Scientific Opinion on the safety and efficacy of vitamin D3 (cholecalciferol) as a feed additive for chickens for fattening, turkeys, other poultry, pigs, piglets (suckling), calves for rearing, calves for fattening, bovines, ovines, equines, fish and other animal species or categories, based on a dossier submitted by DSM

EFSA Journal

Volumn 10, Issue 12, 2012, Pages

[No Author Info available]

Author keywords

cholecalciferol; Nutritional additive; safety; vitamin D3; vitamins and provitamins

Indexed keywords

EID: 85077884469     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2012.2968     Document Type: Article

References (36)

1. Aburto A, Britton WM, 1998a. Effects of different levels of vitamins A and E on the utilization of cholecalciferol by broiler chickens. Poultry Science, 77(4), 570–577.
2. Aburto A, Britton WM, 1998b. Effects and interactions of dietary levels of vitamins A and E and cholecalciferol in broiler chickens. Poultry Science 77(5), 666–673.
3. Aburto A, Edwards HM Jr, Britton WM, 1998. The influence of vitamin A on the utilization and amelioration of toxicity of cholecalciferol, 25-hydroxycholecalciferol, and 1,25 dihydroxycholecalciferol in young broiler chickens. Poultry Science, 77(4), 585–593.
4. AWT (Arbeitsgemeinschaft für Wirkstoffe in der Tierernährung e.V.), 2002. Vitamins in animal nutrition, Agrimedia GmbH. ISBN 3-86037-167-3.
5. EFSA (European Food Safety Authority), 2005. Opinion of the Scientific Panel on additives and products or substances used in animal feed (FEEDAP) on the evaluation of safety and efficacy of “Hy•D” (calcifediol), based on 25-hydroxylcholecalciferol/25-hydroxy-pre-cholecalciferol, as feed additive in accordance with Council Directive 70/524/EEC. The EFSA Journal, 224, 1–35.
6. EFSA (European Food Safety Authority), 2008a. Scientific Opinion of the Panel on Dietetic Products, Nutrition and Allergies on a request from the Association de la Transformation Laitière Française related to the scientific substantiation of a health claim on vitamin D and bone growth. The EFSA Journal, 827, 1–10.
7. EFSA (European Food Safety Authority), 2008b. Scientific Opinion of the Panel on Dietetic Products Nutrition and Allergies on a request from Yoplait Dairy Crest Limited on the scientific substantiation of a health claim related to calcium and vitamin D and bone strength. The EFSA Journal, 828, 1–13.
8. EFSA (European Food Safety Authority), 2009a. Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) on a request from European Commission on the safety and efficacy of 25-hydroxycholecalciferol as feed additive for poultry and pigs. The EFSA Journal, 969, 1–32.
9. EFSA (European Food Safety Authority), 2009b. Scientific Statement of the Panel on Food Additives and Nutrient Sources added to Food on the inability to assess the safety of vitamin D-enriched yeast added for nutritional purposes as a source of vitamin D in food supplements and the bioavailability of vitamin D from this source, based on the supporting dossier, following a request from the European Commission. The EFSA Journal, 1148, 1–6.
10. 3 chewing tablets and reduction of the risk of osteoporotic fractures by reducing bone loss. The EFSA Journal 1180, 1–13.
11. EFSA (European Food Safety Authority) Panel on Dietetic Products, Nutrition and Allergies (NDA), 2009d. Scientific Opinion on the substantiation of health claims related to vitamin D and maintenance of bone and teeth (ID 150, 151, 158), absorption and utilisation of calcium and phosphorus and maintenance of normal blood calcium concentrations (ID 152, 157), cell division (ID 153), and thyroid function (ID 156) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 7(9), 1227, 19 pp.
12. EFSA (European Food Safety Authority) Panel on Dietetic Products, Nutrition and Allergies (NDA), 2009e. Scientific Opinion on the substantiation of health claims related to calcium and vitamin D and maintenance of bone (ID 350) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 7(9), 1272, 14 pp.
13. EFSA (European Food Safety Authority) Panel on Dietetic Products, Nutrition and Allergies (NDA), 2010a. Scientific Opinion on the substantiation of health claims related to vitamin D and normal function of the immune system and inflammatory response (ID 154, 159), maintenance of normal muscle function (ID 155) and maintenance of normal cardiovascular function (ID 159) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 8(2), 1468, 17 pp.
14. EFSA (European Food Safety Authority) Panel on Dietetic Products, Nutrition and Allergies (NDA), 2010b. Scientific Opinion in relation to the authorisation procedure for health claims on calcium and vitamin D and the reduction of the risk of osteoporotic fractures by reducing bone loss pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal, 8(5), 1609, 10 pp.
15. EFSA (European Food Safety Authority) Panel on Dietetic Products, Nutrition and Allergies (NDA), 2011a. Scientific Opinion on health claims already evaluated (ID 215, 568, 674, 712, 1398, 1633, 1974, 4191, 4192, 4193, 4236, 4335, 4698, 4704) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal, 9(6), 2203, 22 pp.
16. EFSA (European Food Safety Authority) Panel on Dietetic Products, Nutrition and Allergies (NDA), 2011b. Scientific Opinion on the substantiation of a health claim related to vitamin D and risk of falling pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal, 9(9), 2382, 18 pp.
17. EFSA (European Food Safety Authority) Panel on Dietetic Products, Nutrition and Allergies (NDA), 2012a. Scientific Opinion on the Tolerable Upper Intake Level of Vitamin D. EFSA Journal 10(7), 2813, 45 pp.
18. EFSA (European Food Safety Authority) Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), 2012b. Guidance for establishing the safety of additives for the consumer. EFSA Journal, 10(1), 2537, 12 pp.
19. EFSA (European Food Safety Authority) Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), 2012c. Guidance on studies concerning the safety of use of the additive for users/workers. EFSA Journal 10(1), 2539, 5 pp.
20. EMA (European Medicines Agency), 2010. VICH GL 18 residual solvents in new veterinamty medicinal products, active substances and excipients, revision. Available online: www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2010/06/WC500091533.pdf
21. European Pharmacopeia (PhEur), 2010. Cholecalciferol, Monograph (MG) 0072, 7th Edition. Strasbourg, France, Council of Europe (COE)–European Directorate for the Quality of Medicines.
22. European Pharmacopeia (PhEur), 2010. Cholecalciferol concentrated, oily form, Monograph (MG) 0575, 7th Edition. Strasbourg, France, Council of Europe (COE)–European Directorate for the Quality of Medicines.
23. European Pharmacopeia (PhEur), 2010. Cholecalciferol concentrated, powder form, Monograph (MG) 0574, 7th Edition. Strasbourg, France. Council of Europe (COE)–European Directorate for the Quality of Medicines.
24. European Pharmacopeia (PhEur), 2010. Cholecalciferol concentrated, water-dispersible form, Monograph (MG) 0598, 7th Edition. Strasbourg, France, Council of Europe (COE)–European Directorate for the Quality of Medicines.
25. Gropp JM. 1994. Vitamin fortification levels in European commercial poultry and swine diets. Proceedings of the Arkansas Nutrition Conference, Fayetteville, AR, pp. 105–134.
26. 3 in pigs-but meat produced has a lower content of vitamin D. British Journal of Nutrition, 98, 908–913.
27. McDowell LR, 2000. Vitamins in animal and human nutrition, 2nd Edition, Iowa State University Press, Ames, IA, 114 pp. ISBN 0-8138-2630-6.
28. Mattila P, Ronkainen R, Lehikoinen K and Piironen V, 1999a. Effect of household cooking on the vitamin content in fish, eggs, and wild mushrooms. Journal of Food Composition and Analysis, 12, 153–160.
29. Mattila P, Lehikoinen K, Kiiskinen T and Piironen V, 1999b. Cholecalciferol and 25-hydroxycholecalciferol content of chicken egg yolk as affected by the cholecalciferol content of feed. Journal of Agricultural and Food Chemistry, 47, 4089–4092.
30. Norman AW, 2000. Vitamin D and milk. Available from vitamind.ucr.edu/milk.html
31. NRC (National Research Council), 1987. Vitamin tolerance of animals. National Academic Press, Washington DC, pp. 11–21.
32. Whittemore CT, Close WH and Hazzledine MJ, 2002. The need for nutrient requirement standards for pigs. A report of the British Society of Animal Science nutritional standards working group: pigs. Pig News and Information, 23, 67N–74N.
33. 3 in pigs-but meat produced has a lower content of vitamin D. British Journal of Nutrition, 98, 908–913.
34. Mattila P, Ronkainen R, Lehikoinen K and Piironen V, 1999a. Effect of household cooking on the vitamin content in fish, eggs, and wild mushrooms. Journal of Food Composition and Analysis, 12, 153–160.
35. Mattila P, Lehikoinen K, Kiiskinen T and Piironen V, 1999b. Cholecalciferol and 25-hydroxycholecalciferol content of chicken egg yolk as affected by the cholecalciferol content of feed. Journal of Agricultural and Food Chemistry, 47, 4089–4092.
36. Norman AW, 2000. Vitamin D and milk. Available from vitamind.ucr.edu/milk.html