Safety, bioavailability and suitability of lutein for the particular nutritional use by infants and young children - Scientific Opinion of the Panel on Dietetic Products, Nutrition and Allergies

EFSA Journal

Volumn 6, Issue 11, 2008, Pages

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EID: 85078369507     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2008.823     Document Type: Article

References (50)

1. Adekelan D, Northop-Clewes CA, Owa J, Oyedeji A, Owoeye A, Thurnham DI (2003). Use of biomarkers of sub-clinical infection, nutrition and neonatal maturity to interpret plasma retinol in Nigerian neonates. Br. L. Nutr. 90: 353–61.
2. Alves-Rodrigues A, Shao A (2004). The science behind lutein. Toxicol. Letters 150: 57–83.
3. Bone RA, Landrum JT, Fernandez L, Tarsis SL (1988). Analysis of the macular pigment by HPLC: retinal distribution and age study. Invest. Opthalmol. Vis. Sci. 29: 843–9.
4. Bone RA, Landrum JT, Hime GW, Cains A (1993). Stereochemistry of the human macular carotenoids. Invest Ophtalmol. Vis. Sci. 34: 2033–40.
5. Calderon F, Tornambé G, Martin B, Pradel P, Chauveau-Duriot B, Nozière P (2006). Effect of mountain grassland on carotenoids in sward and cow's milk. Anim. Res. 55: 533–44.
6. Canfield L, Giuliano A, Neilson E, et al. (1997). Beta-carotene in breast milk and serum is increased after a single beta-carotene dose. Am. J. Clin. Nutr. 66: 52–61.
7. Canfield L, Kaminsky R, Taren D, Shaw E, Sander J (2001). Red palm oil in the maternal diet increases provitamin A carotenoids in breastmilk and serum of the mother-infant dyad. Eur. J. Clin. Nutr. 40: 30–8.
8. Canfield L, Clandinin M, Davies D, Fernandez MC, Jackson J, Hawkes J, Pramuk K, Reyes H, Sablan B, Sonobe T Bo X (2003). Multinational study of major breast milk carotenoids of healthy mothers. Eur. J. Nutr. 42: 133–41.
9. Cho E, Hankinson SE, Rosner B, Willett WC, Colditz GA (2008). Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. Am. J. Clin. Nutr. 87: 1837–43.
10. Chong EWT, Wong TY, Kreis AJ, Simpson JA, Guymer RH (2008). Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. Br. Med. J. 335: 755–62.
11. Chung HY, Rasmussen HM, Johnson EJ (2004). Lutein bio-availability is higher from lutein-enriched eggs than from supplements and spinach in man. J. Nutr. 134: 1887–93.
12. Codex Alimentarius Commission (2007). Joint FAO/WHO standards programme. Alinorm 07/30/26.
13. Dancheck B, Nussenblatt V, Kumwenda N, Lema V, Neville MC, Broadhead R, Taha E, Ricks MO, Semba RD (2005). Status of carotenoids, vitamin A, and vitamin E in the mother-infant dyad and anthropometric status of infants in Malawi. J. Health Pop. Nutr. 23: 343–50.
14. EC (European Commission, 1994). Commission Directive 94/36/EC of 30 June 1994 on colours for use in foodstuffs. Official Journal L. 237, 10/09/1994, p. 13–29.
15. EC (European Commission, 1995). Commission Directive 95/45/EC of 26 July 1995 laying down specific purity criteria concerning colours for use in foodstuffs. Official Journal L 226, 22/09/1995, p. 270.
16. EC (European Commission, 2006). Commission Directive 2006/141/EC of 22 December 2006 on infant formulae and follow-on formulae and amending Directive 1999/21/EC text with EEA relevance. Official Journal L 401, 30/12/2006, p. 1–33.
17. EFSA (European Food Safety Authority, 2006). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food on a request of the Commission related to lutein for use in foods for particular nutritional uses. EFSA Journal 315: 1–12.
18. o CD000253.
19. FDA/CFSAN (2002). Infant formula. Nutrient specification Code of Federal Regulations 21 CFR 107.100. www.cfsan.fda.gov/~lrd/cfr107.html#spD
20. o GRN 000140. www.cfsan.fda.gov/~rdb/opa-g140.html
21. FDA/CFSAN (2005). Qualified health claims: letter of denial – Xangold® lutein esters, lutein, or zeaxanthin and reduced risk of age related macular degeneration or cataract formation. www.cfsan.fda.gov/~dms/qhclutei.html
22. o GRN 000221. www.cfsan.fda.gov/~rdb/opa-g221.html
23. FDA/CFSAN (2008). Listing of colour additives exempt from certification. Code of Federal Regulations 21 CFR 73.295. www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=73.295
24. FSANZ (2008). Final assessment report. Application 594. Addition of lutein as a nutritive substance to infant formula. www.foodstandards.gov.au/_srcfiles/A594%20Lutein%20FAR%20FINAL.pdf-search=%22lutein%22
25. Gossage C, Deyhim M, Yamini S, Douglass L, Moser-Veillon P (2002). Carotenoid composition of human milk during the first month postpartum and the response to b-carotene supplementation. Am. J. Clin. Nutr. 76: 193–197.
26. Hammond BR, Fuld K, Snodderly DM (1996). Iris color and macular optical density. Exp. Eye Res. 62: 293–7.
27. Horwitz W, Kamps LR, Boyer KW (1980). Quality assurance in the analysis of foods and trace constituants. J. Assoc. Off. Anal. Chem. 63: 1344–54.
28. IOM (Institute of Medicine, 2000). ²-carotene and other carotenoids. In: IOM. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Food and nutrition board, Institute of medicine. Washington: National Academy Press: 325–82.
29. IOM (Institute of Medicine, 2004). Infant formula. Evaluating the safety of new ingredients. Committee on the evaluation of the addition of ingredients new to infant formula. Food and nutrition board. Washington, DC: National Academies Press.
30. JECFA (Joint FAO/WHO Expert Committee on Food Additives, 2004). Compendium of food additive specifications. FAO food and Nutrition Paper 52. Addendum 12: 35–7.
31. JECFA (Joint FAO/WHO Expert Committee on Food Additives, 2006a). Safety evaluation of certain food additives prepared by the Sixty-third meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) Lutein from Tagetes erecta L., WHO Food Additives Series 54, page 49–86. www.fao.org/ag/agn/jecfa-additives/specs/monograph3/additive-255.pdf
32. JECFA (Joint FAO/WHO Expert Committee on Food Additives, 2006b). Safety evaluation of certain food additives prepared by the Sixty-third meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) Zeaxanthin (synthetic), WHO Food Additives Series 54, page 159–190. www.fao.org/ag/agn/jecfa-additives/specs/monograph3/additive-492.pdf
33. Jackson JG, Lien EL, White SJ, Bruns NJ, Kulhman CF (1998). Major carotenoids in mature human milk: longitudinal and diurnal patterns. J. Nutr. Biochem. 9: 2–7.
34. Jewell VC, Northrop-Clewes CA, Tubman R, Thurnham DI (2001). Nutritional factors and visual function in premature infants. Proc. Nutr. Soc. 60: 171–8.
35. Jewell VC, Mayes CBD, Tubman TRJ, Northrop-Clewes CA, Thurnham DI (2004). A comparison of lutein and zeaxanthin concentrations in formula and human milk samples from Northern Ireland mothers. Eur. J. Clin. Nutr. 58: 90–7.
36. Johnson L, Norkus E, Abbasi S, Gerdes JS, Bhutani VK (1994). Contribution of beta-carotene enriched formulae to individual and total serum carotenoids in term infants. Pediatr. Res. 36: A186.
37. Johnson EJ, Hammond BR, Yeum KJ, Qin J, Wang XD, Castaneda C, Snodderly DM, Russell RM (2000). Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. Am. J. Clin. Nutr. 71: 1555–62.
38. Kruger CL, Murphy M, DeFreitas Z, Pfannkuch F, Heimbach J (2002). An innovative approach to the determination of safety for a dietary ingredient derived from e new source: case study using lutein product. Food Chem. Toxicol. 40: 1535–49.
39. Lietz G, Mulokozi G, Henry JCK, Tomkins AM. Xanthophyll and Hydrocarbon Carotenoid Patterns Differ in Plasma and Breast Milk of Women Supplemented with Red Palm Oil during. Pregnancy and Lactation. J. Nutr. 2006; 136 (7): 1821–1827.
40. Liu Y, Xu M, Canfield L (1998). Enzymatic hydrolysis, extraction, and quantitation of retinol and major carotenoids in mature human milk. J. Nutr. Biochem. 9: 178–83.
41. Macias C, Schweigert FJ (2001). Changes in the concentration of carotenoids, vitamin A, alpha-tocopherol and total lipids in human milk throughout early lactation. Ann. Nutr. Metab. 2001; 45 (2): 82–85.
42. Meneses F, Trugo NMF (2005). Retinol, beta-carotene, and lutein + zeaxanthin in the milk of Brazilian nursing women: associations with plasma concentrations and influences of maternal characteristics. Nutr. Res. 25: 443–51.
43. Nolan J, O'Donovan O, Kavanagh H, Stack J, Harrison H, Muldoon A, Mellerio J, Beatty S (2004). Macular pigment and percentage of body fat. Invest. Ophtalmol. Vis. Sci. 45: 3940–50.
44. Parker RS (1996). Absorption, metabolism and transport of carotenoids. Faseb. J. 10: 542–51.
45. Thurnham DI, Northrop-Clewes CA, Paracha PI, McLoone UJ (1997). The possible significance of parallel changes in plasma lutein and retinol in Pakistani infants during summer season. Br. J. Nutr. 78: 775–84.
46. Schupp C, Olano-Martin E, Gerth C, Morrissey BM, Cross CE, Werner JS. (2004). Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients. Am. J. Clin. Nutr. 79: 1045–52.
47. Schweigert FJ, Bathe K, Chen F, Busher U, Dudenhausen J (2004). Effect of the stage of lactation in humans on carotenoid levels in milk, blood plasma and plasma lipoprotein fractions. Eur. J. Clin. Nutr. 43: 39–44.
48. Trumbo PR, Ellwood KC (2006). Lutein and zeaxanthin intakes and risk of age related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claim. Am. J. Clin. Nutr. 84: 971–4.
49. Shao A, Hathcock JN (2006). Risk assessment for the carotenoids lutein and lycopen. Regul. Toxicol. Pharmacol. 45: 289–98.
50. Updike AA, Schwartz SJ (2003). Thermal processing of vegetables increases cis isomers of lutein and zeaxanthin. J. Agric. Food Chem. 51: 6184–90.