N95 respirators vs medical masks for preventing influenza among health care personnel: A randomized clinical trial

JAMA - Journal of the American Medical Association

Volumn 322, Issue 9, 2019, Pages 824-833

  Radonovich, Lewis J ^a   Simberkoff, Michael S ^b,c   Bessesen, Mary T ^d,e   Brown, Alexandria C ^f   Cummings, Derek A T ^g,h   Gaydos, Charlotte A ⁱ   Los, Jenna G ⁱ   Krosche, Amanda E ^i,j   Gibert, Cynthia L ^k,l   Gorse, Geoffrey J ^m,n   Nyquist, Ann Christine ^e,o   Reich, Nicholas G ^f   Rodriguez Barradas, Maria C ^p,q   Price, Connie Savor ^e,r   Perl, Trish M ^h,s  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Eastern Colorado Veterans Health Care System   (United States)

^e Anschutz Medical Campus   (United States)

^f UNIVERSITY OF MASSACHUSETTS   (United States)

^g UNIVERSITY OF FLORIDA   (United States)

^h JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

ⁱ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j WEILL CORNELL MEDICAL COLLEGE   (United States)

^k VETERANS AFFAIRS MEDICAL CENTER   (United States)

^l GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^m St Louis Veterans Hospital   (United States)

ⁿ SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^o CHILDREN S HOSPITAL COLORADO   (United States)

^p MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^q BAYLOR COLLEGE OF MEDICINE   (United States)

^r DENVER HEALTH MEDICAL CENTER   (United States)

^s Univ of TX Southwestern Med Center   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACNE; ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; FLU LIKE SYNDROME; HEALTH CARE PERSONNEL; HUMAN; INCIDENCE; INFECTION PREVENTION; INFLUENZA; INFLUENZA A; INFLUENZA B; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRAGMATIC TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN IRRITATION; UNITED STATES; VIRAL RESPIRATORY TRACT INFECTION; AMBULATORY CARE; CLINICAL TRIAL; COMPARATIVE STUDY; DISEASE TRANSMISSION; GAS MASK; INFECTION CONTROL; MASK; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PREVENTION AND CONTROL; PROCEDURES; RESPIRATORY TRACT INFECTION;

ADULT; AMBULATORY CARE; FEMALE; HEALTH PERSONNEL; HUMANS; INCIDENCE; INFECTION CONTROL; INFECTIOUS DISEASE TRANSMISSION, PATIENT-TO-PROFESSIONAL; INFLUENZA, HUMAN; MALE; MASKS; MIDDLE AGED; OCCUPATIONAL EXPOSURE; RESPIRATORY PROTECTIVE DEVICES; RESPIRATORY TRACT INFECTIONS;

EID: 85071775176     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2019.11645     Document Type: Article

References (22)

1. Goins WP, Talbot HK, Talbot TR. Health care-acquired viral respiratory diseases. Infect Dis Clin North Am. 2011; 25 (1): 227-244. doi: 10.1016/j.idc.2010.11.010 21316002
2. MacIntyre CR, Wang Q, Cauchemez S, A cluster randomized clinical trial comparing fit-tested and non-fit-tested N95 respirators to medical masks to prevent respiratory virus infection in health care workers. Influenza Other Respir Viruses. 2011; 5 (3): 170-179. doi: 10.1111/j.1750-2659.2011.00198.x 21477136
3. MacIntyre CR, Wang Q, Seale H, A randomized clinical trial of three options for N95 respirators and medical masks in health workers. Am J Respir Crit Care Med. 2013; 187 (9): 960-966. doi: 10.1164/rccm.201207-1164OC 23413265
4. Noti JD, Lindsley WG, Blachere FM, Detection of infectious influenza virus in cough aerosols generated in a simulated patient examination room. Clin Infect Dis. 2012; 54 (11): 1569-1577. doi: 10.1093/cid/cis237 22460981
5. Loeb M, Dafoe N, Mahony J, Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. JAMA. 2009; 302 (17): 1865-1871. doi: 10.1001/jama.2009.1466 19797474
6. Ford I, Norrie J. Pragmatic trials. N Engl J Med. 2016; 375 (5): 454-463. doi: 10.1056/NEJMra1510059 27518663
7. Janssen L, Ettinger H, Graham S, Shaffer R, Zhuang Z. The use of respirators to reduce inhalation of airborne biological agents. J Occup Environ Hyg. 2013; 10 (8): D97-D103. doi: 10.1080/15459624.2013.799964 23767796
8. MacIntyre CR, Chughtai AA, Rahman B, The efficacy of medical masks and respirators against respiratory infection in healthcare workers. Influenza Other Respir Viruses. 2017; 11 (6): 511-517. doi: 10.1111/irv.12474 28799710
9. Radonovich LJ Jr, Bessesen MT, Cummings DA, The respiratory protection effectiveness clinical trial (ResPECT): a cluster-randomized comparison of respirator and medical mask effectiveness against respiratory infections in healthcare personnel. BMC Infect Dis. 2016; 16: 243. doi: 10.1186/s12879-016-1494-2 27255755
10. Siegel JD, Rhinehart E, Jackson M, Chiarello L; Health Care Infection Control Practices Advisory Committee. 2007 Guideline for isolation precautions: preventing transmission of infectious agents in health care settings. Am J Infect Control. 2007; 35 (10)(suppl 2): S65-S164. doi: 10.1016/j.ajic.2007.10.007 18068815
11. Moulton LH. Covariate-based constrained randomization of group-randomized trials. Clin Trials. 2004; 1 (3): 297-305. doi: 10.1191/1740774504cn024oa 16279255
12. Reich NG, Cummings DA, Lauer SA, Triggering interventions for influenza: the ALERT algorithm. Clin Infect Dis. 2015; 60 (4): 499-504. doi: 10.1093/cid/ciu749 25414260
13. de la Tabla VO, Masiá M, Antequera P, Comparison of combined nose-throat swabs with nasopharyngeal aspirates for detection of pandemic influenza A/H1N1 2009 virus by real-time reverse transcriptase PCR. J Clin Microbiol. 2010; 48 (10): 3492-3495. doi: 10.1128/JCM.01105-10 20702662
14. Tang YW, Lowery KS, Valsamakis A, Clinical accuracy of a PLEX-ID flu device for simultaneous detection and identification of influenza viruses A and B. J Clin Microbiol. 2013; 51 (1): 40-45. doi: 10.1128/JCM.01978-12 23077123
15. Azur MJ, Stuart EA, Frangakis C, Leaf PJ. Multiple imputation by chained equations: what is it and how does it work? Int J Methods Psychiatr Res. 2011; 20 (1): 40-49. doi: 10.1002/mpr.329 21499542
16. Bessesen MT, Savor-Price C, Simberkoff M, Reich NG, Pavia AT, Radonovich LJ. N95 respirators or surgical masks to protect healthcare workers against respiratory infections: are we there yet? Am J Respir Crit Care Med. 2013; 187 (9): 904-905. doi: 10.1164/rccm.201303-0581ED 23634856
17. Sartor C, Zandotti C, Romain F, Disruption of services in an internal medicine unit due to a nosocomial influenza outbreak. Infect Control Hosp Epidemiol. 2002; 23 (10): 615-619. doi: 10.1086/501981 12400893
18. Jacobs JL, Ohde S, Takahashi O, Tokuda Y, Omata F, Fukui T. Use of surgical face masks to reduce the incidence of the common cold among health care workers in Japan: a randomized controlled trial. Am J Infect Control. 2009; 37 (5): 417-419. doi: 10.1016/j.ajic.2008.11.002 19216002
19. Offeddu V, Yung CF, Low MSF, Tam CC. Effectiveness of masks and respirators against respiratory infections in healthcare workers: a systematic review and meta-analysis. Clin Infect Dis. 2017; 65 (11): 1934-1942. doi: 10.1093/cid/cix681 29140516
20. Smith JD, MacDougall CC, Johnstone J, Copes RA, Schwartz B, Garber GE. Effectiveness of N95 respirators versus surgical masks in protecting health care workers from acute respiratory infection: a systematic review and meta-analysis. CMAJ. 2016; 188 (8): 567-574. doi: 10.1503/cmaj.150835 26952529
21. Peterson K, Novak D, Stradtman L, Wilson D, Couzens L. Hospital respiratory protection practices in 6 U.S. states: a public health evaluation study. Am J Infect Control. 2015; 43 (1): 63-71. doi: 10.1016/j.ajic.2014.10.008 25564126
22. Chiu S, Black CL, Yue X, Working with influenza-like illness: presenteeism among US health care personnel during the 2014-2015 influenza season. Am J Infect Control. 2017; 45 (11): 1254-1258. doi: 10.1016/j.ajic.2017.04.008 28526310