Critical care management of adults with community-acquired severe respiratory viral infection

Intensive Care Medicine

Volumn 46, Issue 2, 2020, Pages 315-328

  Arabi, Yaseen M ^a,b,c   Fowler, Robert ^d,e   Hayden, Frederick G ^f  

^a KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^b KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^c KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^d UNIVERSITY OF TORONTO   (Canada)

^e SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^f UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Acute respiratory distress syndrome; Antiviral therapy; Coronavirus; Influenza; Neuraminidase inhibitor

Indexed keywords

ASCORBIC ACID; BALOXAVIR; CORTICOSTEROID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN; MACROLIDE; NEUROMUSCULAR BLOCKING AGENT; RAPAMYCIN; SIALIDASE INHIBITOR; ANTIVIRUS AGENT; COVID-19; OSELTAMIVIR;

ANTIBIOTIC THERAPY; ANTIVIRAL THERAPY; ARTIFICIAL VENTILATION; COMMUNITY ACQUIRED INFECTION; CORTICOSTEROID THERAPY; EVIDENCE BASED PRACTICE; EXTRACORPOREAL OXYGENATION; HIGH FREQUENCY OSCILLATORY VENTILATION; HOSPITAL ADMISSION; HUMAN; IMMUNOTHERAPY; INFECTION CONTROL; INFECTION PREVENTION; INFLUENZA; INTENSIVE CARE; INTENSIVE CARE UNIT; MUSCLE WEAKNESS; NONHUMAN; NONINVASIVE VENTILATION; POSITIVE END EXPIRATORY PRESSURE; PRONE POSITION; REVIEW; SEVERE ACUTE RESPIRATORY SYNDROME; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ADULT; CORONAVIRUS INFECTION; CRITICAL ILLNESS; EVIDENCE BASED MEDICINE; PNEUMONIA; SEVERITY OF ILLNESS INDEX; VIRUS PNEUMONIA;

ADULT; ANTIVIRAL AGENTS; COMMUNITY-ACQUIRED INFECTIONS; CORONAVIRUS INFECTIONS; CRITICAL CARE; CRITICAL ILLNESS; EVIDENCE-BASED MEDICINE; HUMANS; INFLUENZA, HUMAN; INTENSIVE CARE UNITS; MACROLIDES; NONINVASIVE VENTILATION; OSELTAMIVIR; PNEUMONIA; PNEUMONIA, VIRAL; RESPIRATION, ARTIFICIAL; SEVERE ACUTE RESPIRATORY SYNDROME; SEVERITY OF ILLNESS INDEX;

EID: 85079717915     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-020-05943-5     Document Type: Review

References (76)

1. Karhu J, Ala-Kokko TI, Vuorinen T, Ohtonen P, Syrjala H (2014) Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia. Clin Infect Dis 59:62–70
2. Hasvold J, Sjoding M, Pohl K, Cooke C, Hyzy RC (2016) The role of human metapneumovirus in the critically ill adult patient. J Crit Care 31:233–237
3. Zumla A, Memish ZA, Maeurer M, Bates M, Mwaba P, Al-Tawfiq JA, Denning DW, Hayden FG, Hui DS (2014) Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options. Lancet Infect Dis 14:1136–1149
4. Hanfelt-Goade D, Maimon N, Nimer A, et al A phase 2b, randomized, double-blind, placebo-controlled trial of presatovir (GS-5806), a novel oral rsv fusion inhibitor, for the treatment of respiratory syncytial virus (RSV) in hospitalized adults American Thoracic Society 2018 international conference, San Diego, 2018: abstract A4457
5. Gamino-Arroyo AE, Guerrero ML, McCarthy S, Ramirez-Venegas A, Llamosas-Gallardo B, Galindo-Fraga A, Moreno-Espinosa S, Roldan-Aragon Y, Araujo-Melendez J, Hunsberger S, Ibarra-Gonzalez V, Martinez-Lopez J, Garcia-Andrade LA, Kapushoc H, Holley HP Jr, Smolskis MC, Ruiz-Palacios GM, Beigel JH, Mexico Emerging Infectious Diseases Clinical Research N (2019) Efficacy and safety of nitazoxanide in addition to standard of care for the treatment of severe acute respiratory illness. Clin Infect Dis 69:1903–1911
6. Beigel JH, Nam HH, Adams PL, Krafft A, Ince WL, El-Kamary SS, Sims AC (2019) Advances in respiratory virus therapeutics—a meeting report from the 6th isirv Antiviral Group conference. Antiviral Res 167:45–67
7. Muthuri SG, Venkatesan S, Myles PR, Leonardi-Bee J, Al Khuwaitir TS, Al Mamun A, Anovadiya AP, Azziz-Baumgartner E, Baez C, Bassetti M, Beovic B, Bertisch B, Bonmarin I, Booy R, Borja-Aburto VH, Burgmann H, Cao B, Carratala J, Denholm JT, Dominguez SR, Duarte PA, Dubnov-Raz G, Echavarria M, Fanella S, Gao Z, Gerardin P, Giannella M, Gubbels S, Herberg J, Iglesias AL, Hoger PH, Hu X, Islam QT, Jimenez MF, Kandeel A, Keijzers G, Khalili H, Knight M, Kudo K, Kusznierz G, Kuzman I, Kwan AM, Amine IL, Langenegger E, Lankarani KB, Leo YS, Linko R, Liu P, Madanat F, Mayo-Montero E, McGeer A, Memish Z, Metan G, Mickiene A, Mikic D, Mohn KG, Moradi A, Nymadawa P, Oliva ME, Ozkan M, Parekh D, Paul M, Polack FP, Rath BA, Rodriguez AH, Sarrouf EB, Seale AC, Sertogullarindan B, Siqueira MM, Skret-Magierlo J, Stephan F, Talarek E, Tang JW, To KK, Torres A, Torun SH, Tran D, Uyeki TM, Van Zwol A, Vaudry W, Vidmar T, Yokota RT, Zarogoulidis P, Investigators PC, Nguyen-Van-Tam JS (2014) Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data. Lancet Respir Med 2:395–404
8. Adisasmito W, Chan PK, Lee N, Oner AF, Gasimov V, Aghayev F, Zaman M, Bamgboye E, Dogan N, Coker R, Starzyk K, Dreyer NA, Toovey S (2010) Effectiveness of antiviral treatment in human influenza A(H5N1) infections: analysis of a Global Patient Registry. J Infect Dis 202:1154–1160
9. Louie JK, Yang S, Acosta M, Yen C, Samuel MC, Schechter R, Guevara H, Uyeki TM (2012) Treatment with neuraminidase inhibitors for critically ill patients with influenza A (H1N1)pdm09. Clin Infect Dis 55:1198–1204
10. Uyeki TM, Bernstein HH, Bradley JS, Englund JA, File TM, Fry AM, Gravenstein S, Hayden FG, Harper SA, Hirshon JM, Ison MG, Johnston BL, Knight SL, McGeer A, Riley LE, Wolfe CR, Alexander PE, Pavia AT (2019) Clinical practice guidelines by the infectious diseases society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenzaa. Clin Infect Dis 68:895–902
11. Welch SC, Lam SW, Neuner EA, Bauer SR, Bass SN (2015) High-dose versus standard dose oseltamivir for treatment of severe influenza in adult intensive care unit patients. Intensive Care Med 41:1365–1366
12. Lee N, Hui DS, Zuo Z, Ngai KL, Lui GC, Wo SK, Tam WW, Chan MC, Wong BC, Wong RY, Choi KW, Sin WW, Lee EL, Tomlinson B, Hayden FG, Chan PK (2013) A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza a and B infections. Clin Infect Dis 57:1511–1519
13. Noel ZR, Bastin MLT, Montgomery AA, Flannery AH (2017) Comparison of high-dose versus standard dose oseltamivir in critically ill patients with influenza. J Intensive Care Med 32:574–577
14. South East Asia Infectious Disease Clinical Research N (2013) Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial. BMJ 346:f3039
15. Lemaitre F, Luyt CE, Roullet-Renoleau F, Nieszkowska A, Zahr N, Corvol E, Fernandez C, Antignac M, Farinotti R, Combes A (2012) Impact of extracorporeal membrane oxygenation and continuous venovenous hemodiafiltration on the pharmacokinetics of oseltamivir carboxylate in critically ill patients with pandemic (H1N1) influenza. Ther Drug Monit 34:171–175
16. Lee N, Chan PK, Wong CK, Wong KT, Choi KW, Joynt GM, Lam P, Chan MC, Wong BC, Lui GC, Sin WW, Wong RY, Lam WY, Yeung AC, Leung TF, So HY, Yu AW, Sung JJ, Hui DS (2011) Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A(H1N1) virus pneumonia. Antivir Ther 16:237–247
17. Behillil S, May F, Fourati S, Luyt CE, Chicheportiche T, Sonneville R, Tandjaoui-Lambiotte Y, Roux D, Guerin L, Mayaux J, Maury E, Ferre A, Georger JF, Voiriot G, Enouf V, van der Werf S, Mekontso DA, de Prost N (2019) Oseltamivir resistance in severe influenza A(H1N1)pdm09 pneumonia and acute respiratory distress syndrome: a French multicenter observational cohort study. Clin Infect Dis. 10.1093/cid/ciz904
18. Marty FM, Vidal-Puigserver J, Clark C, Gupta SK, Merino E, Garot D, Chapman MJ, Jacobs F, Rodriguez-Noriega E, Husa P, Shortino D, Watson HA, Yates PJ, Peppercorn AF (2017) Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial. Lancet Respir Med 5:135–146
19. de Jong MD, Ison MG, Monto AS, Metev H, Clark C, O’Neil B, Elder J, McCullough A, Collis P, Sheridan WP (2014) Evaluation of intravenous peramivir for treatment of influenza in hospitalized patients. Clin Infect Dis 59:e172–e185
20. Hayden FG, Shindo N (2019) Influenza virus polymerase inhibitors in clinical development. Curr Opin Infect Diseases 32(2):176–186
21. Ison MG, Portsmouth S, Yoshida Y, Shishido T, Hayden F, Uehara T (2018) LB16. Phase 3 trial of baloxavir marboxil in high-risk influenza patients (CAPSTONE-2 study). Open Forum Infect Dis 5:S764–S765
22. Hung IFN, To KKW, Chan JFW, Cheng VCC, Liu KSH, Tam A, Chan TC, Zhang AJ, Li P, Wong TL, Zhang R, Cheung MKS, Leung W, Lau JYN, Fok M, Chen H, Chan KH, Yuen KY (2017) Efficacy of clarithromycin-naproxen-oseltamivir combination in the treatment of patients hospitalized for influenza A(H3N2) infection: an open-label randomized, controlled, phase IIb/III trial. Chest 151:1069–1080
23. Martin-Loeches I, Bermejo-Martin JF, Valles J, Granada R, Vidaur L, Vergara-Serrano JC, Martin M, Figueira JC, Sirvent JM, Blanquer J, Suarez D, Artigas A, Torres A, Diaz E, Rodriguez A (2013) Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumonia. Intensive Care Med 39:693–702
24. Arabi YM, Deeb AM, Al-Hameed F, Mandourah Y, Almekhlafi GA, Sindi AA, Al-Omari A, Shalhoub S, Mady A, Alraddadi B, Almotairi A, Al Khatib K, Abdulmomen A, Qushmaq I, Solaiman O, Al-Aithan AM, Al-Raddadi R, Ragab A, Al Harthy A, Kharaba A, Jose J, Dabbagh T, Fowler RA, Balkhy HH, Merson L, Hayden FG, Saudi Critical Care Trials g (2019) Macrolides in critically ill patients with Middle East Respiratory Syndrome. Int J Infect Dis 81:184–190
25. Han K, Ma H, An X, Su Y, Chen J, Lian Z, Zhao J, Zhu BP, Fontaine RE, Feng Z, Zeng G (2011) Early use of glucocorticoids was a risk factor for critical disease and death from pH1N1 infection. Clin Infect Dis 53:326–333
26. Delaney JW, Pinto R, Long J, Lamontagne F, Adhikari NK, Kumar A, Marshall JC, Cook DJ, Jouvet P, Ferguson ND, Griesdale D, Burry LD, Burns KE, Hutchison J, Mehta S, Menon K, Fowler RA, Canadian Critical Care Trials Group HNC (2016) The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness. Crit Care 20:75
27. Lee FE, Walsh EE, Falsey AR (2011) The effect of steroid use in hospitalized adults with respiratory syncytial virus-related illness. Chest 140:1155–1161
28. Lee N, Allen Chan KC, Hui DS, Ng EK, Wu A, Chiu RW, Wong VW, Chan PK, Wong KT, Wong E, Cockram CS, Tam JS, Sung JJ, Lo YM (2004) Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients. J Clin Virol 31:304–309
29. Arabi YM, Mandourah Y, Al-Hameed F, Sindi AA, Almekhlafi GA, Hussein MA, Jose J, Pinto R, Al-Omari A, Kharaba A, Almotairi A, Al Khatib K, Alraddadi B, Shalhoub S, Abdulmomen A, Qushmaq I, Mady A, Solaiman O, Al-Aithan AM, Al-Raddadi R, Ragab A, Balkhy HH, Al Harthy A, Deeb AM, Al Mutairi H, Al-Dawood A, Merson L, Hayden FG, Fowler RA, Saudi Critical Care Trial G (2018) Corticosteroid therapy for critically ill patients with middle east respiratory syndrome. Am J Respir Crit Care Med 197:757–767
30. Lee SM, Cheung CY, Nicholls JM, Hui KP, Leung CY, Uiprasertkul M, Tipoe GL, Lau YL, Poon LL, Ip NY, Guan Y, Peiris JS (2008) Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection. J Infect Dis 198:525–535
31. Hung IF, Wang To KK, Chan J, Chan KH, Yuen KY. ECCMID 2019. O0815 Treatment of severe influenza A infection with celecoxib. https://www.escmid.org. Accessed 14 Sep 2019
32. Jia X, Liu B, Bao L, Lv Q, Li F, Li H, An Y, Zhang X, Cao B, Wang C (2018) Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration. PLoS Pathog 14:e1007428
33. Huang CT, Hung CY, Chen TC, Lin CY, Lin YC, Chang CS, He YC, Huang YL, Dutta A (2017) Rapamycin adjuvant and exacerbation of severe influenza in an experimental mouse model. Sci Rep 7:4136
34. Wang CH, Chung FT, Lin SM, Huang SY, Chou CL, Lee KY, Lin TY, Kuo HP (2014) Adjuvant treatment with a mammalian target of rapamycin inhibitor, sirolimus, and steroids improves outcomes in patients with severe H1N1 pneumonia and acute respiratory failure. Crit Care Med 42:313–321
35. McAuley DF, Laffey JG, O’Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, McDowell C, McNally C, Investigators H-, Irish Critical Care Trials G (2014) Simvastatin in the acute respiratory distress syndrome. N Engl J Med 371:1695–1703
36. Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O’Kane CM, McAuley DF, Irish Critical Care Trials G (2018) Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med 6:691–698
37. Hung IF, To KK, Lee CK, Lee KL, Yan WW, Chan K, Chan WM, Ngai CW, Law KI, Chow FL, Liu R, Lai KY, Lau CC, Liu SH, Chan KH, Lin CK, Yuen KY (2013) Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection. Chest 144:464–473
38. Davey RT, Jr., Fernández-Cruz E, Markowitz N, Pett S, Babiker AG, Wentworth D, Khurana S, Engen N, Gordin F, Jain MK, Kan V, Polizzotto MN, Riska P, Ruxrungtham K, Temesgen Z, Lundgren J, Beigel JH, Lane HC, Neaton JD, Davey RT, Fernández-Cruz E, Markowitz N, Pett S, Babiker AG, Wentworth D, Khurana S, Engen N, Gordin F, Jain MK, Kan V, Polizzotto MN, Riska P, Ruxrungtham K, Temesgen Z, Lundgren J, Beigel JH, Lane HC, Neaton JD, Butts J, Denning E, DuChene A, Krum E, Harrison M, Meger S, Peterson R, Quan K, Shaughnessy M, Thompson G, Vock D, Metcalf J, Dewar R, Rehman T, Natarajan V, McConnell R, Flowers E, Smith K, Hoover M, Coyle EM, Munroe D, Aagaard B, Pearson M, Cursley A, Webb H, Hudson F, Russell C, Sy A, Purvis C, Jackson B, Collaco-Moraes Y, Carey D, Robson R, Sánchez A, Finley E, Conwell D, Losso MH, Gambardella L, Abela C, Lopez P, Alonso H, Touloumi G, Gioukari V, Anagnostou O, Avihingsanon A, Pussadee K, Ubolyam S, Omotosho B, Solórzano C, Petersen T, Vysyaraju K, Rizza SA, Whitaker JA, Nahra R, Baxter J, Coburn P, Gardner EM, Scott JA, Faber L, Pastor E, Makohon L, MacArthur RA, Hillman LM, Farrough MJ, Polenakovik HM, Clark LA, Colon RJ, Kunisaki KM, DeConcini M, Johnson SA, Wolfe CR, Mkumba L, Carbonneau JY, Morris A, Fitzpatrick ME, Kessinger CJ, Salata RA, Arters KA, Tasi CM, Panos RJ, Lach LA, Glesby MJ, Ham KA, Hughes VG, Schooley RT, Crouch D, Muttera L, Novak RM, Bleasdale SC, Zuckerman AE, Manosuthi W, Thaonyen S, Chiewcharn T, Suwanpimolkul G, Gatechumpol S, Bunpasang S, Angus BJ, Anderson M, Morgan M, Minton J, Gkamaletsou MN, Hambleton J, Price DA, Llewelyn MJ, Sweetman J, Carbone J, Arribas JR, Montejano R, Lobo Beristain JL, Martinez IZ, Barberan J, Hernandez P, Dwyer DE, Kok J, Borges A, Brandt CT, Knudsen LS, Sypsas N, Constantinou C, Markogiannakis A, Zakynthinos S, Katsaounou P, Kalomenidis I, Mykietiuk A, Alzogaray MF, Obed M, Macias LM, Ebensrtejin J, Burgoa P, Nannini E, Lahitte M, Perez-Patrigeon S, Martínez-Orozco JA, Ramírez-Hinojosa JP (2019) Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial. Lancet Respir Med. 7:951–963. 10.1016/S2213-2600(19)30253-X
39. Beigel JH, Aga E, Elie-Turenne M-C, Cho J, Tebas P, Clark CL, Metcalf JP, Ozment C, Raviprakash K, Beeler J, Holley HP, Jr., Warner S, Chorley C, Lane HC, Hughes MD, Davey RT, Jr., Beigel JH, Aga E, Elie-Turenne M-C, Cho J, Tebas P, Clark CL, Metcalf JP, Ozment C, Raviprakash K, Beeler J, Holley HP, Jr., Warner S, Chorley C, Lane HC, Hughes MD, Davey RT, Barron M, Bastani A, Bauer P, Borkowsky W, Cairns C, Deville J, Elie M-C, Fichtenbaum C, Finberg R, Jain M, Kaufman D, Lin M, Lin J, Maves R, Morrow L, Nguyen M-H, Park P, Polk C, Randolph A, Rao S, Rubinson L, Schofield C, Shoham S, Stalets E, Stapleton RD (2019) Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial. Lancet Respir Med. 7:941–950. 10.1016/S2213-2600(19)30199-7
40. Fowler AA 3rd, Truwit JD, Hite RD, Morris PE, DeWilde C, Priday A, Fisher B, Thacker LR 2nd, Natarajan R, Brophy DF, Sculthorpe R, Nanchal R, Syed A, Sturgill J, Martin GS, Sevransky J, Kashiouris M, Hamman S, Egan KF, Hastings A, Spencer W, Tench S, Mehkri O, Bindas J, Duggal A, Graf J, Zellner S, Yanny L, McPolin C, Hollrith T, Kramer D, Ojielo C, Damm T, Cassity E, Wieliczko A, Halquist M (2019) Effect of vitamin c infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI Randomized clinical trial. JAMA 322:1261–1270
41. Verweij PE, Bruggemann RJM, Wauters J, Rijnders BJA, Chiller T, van de Veerdonk F (2019) Influenza coinfection: be(a)ware of invasive aspergillosis. Clin Infect Dis 70:349–350
42. Rochwerg B, Brochard L, Elliott MW, Hess D, Hill NS, Nava S, Navalesi PMOTSC, Antonelli M, Brozek J, Conti G, Ferrer M, Guntupalli K, Jaber S, Keenan S, Mancebo J, Mehta S, Raoof SMOTTF (2017) Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J 50:1602426
43. Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon AF, Lapinsky S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler RA, Canadian Critical Care Trials Group HNC (2009) Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA 302:1872–1879
44. Rodriguez A, Ferri C, Martin-Loeches I, Diaz E, Masclans JR, Gordo F, Sole-Violan J, Bodi M, Aviles-Jurado FX, Trefler S, Magret M, Moreno G, Reyes LF, Marin-Corral J, Yebenes JC, Esteban A, Anzueto A, Aliberti S, Restrepo MI, Grupo Espanol de Trabajo Gripe A Grave/Sociedad Espanola de Medicina Intensiva CyUCWG, investigators HNSWG (2017) Risk factors for noninvasive ventilation failure in critically ill subjects with confirmed influenza infection. Respir Care 62:1307–1315
45. Cheung TM, Yam LY, So LK, Lau AC, Poon E, Kong BM, Yung RW (2004) Effectiveness of noninvasive positive pressure ventilation in the treatment of acute respiratory failure in severe acute respiratory syndrome. Chest 126:845–850
46. Fowler RA, Guest CB, Lapinsky SE, Sibbald WJ, Louie M, Tang P, Simor AE, Stewart TE (2004) Transmission of severe acute respiratory syndrome during intubation and mechanical ventilation. Am J Respir Crit Care Med 169:1198–1202
47. Alraddadi BM, Qushmaq I, Al-Hameed FM, Mandourah Y, Almekhlafi GA, Jose J, Al-Omari A, Kharaba A, Almotairi A, Al Khatib K, Shalhoub S, Abdulmomen A, Mady A, Solaiman O, Al-Aithan AM, Al-Raddadi R, Ragab A, Balkhy HH, Al Harthy A, Sadat M, Tlayjeh H, Merson L, Hayden FG, Fowler RA, Arabi YM, Saudi Critical Care Trials G (2019) Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome. Influenza Other Respir Viruses 13:382–390
48. Patel BK, Wolfe KS, Pohlman AS, Hall JB, Kress JP (2016) Effect of noninvasive ventilation delivered by helmet vs face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: a randomized clinical trial. JAMA 315:2435–2441
49. Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Beduneau G, Deletage-Metreau C, Richard JC, Brochard L, Robert R, Group FS, Network R (2015) High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 372:2185–2196
50. Rello J, Perez M, Roca O, Poulakou G, Souto J, Laborda C, Balcells J, Serra J, Masclans JR, Investigators C (2012) High-flow nasal therapy in adults with severe acute respiratory infection: a cohort study in patients with 2009 influenza A/H1N1v. J Crit Care 27:434–439
51. Briel M, Meade M, Mercat A, Brower RG, Talmor D, Walter SD, Slutsky AS, Pullenayegum E, Zhou Q, Cook D, Brochard L, Richard JC, Lamontagne F, Bhatnagar N, Stewart TE, Guyatt G (2010) Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA 303:865–873
52. Writing Group for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial I, Cavalcanti AB, Suzumura EA, Laranjeira LN, Paisani DM, Damiani LP, Guimaraes HP, Romano ER, Regenga MM, Taniguchi LNT, Teixeira C, Pinheiro de Oliveira R, Machado FR, Diaz-Quijano FA, Filho MSA, Maia IS, Caser EB, Filho WO, Borges MC, Martins PA, Matsui M, Ospina-Tascon GA, Giancursi TS, Giraldo-Ramirez ND, Vieira SRR, Assef M, Hasan MS, Szczeklik W, Rios F, Amato MBP, Berwanger O, Ribeiro de Carvalho CR, (2017) Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on Mortality in patients with acute respiratory distress syndrome: a randomized clinical trial. JAMA 318:1335–1345
53. Boots RJ, Lipman J, Lassig-Smith M, Stephens DP, Thomas J, Shehabi Y, Bass F, Anthony A, Long D, Seppelt IM, Weisbrodt L, Erickson S, Beca J, Sherring C, McGuiness S, Parke R, Stachowski ER, Boyd R, Howet B (2011) Experience with high frequency oscillation ventilation during the 2009 H1N1 influenza pandemic in Australia and New Zealand. Anaesth Intensive Care 39:837–846
54. Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO, Investigators OT, Investigators OT, Canadian Critical Care Trials G (2013) High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 368:795–805
55. Young D, Lamb SE, Shah S, MacKenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH, Group OS (2013) High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med 368:806–813
56. Meade MO, Young D, Hanna S, Zhou Q, Bachman TE, Bollen C, Slutsky AS, Lamb SE, Adhikari NKJ, Mentzelopoulos SD, Cook DJ, Sud S, Brower RG, Thompson BT, Shah S, Stenzler A, Guyatt G, Ferguson ND (2017) Severity of hypoxemia and effect of high-frequency oscillatory ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 196:727–733
57. Guerin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Girard R, Baboi L, Ayzac L, Group PS (2013) Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 368:2159–2168
58. Xu Y, Deng X, Han Y, Zhou L, He W, Chen S, Nong L, Huang H, Zhang Y, Yu T, Li Y, Liu X (2015) A multicenter retrospective review of prone position ventilation (PPV) in treatment of severe human H7N9 avian flu. PLoS One 10:e0136520
59. Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal JM, Perez D, Seghboyan JM, Constantin JM, Courant P, Lefrant JY, Guerin C, Prat G, Morange S, Roch A, Investigators AS (2010) Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 363:1107–1116
60. National Heart L, Blood Institute PCTN, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC (2019) Early neuromuscular blockade in the acute respiratory distress syndrome. N Engl J Med 380:1997–2008
61. Combes A, Hajage D, Capellier G, Demoule A, Lavoue S, Guervilly C, Da Silva D, Zafrani L, Tirot P, Veber B, Maury E, Levy B, Cohen Y, Richard C, Kalfon P, Bouadma L, Mehdaoui H, Beduneau G, Lebreton G, Brochard L, Ferguson ND, Fan E, Slutsky AS, Brodie D, Mercat A, Eolia Trial Group R, Ecmonet (2018) Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. N Engl J Med 378:1965–1975
62. Goligher EC, Tomlinson G, Hajage D, Wijeysundera DN, Fan E, Juni P, Brodie D, Slutsky AS, Combes A (2018) Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc bayesian analysis of a randomized clinical trial. JAMA 320:2251–2259
63. Noah MA, Peek GJ, Finney SJ, Griffiths MJ, Harrison DA, Grieve R, Sadique MZ, Sekhon JS, McAuley DF, Firmin RK, Harvey C, Cordingley JJ, Price S, Vuylsteke A, Jenkins DP, Noble DW, Bloomfield R, Walsh TS, Perkins GD, Menon D, Taylor BL, Rowan KM (2011) Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1). JAMA 306:1659–1668
64. Alshahrani MS, Sindi A, Alshamsi F, Al-Omari A, El Tahan M, Alahmadi B, Zein A, Khatani N, Al-Hameed F, Alamri S, Abdelzaher M, Alghamdi A, Alfousan F, Tash A, Tashkandi W, Alraddadi R, Lewis K, Badawee M, Arabi YM, Fan E, Alhazzani W (2018) Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus. Ann Intensive Care 8:3
65. National Heart L, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials N, Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B, Connors AF, Jr., Hite RD, Harabin AL, (2006) Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 354:2564–2575
66. Brown SM, Pittman J, Miller Iii RR, Horton KD, Markewitz B, Hirshberg E, Jones J, Grissom CK (2011) Right and left heart failure in severe H1N1 influenza A infection. Eur Respir J 37:112–118
67. Paddock CD, Liu L, Denison AM, Bartlett JH, Holman RC, Deleon-Carnes M, Emery SL, Drew CP, Shieh WJ, Uyeki TM, Zaki SR (2012) Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infection. J Infect Dis 205:895–905
68. Kwong JC, Schwartz KL, Campitelli MA, Chung H, Crowcroft NS, Karnauchow T, Katz K, Ko DT, McGeer AJ, McNally D, Richardson DC, Rosella LC, Simor A, Smieja M, Zahariadis G, Gubbay JB (2018) Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med 378:345–353
69. Chacko B, Peter JV, Pichamuthu K, Ramakrishna K, Moorthy M, Karthik R, John G (2012) Cardiac manifestations in patients with pandemic (H1N1) 2009 virus infection needing intensive care. J Crit Care 27(106):e101–e106
70. Mohite PN, Popov AF, Bartsch A, Zych B, Dhar D, Moza A, Krueger H, Simon AR (2011) Successful treatment of novel H1N1 influenza related fulminant myocarditis with extracorporeal life support. J Cardiothorac Surg 6:164
71. Tran K, Cimon K, Severn M, Pessoa-Silva CL, Conly J (2012) Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review. PLoS One 7:e35797
72. Radonovich LJ Jr, Simberkoff MS, Bessesen MT, Brown AC, Cummings DAT, Gaydos CA, Los JG, Krosche AE, Gibert CL, Gorse GJ, Nyquist AC, Reich NG, Rodriguez-Barradas MC, Price CS, Perl TM, Pi Res (2019) N95 respirators vs medical masks for preventing influenza among health care personnel: a randomized clinical trial. JAMA 322:824–833
73. Loeb M, Dafoe N, Mahony J, John M, Sarabia A, Glavin V, Webby R, Smieja M, Earn DJ, Chong S, Webb A, Walter SD (2009) Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. JAMA 302:1865–1871
74. MacIntyre CR, Seale H, Dung TC, Hien NT, Nga PT, Chughtai AA, Rahman B, Dwyer DE, Wang Q (2015) A cluster randomised trial of cloth masks compared with medical masks in healthcare workers. BMJ Open 5:e006577
75. Hirose R, Nakaya T, Naito Y, Daidoji T, Bandou R, Inoue K, Dohi O, Yoshida N, Konishi H, Itoh Y (2019) Situations leading to reduced effectiveness of current hand hygiene against infectious mucus from influenza virus-infected patients. mSphere 4:e00474–e00479
76. WHO public health research agenda for influenza. https://www.who.int/influenza/resources/research/en/. Last accessed Jan 4-2020