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Volumn 8, Issue 20, 2019, Pages

SGLT-2 Inhibitors in Heart Failure: Current Management, Unmet Needs, and Therapeutic Prospects

Author keywords

heart failure; SGLT 2 inhibitors; type 2 diabetes mellitus; unmet needs

Indexed keywords

CANAGLIFLOZIN; DAPAGLIFLOZIN; EMPAGLIFLOZIN; PLACEBO; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR;

EID: 85073166325     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.119.013389     Document Type: Review
Times cited : (127)

References (115)
  • 2
    • 85031738724 scopus 로고    scopus 로고
    • Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
    • GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390:1211–1259.
    • (2017) Lancet , vol.390 , pp. 1211-1259
  • 3
    • 85044713375 scopus 로고    scopus 로고
    • Global public health burden of heart failure
    • Savarese G, Lund LH. Global public health burden of heart failure. Card Fail Rev. 2017;3:7–11.
    • (2017) Card Fail Rev , vol.3 , pp. 7-11
    • Savarese, G.1    Lund, L.H.2
  • 4
    • 84888051845 scopus 로고    scopus 로고
    • The emerging epidemic of heart failure with preserved ejection fraction
    • Oktay AA, Rich JD, Shah SJ. The emerging epidemic of heart failure with preserved ejection fraction. Curr Heart Fail Rep. 2013;10:401–410.
    • (2013) Curr Heart Fail Rep , vol.10 , pp. 401-410
    • Oktay, A.A.1    Rich, J.D.2    Shah, S.J.3
  • 7
    • 0026785561 scopus 로고
    • Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions
    • Yusuf S, Pitt B, Davis CE, Hood WB Jr, Cohn JN. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 1992;327:685–691.
    • (1992) N Engl J Med , vol.327 , pp. 685-691
    • Yusuf, S.1    Pitt, B.2    Davis, C.E.3    Hood, W.B.4    Cohn, J.N.5
  • 9
    • 84885005521 scopus 로고    scopus 로고
    • PONTIAC (NT-proBNP selected prevention of cardiac events in a population of diabetic patients without a history of cardiac disease): a prospective randomized controlled trial
    • Huelsmann M, Neuhold S, Resl M, Strunk G, Brath H, Francesconi C, Adlbrecht C, Prager R, Luger A, Pacher R, Clodi M. PONTIAC (NT-proBNP selected prevention of cardiac events in a population of diabetic patients without a history of cardiac disease): a prospective randomized controlled trial. J Am Coll Cardiol. 2013;62:1365–1372.
    • (2013) J Am Coll Cardiol , vol.62 , pp. 1365-1372
    • Huelsmann, M.1    Neuhold, S.2    Resl, M.3    Strunk, G.4    Brath, H.5    Francesconi, C.6    Adlbrecht, C.7    Prager, R.8    Luger, A.9    Pacher, R.10    Clodi, M.11
  • 15
    • 85052903176 scopus 로고    scopus 로고
    • Clinical practices and attitudes regarding the diagnosis and management of heart failure: findings from the CORE Needs Assessment Survey
    • Howlett J, Comin-Colet J, Dickstein K, Fuat A, Polzl G, Delaney S. Clinical practices and attitudes regarding the diagnosis and management of heart failure: findings from the CORE Needs Assessment Survey. ESC Heart Fail. 2018;5:172–183.
    • (2018) ESC Heart Fail , vol.5 , pp. 172-183
    • Howlett, J.1    Comin-Colet, J.2    Dickstein, K.3    Fuat, A.4    Polzl, G.5    Delaney, S.6
  • 18
    • 0030002580 scopus 로고    scopus 로고
    • The progression from hypertension to congestive heart failure
    • Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK. The progression from hypertension to congestive heart failure. JAMA. 1996;275:1557–1562.
    • (1996) JAMA , vol.275 , pp. 1557-1562
    • Levy, D.1    Larson, M.G.2    Vasan, R.S.3    Kannel, W.B.4    Ho, K.K.5
  • 20
    • 84925507164 scopus 로고    scopus 로고
    • Predictors of delay in heart failure patients and consequences for outcomes
    • Sethares KA, Chin E, Jurgens CY. Predictors of delay in heart failure patients and consequences for outcomes. Curr Heart Fail Rep. 2015;12:94–105.
    • (2015) Curr Heart Fail Rep , vol.12 , pp. 94-105
    • Sethares, K.A.1    Chin, E.2    Jurgens, C.Y.3
  • 21
    • 48449095408 scopus 로고    scopus 로고
    • Timing of immunoreactive B-type natriuretic peptide levels and treatment delay in acute decompensated heart failure: an ADHERE (Acute Decompensated Heart Failure National Registry) analysis
    • Maisel AS, Peacock WF, McMullin N, Jessie R, Fonarow GC, Wynne J, Mills RM. Timing of immunoreactive B-type natriuretic peptide levels and treatment delay in acute decompensated heart failure: an ADHERE (Acute Decompensated Heart Failure National Registry) analysis. J Am Coll Cardiol. 2008;52:534–540.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 534-540
    • Maisel, A.S.1    Peacock, W.F.2    McMullin, N.3    Jessie, R.4    Fonarow, G.C.5    Wynne, J.6    Mills, R.M.7
  • 22
    • 85061577665 scopus 로고    scopus 로고
    • Trends in survival after a diagnosis of heart failure in the United Kingdom 2000–2017: population based cohort study
    • Taylor CJ, Ordonez-Mena JM, Roalfe AK, Lay-Flurrie S, Jones NR, Marshall T, Hobbs FDR. Trends in survival after a diagnosis of heart failure in the United Kingdom 2000–2017: population based cohort study. BMJ. 2019;364:l223.
    • (2019) BMJ , vol.364 , pp. l223
    • Taylor, C.J.1    Ordonez-Mena, J.M.2    Roalfe, A.K.3    Lay-Flurrie, S.4    Jones, N.R.5    Marshall, T.6    Hobbs, F.D.R.7
  • 23
    • 40949086056 scopus 로고    scopus 로고
    • Heart failure incidence and survival (from the Atherosclerosis Risk in Communities study)
    • Loehr LR, Rosamond WD, Chang PP, Folsom AR, Chambless LE. Heart failure incidence and survival (from the Atherosclerosis Risk in Communities study). Am J Cardiol. 2008;101:1016–1022.
    • (2008) Am J Cardiol , vol.101 , pp. 1016-1022
    • Loehr, L.R.1    Rosamond, W.D.2    Chang, P.P.3    Folsom, A.R.4    Chambless, L.E.5
  • 24
    • 85071941245 scopus 로고    scopus 로고
    • National Institute for Cardiovascular Outcomes Research (NICOR). Institute of Cardiovascular Science, University College London., Accessed March 7, 2019
    • National Heart Failure Audit 2016-2017. National Institute for Cardiovascular Outcomes Research (NICOR). Institute of Cardiovascular Science, University College London. 2016. Available at: https://www.nicor.org.uk/wp-content/uploads/2018/11/Heart-Failure-Summary-Report-2016-17.pdf. Accessed March 7, 2019.
    • (2016) National Heart Failure Audit 2016-2017
  • 25
    • 65549145093 scopus 로고    scopus 로고
    • 2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation
    • Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW. 2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119:e391–e479.
    • (2009) Circulation , vol.119 , pp. e391-e479
    • Hunt, S.A.1    Abraham, W.T.2    Chin, M.H.3    Feldman, A.M.4    Francis, G.S.5    Ganiats, T.G.6    Jessup, M.7    Konstam, M.A.8    Mancini, D.M.9    Michl, K.10    Oates, J.A.11    Rahko, P.S.12    Silver, M.A.13    Stevenson, L.W.14    Yancy, C.W.15
  • 27
    • 0025913812 scopus 로고
    • Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure
    • Yusuf S, Pitt B, Davis CE, Hood WB, Cohn JN. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991;325:293–302.
    • (1991) N Engl J Med , vol.325 , pp. 293-302
    • Yusuf, S.1    Pitt, B.2    Davis, C.E.3    Hood, W.B.4    Cohn, J.N.5
  • 28
    • 0033514046 scopus 로고    scopus 로고
    • The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial
    • The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet. 1999;353:9–13.
    • (1999) Lancet , vol.353 , pp. 9-13
  • 29
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999;341:709–717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6    Palensky, J.7    Wittes, J.8
  • 35
    • 0041408234 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
    • Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet. 2003;362:777–781.
    • (2003) Lancet , vol.362 , pp. 777-781
    • Yusuf, S.1    Pfeffer, M.A.2    Swedberg, K.3    Granger, C.B.4    Held, P.5    McMurray, J.J.6    Michelson, E.L.7    Olofsson, B.8    Ostergren, J.9
  • 36
    • 33646241541 scopus 로고    scopus 로고
    • Chronic aspirin therapy for the prevention of cardiovascular events: a waste of time, or worse?
    • Cleland JG. Chronic aspirin therapy for the prevention of cardiovascular events: a waste of time, or worse? Nat Clin Pract Cardiovasc Med. 2006;3:234–235.
    • (2006) Nat Clin Pract Cardiovasc Med , vol.3 , pp. 234-235
    • Cleland, J.G.1
  • 41
    • 73849141245 scopus 로고    scopus 로고
    • Cardiorenal syndrome in acute decompensated heart failure
    • Sarraf M, Masoumi A, Schrier RW. Cardiorenal syndrome in acute decompensated heart failure. Clin J Am Soc Nephrol. 2009;4:2013–2026.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 2013-2026
    • Sarraf, M.1    Masoumi, A.2    Schrier, R.W.3
  • 42
    • 84857857236 scopus 로고    scopus 로고
    • Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction
    • Ather S, Chan W, Bozkurt B, Aguilar D, Ramasubbu K, Zachariah AA, Wehrens XH, Deswal A. Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction. J Am Coll Cardiol. 2012;59:998–1005.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 998-1005
    • Ather, S.1    Chan, W.2    Bozkurt, B.3    Aguilar, D.4    Ramasubbu, K.5    Zachariah, A.A.6    Wehrens, X.H.7    Deswal, A.8
  • 45
    • 0035458604 scopus 로고    scopus 로고
    • Congestive heart failure in type 2 diabetes: prevalence, incidence, and risk factors
    • Nichols GA, Hillier TA, Erbey JR, Brown JB. Congestive heart failure in type 2 diabetes: prevalence, incidence, and risk factors. Diabetes Care. 2001;24:1614–1619.
    • (2001) Diabetes Care , vol.24 , pp. 1614-1619
    • Nichols, G.A.1    Hillier, T.A.2    Erbey, J.R.3    Brown, J.B.4
  • 48
    • 85078225151 scopus 로고    scopus 로고
    • Empagliflozin reduces heart failure irrespective of control of blood pressure, low density lipoprotein cholesterol and HbA1c
    • Fitchett D, McKnight J, Lee J. Empagliflozin reduces heart failure irrespective of control of blood pressure, low density lipoprotein cholesterol and HbA1c. Eur Heart J. 2017;38. Available at: https://doi.org/10.1093/eurheartj/ehx493.P4903.
    • (2017) Eur Heart J , vol.38
    • Fitchett, D.1    McKnight, J.2    Lee, J.3
  • 50
    • 84988629139 scopus 로고    scopus 로고
    • Heart failure outcomes in clinical trials of glucose-lowering agents in patients with diabetes
    • Fitchett DH, Udell JA, Inzucchi SE. Heart failure outcomes in clinical trials of glucose-lowering agents in patients with diabetes. Eur J Heart Fail. 2017;19:43–53.
    • (2017) Eur J Heart Fail , vol.19 , pp. 43-53
    • Fitchett, D.H.1    Udell, J.A.2    Inzucchi, S.E.3
  • 57
    • 85019731757 scopus 로고    scopus 로고
    • Lower risk of heart failure and death in patients initiated on sodium-glucose cotransporter-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL study (Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose Cotransporter-2 Inhibitors)
    • Kosiborod M, Cavender MA, Fu AZ, Wilding JP, Khunti K, Holl RW, Norhammar A, Birkeland KI, Jorgensen ME, Thuresson M, Arya N, Bodegard J, Hammar N, Fenici P. Lower risk of heart failure and death in patients initiated on sodium-glucose cotransporter-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL study (Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose Cotransporter-2 Inhibitors). Circulation. 2017;136:249–259.
    • (2017) Circulation , vol.136 , pp. 249-259
    • Kosiborod, M.1    Cavender, M.A.2    Fu, A.Z.3    Wilding, J.P.4    Khunti, K.5    Holl, R.W.6    Norhammar, A.7    Birkeland, K.I.8    Jorgensen, M.E.9    Thuresson, M.10    Arya, N.11    Bodegard, J.12    Hammar, N.13    Fenici, P.14
  • 58
    • 84941340656 scopus 로고    scopus 로고
    • Impact of diabetes mellitus on hospitalization for heart failure, cardiovascular events, and death: outcomes at 4 years from the reduction of atherothrombosis for continued health (REACH) Registry
    • Cavender MA, Steg PG, Smith SC Jr, Eagle K, Ohman EM, Goto S, Kuder J, Im K, Wilson PW, Bhatt DL. Impact of diabetes mellitus on hospitalization for heart failure, cardiovascular events, and death: outcomes at 4 years from the reduction of atherothrombosis for continued health (REACH) Registry. Circulation. 2015;132:923–931.
    • (2015) Circulation , vol.132 , pp. 923-931
    • Cavender, M.A.1    Steg, P.G.2    Smith, S.C.3    Eagle, K.4    Ohman, E.M.5    Goto, S.6    Kuder, J.7    Im, K.8    Wilson, P.W.9    Bhatt, D.L.10
  • 59
    • 85065971899 scopus 로고    scopus 로고
    • Empagliflozin and the risk of heart failure hospitalization in routine clinical care: a first analysis from the empagliflozin comparative effectiveness and safety (EMPRISE) study
    • Patorno E, Pawar A, Franklin J, Najafzadeh M, Déruaz-Luyet A, Brodovicz K, Bartels D, Gopalakrishnan C, Kulldorff M, Schneeweiss S. Empagliflozin and the risk of heart failure hospitalization in routine clinical care: a first analysis from the empagliflozin comparative effectiveness and safety (EMPRISE) study. Circulation. 2019;138:2822–2830.
    • (2019) Circulation , vol.138 , pp. 2822-2830
    • Patorno, E.1    Pawar, A.2    Franklin, J.3    Najafzadeh, M.4    Déruaz-Luyet, A.5    Brodovicz, K.6    Bartels, D.7    Gopalakrishnan, C.8    Kulldorff, M.9    Schneeweiss, S.10
  • 63
    • 85078244642 scopus 로고    scopus 로고
    • Accessed December 13, 2018
    • European Medicines Agency. Pharmacovigilance Risk Assessment Committee (PRAC) assessment report. 2018. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-Assessment_Report_-_Variation/human/002656/WC500230546.pdf. Accessed December 13, 2018.
    • (2018) Pharmacovigilance Risk Assessment Committee (PRAC) assessment report
  • 71
    • 85063954068 scopus 로고    scopus 로고
    • Effects of canagliflozin on heart failure outcomes associated with preserved and reduced ejection fraction in Type 2 diabetes: results from the CANVAS program
    • Figtree GA, Radholm K, Barrett TD, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Matthews DR, Shaw W, Neal B. Effects of canagliflozin on heart failure outcomes associated with preserved and reduced ejection fraction in Type 2 diabetes: results from the CANVAS program. Circulation. 2019;139:2591–2593.
    • (2019) Circulation , vol.139 , pp. 2591-2593
    • Figtree, G.A.1    Radholm, K.2    Barrett, T.D.3    Perkovic, V.4    Mahaffey, K.W.5    de Zeeuw, D.6    Fulcher, G.7    Matthews, D.R.8    Shaw, W.9    Neal, B.10
  • 72
    • 85030655315 scopus 로고    scopus 로고
    • The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweet spot in heart failure
    • Verma S, McMurray JJV, Cherney DZI. The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweet spot in heart failure. JAMA Cardiol. 2017;2:939–940.
    • (2017) JAMA Cardiol , vol.2 , pp. 939-940
    • Verma, S.1    McMurray, J.J.V.2    Cherney, D.Z.I.3
  • 73
    • 85034093732 scopus 로고    scopus 로고
    • Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis
    • Hallow KM, Helmlinger G, Greasley PJ, McMurray JJV, Boulton DW. Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis. Diabetes Obes Metab. 2018;20:479–487.
    • (2018) Diabetes Obes Metab , vol.20 , pp. 479-487
    • Hallow, K.M.1    Helmlinger, G.2    Greasley, P.J.3    McMurray, J.J.V.4    Boulton, D.W.5
  • 74
    • 85030993345 scopus 로고    scopus 로고
    • Effects of the selective sodium-glucose cotransporter 2 inhibitor empagliflozin on vascular function and central hemodynamics in patients with type 2 diabetes mellitus
    • Striepe K, Jumar A, Ott C, Karg MV, Schneider MP, Kannenkeril D, Schmieder RE. Effects of the selective sodium-glucose cotransporter 2 inhibitor empagliflozin on vascular function and central hemodynamics in patients with type 2 diabetes mellitus. Circulation. 2017;136:1167–1169.
    • (2017) Circulation , vol.136 , pp. 1167-1169
    • Striepe, K.1    Jumar, A.2    Ott, C.3    Karg, M.V.4    Schneider, M.P.5    Kannenkeril, D.6    Schmieder, R.E.7
  • 75
    • 84945455839 scopus 로고    scopus 로고
    • Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
    • Chilton R, Tikkanen I, Cannon CP, Crowe S, Woerle HJ, Broedl UC, Johansen OE. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab. 2015;17:1180–1193.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 1180-1193
    • Chilton, R.1    Tikkanen, I.2    Cannon, C.P.3    Crowe, S.4    Woerle, H.J.5    Broedl, U.C.6    Johansen, O.E.7
  • 76
    • 84975853831 scopus 로고    scopus 로고
    • CV Protection in the EMPA-REG OUTCOME Trial: a “thrifty substrate” hypothesis
    • Ferrannini E, Mark M, Mayoux E. CV Protection in the EMPA-REG OUTCOME Trial: a “thrifty substrate” hypothesis. Diabetes Care. 2016;39:1108–1114.
    • (2016) Diabetes Care , vol.39 , pp. 1108-1114
    • Ferrannini, E.1    Mark, M.2    Mayoux, E.3
  • 79
    • 85032620814 scopus 로고    scopus 로고
    • Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action
    • Packer M, Anker SD, Butler J, Filippatos G, Zannad F. Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action. JAMA Cardiol. 2017;2:1025–1029.
    • (2017) JAMA Cardiol , vol.2 , pp. 1025-1029
    • Packer, M.1    Anker, S.D.2    Butler, J.3    Filippatos, G.4    Zannad, F.5
  • 80
    • 85052567080 scopus 로고    scopus 로고
    • Direct effects of empagliflozin on extracellular matrix remodeling in human cardiac fibroblasts: novel translational clues to EMPA-REG outcome
    • Abs 274
    • Kang S, Verma S, Teng G, Belke D, Svystonyuk D, Guzzardi D, Park D, Turnbull J, Malik G, Fedak P. Direct effects of empagliflozin on extracellular matrix remodeling in human cardiac fibroblasts: novel translational clues to EMPA-REG outcome. Can J Cardiol. 2017;33:S169. Abs 274.
    • (2017) Can J Cardiol , vol.33 , pp. S169
    • Kang, S.1    Verma, S.2    Teng, G.3    Belke, D.4    Svystonyuk, D.5    Guzzardi, D.6    Park, D.7    Turnbull, J.8    Malik, G.9    Fedak, P.10
  • 82
    • 85006172812 scopus 로고    scopus 로고
    • Effect of empagliflozin on left ventricular mass and diastolic function in individuals with diabetes: an important clue to the EMPA-REG OUTCOME trial?
    • Verma S, Garg A, Yan AT, Gupta AK, Al-Omran M, Sabongui A, Teoh H, Mazer CD, Connelly KA. Effect of empagliflozin on left ventricular mass and diastolic function in individuals with diabetes: an important clue to the EMPA-REG OUTCOME trial? Diabetes Care. 2016;39:e212–e213.
    • (2016) Diabetes Care , vol.39 , pp. e212-e213
    • Verma, S.1    Garg, A.2    Yan, A.T.3    Gupta, A.K.4    Al-Omran, M.5    Sabongui, A.6    Teoh, H.7    Mazer, C.D.8    Connelly, K.A.9
  • 85
    • 85010842028 scopus 로고    scopus 로고
    • Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts
    • Lee TM, Chang NC, Lin SZ. Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts. Free Radic Biol Med. 2017;104:298–310.
    • (2017) Free Radic Biol Med , vol.104 , pp. 298-310
    • Lee, T.M.1    Chang, N.C.2    Lin, S.Z.3
  • 86
    • 84884324699 scopus 로고    scopus 로고
    • Endothelial dysfunction—a major mediator of diabetic vascular disease
    • Sena CM, Pereira AM, Seica R. Endothelial dysfunction—a major mediator of diabetic vascular disease. Biochim Biophys Acta. 2013;1832:2216–2231.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 2216-2231
    • Sena, C.M.1    Pereira, A.M.2    Seica, R.3
  • 87
    • 85031924469 scopus 로고    scopus 로고
    • Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study
    • Solini A, Giannini L, Seghieri M, Vitolo E, Taddei S, Ghiadoni L, Bruno RM. Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study. Cardiovasc Diabetol. 2017;16:138.
    • (2017) Cardiovasc Diabetol , vol.16 , pp. 138
    • Solini, A.1    Giannini, L.2    Seghieri, M.3    Vitolo, E.4    Taddei, S.5    Ghiadoni, L.6    Bruno, R.M.7
  • 89
    • 85019123808 scopus 로고    scopus 로고
    • Dapagliflozin modulates glucagon secretion in an SGLT2-independent manner in murine alpha cells
    • Solini A, Sebastiani G, Nigi L, Santini E, Rossi C, Dotta F. Dapagliflozin modulates glucagon secretion in an SGLT2-independent manner in murine alpha cells. Diabetes Metab. 2017;43:512–520.
    • (2017) Diabetes Metab , vol.43 , pp. 512-520
    • Solini, A.1    Sebastiani, G.2    Nigi, L.3    Santini, E.4    Rossi, C.5    Dotta, F.6
  • 93
    • 85077993568 scopus 로고    scopus 로고
    • Inter-organ communication pathway manifested by non-physiological stress to the kidney in type II diabetic patients: why are diabetic patients prone to develop heart failure?
    • Sano M. Inter-organ communication pathway manifested by non-physiological stress to the kidney in type II diabetic patients: why are diabetic patients prone to develop heart failure? Intern Med. 2019. Available at: https://doi.org/10.2169/internalmedicine.2870-19.
    • (2019) Intern Med
    • Sano, M.1
  • 94
    • 85039943841 scopus 로고    scopus 로고
    • Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission
    • Zhou H, Wang S, Zhu P, Hu S, Chen Y, Ren J. Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission. Redox Biol. 2018;15:335–346.
    • (2018) Redox Biol , vol.15 , pp. 335-346
    • Zhou, H.1    Wang, S.2    Zhu, P.3    Hu, S.4    Chen, Y.5    Ren, J.6
  • 99
    • 84878947970 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks’ treatment with empagliflozin once daily in patients with type 2 diabetes
    • Heise T, Seewaldt-Becker E, Macha S, Hantel S, Pinnetti S, Seman L, Woerle HJ. Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks’ treatment with empagliflozin once daily in patients with type 2 diabetes. Diabetes Obes Metab. 2013;15:613–621.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 613-621
    • Heise, T.1    Seewaldt-Becker, E.2    Macha, S.3    Hantel, S.4    Pinnetti, S.5    Seman, L.6    Woerle, H.J.7
  • 100
    • 84877652575 scopus 로고    scopus 로고
    • Empagliflozin (BI 10773), a potent and selective SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects
    • Seman L, Macha S, Nehmiz G, Simons G, Ren B, Pinnetti S, Woerle HJ, Dugi K. Empagliflozin (BI 10773), a potent and selective SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin Pharmacol Drug Dev. 2013;2:152–161.
    • (2013) Clin Pharmacol Drug Dev , vol.2 , pp. 152-161
    • Seman, L.1    Macha, S.2    Nehmiz, G.3    Simons, G.4    Ren, B.5    Pinnetti, S.6    Woerle, H.J.7    Dugi, K.8
  • 101
    • 85017099681 scopus 로고    scopus 로고
    • Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?
    • Shi X, Verma S, Yun J, Brand-Arzamendi K, Singh KK, Liu X, Garg A, Quan A, Wen XY. Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial? Mol Cell Biochem. 2017;433:97–102.
    • (2017) Mol Cell Biochem , vol.433 , pp. 97-102
    • Shi, X.1    Verma, S.2    Yun, J.3    Brand-Arzamendi, K.4    Singh, K.K.5    Liu, X.6    Garg, A.7    Quan, A.8    Wen, X.Y.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.