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Volumn 19, Issue 12, 2019, Pages

Natural Alternative Sweeteners and Diabetes Management

Author keywords

Diabetes; Natural alternative sweeteners; Rare sugars; Stevia; Sugar alcohols

Indexed keywords

ALLOSE; ANTIOXIDANT; PLANT EXTRACT; PSICOSE; SCHISANDRA CHINENSIS EXTRACT; SORBOSE; STEVIA REBAUDIANA EXTRACT; SUGAR ALCOHOL; SWEETENING AGENT; TAGATOSE; UNCLASSIFIED DRUG; CARBOHYDRATE; GLUCOSE; PLANT MEDICINAL PRODUCT;

EID: 85075476471     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-019-1273-8     Document Type: Review
Times cited : (32)

References (41)
  • 2
    • 0032913309 scopus 로고    scopus 로고
    • Role of oxidative stress in diabetic complications: a new perspective on an old paradigm
    • Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes. 1999;48(1):1–9. 10.2337/diabetes.48.1.1.
    • (1999) Diabetes. , vol.48 , Issue.1 , pp. 1-9
    • Baynes, J.W.1    Thorpe, S.R.2
  • 3
    • 85029604474 scopus 로고    scopus 로고
    • Glycosides from Stevia rebaudiana bertoni possess insulin-mimetic and antioxidant activities in rat cardiac fibroblasts
    • Prata C, Zambonin L, Rizzo B, Maraldi T, Angeloni C, Vieceli Dalla Sega F, et al. Glycosides from Stevia rebaudiana bertoni possess insulin-mimetic and antioxidant activities in rat cardiac fibroblasts. Oxid Med Cell Longev. 2017;2017:3724545. 10.1155/2017/3724545.
    • (2017) Oxid Med Cell Longev , vol.2017 , pp. 3724545
    • Prata, C.1    Zambonin, L.2    Rizzo, B.3    Maraldi, T.4    Angeloni, C.5    Vieceli Dalla Sega, F.6
  • 5
    • 85044616642 scopus 로고    scopus 로고
    • Accessed 6/23/19
    • Adult obesity facts. Center for Disease Control and Prevention. 2018. https://www.cdc.gov/obesity/data/adult.html. Accessed 6/23/19.
    • (2018) Center for Disease Control and Prevention
  • 7
    • 84938068687 scopus 로고    scopus 로고
    • Study of Stevia rebaudiana Bertoni antioxidant activities and cellular properties
    • COI: 1:CAS:528:DC%2BC2MXht1agsrvJ
    • Bender C, Graziano S, Zimmermann BF. Study of Stevia rebaudiana Bertoni antioxidant activities and cellular properties. Int J Food Sci Nutr. 2015;66(5):553–8.
    • (2015) Int J Food Sci Nutr , vol.66 , Issue.5 , pp. 553-558
    • Bender, C.1    Graziano, S.2    Zimmermann, B.F.3
  • 8
    • 85031732652 scopus 로고    scopus 로고
    • Stevia rebaudiana Bertoni: a natural alternative for treating diseases associated with metabolic syndrome
    • Carrera-Lanestosa A, Moguel-Ordonez Y, Segura-Campos M. Stevia rebaudiana Bertoni: a natural alternative for treating diseases associated with metabolic syndrome. J Med Food. 2017;20(10):933–43. 10.1089/jmf.2016.0171.
    • (2017) J Med Food , vol.20 , Issue.10 , pp. 933-943
    • Carrera-Lanestosa, A.1    Moguel-Ordonez, Y.2    Segura-Campos, M.3
  • 9
    • 85017094502 scopus 로고    scopus 로고
    • Effects of non-nutritive (artificial vs natural) sweeteners on 24-h glucose profiles
    • Tey SL, Salleh NB, Henry CJ, Forde CG. Effects of non-nutritive (artificial vs natural) sweeteners on 24-h glucose profiles. Eur J Clin Nutr. 2017;71(9):1129–32. 10.1038/ejcn.2017.37.
    • (2017) Eur J Clin Nutr , vol.71 , Issue.9 , pp. 1129-1132
    • Tey, S.L.1    Salleh, N.B.2    Henry, C.J.3    Forde, C.G.4
  • 10
    • 85008657138 scopus 로고    scopus 로고
    • Effects of aspartame-, monk fruit-, stevia-and sucrose-sweetened beverages on postprandial glucose, insulin and energy intake
    • COI: 1:CAS:528:DC%2BC2sXmslCkuw%3D%3D
    • Tey S, Salleh N, Henry J, Forde C. Effects of aspartame-, monk fruit-, stevia-and sucrose-sweetened beverages on postprandial glucose, insulin and energy intake. Int J Obes. 2017;41(3):450.
    • (2017) Int J Obes , vol.41 , Issue.3 , pp. 450
    • Tey, S.1    Salleh, N.2    Henry, J.3    Forde, C.4
  • 11
    • 84979294616 scopus 로고    scopus 로고
    • Nutritional composition of Stevia rebaudiana, a sweet herb, and its hypoglycaemic and hypolipidaemic effect on patients with non-insulin dependent diabetes mellitus
    • COI: 1:CAS:528:DC%2BC28XivVWns7o%3D
    • Ritu M, Nandini J. Nutritional composition of Stevia rebaudiana, a sweet herb, and its hypoglycaemic and hypolipidaemic effect on patients with non-insulin dependent diabetes mellitus. J Sci Food Agric. 2016;96(12):4231–4.
    • (2016) J Sci Food Agric , vol.96 , Issue.12 , pp. 4231-4234
    • Ritu, M.1    Nandini, J.2
  • 12
    • 84947434045 scopus 로고    scopus 로고
    • Effect of the natural sweetener, steviol glycoside, on cardiovascular risk factors: a systematic review and meta-analysis of randomised clinical trials
    • Onakpoya IJ, Heneghan CJ. Effect of the natural sweetener, steviol glycoside, on cardiovascular risk factors: a systematic review and meta-analysis of randomised clinical trials. Eur J Prev Cardiol. 2015;22(12):1575–87.
    • (2015) Eur J Prev Cardiol , vol.22 , Issue.12 , pp. 1575-1587
    • Onakpoya, I.J.1    Heneghan, C.J.2
  • 13
    • 85048333817 scopus 로고    scopus 로고
    • Anti diabetic property of aqueous extract of Stevia rebaudiana bertoni leaves in streptozotocin-induced diabetes in albino rats
    • Ahmad U, Ahmad RS. Anti diabetic property of aqueous extract of Stevia rebaudiana bertoni leaves in streptozotocin-induced diabetes in albino rats. BMC Complement Altern Med. 2018;18(1):179–11. 10.1186/s12906-018-2245-2.
    • (2018) BMC Complement Altern Med , vol.18 , Issue.1 , pp. 111-179
    • Ahmad, U.1    Ahmad, R.S.2
  • 14
    • 85021649317 scopus 로고    scopus 로고
    • Effect of stevia sweetener consumption as non-caloric sweetening on body weight gain and biochemical’s parameters in overweight female rats
    • Elnaga NA, Massoud MI, Yousef M, Mohamed HH. Effect of stevia sweetener consumption as non-caloric sweetening on body weight gain and biochemical’s parameters in overweight female rats. Annals of Agricultural Sciences. 2016;61(1):155–63.
    • (2016) Annals of Agricultural Sciences , vol.61 , Issue.1 , pp. 155-163
    • Elnaga, N.A.1    Massoud, M.I.2    Yousef, M.3    Mohamed, H.H.4
  • 15
    • 84960076144 scopus 로고    scopus 로고
    • Hypoglycemic effect of aquatic extract of Stevia in pancreas of diabetic rats: PPARγ-dependent regulation or antioxidant potential
    • PID: 27141265
    • Assaei R, Mokarram P, Dastghaib S, Darbandi S, Darbandi M, Zal F, et al. Hypoglycemic effect of aquatic extract of Stevia in pancreas of diabetic rats: PPARγ-dependent regulation or antioxidant potential. Avicenna journal of medical biotechnology. 2016;8(2):65.
    • (2016) Avicenna journal of medical biotechnology , vol.8 , Issue.2 , pp. 65
    • Assaei, R.1    Mokarram, P.2    Dastghaib, S.3    Darbandi, S.4    Darbandi, M.5    Zal, F.6
  • 16
    • 84988327848 scopus 로고    scopus 로고
    • Evaluation of the antihyperglycemic effect of minor steviol glycosides in normoglycemic and induced-diabetic Wistar rats
    • Aranda-González I, Moguel-Ordóñez Y, Chel-Guerrero L, Segura-Campos M, Betancur-Ancona D. Evaluation of the antihyperglycemic effect of minor steviol glycosides in normoglycemic and induced-diabetic Wistar rats. J Med Food. 2016;19(9):844–52. 10.1089/jmf.2016.0014.
    • (2016) J Med Food , vol.19 , Issue.9 , pp. 844-852
    • Aranda-González, I.1    Moguel-Ordóñez, Y.2    Chel-Guerrero, L.3    Segura-Campos, M.4    Betancur-Ancona, D.5
  • 17
    • 84924411144 scopus 로고    scopus 로고
    • The effect of Stevia rebaudiana on serum omentin and visfatin level in STZ-induced diabetic rats
    • Proposed molecular mechanism for stevia’s insulin-mimetic properties
    • • Akbarzadeh S, Eskandari F, Tangestani H, Bagherinejad ST, Bargahi A, Bazzi P et al. The effect of Stevia rebaudiana on serum omentin and visfatin level in STZ-induced diabetic rats. Journal of dietary supplements. 2015;12(1):11-22. Proposed molecular mechanism for stevia’s insulin-mimetic properties.
    • (2015) Journal of Dietary Supplements , vol.12 , Issue.1 , pp. 11-22
    • Akbarzadeh, S.1    Eskandari, F.2    Tangestani, H.3    Bagherinejad, S.T.4    Bargahi, A.5    Bazzi, P.6
  • 18
    • 85011369451 scopus 로고    scopus 로고
    • The role of artificial and natural sweeteners in reducing the consumption of table sugar: a narrative review
    • Mooradian AD, Smith M, Tokuda M. The role of artificial and natural sweeteners in reducing the consumption of table sugar: a narrative review. Clinical nutrition eSPen. 2017;18:1–8.
    • (2017) Clinical nutrition eSPen , vol.18 , pp. 1-8
    • Mooradian, A.D.1    Smith, M.2    Tokuda, M.3
  • 19
    • 85053075902 scopus 로고    scopus 로고
    • The effect of small doses of fructose and allulose on postprandial glucose metabolism in type 2 diabetes: a double-blind, randomized, controlled, acute feeding, equivalence trial
    • Noronha JC, Braunstein CR, Glenn AJ, Khan TA, Viguiliouk E, Noseworthy R, et al. The effect of small doses of fructose and allulose on postprandial glucose metabolism in type 2 diabetes: a double-blind, randomized, controlled, acute feeding, equivalence trial. Diabetes Obes Metab. 2018;20(10):2361–70. 10.1111/dom.13374.
    • (2018) Diabetes Obes Metab , vol.20 , Issue.10 , pp. 2361-2370
    • Noronha, J.C.1    Braunstein, C.R.2    Glenn, A.J.3    Khan, T.A.4    Viguiliouk, E.5    Noseworthy, R.6
  • 20
    • 85041355911 scopus 로고    scopus 로고
    • A preliminary study for evaluating the dose-dependent effect of d-allulose for fat mass reduction in adult humans: a randomized, double-blind
    • Han Y, Kwon E-Y, Yu M, Lee S, Kim H-J, Kim S-B, et al. A preliminary study for evaluating the dose-dependent effect of d-allulose for fat mass reduction in adult humans: a randomized, double-blind. Placebo-Controlled Trial Nutrients. 2018;10(2):160. 10.3390/nu10020160.
    • (2018) Placebo-Controlled Trial Nutrients , vol.10 , Issue.2 , pp. 160
    • Han, Y.1    Kwon, E.-Y.2    Yu, M.3    Lee, S.4    Kim, H.-J.5    Kim, S.-B.6
  • 21
    • 84926348803 scopus 로고    scopus 로고
    • Weight reducing effect and safety evaluation of rare sugar syrup by a randomized double-blind, parallel-group study in human
    • Hayashi N, Yamada T, Takamine S, Iida T, Okuma K, Tokuda M. Weight reducing effect and safety evaluation of rare sugar syrup by a randomized double-blind, parallel-group study in human. J Funct Foods. 2014;11:152–9. 10.1016/j.jff.2014.09.020.
    • (2014) J Funct Foods , vol.11 , pp. 152-159
    • Hayashi, N.1    Yamada, T.2    Takamine, S.3    Iida, T.4    Okuma, K.5    Tokuda, M.6
  • 22
    • 85015624696 scopus 로고    scopus 로고
    • Effects of three low-doses of D-tagatose on glycemic control over six months in subjects with mild type 2 diabetes mellitus under control with diet and exercise
    • Identifies minimum dosage required to see positive effects on blood glucose after six months of treatment
    • • Ensor M, Williams J, Smith R, Banfield A, Lodder RA. Effects of three low-doses of D-tagatose on glycemic control over six months in subjects with mild type 2 diabetes mellitus under control with diet and exercise. Journal of endocrinology, diabetes & obesity. 2014;2(4):1057. Identifies minimum dosage required to see positive effects on blood glucose after six months of treatment.
    • (2014) Journal of Endocrinology, Diabetes & Obesity , vol.2 , Issue.4 , pp. 1057
    • Ensor, M.1    Williams, J.2    Smith, R.3    Banfield, A.4    Lodder, R.A.5
  • 23
    • 85032479801 scopus 로고    scopus 로고
    • Safety and efficacy of D-tagatose in glycemic control in subjects with type 2 diabetes
    • Results were reproducible with a longer treatment period with a larger and more diverse participant population
    • •• Ensor M, Banfield AB, Smith RR, Williams J, Lodder RA. Safety and efficacy of D-tagatose in glycemic control in subjects with type 2 diabetes. Journal of endocrinology, diabetes & obesity. 2015;3(1). Results were reproducible with a longer treatment period with a larger and more diverse participant population.
    • (2015) Journal of Endocrinology, Diabetes & Obesity , vol.3 , Issue.1
    • Ensor, M.1    Banfield, A.B.2    Smith, R.R.3    Williams, J.4    Lodder, R.A.5
  • 24
    • 85032933825 scopus 로고    scopus 로고
    • Rare sugars, d -allulose, d -tagatose and d -sorbose, differently modulate lipid metabolism in rats
    • Nagata Y, Mizuta N, Kanasaki A, Tanaka K. Rare sugars, d -allulose, d -tagatose and d -sorbose, differently modulate lipid metabolism in rats. J Sci Food Agric. 2018;98(5):2020–6. 10.1002/jsfa.8687.
    • (2018) J Sci Food Agric , vol.98 , Issue.5 , pp. 2020-2026
    • Nagata, Y.1    Mizuta, N.2    Kanasaki, A.3    Tanaka, K.4
  • 25
    • 85017109204 scopus 로고    scopus 로고
    • Rare Sugar Syrup Containingd-Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats
    • COI: 1:CAS:528:DC%2BC2sXislKksLs%3D
    • • Shintani T, Yamada T, Hayashi N, Iida T, Nagata Y, Ozaki N et al. Rare sugar syrup containing D-allulose but not high-fructose corn syrup maintains glucose tolerance and insulin sensitivity partly via hepatic glucokinase translocation in Wistar rats. Journal of agricultural and food chemistry. 2017;65(13):2888-94. Evaluates the mechanism of action of rare sugars and suggests that RSS affects glucose metabolism through GK and increased glycogen levels.
    • (2017) Journal of Agricultural and Food Chemistry , vol.65 , Issue.13 , pp. 2888-2894
    • Shintani, T.1    Yamada, T.2    Hayashi, N.3    Iida, T.4    Nagata, Y.5    Ozaki, N.6    Toyoda, Y.7
  • 26
    • 85040536014 scopus 로고    scopus 로고
    • GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
    • (,)., https://doi.org/10.1038/s41467-017-02488-y
    • Iwasaki Y, Sendo M, Dezaki K, Hira T, Sato T, Nakata M, et al. GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose. Nature Communications. 2018;9(1). 10.1038/s41467-017-02488-y.
    • (2018) Nature Communications , vol.9 , Issue.1
    • Iwasaki, Y.1    Sendo, M.2    Dezaki, K.3    Hira, T.4    Sato, T.5    Nakata, M.6
  • 27
    • 85026646355 scopus 로고    scopus 로고
    • Comparison of anti-obesity effect between two types of syrup containing rare sugars in Wistar rats
    • Ochiai M, Misaki K, Yamada T, Iida T, Okuma K, Matsuo T. Comparison of anti-obesity effect between two types of syrup containing rare sugars in Wistar rats. J Nutr Sci Vitaminol. 2017;63(3):208–13. 10.3177/jnsv.63.208.
    • (2017) J Nutr Sci Vitaminol , vol.63 , Issue.3 , pp. 208-213
    • Ochiai, M.1    Misaki, K.2    Yamada, T.3    Iida, T.4    Okuma, K.5    Matsuo, T.6
  • 28
    • 84926285954 scopus 로고    scopus 로고
    • d-Psicose, an Epimer ofd-Fructose, Favorably Alters Lipid Metabolism in Sprague–Dawley Rats
    • COI: 1:CAS:528:DC%2BC2MXjvFymtLc%3D
    • • Nagata Y, Kanasaki A, Tamaru S, Tanaka K. D-psicose, an epimer of D-fructose, favorably alters lipid metabolism in Sprague–Dawley rats. Journal of agricultural and food chemistry. 2015;63(12):3168–76. First study to show that allulose may modulate lipid absorption in the small intestine, explaining its hypolipidemic actions.
    • (2015) Journal of Agricultural and Food Chemistry , vol.63 , Issue.12 , pp. 3168-3176
    • Nagata, Y.1    Kanasaki, A.2    Tamaru, S.3    Tanaka, K.4
  • 29
    • 84921788682 scopus 로고    scopus 로고
    • Rare sugar D-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats
    • Long term (greater than 1 year) provides evidence supporting rare sugars’ role in decreasing inflammation
    • • Hossain A, Yamaguchi F, Hirose K, Matsunaga T, Sui L, Hirata Y et al. Rare sugar D-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats. Drug Design, Development and Therapy. 2015:525. doi:10.2147/dddt.s71289. Long term (greater than 1 year) provides evidence supporting rare sugars’ role in decreasing inflammation.
    • (2015) Drug Design, Development and Therapy , pp. 525
    • Hossain, A.1    Yamaguchi, F.2    Hirose, K.3    Matsunaga, T.4    Sui, L.5    Hirata, Y.6
  • 34
    • 84989857905 scopus 로고    scopus 로고
    • Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people
    • Overduin J, Collet T-H, Medic N, Henning E, Keogh JM, Forsyth F, et al. Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people. Appetite. 2016;107:596–603. 10.1016/j.appet.2016.09.009.
    • (2016) Appetite. , vol.107 , pp. 596-603
    • Overduin, J.1    Collet, T.-H.2    Medic, N.3    Henning, E.4    Keogh, J.M.5    Forsyth, F.6
  • 35
    • 85062620867 scopus 로고    scopus 로고
    • The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the possible adverse reactions: A phase I double-blind, three-way randomized cross-over clinical trial
    • Mohsenpour MA, Kaseb F, Nazemian R, Mozaffari-Khosravi H, Fallahzadeh H, Salehi-Abargouei A. The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the possible adverse reactions: a phase I double-blind, three-way randomized cross-over clinical trial. Endocrinologia, diabetes y nutricion. 2019.
    • (2019) Endocrinologia, Diabetes Y Nutricion
    • Mohsenpour, M.A.1    Kaseb, F.2    Nazemian, R.3    Mozaffari-Khosravi, H.4    Fallahzadeh, H.5    Salehi-Abargouei, A.6
  • 36
    • 85042022718 scopus 로고    scopus 로고
    • Erythritol attenuates postprandial blood glucose by inhibiting α-glucosidase
    • Wen H, Tang B, Stewart AJ, Tao Y, Shao Y, Cui Y, et al. Erythritol attenuates postprandial blood glucose by inhibiting α-glucosidase. J Agric Food Chem. 2018;66(6):1401–7. 10.1021/acs.jafc.7b05033.
    • (2018) J Agric Food Chem , vol.66 , Issue.6 , pp. 1401-1407
    • Wen, H.1    Tang, B.2    Stewart, A.J.3    Tao, Y.4    Shao, Y.5    Cui, Y.6
  • 37
    • 85019673589 scopus 로고    scopus 로고
    • Xylitol improves anti-oxidative defense system in serum, liver, heart, kidney and pancreas of normal and type 2 diabetes model of rats
    • COI: 1:CAS:528:DC%2BC1cXhvFOitr7E, PID: 29513951
    • Chukwuma CI, Islam S. Xylitol improves anti-oxidative defense system in serum, liver, heart, kidney and pancreas of normal and type 2 diabetes model of rats. Acta Pol Pharm. 2017;74(3):817–26.
    • (2017) Acta Pol Pharm , vol.74 , Issue.3 , pp. 817-826
    • Chukwuma, C.I.1    Islam, S.2
  • 38
    • 84904339882 scopus 로고    scopus 로고
    • Xylitol improves pancreatic islets morphology to ameliorate type 2 diabetes in rats: a dose response study
    • Rahman MA, Islam MS. Xylitol improves pancreatic islets morphology to ameliorate type 2 diabetes in rats: a dose response study. J Food Sci. 2014;79(7):H1436–42. 10.1111/1750-3841.12520.
    • (2014) J Food Sci , vol.79 , Issue.7 , pp. H1436-H1442
    • Rahman, M.A.1    Islam, M.S.2
  • 39
    • 85075474001 scopus 로고    scopus 로고
    • The positive effect of luohanguo as sugar substitute on blood glucose and metabolism in streptozotocin-induced diabetic mice
    • Lee YJ, Jeong J, Kim MO, Nam J-O. The positive effect of luohanguo as sugar substitute on blood glucose and metabolism in streptozotocin-induced diabetic mice. Applied Microscopy. 2016;46(3):140–9.
    • (2016) Applied Microscopy , vol.46 , Issue.3 , pp. 140-149
    • Lee, Y.J.1    Jeong, J.2    Kim, M.O.3    Nam, J.-O.4
  • 41
    • 85060218573 scopus 로고    scopus 로고
    • AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet/streptozotocin-induced diabetic mice
    • Liu H, Qi X, Yu K, Lu A, Lin K, Zhu J, et al. AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet/streptozotocin-induced diabetic mice. Food Funct. 2019. 10.1039/c8fo01486h.
    • (2019) Food & Function , vol.10 , Issue.1 , pp. 151-162
    • Liu, H.1    Qi, X.2    Yu, K.3    Lu, A.4    Lin, K.5    Zhu, J.6    Zhang, M.7    Sun, Z.8


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