Mol Biol , vol.366 , pp. 517-524
    • Ebie, A.Z.1    Fleming, K.G.2
  • 37
    • 53549097076 scopus 로고    scopus 로고
    • Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response
    • 10.1111/j.1365-2796.2008.02024.x, 19017170
    • Brines M, Cerami A. Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response. J Intern Med 2008, 264:405-432. 10.1111/j.1365-2796.2008.02024.x, 19017170.
    • (2008) J Intern Med , vol.264 , pp. 405-432
    • Brines, M.1    Cerami, A.2
  • 38
    • 84862162820 scopus 로고    scopus 로고
    • The receptor that tames the innate immune response
    • Brines M, Cerami A. The receptor that tames the innate immune response. Mol Med 2012, 18:486-496.
    • (2012) Mol Med , vol.18 , pp. 486-496
    • Brines, M.1    Cerami, A.2
  • 39
    • 33846239262 scopus 로고    scopus 로고
    • A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells
    • 10.1016/j.cellsig.2006.08.014, 17045782
    • Um M, Gross AW, Lodish HF. A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. Cell Signal 2007, 19:634-645. 10.1016/j.cellsig.2006.08.014, 17045782.
    • (2007) Cell Signal , vol.19 , pp. 634-645
    • Um, M.1    Gross, A.W.2    Lodish, H.F.3
  • 42
    • 84858760523 scopus 로고    scopus 로고
    • A non-erythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock
    • 3188881, 21607291
    • Patel NS, Nandra KK, Brines M, Collino M, Wong WS, Kapoor A, Benetti E, Goh FY, Fantozzi R, Cerami A, Thiemermann C. A non-erythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock. Mol Med 2011, 17:883-892. 3188881, 21607291.
    • (2011) Mol Med , vol.17 , pp. 883-892
    • Patel, N.S.1    Nandra, K.K.2    Brines, M.3    Collino, M.4    Wong, W.S.5    Kapoor, A.6    Benetti, E.7    Goh, F.Y.8    Fantozzi, R.9    Cerami, A.10    Thiemermann, C.11
  • 43
    • 79952853429 scopus 로고    scopus 로고
    • A small nonerythropoietic helix B surface peptide based upon erythropoietin structure is cardioprotective against ischemic myocardial damage
    • 3060982, 21170473
    • Ahmet I, Tae HJ, Juhaszova M, Riordon DR, Boheler KR, Sollott SJ, Brines M, Cerami A, Lakatta EG, Talan MI. A small nonerythropoietic helix B surface peptide based upon erythropoietin structure is cardioprotective against ischemic myocardial damage. Mol Med 2011, 17:194-200. 3060982, 21170473.
    • (2011) Mol Med , vol.17 , pp. 194-200
    • Ahmet, I.1    Tae, H.J.2    Juhaszova, M.3    Riordon, D.R.4    Boheler, K.R.5    Sollott, S.J.6    Brines, M.7    Cerami, A.8    Lakatta, E.G.9    Talan, M.I.10
  • 44
    • 77956291349 scopus 로고    scopus 로고
    • Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin
    • 10.1073/pnas.1003019107, 2922582, 20660739
    • Ueba H, Brines M, Yamin M, Umemoto T, Ako J, Momomura S, Cerami A, Kawakami M. Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin. Proc Natl Acad Sci USA 2010, 107:14357-14362. 10.1073/pnas.1003019107, 2922582, 20660739.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14357-14362
    • Ueba, H.1    Brines, M.2    Yamin, M.3    Umemoto, T.4    Ako, J.5    Momomura, S.6    Cerami, A.7    Kawakami, M.8
  • 45
    • 80054972807 scopus 로고    scopus 로고
    • ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain: an experimental study in rats and beta-common receptor knockout mice
    • 10.1097/ALN.0b013e31822fcefd, 21873879
    • Swartjes M, Morariu A, Niesters M, Brines M, Cerami A, Aarts L, Dahan A. ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain: an experimental study in rats and beta-common receptor knockout mice. Anesthesiology 2011, 115:1084-1092. 10.1097/ALN.0b013e31822fcefd, 21873879.
    • (2011) Anesthesiology , vol.115 , pp. 1084-1092
    • Swartjes, M.1    Morariu, A.2    Niesters, M.3    Brines, M.4    Cerami, A.5    Aarts, L.6    Dahan, A.7
  • 46
    • 0028880455 scopus 로고
    • Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
    • 10.1016/0092-8674(95)90234-1, 7553874
    • Wu H, Liu X, Jaenisch R, Lodish HF. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 1995, 83:59-67. 10.1016/0092-8674(95)90234-1, 7553874.
    • (1995) Cell , vol.83 , pp. 59-67
    • Wu, H.1    Liu, X.2    Jaenisch, R.3    Lodish, H.F.4
  • 49
    • 33750983605 scopus 로고    scopus 로고
    • Correction of anemia with epoetin alfa in chronic kidney disease
    • 10.1056/NEJMoa065485, 17108343
    • Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, Reddan D. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006, 355:2085-2098. 10.1056/NEJMoa065485, 17108343.
    • (2006) N Engl J Med , vol.355 , pp. 2085-2098
    • Singh, A.K.1    Szczech, L.2    Tang, K.L.3    Barnhart, H.4    Sapp, S.5    Wolfson, M.6    Reddan, D.7
  • 50
    • 66149129192 scopus 로고    scopus 로고
    • Prevention of acute kidney injury by erythropoietin in patients undergoing coronary artery bypass grafting: a pilot study
    • 10.1159/000223229, 19494484
    • Song YR, Lee T, You SJ, Chin HJ, Chae DW, Lim C, Park KH, Han S, Kim JH, Na KY. Prevention of acute kidney injury by erythropoietin in patients undergoing coronary artery bypass grafting: a pilot study. Am J Nephrol 2009, 30:253-260. 10.1159/000223229, 19494484.
    • (2009) Am J Nephrol , vol.30 , pp. 253-260
    • Song, Y.R.1    Lee, T.2    You, S.J.3    Chin, H.J.4    Chae, D.W.5    Lim, C.6    Park, K.H.7    Han, S.8    Kim, J.H.9    Na, K.Y.10
  • 51
    • 68949215056 scopus 로고    scopus 로고
    • Carbamylated erythropoietin protects the myocardium from acute ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism
    • 10.1016/j.surg.2009.03.022, 19715808
    • Xu X, Cao Z, Cao B, Li J, Guo L, Que L, Ha T, Chen Q, Li C, Li Y. Carbamylated erythropoietin protects the myocardium from acute ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism. Surgery 2009, 146:506-514. 10.1016/j.surg.2009.03.022, 19715808.
    • (2009) Surgery , vol.146 , pp. 506-514
    • Xu, X.1    Cao, Z.2    Cao, B.3    Li, J.4    Guo, L.5    Que, L.6    Ha, T.7    Chen, Q.8    Li, C.9    Li, Y.10
  • 52
    • 78650181656 scopus 로고    scopus 로고
    • Erythropoietin derivate improves left ventricular systolic performance and attenuates left ventricular remodeling in rats with myocardial infarct-induced heart failure
    • 10.1097/FJC.0b013e3181f4f05a, 20881614
    • Xu K, George I, Klotz S, Hay I, Xydas S, Zhang G, Cerami A, Wang J. Erythropoietin derivate improves left ventricular systolic performance and attenuates left ventricular remodeling in rats with myocardial infarct-induced heart failure. J Cardiovasc Pharmacol 2010, 56:506-512. 10.1097/FJC.0b013e3181f4f05a, 20881614.
    • (2010) J Cardiovasc Pharmacol , vol.56 , pp. 506-512
    • Xu, K.1    George, I.2    Klotz, S.3    Hay, I.4    Xydas, S.5    Zhang, G.6    Cerami, A.7    Wang, J.8
  • 53
    • 42249101919 scopus 로고    scopus 로고
    • Carbamylated erythropoietin improves angiogenesis and protects the kidneys from ischemia-reperfusion injury
    • 10.3727/000000008783907044, 18468243
    • Imamura R, Okumi M, Isaka Y, Ichimaru N, Moriyama T, Imai E, Nonomura N, Takahara S, Okuyama A. Carbamylated erythropoietin improves angiogenesis and protects the kidneys from ischemia-reperfusion injury. Cell Transplant 2008, 17:135-141. 10.3727/000000008783907044, 18468243.
    • (2008) Cell Transplant , vol.17 , pp. 135-141
    • Imamura, R.1    Okumi, M.2    Isaka, Y.3    Ichimaru, N.4    Moriyama, T.5    Imai, E.6    Nonomura, N.7    Takahara, S.8    Okuyama, A.9
  • 55
    • 8644228438 scopus 로고    scopus 로고
    • The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin
    • 10.1111/j.1471-4159.2004.02769.x, 15525344
    • Wang X, Zhu C, Wang X, Gerwien JG, Schrattenholz A, Sandberg M, Leist M, Blomgren K. The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin. J Neurochem 2004, 91:900-910. 10.1111/j.1471-4159.2004.02769.x, 15525344.
    • (2004) J Neurochem , vol.91 , pp. 900-910
    • Wang, X.1    Zhu, C.2    Wang, X.3    Gerwien, J.G.4    Schrattenholz, A.5    Sandberg, M.6    Leist, M.7    Blomgren, K.8
  • 59
    • 75649142879 scopus 로고    scopus 로고
    • Effect of continuous infusion of asialoerythropoietin on short-term changes in infarct volume, penumbra apoptosis and behaviour following middle cerebral artery occlusion in rats
    • 10.1111/j.1440-1681.2009.05257.x, 19650797
    • Price CD, Yang Z, Karlnoski R, Kumar D, Chaparro R, Camporesi EM. Effect of continuous infusion of asialoerythropoietin on short-term changes in infarct volume, penumbra apoptosis and behaviour following middle cerebral artery occlusion in rats. Clin Exp Pharmacol Physiol 2010, 37:185-192. 10.1111/j.1440-1681.2009.05257.x, 19650797.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 185-192
    • Price, C.D.1    Yang, Z.2    Karlnoski, R.3    Kumar, D.4    Chaparro, R.5    Camporesi, E.M.6
  • 61
    • 77957552870 scopus 로고    scopus 로고
    • Asialoerythropoietin attenuates neuronal cell death in the hippocampal CA1 region after transient forebrain ischemia in a gerbil model
    • 10.1179/016164110X12700393823336, 20444326
    • Yamashita T, Nonoguchi N, Ikemoto T, Miyatake S, Kuroiwa T. Asialoerythropoietin attenuates neuronal cell death in the hippocampal CA1 region after transient forebrain ischemia in a gerbil model. Neurol Res 2010, 32:957-962. 10.1179/016164110X12700393823336, 20444326.
    • (2010) Neurol Res , vol.32 , pp. 957-962
    • Yamashita, T.1    Nonoguchi, N.2    Ikemoto, T.3    Miyatake, S.4    Kuroiwa, T.5
  • 63
    • 79551514786 scopus 로고    scopus 로고
    • Effects of asialo-erythropoietin on pain-related behavior and expression of phosphorylated-p38 map kinase and tumor necrosis factor-alpha induced by application of autologous nucleus pulposus on nerve root in rat
    • 10.1097/BRS.0b013e3181f137a8, 21228694
    • Sasaki N, Sekiguchi M, Kikuchi S, Konno S. Effects of asialo-erythropoietin on pain-related behavior and expression of phosphorylated-p38 map kinase and tumor necrosis factor-alpha induced by application of autologous nucleus pulposus on nerve root in rat. Spine (Phila Pa 1976) 2011, 36:E86-94. 10.1097/BRS.0b013e3181f137a8, 21228694.
    • (2011) Spine (Phila Pa 1976) , vol.36
    • Sasaki, N.1    Sekiguchi, M.2    Kikuchi, S.3    Konno, S.4


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