Chronic inhibition of the Na +/H +- exchanger causes regression of hypertrophy, heart failure, and ionic and electrophysiological remodelling

British Journal of Pharmacology

Volumn 154, Issue 6, 2008, Pages 1266-1275

  Baartscheer, A ^a   Hardziyenka, M ^a   Schumacher, C A ^a   Belterman, C N W ^a   Van Borren, M M G J ^a   Verkerk, A O ^a   Coronel, R ^a   Fiolet, J W T ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Arrhythmias; Calcium (cellular); Heart failure; Na channel; Na Ca exchanger; Na H exchanger; Regression; Remodelling; Sodium; SR function

Indexed keywords

CARIPORIDE; SODIUM PROTON EXCHANGE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CHANNEL GATING; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG EFFECT; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART VENTRICLE REMODELING; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; REMISSION; SARCOPLASMIC RETICULUM; SODIUM CELL LEVEL; SODIUM CURRENT;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM; CALCIUM SIGNALING; CARDIOMEGALY; CARDIOMYOPATHY, DILATED; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; GUANIDINES; ION CHANNELS; MALE; RABBITS; SARCOPLASMIC RETICULUM; SODIUM; SODIUM CHANNELS; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 47249152693     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.189     Document Type: Article

References (37)

1. + )-dependent pathways. Hypertension 45: 288-243.
2. +-exchanger in the heart. Curr Vasc Pharmacol 4: 23-29.
3. i in heart failure and underlies disturbed calcium handling. Cardiovasc Res 57: 1015-1024.
4. 2+-exchanger in heart failure. Cardiovasc Res 57: 986-995.
5. Baartscheer A, Schumacher CA, Belterman CNW, Coronel R, Fiolet JWT (2003c). SR calcium handling and calcium after-transients in a rabbit model of heart failure. Cardiovasc Res 58: 99-108.
6. +-exchanger attenuates cardiac hypertrophy and prevents cellular remodelling in heart failure. Cardiovasc Res 65: 83-92.
7. 2+-exchanger in rat ventricular myocytes. J Mol Cell Cardiol 32: 1025-1037.
8. 2+-exchanger in isolated rat ventricular myocytes. J Mol Cell Cardiol 28: 1963-1973.
9. Bers DM, Despa S (2006). Cardiac myocytes Ca2+ and Na+ regulation in failing and normal hearts. J Pharmacol Sci 100: 315-322.
10. +-exchanger. Cardiovasc Res 53: 862-868.
11. Chahine M, Bkaily G, Nader M, Al-Khoury J, Jacques D, Beier N et al. (2005). NHE-1-dependent intracellular sodium overload in hypertrophic hereditary cardiomyopathy: prevention by NHE-1 inhibitor. J Mol Cell Cardiol 38: 571-582.
12. Chandler MP, Stanley WC, Morita H, Suzuki G, Roth BA, Blackburn B et al. (2002). Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure. Circ Res 91: 278-280.
13. Chattou S, Coulombe A, Diacono J, Le Grand B, John G, Feuvray D (2000). Slowly inactivating component of sodium current in ventricular myocytes is decreased by diabetes and partially inhibited by known Na+-H+ exchange blockers. J Mol Cell Cardiol 32: 1181-1192.
14. Chen L, Chen CX, Can XT, Beier N, Scolz W, Karmazyn M (2004). Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition. Am J Physiol 286: H381-H387.
15. +-exchange inhibitor cariporide. J Pharmacol Exp Ther 298: 469-476.
16. Cingolani HE, Ennis IL (2007). Sodium-hydrogen exchanger, cardiac overload and myocardial hypertrophy. Circulation 115: 1090-1100.
17. Eguchi S, Matsumoto T, Motley ED, Utsunomiya H, Inagami T (1996). Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. J Biol Chem 271: 14169-14175.
18. 1-adrenergic receptor transgenic mice. Circ Res 90: 814-819.
19. Gao X, Kiriazis H, Moore X, Feng X, Sheppard K, Dart A et al. (2005). Regression of pressure overload-induced left ventricular hypertrophy in mice. Am J Physiol 288: H2702-H2707.
20. Gu JW, Anand V, Shek EW, Moore MC, Brady AL, Kelly EC (1998). Sodium induces hypertrophy of cultured myocardial myoblasts and vascular smooth muscle cells. Hypertension 31: 1083-1087.
21. Hove-Madsen L, Bers DM (1993). Passsive Ca buffering and SR Ca uptake in permeabilized rabbit ventricular myocytes. Am J Physiol 33: C677-C686.
22. Hwang JJ (2001). Genomics and the pathophysiology of heart failure. J Am Coll Curr Cardiol Rep 3: 198-207.
23. Janse MJ (2004). Electrophysiological changes in heart failure and their relationship to arrhythmogenesis. Cardiovasc Res 61: 208-217.
24. Maltsev VA, Silverman N, Sabbah HN, Undrovinas AI (2007). Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability. Eur J Heart Fail 9: 219-227.
25. Marban E, Koretsune Y (1990). Cell calcium, oncognese and hypertrophy. Hypertension 15: 652-658.
26. +-exchange inhibition by cariporide on death and nonfatal myocardial infarction in patient undergoing coronary artery bypass graft surgery: the EXPEDITION study. Circulation 108: 3M (abstract).
27. Mulder P, Devaux B, Richard V (1997). Early versus delayed angiotensin-converting enzyme inhibition in experimental chronic heart failure. Effects on survival, hemodynamics and cardiovascular remodelling. Circulation 95: 1314-1319.
28. 2+-dependent expression of early response genes in cardiac myocytes. J Biol Chem 271: 10372-10378.
29. +-exchanger and angiotension-converting enzyme in rats with congestive heart failure after myocardial infarction. Br J Pharmacol 146: 723-731.
30. Siehl D, Chua BH, Lautensack-Belser N, Morgan HE (1985). Faster protein and ribosome synthesis in thyroxine-induced hypertrophy of rat heart. Am J Physiol 248: C309-C319.
31. Takewaki S, Kuro-o M, Hiroi Y (1995). Activation of Na(+)-H+ antiporter (NHE-1) gene expression during growth, hypertrophy and proliferation of the rabbit cardiovascular system. J Moll Cell Cardiol 25: 729-742.
32. Theroux P, Chaitman BR, Danchin N, Erhardt L, Meinertz T, Schroeder JS et al. (2000). Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardaial infarction in high-risk ischemic situations. Main results of the GUARDIAN Trial Guard During Ischemic Against Necrosis (GUARDIAN) Investigators. Circulation 102: 3032-3038.
33. van Borren MMGJ, Baartscheer A, Wilders R, Ravesloot JH (2004). NHE-1 and NBC during pseudo-ischemia/reperfusion in rabbit ventricular myocytes. J Mol Cell Cardiol 37: 567-577.
34. van Borren MM, Zeegers JG, Baartscheer A, Ravesloot JH (2006). Contribution of NHE-1 to cell length shortening of normal and failing rabbit cardiac myocytes. J Mol Cell Cardiol 41: 706-715.
35. 2+ homeostasis in rabbits with pacing-induced heart failure. Am J Physiol 275: H1441-H1448.
36. +-exchange inhibitor eniporide as an adjunct reperfusion therapy for acute myocardial infarction. Results of the Evaluation of the Safety and Cardioprotective Effects of Eniporide in Acute Myocardial Infarction (ESCAMI) Trial. J Am Coll Cardiol 38: 1644-1650.
37. Zou Y, Komuro I, Yamazaki T (1996). Protein kinase C, but not tyrosine kinase of Ras, plays a critical role in angiotensin II-induced activation of Raf-I kinase and extracellular signal regulated protein kinase in cardiac myocytes. J Biol Chem 271: 33592-33597.