Effect of lung recruitment and titrated Positive End-Expiratory Pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome - A randomized clinical trial

JAMA - Journal of the American Medical Association

Volumn 318, Issue 14, 2017, Pages 1335-1345

  Cavalcanti, Alexandre Biasi ^a   Suzumura, Érica Aranha ^a   Laranjeira, Ligia Nasi ^a   De Moraes Paisani, Denise ^a   Damiani, Lucas Petri ^a   Guimarães, Helio Penna ^a   Romano, Edson Renato ^a   De Moraes Regenga, Marisa ^a   Taniguchi, Luzia Noriko Takahashi ^a   Teixeira, Cassiano ^c   De Oliveira, Roselaine Pinheiro ^d   Machado, Flavia Ribeiro ^e   Diaz Quijano, Fredi Alexander ^b   De Alencar Filho, Meton Soares ^f   Maia, Israel Silva ^g   Caser, Eliana Bernardete ^h   De Oliveira Filho, Wilson ⁱ   De Carvalho Borges, Marcos ^b   De Aquino Martins, Priscilla ^j   Matsui, Mirna ^k   Ospina Tascón, Gustavo Adolfo ^l   Giancursi, Thiago Simões ^m   Giraldo Ramirez, Nelson Dario ⁿ   Vieira, Silvia Regina Rios ^o   De Lima Assef, Maria da Graça Pasquotto ^p   Hasan, Mohd Shahnaz ^q,t   Szczeklik, Wojciech ^r   Rios, Fernando ^s   Amato, Marcelo Britto Passos ^b   Berwanger, Otávio ^a   De Carvalho, Carlos Roberto Ribeiro ^b   Tucci, M R ^t   Souza Dos Santos, L ^t   Franca de Oliveira M C ^t   Peres, I ^t   Freitas, I ^t   Reis, H ^t   Verissimo A ^t   Torres, D ^t   Barroso, A ^t   Semboloni Bitencourt, W ^t   Franco, M R ^t   Oliveira Lage, J ^t   Aparecida Pessoa Conde, K ^t   Charro, F A ^t   Naia, A ^t   de Brito Sobrinho, E ^t   Lameira Verissimo A ^t   Barros de Oliveira, M E ^t   Zampieri, F ^t   Ladeira, J P ^t   Cordioli, R ^t   Diogo Sala, A ^t   Tadahiro Ikeoka, D ^t   Baptista Filho, M L A ^t   Ray, A ^t   Guerra de Almeida, A ^t   Nazareno Conceicao C ^t   Ribeiro Salgado, D ^t   Rosso Verdeal, J C ^t   Martins, G A ^t   Junqueira Ribeiro, L ^t   Vilela Siqueira, H ^t   Flavio Costa Filho F ^t   Adler Maccagnan Pinheiro Besen, B ^t   Vieira Do Nascimento Martins, E ^t   Aparecida Pereira, J ^t   Milioli Ferreira, D ^t   Alves Ferreira Goncalves F ^t   de Souza Nobrega, M ^t   Barros Duarte, I J ^t   Nobre, V ^t   Miranda Barreto Mourao L ^t   Gomez Ravetti C ^t   Scalzo, A C ^t   Martins De Stefano, L ^t   Gut, A L ^t   Nogueira Filho, W ^t   Gatti Cirillo, C ^t   Ishiwaki, S ^t   Lobo, S ^t   Elias de Oliveira, N ^t   Fernandes Machado, L ^t   Sisconetto, L ^t   Rios Vieira, S R ^t   Fialkow, L ^t   Fontoura Prado, K ^t   Franke, C ^t   Barberena Moraes, R ^t   Christmann Wawrzeniak, I ^t   Rech, T H ^t   Parolo, E ^t   Almeida Victorino, J ^t   Marques Barroso, C ^t   Marcal de Vasconcelos M O ^t   Souza da Silva, R ^t   Lesti Esteves, A R ^t   Camassola, A P ^t   Antoniazzi, R ^t   Griebler, M ^t   Favretto, J ^t   Romano, M ^t   Franz da Costa, A ^t   Werneck, V ^t   Miura, M C ^t   Farran, J ^t   Vasconcelos, R ^t   Isola, A ^t   Resende, E ^t   Goulart, R ^t   Luzzi, S ^t   Rea Neto A ^t   de Oliveira, M C ^t   Bruinje Cosentino, M F ^t   Martins Dzivielevski, B ^t   Reese, F B ^t   Ferreira da Silva, S D ^t   Elias Aquim, E ^t   Girotto, F ^t   Helenditi Fernandes Camurca Martins R ^t   Lima de Andrade, A ^t   Breckenfeld Heirel, D C ^t   Ryoji Takatani, R ^t   Dias de Almeida, S ^t   Medina Matos, A ^t   Iwamoto, T ^t   Do Val Tavares, P E ^t   Valiatti, J L ^t   de Lucca, F C ^t   Fornazari, J C ^t   Dias Brugugnolli, I ^t   de Araujo Nazare M ^t   Nascimento Loureiro, N ^t   Vasconcelos de Sousa, G ^t   Staffa Gonzaga da Silva, L ^t   Dos Anjos Sad, F C ^t   Stucchi, E M ^t   Melo Silva, R ^t   Fonseca Silva, T ^t   Mendes Filho, S P ^t   Borba Pereira, T ^t   da Silva, P N ^t   Martines Moralez, G ^t   Abrantes Saraiva, S ^t   Abrunhosa, A ^t   Chagas, CE Ranger C ^t   Thompson, M M ^t   Pinto Goncalves C H ^t   de Oliveira Dias, R ^t   Schwan Filho, F ^t   Magalhaes Carvalho Grion C ^t   Mezzaroba, A L ^t   Festti, J ^t   Massariol, T C ^t   de Souza, G F ^t   Martins Lima Silva, M ^t   de Souza Andrade Neto, J ^t   Costa, G ^t   Souza Ribeiro, M ^t   Coelho, M ^t   Cruz Carbonell, R C ^t   de Souza Trindade, R ^t   Valente Barbas, C S ^t   Domingos Correa, T ^t   Serpa Neto, A ^t   Santucci Cesar de Assuncao M ^t   Vilela Costa Pinto, B ^t   Goncalves Libanio P ^t   da Silva Motta, J ^t   Santa Maria Lucin, G ^t   Macedo Araujo, L ^t   Anibal Leite Barros Agostinho, T ^t   de Andrade, K M ^t   da Silva, M S ^t   Pereira da Silva, E ^t   Mousinho Gomes, R L ^t   Campos, N M P ^t   Fonseca de Sousa, J ^t   Ramos Nicolau da Costa, L ^t   de Carvalho Fonseca Assuncao N S ^t   Martins de Lima, G ^t   Pinheiro de Oliveira, R ^t   Gasparetto Maccari, J ^t   de Campos Balzano, P ^t   Tagliari, L ^t   Metran Nascente, A P ^t   de Carvalho, M A ^t   Buttignol, M ^t   Henn Moura, R ^t   Vinicius Pereira, M ^t   Alberti da Silva, G ^t   Akemi Higo, M ^t   Morales, M ^t   Andrade, A H V ^t   de Paiva, A P ^t   da Silva, K S ^t   Andrioli de Araujo, P ^t   Cordeiro de Abreu Filho, C A ^t   Abdalla, G ^t   Loureiro Sebold, M ^t   Moreira, R ^t   Caldeira Filho, M ^t   de Brito Cordeiro, R ^t   Pfuetzenreiter, F ^t   Costa Carvalho, L F ^t   da Silva Guimaraes B L ^t   de Faria Cordeiro, H ^t   Pimentel Alvim, S H ^t   Do Espirito Santo, J A ^t   Silva Maia, I ^t   Pincelli, M ^t   Zandonai, C L ^t   Burigo Grumann, A C ^t   Kretzer, L P ^t   Nedel, W ^t   Manozzo Boniatti, M ^t   Santos Pellegrini, J A ^t   da Silva Marques, L ^t   Girardelli Baptista, W C ^t   da Silva Franco, R S ^t   Moreira de Sousa, M ^t   de Marchi Benfica, A F ^t   Veiga de Oliveira, A L ^t   Reis, D L ^t   Morais, M O ^t   Santa Rosa Santana, H ^t   Murilo Domingues, S ^t   de Menezes Ferreira, C ^t   Amado Rabelo, L ^t   Menezes de Rezende, C ^t   Riccio, P ^t   Silva de Almeida, P ^t   Rubini, P ^t   da Graca Pasquotto de Lima Assef M ^t   Nardela, R ^t   Locks Stahlhofer L ^t   Gatelli Noronha, C ^t   de Azevedo Naves, S ^t   Dias da Silva, F ^t   Mazza, B F ^t   Longhi Simoes de Almeida S ^t   Mayumi Higa, R ^t   Papacidero C H ^t   Lima Silva, M M ^t   de Assuncao Melo L ^t   Miranda Mafra Oliveira, M ^t   Matos Brito Coelho, C ^t   Machado, J A ^t   de Souza Machado, Y L ^t   Vitor Fera, J ^t   Dos Santos Ramos, N C ^t   Botelho Foernges, R ^t   de Souza, R R ^t   Rutzen, W ^t   Villasante Troncoso, E M ^t   Paiva, T K B ^t   Vieira de Lacerda, N M ^t   Aires de Araujo Neto J ^t   de Oliveira Maia, M ^t   Bastos de Moura, E ^t   Brocco Magnan, G ^t   Soares Nasrala, M L ^t   Campos Tonussi, R L ^t   Kohl Pinheiro, E ^t   Simoes da Silva F ^t   Dal Pizzol, F ^t   Schmitz de Figueiredo, F ^t   Ritter, C ^t   de Vasconcellos Baldisserotto, S ^t   Blattner, C ^t   Saldanha Dos Santos, R ^t   da Silva Bettega, F ^t   Almeida Delfino Duarte, P ^t   Tozo, T C ^t   Peliser, P ^t   Deczka Morsch, R ^t   Guimaraes Leal Guadalupe E ^t   Souza Amorim, D ^t   Rezegue de Moraes Rego, L ^t   Azevedo, L ^t   Ramos, F ^t   Pastore, L ^t   Nery, P ^t   Spegiorin Moreno, M ^t   Nakad Orsatti, V ^t   Yudi Horikawa, F ^t   Samartino Zavanelli, G ^t   Adrieno Westphal, G ^t   Sperotto, G ^t   Dadam, M ^t   Nunes, M ^t   Pantaleao S L ^t   Camargo Narciso, R ^t   Bernadete Caser, E ^t   Falcao J G ^t   Genelhu, G ^t   Lessa Soares, F ^t   Silva Sales, B ^t   Rebello de Jesus, K ^t   Correia Santos Bonomo, D ^t   Martins Arruda, J ^t   de Pinho, J C ^t   Belacho Azeredo Coutinho, J ^t   Braga Hagreaves Ribeiro de Freitas, R ^t   de Souza Oliveira Garcia, T ^t   Frizera Vassallo, P ^t   Buarque Souza de Lima, M H ^t   Eberhart Neto, E ^t   Satoshi Inagaki, A ^t   Oliveira de Paula, A E ^t   Amador Correia, T ^t   Nomoto, S ^t   Seiji Ueno Gil, F ^t   Florizel Almeida de Araujo M ^t   Bezerra Lima, Z ^t   Simoes Giancursi T ^t   Rejane de Lima, C ^t   Costa, M ^t   Osaku, E F ^t   Jorge, A C ^t   Rodrigues da Cruz, M ^t   da Cunha, S ^t   Silva Cavallaro Torres, K ^t   Rocha Rodrigues da Silva, F ^t   Lisboa de Souza, R ^t   Osni Machado, F ^t   Buss, E K ^t   Cattelan Bonorino, K ^t   Germano, A ^t   Bin da Silva, S R ^t   Herek, A ^t   Tavares Gurgel, S J ^t   Sanches Laranjeira, A ^t   Toshiyuki Tanita, M ^t   Tibery Queiroz Cardoso, L ^t   Osorio Guerreiro, M ^t   Peres Bainy, M ^t   de Oliveira Teixeira, L ^t   Colozza Mecatti, G ^t   Carolina Salomao M ^t   Ribeiro Moreira, A ^t   Vantini Capasso Palamim, C ^t   Deucher, R A O ^t   Castro Escobar Furlan, F ^t   Rodrigues Torres de Carvalho, F ^t   Muniz, R ^t   Penna Guimaraes H ^t   Conceicao Andrade L ^t   Abrahao Hajjar L ^t   Barbosa Gomes Galas, F R ^t   Pinheiro de Almeida, J ^t   Marco, R ^t   Peixoto, E ^t   Hirata, F ^t   Yen Ju, C ^t   Bonaccorsi Fernandino, B ^t   Lage de Assis Rocha, D ^t   Azzi Barbosa, N ^t   Dias Alves, J ^t   Furtado Lamego, L ^t   de Linhares, J M ^t   Ferreira Sousa, M ^t   Ferreira de Souza, M M ^t   Guimaraes de Carvalho F L ^t   Aparecida Leite, M ^t   Torres, P ^t   Bolognese, D ^t   Lacerda, V ^t   Cisari, G ^t   Souza Marques, A ^t   Amarante Costa, A ^t   Bonin Campos, L ^t   Lovato, W J ^t   Guimaraes Dantas B ^t   Ribeiro Campos, D ^t   Pires Barrientto, L C ^t   Rossi Peras Americo V ^t   Barboza Carnevalli Bueno, T ^t   Morales, D ^t   Mara Gomes, T ^t   Barbosa Cerantola, R ^t   Hoher J ^t   Sa Malbouisson L M ^t   Matheus Cadamuro, F ^t   Bassi, E ^t   Maia, R ^t   Dias E Santos, J A ^t   Oliveira, C ^t   Balzi, A P ^t   Tierno, P ^t   Marques Andrade, G ^t   Delascio Lopes, R ^t   Ramos Mello, M ^t   Vendrame, L S ^t   Ribeiro Machado, F ^t   Baccaro Rossetti Santana, H ^t   de Carvalho, A ^t   Marques Ferreira Mendez, V ^t   de Araujo Macedo Pinto, W ^t   Dos Santos Francisco, R ^t   Steponovicius Piedade Cruz, F ^t   Silva de Araujo, A ^t   Paiva de Souza, A ^t   Teixeira Pinheiro, T ^t   Martins Santos, T ^t   Gontijo Coutinho, C M ^t   Franci, D ^t   de Carvalho Filho, M A ^t   Ribas Rosa de Oliveira, A M ^t   Silva, J M ^t   Costa Lisboa, T ^t   Peretti Torelly, A ^t   Silva de Souza, A ^t   Hadrich, M ^t   Schwarz, P ^t   Berto, P ^t   Teixeira de Gois, A F ^t   Silva, M ^t   Gessolo Lins, P ^t   Cavalcante Lola Biazzoto, E P ^t   Dragosavac, D ^t   Ribeiro de Carvalho, C R ^t   Passos Amato, M B ^t   Toufen, C ^t   Ribeiro de Santis Santiago, R ^t   Hirota, A S ^t   Rodrigues, M ^t   Dias Chiavegato, L ^t   Bastos Vieira, P C ^t   de Almeida, Marcella Marson M F ^t   Barbosa, P G ^t   Pereira Santos, J R ^t   Nogueira de Paula, L ^t   Piras, C ^t   Giuberti, J ^t   Siqueira da Silva, A ^t   Conti Ramos, R ^t   Plata Valdivieso, R ^t   Gonzalez, H H ^t   Ortiz, M ^t   Bautista Rincon D F ^t   Quinones E ^t   Calderon, L E ^t   Vargas, M ^t   Pizarro, C ^t   Orozco Levi, M ^t   Espitia Hernandez A M ^t   Cadavid Gutierrez, C ^t   Giraldo Ramirez, N ^t   Gallego, D A ^t   Naranjo Sierra, S ^t   Ortiz, G ^t   Esneda Rocha Gaona, M ^t   Garay, M ^t   Vieda, E ^t   Bermudez W F ^t   Castaneda J A ^t   Cortegiani, A ^t   Russotto, V ^t   Raineri, S M ^t   Giarratano, A ^t   Rai Hakumat Rai, V ^t   Fadhil Hadi Bin Jamaluddin, M ^t   Afiq Syahmi Ramli, M ^t   Gorka, J ^t   Nowak, I ^t   Seczynska, B ^t   Sega, A ^t   Paulino, C ^t   Povoa P ^t   Belda, F J ^t   Ferrando, C ^t   Carbonell, J A ^t   Puig, J ^t   Soro, M ^t   Nin, N ^t   Hurtado, J ^t   Gacel, A ^t   Gaudin, A ^t   Sande, L ^t   more..

^a Research Institute Cardiac Hospital (HCor)   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c HOSPITAL MOINHOS DE VENTO   (Brazil)

^d Irmandade da Santa Casa de Misericordia de Porto Alegre   (Brazil)

^e FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^f São Vicente de Paulo Hospital and Maternity Hospital   (Brazil)

^g Nereu Ramos Hospital   (Brazil)

^h Hospital Unimed Vitoria   (Brazil)

ⁱ Hospital e Pronto Socorro Municipal '28 de Agosto'   (Brazil)

^j Hospital Estadual Dr Jayme Santos Neves   (Brazil)

^k UNIVERSIDADE FEDERAL DA GRANDE DOURADOS   (Brazil)

^l UNIVERSIDAD ICESI   (Colombia)

^m Hospital Universitário do Oeste do Paraná   (Brazil)

ⁿ HOSPITAL PABLO TOBÓN URIBE   (Colombia)

^o HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^p Hospital Regional Hans Dieter Schmidt   (Brazil)

^q UNIVERSITY MALAYA MEDICAL CENTRE   (Malaysia)

^r JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^s HOSPITAL NACIONAL PROFESOR ALEJANDRO POSADAS   (Argentina)

^t Hospital Nacional Alejandro Posadas ^*

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARGENTINA; ARTICLE; BAROTRAUMA; BRAZIL; COLOMBIA; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOLLOW UP; HAZARD RATIO; HOSPITAL MORTALITY; HUMAN; INTENSIVE CARE UNIT; INTERMETHOD COMPARISON; ITALY; LENGTH OF STAY; LUNG COMPLIANCE; MAJOR CLINICAL STUDY; MALAYSIA; MALE; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; PNEUMOTHORAX; POLAND; PORTUGAL; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPAIN; THORAX DRAINAGE; TREATMENT OUTCOME; URUGUAY; VENTILATOR WEANING; ADVERSE EFFECTS; AGED; CLINICAL TRIAL; COMPARATIVE STUDY; PROCEDURES; RESPIRATORY DISTRESS SYNDROME, ADULT; TIDAL VOLUME; TREATMENT FAILURE;

ADULT; AGED; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PNEUMOTHORAX; POSITIVE-PRESSURE RESPIRATION; RESPIRATORY DISTRESS SYNDROME, ADULT; TIDAL VOLUME; TREATMENT FAILURE;

EID: 85031327535     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2017.14171     Document Type: Article

References (30)

1. Bellani G, Laffey JG, Pham T, et al; LUNG SAFE Investigators; ESICM Trials Group. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315(8):788-800.
2. Herridge MS, Tansey CM, Matté A, et al; Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med. 2011;364(14):1293-1304.
3. Gattinoni L, Marini JJ, Pesenti A, Quintel M, Mancebo J, Brochard L. The “baby lung” became an adult. Intensive Care Med. 2016;42(5):663-673.
4. Gattinoni L, Protti A, Caironi P, Carlesso E. Ventilator-induced lung injury: the anatomical and physiological framework. Crit Care Med. 2010;38 (10)(suppl):S539-S548.
5. Amato MB, Barbas CS, Medeiros DM, et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med. 1998;338(6):347-354.
6. Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A; Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000; 342(18):1301-1308.
7. Borges JB, Okamoto VN, Matos GF, et al. Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome. Am J Respir Crit Care Med. 2006;174(3):268-278.
8. de Matos GF, Stanzani F, Passos RH, et al. How large is the lung recruitability in early acute respiratory distress syndrome: a prospective case series of patients monitored by computed tomography. Crit Care. 2012;16(1):R4.
9. Hodgson CL, Tuxen DV, Davies AR, et al. A randomised controlled trial of an open lung strategy with staircase recruitment, titrated PEEP and targeted low airway pressures in patients with acute respiratory distress syndrome. Crit Care. 2011; 15(3):R133.
10. Kacmarek RM, Villar J, Sulemanji D, et al; Open Lung Approach Network. Open lung approach for the acute respiratory distress syndrome: a pilot, randomized controlled trial. Crit Care Med. 2016;44 (1):32-42.
11. Suzumura EA, Figueiró M, Normilio-Silva K, et al. Effects of alveolar recruitment maneuvers on clinical outcomes in patients with acute respiratory distress syndrome: a systematic review and meta-analysis. Intensive Care Med. 2014;40(9): 1227-1240.
12. Hodgson C, Goligher EC, Young ME, et al. Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation. Cochrane Database Syst Rev. 2016;11: CD006667.
13. ART Investigators. Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial. Trials. 2012;13(1):153.
14. Damiani L, Berwanger O, Paisani D, et al. Statistical analysis plan for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial (ART): a randomized controlled trial. Rev Bras Ter Intensiva. 2017;29(2):142-153.
15. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149(3 pt 1):818-824.
16. Guérin C, Reignier J, Richard JC, et al; PROSEVA Study Group. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013; 368(23):2159-2168.
17. Mercat A, Richard JC, Vielle B, et al; Expiratory Pressure (Express) Study Group. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008;299(6): 646-655.
18. Retamal J, Bugedo G, Larsson A, Bruhn A. High PEEP levels are associated with overdistension and tidal recruitment/derecruitment in ARDS patients. Acta Anaesthesiol Scand. 2015;59(9):1161-1169.
19. Guerin C, Debord S, Leray V, et al. Efficacy and safety of recruitment maneuvers in acute respiratory distress syndrome. Ann Intensive Care. 2011;1(1):9.
20. Amato MB, Meade MO, Slutsky AS, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. 2015; 372(8):747-755.
21. Guérin C, Papazian L, Reignier J, Ayzac L, Loundou A, Forel JM; investigators of the Acurasys and Proseva trials. Effect of driving pressure on mortality in ARDS patients during lung protective mechanical ventilation in two randomized controlled trials. Crit Care. 2016;20(1):384.
22. Briel M, Meade M, Mercat A, et al. Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA. 2010;303(9):865-873.
23. Brower RG, Lanken PN, MacIntyre N, et al; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004;351(4):327-336.
24. Beitler JR, Sands SA, Loring SH, et al. Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Med. 2016;42(9):1427-1436.
25. Chanques G, Kress JP, Pohlman A, et al. Impact of ventilator adjustment and sedation-analgesia practices on severe asynchrony in patients ventilated in assist-control mode. Crit Care Med. 2013;41(9):2177-2187.
26. Meade MO, Cook DJ, Guyatt GH, et al; Lung Open Ventilation Study Investigators. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008;299(6):637-645.
27. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA; NHLBI ARDS Network. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med. 2014;2(8):611-620.
28. Famous KR, Delucchi K, Ware LB, et al; ARDS Network. Acute respiratory distress syndrome subphenotypes respond differently to randomized fluid management strategy. Am J Respir Crit Care Med. 2017;195(3):331-338.
29. Gattinoni L, Caironi P, Cressoni M, et al. Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med. 2006;354(17): 1775-1786.
30. Goligher EC, Kavanagh BP, Rubenfeld GD, Ferguson ND. Physiologic Responsiveness Should Guide Entry into Randomized Controlled Trials. Am J Respir Crit Care Med. 2015;192(12):1416-1419.