Bioreactor Technology for Sustainable Production of Plant Cell-Derived Products

Reference Series in Phytochemistry

Volumn , Issue , 2017, Pages 1-20

  Werner, Sören ^a   Maschke, Rüdiger W ^a   Eibl, Dieter ^a   Eibl, Regine ^a  

^a ZURICH UNIVERSITY OF APPLIED SCIENCES   (Switzerland)

Author keywords

Bioreactor selection; Plant cell cultures; Plant tissue cultures; Production scale; Scale up

Indexed keywords

EID: 85084563117     PISSN: 2511834X     EISSN: 25118358     Source Type: Book Series    
DOI: 10.1007/978-3-319-32004-5_6-1     Document Type: Chapter

References (99)

1. Steingroewer J, Bley T, Georgiev V, Ivanov I, Lenk F, Marchev A, Pavlov A (2013) Bioprocessing of differentiated plant in vitro systems. Eng Life Sci 13:26-38. doi:10.1002/elsc.201100226
2. Santos RB, Abranches R, Fischer R, Sack M, Holland T (2016) Putting the spotlight back on plant suspension cultures. Front Plant Sci 7:1-12. doi:10.3389/fpls.2016.00297
3. Sack M, Hofbauer A, Fischer R, Stoger E (2015) The increasing value of plant-made proteins. Curr Opin Biotechnol 32:163-170. doi:10.1016/j.copbio.2014.12.008
4. Doran PM (2010) Bioreactors, stirred tank for culture of plant cells. Encycl Ind Biotechnol 1-35. doi: 10.1002/9780470054581.eib150
5. Ramachandra Rao S, Ravishankar GA (2002) Plant cell cultures: Chemical factories of secondary metabolites. Biotechnol Adv 20:101-153. doi:10.1016/S0734-9750(02)00007-1
6. Harborne JB (1999) Classes and functions of secondary products from plants. In: Walton NJ, Brown DE (eds) Chemicals from plants. Imperial Collage Press, London
7. DiCosmo F, Misawa M (1995) Plant cell and tissue culture: Alternatives for metabolite production. Biotechnol Adv 13:425-453. doi:10.1016/0734-9750(95)02005-N
8. Bhatia S, Bera T (2015) Classical and nonclassical techniques for secondary metabolite production in plant cell culture. In: Bhatia S (ed) Modern applications of plant biotechnology in pharmaceutical sciences. Elsevier, Amsterdam
9. Oksman-Caldentey KM, Inzé D (2004) Plant cell factories in the post-genomic era: New ways to produce designer secondary metabolites. Trends Plant Sci 9:433-440. doi:10.1016/j.tplants.2004.07.006
10. Bourgaud F, Gravot A, Milesi S, Gontier E (2001) Production of plant secondary metabolites: A historical perspective. Plant Sci 161:839-851. doi:10.1016/S0168-9452(01)00490-3
11. Imseng N, Schillberg S, Schürch C, Schmid D, Schütte K, Gorr G, Eibl D, Eibl R (2014) Suspension culture of plant cells under heterotrophic conditions. In: Meyer H-P, Schmidhalter DR (eds) Industrial scale suspension culture. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
12. Rittershaus E, Ulrich J, Weiss A, Westphal K (1989) Large scale industrial fermentation: Design, installation and initial operation of a fermenation unit. Bioengineering 5:8-10
13. Lehmann N, Dittler I, Lämsä M, Ritala A, Rischer H, Eibl D, Oksman-Caldentey K-M, Eibl R (2014) Disposable bioreactors for cultivation of plant cell cultures. In: Paek KY, Murthy HN, Zhong JJ (eds) Production of biomass and bioactive compounds using bioreactor technology. Springer, Dordrecht
14. Schürch C, Blum P, Zülli F (2008) Potential of plant cells in culture for cosmetic application. Phytochem Rev 7:599-605. doi:10.1007/s11101-007-9082-0
15. Xu J, Zhang N (2014) On the way to commercializing plant cell culture platform for biopharmaceuticals: Present status and prospect. Pharm Bioprocess 2:499-518. doi:10.4155/pbp.14.32
16. Maxmen A (2012) Drug-making plant blooms. Nature 485:160-160. doi:10.1038/485160a
17. Tekoah Y, Shulman A, Kizhner T, Ruderfer I, Fux L, Nataf Y, Bartfeld D, Ariel T, GingisVelitski S, Hanania U, Shaaltiel Y (2015) Large-scale production of pharmaceutical proteins in plant cell culture-the protalix experience. Plant Biotechnol J 13:1199-1208. doi:10.1111/pbi.12428
18. Shaaltiel Y, Gingis-Velitski S, Tzaban S, Fiks N, Tekoah Y, Aviezer D (2015) Plant-based oral delivery of β-glucocerebrosidase as an enzyme replacement therapy for Gaucher’s disease. Plant Biotechnol J 13:1033-1040. doi:10.1111/pbi.12366
19. Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, BoldinAdamsky SA, Silman I, Sussman JL, Futerman AH, Aviezer D (2007) Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher’s disease using a plant cell system. Plant Biotechnol J 5:579-590. doi:10.1111/j.1467-7652.2007.00263.x
20. Liew PS, Hair-Bejo M (2015) Farming of plant-based veterinary vaccines and their applications for disease prevention in animals. Adv Virol 2015:1-12. doi:10.1155/2015/936940
21. Bhatia S (2015) History and scope of plant biotechnology. In: Bhatia S (ed) Modern applications of plant biotechnology in pharmaceutical sciences. Elsevier, Amsterdam
22. Huang T-K, McDonald KA (2009) Bioreactor engineering for recombinant protein production in plant cell suspension cultures. Biochem Eng J 45:168-184. doi:10.1016/j.bej.2009.02.008
23. Huang T-K, McDonald KA (2012) Bioreactor systems for in vitro production of foreign proteins using plant cell cultures. Biotechnol Adv 30:398-409. doi:10.1016/j.biotechadv.2011.07.016
24. Chen Q, Davis KR (2016) The potential of plants as a system for the development and production of human biologics. F1000Res 5:912. doi:10.12688/f1000research.8010.1
25. Merlin M, Gecchele E, Capaldi S, Pezzotti M, Avesani L (2014) Comparative evaluation of recombinant protein production in different biofactories: The green perspective. Biomed Res Int. doi:10.1155/2014/136419
26. Takeyama N, Kiyono H, Yuki Y (2015) Plant-based vaccines for animals and humans: Recent advances in technology and clinical trials. Ther Adv Vaccines 3:139-154. doi:10.1177/2051013615613272
27. Bendandi M, Marillonnet S, Kandzia R, Thieme F, Nickstadt A, Herz S, Fröde R, Inogés S, Lòpez-Dìaz de Cerio A, Soria E, Villanueva H, Vancanneyt G, McCormick A, Tusé D, Lenz J, Butler-Ransohoff J-E, Klimyuk V, Gleba Y (2010) Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin’s lymphoma. Ann Oncol Off J Eur Soc Med Oncol 21:2420-2427. doi:10.1093/annonc/mdq256
28. Xu J, Dolan MC, Medrano G, Cramer CL, Weathers PJ (2012) Green factory: Plants as bioproduction platforms for recombinant proteins. Biotechnol Adv 30:1171-1184. doi:10.1016/j.biotechadv.2011.08.020
29. Ashkenazi A, Chamow SM (1995) Immunoadhesins: An alternative to human monoclonal antibodies. Methods 8:104-115. doi:10.1006/meth.1995.9996
30. Wycoff K, Maclean J, Belle A, Yu L, Tran Y, Roy C, Hayden F (2015) Anti-infective immunoadhesins from plants. Plant Biotechnol J 13:1078-1093. doi:10.1111/pbi.12441
31. Company Homepage. http://www.nbms.co.kr. Accessed 31 Mar 2017
32. Merseburger T, Pahl I, Müller D, Tanner M (2013) A risk analysis for production processes with disposable bioreactors. In: Eibl R, Eibl D (eds) Disposable bioreactors II. Springer, Berlin
33. Fischer R, Vasilev N, Twyman RM, Schillberg S (2015) High-value products from plants: The challenges of process optimization. Curr Opin Biotechnol 32:156-162. doi:10.1016/j.copbio.2014.12.018
34. Hellwig S, Drossard J, Twyman RM, Fischer R (2004) Plant cell cultures for the production of recombinant proteins. Nat Biotechnol 22:1415-1422. doi:10.1038/nbt1027
35. Eibl R, Werner S, Eibl D (2009) Disposable bioreactors for plant liquid cultures at litre-scale. Eng Life Sci 9:156-164. doi:10.1002/elsc.200800102
36. Georgiev M, Georgiev V, Weber J, Bley T, Ilieva M, Pavlov A (2008) Agrobacterium rhizogenes-mediated genetic transformations: A powerful tool for the production of metabolites. In: Wolf T, Koch J (eds) Genetically modified plants. Nova Science Publishers, New York
37. Georgiev MI, Ludwig-Müller J, Bley T (2010) Hairy root culture: Copying nature in new bioprocesses. In: Arora R (ed) Medicinal plant biotechnology. CABI, Wallingford
38. Kieran PM, MacLoughlin PF, Malone DM (1997) Plant cell suspension cultures: Some engineering considerations. J Biotechnol 59:39-52. doi:10.1016/S0168-1656(97)00163-6
39. Routledge SJ (2012) Beyond de-foaming: The effects of antifoams on bioprocess productivity. Comput Struct Biotechnol J 3. doi:10.5936/csbj.201210014
40. Morão A, Maia CI, Fonseca MMR, Vasconcelos JMT, Alves SS (1999) Effect of antifoam addition on gas-liquid mass transfer in stirred fermenters. Bioprocess Eng 20:165. doi:10.1007/s004490050576
41. Wongsamuth R, Doran PM (1994) Foaming and cell flotation in suspended plant cell cultures and the effect of chemical antifoams. Biotechnol Bioeng 44:481-488. doi:10.1002/bit.260440411
42. Chang J-S, Show P-L, Ling T-C, Chen C-Y, Ho S-H, Tan C-H, Nagarajan D, Phong W-N (2017) Photobioreactors. In: Larroche C (ed) Current developments in biotechnology and bioengineering. Elsevier, Amsterdam
43. Ho S-H, Chen C-Y, Chang J-S (2012) Effect of light intensity and nitrogen starvation on CO2 fixation and lipid/carbohydrate production of an indigenous microalga Scenedesmus obliquus CNW-N. Bioresour Technol 113:244-252. doi:10.1016/j.biortech.2011.11.133
44. Srivastava S, Srivastava AK (2007) Hairy root culture for mass-production of high-value secondary metabolites. Crit Rev Biotechnol 27:29-43. doi:10.1080/07388550601173918
45. Eibl R, Eibl D (2002) Bioreactors for plant cell and tissue cultures. Plant Biotechnol Transgenic Plants. doi:10.1201/9780203910849.ch8
46. Georgiev MI, Eibl R, Zhong J-J (2013) Hosting the plant cells in vitro: Recent trends in bioreactors. Appl Microbiol Biotechnol 97:3787-3800. doi:10.1007/s00253-013-4817-x
47. Paek K-Y, Hahn E-J, Son S-H (2001) Application of bioreactors for large-scale micropropagation systems of plants. In Vitro Cell Dev Biol Plant 37:149-157. doi:10.1007/s11627-001-0027-9
48. Choi Y-E, Kim Y-S, Paek K-Y (2006) Types and designs of bioreactors for hairy root culture. In: Dutta Gupta S, Ibaraki Y (eds) Plant tissue culture engineering. Springer, Dordrecht
49. Kusakari K, Yokoyama M, Inomata S, Gozu Y, Katagiri C, Sugimoto Y (2012) Large-scale production of saikosaponins through root culturing of Bupleurum falcatum L. using modified airlift reactors. J Biosci Bioeng 113:99-105. doi:10.1016/j.jbiosc.2011.08.019
50. Ruffoni B, Pistelli L, Bertoli A, Pistelli L (2010) Plant cell cultures: Bioreactors for industrial production. Adv Exp Med Biol 698:203-221
51. Mishra BN, Ranjan R (2008) Growth of hairy-root cultures in various bioreactors for the production of secondary metabolites. Biotechnol Appl Biochem 49:1-10. doi:10.1042/BA20070103
52. Wen Su W, Jun He B, Liang H, Sun S (1996) A perfusion air-lift bioreactor for high density plant cell cultivation and secreted protein production. J Biotechnol 50:225-233. doi:10.1016/0168-1656(96)01568-4
53. Fischer U, Alfermann A W (1995) Cultivation of photoautotrophic plant-cell suspensions in the bioreactor influence of culture conditions. J Biotechnol 41:19-28. doi: 10.1016/0168-1656(95)00043-P
54. Geipel K, Socher ML, Haas C, Bley T, Steingroewer J (2013) Growth kinetics of a Helianthus annuus and a Salvia fruticosa suspension cell line: Shake flask cultivations with online monitoring system. Eng Life Sci 13:593-602. doi:10.1002/elsc.201200148
55. Meister J, Maschke RW, Werner S, John GT, Eibl D (2016) How to efficiently shake viscous culture broths: Culture broth viscosity evaluated in shake flasks studies. Genet Eng Biotechnol News 36:28-29
56. Werner S, Greulich J, Geipel K, Steingroewer J, Bley T, Eibl D (2014) Mass propagation of Helianthus annuus suspension cells in orbitally shaken bioreactors: Improved growth rate in single-use bag bioreactors. Eng Life Sci 14:676-684. doi:10.1002/elsc.201400024
57. Raven N, Rasche S, Kuehn C, Anderlei T, Klöckner W, Schuster F, Henquet M, Bosch D, Büchs J, Fischer R, Schillberg S (2015) Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200-L orbitally-shaken disposable bioreactor. Biotechnol Bioeng 112:308-321. doi:10.1002/bit.25352
58. Raven N, Schillberg S, Rasche S (2016) Plant cell-based recombinant antibody manufacturing with a 200 L orbitally shaken disposable bioreactor. Methods Mol Biol 1385:161-172. doi:10.1007/978-1-4939-3289-4_12
59. Kaiser SC, Kraume M, Eibl D (2013) Development of the travelling wave bioreactor a concept study. Chem Ing Tech 85:136-143. doi:10.1002/cite.201200127
60. Kaiser SC, Kraume M, Eibl D (2016) Development of the travelling wave bioreactor. Part I: Design studies based on numerical models. Chem Ing Tech 88:77-85. doi:10.1002/cite.201500092
61. Kaiser SC, Perepelitsa N, Kraume M, Eibl D (2015) Development of the travelling wave bioreactor. Part II: Engineering characteristics and cultivation results. Chem Ing Techn/a-n/a. doi: 10.1002/cite.201500091
62. Eibl R, Eibl D (2006) Design and use of the wave bioreactor for plant cell culture. In: Gupta SD, Ibaraki Y (eds) Plant tissue culture engineering. Springer, Dordrecht
63. Werner S, Eibl R, Lettenbauer C, Röll M, Eibl D, De Jesus M, Zhang X, Stettler M, Tissot S, Bürkie C, Broccard G, Kühner M, Tanner R, Baldi L, Hacker D, Wurm FM (2010) Innovative, non-stirred bioreactors in scales from milliliters up to 1000 liters for suspension cultures of cells using disposable bags and containers a Swiss contribution. Chim Int J Chem 64:819-823. doi:10.2533/chimia.2010.819
64. Scholz J, Suppmann S (2016) A re-usable wave bioreactor for protein production in insect cells. MethodsX 3:497-501. doi:10.1016/j.mex.2016.08.001
65. Eibl R, Werner S, Eibl D (2010) Bag bioreactor based on wave-induced motion: Characteristics and applications. Adv Biochem Eng Biotechnol 115:55-87. doi:10.1007/10_2008_15
66. Eibl R, Kaiser S, Lombriser R, Eibl D (2010) Disposable bioreactors: The current state-of-the-art and recommended applications in biotechnology. Appl Microbiol Biotechnol 86:41-49. doi:10.1007/s00253-009-2422-9
67. Kim Y, Wyslouzil BE, Weathers PJ (2002) Secondary metabolism of hairy root cultures in bioreactors. In Vitro Cell Dev Biol Plant 38:1-10. doi:10.1079/IVP2001243
68. Tscheschke B, Dreimann J, von der Ruhr JW, Schmidt T, Stahl F, Just L, Scheper T (2015) Evaluation of a new mist-chamber bioreactor for biotechnological applications. Biotechnol Bioeng 112:1155-1164. doi:10.1002/bit.25523
69. Suresh B, Bais H, Raghavarao KSMS, Ravishankar GA, Ghildyal NP (2005) Comparative evaluation of bioreactor design using Tagetes patula L. hairy roots as a model system. Process Biochem 40:1509-1515. doi:10.1016/j.procbio.2003.10.017
70. Nuutila AM, Lindqvist A-S, Kauppinen V (1997) Growth of hairy root cultures of strawberry (Fragaria ananassa Duch.) in three different types of bioreactors. Biotechnol Tech 11:363-366. doi:10.1023/A:1018444117681
71. M. Paula W (2012) The status of temporary immersion system (TIS) technology for plant micropropagation. Afr J Biotechnol doi: 10.5897/AJB12.1693
72. Ducos JP, Terrier B, Courtois D, Pétiard V (2008) Improvement of plastic-based disposable bioreactors for plant science needs. Phytochem Rev 7:607-613. doi:10.1007/s11101-008-9089-1
73. Ashraf MF, Aziz MA, Stanslas J, Kadir MA (2013) Optimization of immersion frequency and medium substitution on microtuberization of Chlorophytum borivilianum in RITA system on production of saponins. Process Biochem 48:73-77. doi:10.1016/j.procbio.2012.12.001
74. Georgiev V, Schumann A, Pavlov A, Bley T (2014) Temporary immersion systems in plant biotechnology. Eng Life Sci 14:607-621. doi:10.1002/elsc.201300166
75. Noorman H (2015) Scale-up and scale-down. In: Villadsen J (ed) Fundamental bioengineering. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
76. Zlokarnik M (1991) Dimensional analysis and scale-up in chemical engineering. Springer, Berlin. doi:10.1007/978-3-642-76673-2
77. Werner S, Olownia J, Egger D, Eibl D (2013) An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors. Chem Ing Tech 85:118-126. doi:10.1002/cite.201200153
78. Garcia-Ochoa F, Gomez E (2009) Bioreactor scale-up and oxygen transfer rate in microbial processes: An overview. Biotechnol Adv 27:153-176. doi:10.1016/j.biotechadv.2008.10.006
79. Platas Barradas O, Jandt U, Da Minh Phan L, Villanueva ME, Schaletzky M, Rath A, Freund S, Reichl U, Skerhutt E, Scholz S, Noll T, Sandig V, Pörtner R, Zeng A-P (2012) Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture. Eng Life Sci 12:518-528. doi: 10.1002/elsc.201100163
80. Platas Barradas O, Jandt U, Da Minh PL, Villanueva M, Rath A, Reichl U, Schräder E, Scholz S, Noll T, Sandig V, Pörtner R, Zeng A-P (2011) Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture. BMC Proc 5(Suppl 8):P47. doi:10.1186/1753-6561-5-S8-P47
81. Minow B, de Witt H, Knabben I (2013) Fast track API manufacturing from shake flask to production scale using a 1000-L single-use facility. Chem Ing Tech 85:87-94. doi:10.1002/cite.201200136
82. Rodríguez-Monroy M, Galindo E (1999) Broth rheology, growth and metabolite production of Beta vulgaris suspension culture: A comparative study between cultures grown in shake flasks and in a stirred tank. Enzym Microb Technol 24:687-693. doi:10.1016/S0141-0229(99)00002-2
83. Sánchez MJ, Jiménez-Aparicio A, Gutiérrez López G, Trejo Tapia G, Rodríguez-Monroy M (2002) Broth rheology of Beta vulgaris cultures growing in an air lift bioreactor. Biochem Eng J 12:37-41. doi:10.1016/S1369-703X(02)00043-8
84. Chattopadhyay S, Farkya S, Srivastava AK, Bisaria VS (2002) Bioprocess considerations for production of secondary metabolites by plant cell suspension cultures. Biotechnol Bioprocess Eng 7:138-149. doi:10.1007/BF02932911
85. Zlokarnik M (2008) Stirring: Theory and practice. Wiley-VCH Verlag GmbH, Weinheim
86. Metzner AB, Otto RE (1957) Agitation of non-Newtonian fluids. AICHE J 3:3-10. doi:10.1002/aic.690030103
87. Kraume M (2004) Transportvorgänge in der Verfahrenstechnik. Springer, Berlin
88. Thakur RK, Vial C, Djelveh G, Labbafi M (2004) Mixing of complex fluids with flat-bladed impellers: Effect of impeller geometry and highly shear-thinning behavior. Chem Eng Process Process Intensif 43:1211-1222. doi:10.1016/j.cep.2003.11.005
89. Su W wen (1995) Bioprocessing technology for plant cell suspension cultures. Appl Biochem Biotechnol 50:189-230. doi: 10.1007/BF02783455
90. Löffelholz C, Husemann U, Greller G, Meusel W, Kauling J, Ay P, Kraume M, Eibl R, Eibl D (2013) Bioengineering parameters for single-use bioreactors: Overview and evaluation of suitable methods. Chem Ing Tech 85:40-56. doi:10.1002/cite.201200125
91. Meusel W, Kauling J, Löffelholz C (2013) Single-use technologies for biopharmaceutical production: Report from the working group bioprocess technology upstream processing. Chem Ing Tech 85:23-25. doi:10.1002/cite.201200217
92. Ducos JP, Pareilleux A (1986) Effect of aeration rate and influence of pCO2 in large-scale cultures of Catharanthus roseus cells. Appl Microbiol Biotechnol 25:101-105. doi:10.1007/BF00938932
93. Taticek RA, Mooyoung M, Legge RL (1991) The scale-up of plant-cell culture engineering considerations. Plant Cell Tissue Organ Cult 24:139-158. doi:10.1007/BF00039742
94. Kieran PM, Malone DM, MacLoughlin PF (2000) Effects of hydrodynamic and interfacial forces on plant cell suspension systems. Adv Biochem Eng Biotechnol 67:139-177
95. Georgiev MI, Pavlov AI, Bley T (2007) Hairy root type plant in vitro systems as sources of bioactive substances. Appl Microbiol Biotechnol 74:1175-1185. doi:10.1007/s00253-007-0856-5
96. Baíza AM, Quiroz-Moreno A, Ruíz JA, Loyola-Vargas VM (1999) Genetic stability of hairy root cultures of Datura stramonium. Plant Cell Tissue Organ Cult 59:9-17. doi:10.1023/A:1006398727508
97. Balandrin M, Klocke J, Wurtele E, Bollinger W (1985) Natural plant chemicals: Sources of industrial and medicinal materials. Science 228:1154-1160. doi:10.1126/science.3890182
98. Berlin J, Beier H, Fecker L, Forche E, Noé W, Sasse F, Schiel O, Wray V (1985) Conventional and new approaches to increase the alkaloid production of plant cell cultures. In: Neumann K-H (ed) Primary and secondary metabolism of plant cell cultures. Springer, Berlin
99. Palavalli RR, Srivastava S, Srivastava AK (2012) Development of a mathematical model for growth and oxygen transfer in in vitro plant hairy root cultivations. Appl Biochem Biotechnol 167:1831-1844. doi:10.1007/s12010-011-9515-5