Clinical and immunological features of severe and moderate coronavirus disease 2019

Journal of Clinical Investigation

Volumn 130, Issue 5, 2020, Pages 2620-2629

  Chen, Guang ^a   Wu, Di ^a   Guo, Wei ^a   Cao, Yong ^a   Huang, Da ^a   Wang, Hongwu ^a   Wang, Tao ^a   Zhang, Xiaoyun ^a   Chen, Huilong ^a   Yu, Haijing ^a   Zhang, Xiaoping ^a   Zhang, Minxia ^a   Wu, Shiji ^a   Song, Jianxin ^a   Chen, Tao ^a   Han, Meifang ^a   Li, Shusheng ^a   Luo, Xiaoping ^b   Zhao, Jianping ^a   Ning, Qin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CEPHALOSPORIN; D DIMER; FERRITIN; GANCICLOVIR; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; LACTATE DEHYDROGENASE; METHYLPREDNISOLONE; MOXIFLOXACIN; OSELTAMIVIR; PROCALCITONIN; TUMOR NECROSIS FACTOR;

ACUTE KIDNEY FAILURE; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ANTIVIRAL THERAPY; ARTICLE; BRAIN DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHEST TIGHTNESS; CHINA; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL OUTCOME; COMPUTER ASSISTED TOMOGRAPHY; CORONAVIRUS DISEASE 2019; COUGHING; DIARRHEA; DISEASE SEVERITY; DYSPNEA; FATIGUE; FEMALE; FEVER; HEADACHE; HEART INJURY; HEMOPTYSIS; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; HYPOALBUMINEMIA; LEUKOCYTE COUNT; LIVER INJURY; LYMPHOCYTOPENIA; MALE; MYALGIA; NEUTROPHIL COUNT; OBSERVATIONAL STUDY; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; SECONDARY INFECTION; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SHOCK; TACHYPNEA;

EID: 85082860580     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI137244     Document Type: Article

References (26)

1. Drosten C, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003;348(20):1967-1976.
2. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367(19):1814-1820.
3. Zhu N, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733.
4. Gralinski LE, Menachery VD. Return of the coronavirus: 2019-nCoV. Viruses. 2020;12(2):E135.
5. Li Q, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382(13):1199-1207.
6. Chan JF, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514-523.
7. Zhou P, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273.
8. Huang C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.
9. [No authors listed]. Interpretation of New Corona-virus Pneumonia Diagnosis and Treatment Plan (Trial Version 6) (in Chinese). The National Health Commission of People's Republic of China. http://www.nhc.gov.cn/yzygj/s7652m/202002/54e1ad5c2aac45c19eb541799bf637e9.shtml. Accessed April 3, 2020.
10. Chen N, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-513.
11. Channappanavar R, et al. Dysregulated type I interferon and inflammatory monocytemacrophage responses cause lethal pneumonia in SARS-CoV-infected Mice. CellHostMicrobe. 2016;19(2):181-193.
12. low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J Immunol. 2008;180(9):6411-6420.
13. Xu X, Gao X. Immunological responses against SARS-coronavirus infection in humans. CellMol Immunol. 2004;1(2):119-122.
14. Frasca L, Piazza C, Piccolella E. CD4+ T cells orchestrate both amplification and deletion of CD8+ T cells. Crit Rev Immunol. 1998;18(6):569-594.
15. Taylor GA, Feng CG, Sher A. p47 GTPases: regulators of immunity to intracellular pathogens. Nat Rev Immunol. 2004;4(2):100-109.
16. Xu Z, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420-422.
17. Arabi YM, et al. Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection. Ann Intern Med. 2014;160(6):389-397.
18. Ying T, Li W, Dimitrov DS. Discovery of T-cell infection and apoptosis by Middle East respiratory syndrome coronavirus. JInfectDis. 2016;213(6):877-879.
19. Chen J, et al. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. J Virol. 2010;84(3):1289-1301.
20. Zhao JM, et al. [Clinical pathology and pathogenesis of severe acute respiratory syndrome]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003;17(3):217-221.
21. Zhao J, et al. Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A. 2014;111(13):4970-4975.
22. Li CK, et al. T cell responses to whole SARS coronavirus in humans. J Immunol. 2008;181(8):5490-5500.
23. Chu H, et al. Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways. J Infect Dis. 2016;213(6):904-914.
24. He Z, et al. Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets. Int J Infect Dis. 2005;9(6):323-330.
25. Yang M, et al. Hematological findings in SARS patients and possible mechanisms (review). Int J Mol Med. 2004;14(2):311-315.
26. [No authors listed]. Clinical management of severe acute respiratory infection when Novel coronavirus (nCoV) infection is suspected: interim guidance. World Health Organization. https://www.who.int/publications-detail/clinicalmanagement-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)infection-is-suspected. Updated March 13, 2020. Accessed March 27, 2020.