Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life

JCI Insight

Volumn 4, Issue 17, 2019, Pages

  Allen, Michele D ^a   Springer, Danielle A ^a   Burg, Maurice B ^a   Boehm, Manfred ^a   Dmitrieva, Natalia I ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; C REACTIVE PROTEIN; D DIMER; FIBRINOGEN; INTERLEUKIN 6; SODIUM; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT5; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; BIOLOGICAL MARKER;

ADULT; AGE RELATED MACULAR DEGENERATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BODY COMPOSITION; BODY WEIGHT LOSS; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CHRONIC KIDNEY FAILURE; CHRONIC LUNG DISEASE; CLAUDICATION; CONTROLLED STUDY; DEMENTIA; DIABETES MELLITUS; DISEASE ASSOCIATION; ENERGY BALANCE; ENERGY EXPENDITURE; ESTIMATED GLOMERULAR FILTRATION RATE; FAT MASS; FEMALE; FLUID BALANCE; FLUID INTAKE; FOOD INTAKE; GLOMERULONEPHRITIS; GLUCOSE BLOOD LEVEL; HEART FAILURE; HEART MUSCLE FIBROSIS; HEMATOCRIT; HUMAN; HYDRATION; HYPERTENSION; ISCHEMIC HEART DISEASE; LEUKOCYTE COUNT; LIFESPAN; LUNG GAS EXCHANGE; MAJOR CLINICAL STUDY; MALE; MORTALITY RISK; MOTOR COORDINATION; MOUSE; NONHUMAN; PREVALENCE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RISK FACTOR; SALT INTAKE; SODIUM BLOOD LEVEL; URINE OSMOLALITY; WATER DEPRIVATION; ACUTE KIDNEY FAILURE; AGING; ANIMAL; ATHEROSCLEROSIS; BLOOD; CHRONIC DISEASE; DEGENERATIVE DISEASE; DEHYDRATION; ELECTROLYTE BALANCE; FIBROSIS; HYDRATION STATUS; INFLAMMATION; LIFE; LUNG DISEASE; METABOLISM; REGRESSION ANALYSIS;

ACUTE KIDNEY INJURY; AGING; ANIMALS; ATHEROSCLEROSIS; BIOMARKERS; CHRONIC DISEASE; DEHYDRATION; DEMENTIA; FIBROSIS; HEART FAILURE; HUMANS; INFLAMMATION; LIFE; LUNG DISEASES; MALE; MICE; NEURODEGENERATIVE DISEASES; ORGANISM HYDRATION STATUS; REGRESSION ANALYSIS; RISK FACTORS; SODIUM; WATER-ELECTROLYTE BALANCE;

EID: 85072252766     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.130949     Document Type: Article

References (66)

1. Prince MJ, et al. The burden of disease in older people and implications for health policy and practice. Lancet. 2015;385(9967):549-562.
2. Jéquier E, Constant F. Water as an essential nutrient: the physiological basis of hydration. Eur J Clin Nutr. 2010;64(2):115-123.
3. Bankir L, Bichet DG, Morgenthaler NG. Vasopressin: physiology, assessment and osmosensation. J Intern Med. 2017;282(4):284-297.
4. Bourque CW. Central mechanisms of osmosensation and systemic osmoregulation. Nat Rev Neurosci. 2008;9(7):519-531.
5. Popkin BM, D'Anci KE, Rosenberg IH. Water, hydration, and health. Nutr Rev. 2010;68(8):439-458.
6. Robertson GL, Shelton RL, Athar S. The osmoregulation of vasopressin. Kidney Int. 1976;10(1):25-37.
7. Armstrong LE, Johnson EC. Water intake, water balance, and the elusive daily water requirement. Nutrients. 2018;10(12):E1928.
8. Re RN. The renin-angiotensin systems. Med Clin North Am. 1987;71(5):877-895.
9. Zerbe RL, Miller JZ, Robertson GL. The reproducibility and heritability of individual differences in osmoregulatory function in normal human subjects. J Lab Clin Med. 1991;117(1):51-59.
10. Dmitrieva NI, Burg MB. Secretion of von Willebrand factor by endothelial cells links sodium to hypercoagulability and thrombosis. Proc Natl Acad Sci USA. 2014;111(17):6485-6490.
11. Dmitrieva NI, Burg MB. Elevated sodium and dehydration stimulate inflammatory signaling in endothelial cells and promote atherosclerosis. PLoS ONE. 2015;10(6):e0128870.
12. Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I. Rubbing salt into wounded endothelium: sodium potentiates proatherogenic effects of TNF-α under non-uniform shear stress. Thromb Haemost. 2014;112(1):183-195.
13. Oberleithner H, Riethmüller C, Schillers H, MacGregor GA, de Wardener HE, Hausberg M. Plasma sodium stiffens vascular endothelium and reduces nitric oxide release. Proc Natl Acad Sci USA. 2007;104(41):16281-16286.
14. Oberleithner H, et al. Salt overload damages the glycocalyx sodium barrier of vascular endothelium. Pflugers Arch. 2011;462(4):519-528.
15. Liew H, Roberts MA, MacGinley R, McMahon LP. Endothelial glycocalyx in health and kidney disease: rising star or false Dawn? Nephrology (Carlton). 2017;22(12):940-946.
16. Re RN. Mechanisms of disease: local renin-angiotensin-aldosterone systems and the pathogenesis and treatment of cardiovascular disease. Nat Clin Pract Cardiovasc Med. 2004;1(1):42-47.
17. Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018;15(9):505-522.
18. Jones DP. Redox theory of aging. Redox Biol. 2015;5:71-79.
19. de Cabo R, Carmona-Gutierrez D, Bernier M, Hall MN, Madeo F. The search for antiaging interventions: from elixirs to fasting regimens. Cell. 2014;157(7):1515-1526.
20. Favaloro EJ, Franchini M, Lippi G. Aging hemostasis: changes to laboratory markers of hemostasis as we age-A narrative review. Semin Thromb Hemost. 2014;40(6):621-633.
21. Redman LM, Smith SR, Burton JH, Martin CK, Il'yasova D, Ravussin E. Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging. Cell Metab. 2018;27(4):805-815.e4.
22. Zhang Z, et al. Individuality of the plasma sodium concentration. Am J Physiol Renal Physiol. 2014;306(12):F1534-F1543.
23. Gao S, Cui X, Wang X, Burg MB, Dmitrieva NI. Cross-sectional positive association of serum lipids and blood pressure with serum sodium within the normal reference range of 135-145 mmol/L. Arterioscler Thromb Vasc Biol. 2017;37(3):598-606.
24. Ravussin Y, Gutman R, LeDuc CA, Leibel RL. Estimating energy expenditure in mice using an energy balance technique. Int J Obes (Lond). 2013;37(3):399-403.
25. Donald J, Pannabecker T. Osmoregulation in desert-adapted mammals. In: Hyndman KA, Pannabecker T, eds. Sodium and Water Homeostasis: Comparative, Evolutionary and Genetic Models. Springer; 2015:191-211.
26. Takei Y, Bartolo RC, Fujihara H, Ueta Y, Donald JA. Water deprivation induces appetite and alters metabolic strategy in Notomys alexis: unique mechanisms for water production in the desert. Proc Biol Sci. 2012;279(1738):2599-2608.
27. Rowland NE. Food or fluid restriction in common laboratory animals: balancing welfare considerations with scientific inquiry. Comp Med. 2007;57(2):149-160.
28. Bekkevold CM, Robertson KL, Reinhard MK, Battles AH, Rowland NE. Dehydration parameters and standards for laboratory mice. J Am Assoc Lab Anim Sci. 2013;52(3):233-239.
29. Sands JM. Urine concentrating and diluting ability during aging. J Gerontol A Biol Sci Med Sci. 2012;67(12):1352-1357.
30. Kannel WB. Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA. 1996;275(20):1571-1576.
31. Kannel WB, Wilson PW, Zhang TJ. The epidemiology of impaired glucose tolerance and hypertension. Am Heart J. 1991;121(4 Pt 2):1268-1273.
32. Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev. 2011;10(3):319-329.
33. ARIC investigators. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. Am J Epidemiol. 1989;129(4):687-702.
34. Adrogué HJ, Madias NE. Hypernatremia. N Engl J Med. 2000;342(20):1493-1499.
35. Moulin F, et al. A population-based approach to assess the heritability and distribution of renal handling of electrolytes. Kidney Int. 2017;92(6):1536-1543.
36. Wilmot B, et al. Heritability of serum sodium concentration: evidence for sex-and ethnic-specific effects. Physiol Genomics. 2012;44(3):220-228.
37. Böger CA, et al. NFAT5 and SLC4A10 loci associate with plasma osmolality. J Am Soc Nephrol. 2017;28(8):2311-2321.
38. Katz MA. Hyperglycemia-induced hyponatremia-calculation of expected serum sodium depression. N Engl J Med. 1973;289(16):843-844.
39. Adrogué HJ, Madias NE. Primary care: Hyponatremia. N Engl J Med. 2000;342(21):1581-1589.
40. Prospective Studies Collaboration, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007;370(9602):1829-1839.
41. Kawecki C, Lenting PJ, Denis CV. von Willebrand factor and inflammation. J Thromb Haemost. 2017;15(7):1285-1294.
42. Cole NI, Suckling RJ, Desilva V, He FJ, MacGregor GA, Swift PA. Serum sodium concentration and the progression of established chronic kidney disease. J Nephrol. 2019;32(2):259-264.
43. Clark WF, Sontrop JM, Huang SH, Moist L, Bouby N, Bankir L. Hydration and chronic kidney disease progression: a critical review of the evidence. Am J Nephrol. 2016;43(4):281-292.
44. Kuwabara M, et al. Increased serum sodium and serum osmolarity are independent risk factors for developing chronic kidney disease; 5 year cohort study. PLoS ONE. 2017;12(1):e0169137.
45. Kivipelto M, Mangialasche F, Ngandu T. Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol. 2018;14(11):653-666.
46. Wagner M, Helmer C, Tzourio C, Berr C, Proust-Lima C, Samieri C. Evaluation of the concurrent trajectories of cardiometabolic risk factors in the 14 years before dementia. JAMA Psychiatry. 2018;75(10):1033-1042.
47. Walker KA, et al. Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study. Neurology. 2019;92(11):e1256-e1267.
48. von Haehling S, Ebner N, Dos Santos MR, Springer J, Anker SD. Muscle wasting and cachexia in heart failure: mechanisms and therapies. Nat Rev Cardiol. 2017;14(6):323-341.
49. Berry C, Clark AL. Catabolism in chronic heart failure. Eur Heart J. 2000;21(7):521-532.
50. Sridhar MK. Why do patients with emphysema lose weight? Lancet. 1995;345(8959):1190-1191.
51. Muers MF, Green JH. Weight loss in chronic obstructive pulmonary disease. Eur Respir J. 1993;6(5):729-734.
52. Congleton J. The pulmonary cachexia syndrome: aspects of energy balance. Proc Nutr Soc. 1999;58(2):321-328.
53. Ahmed RM, et al. Energy expenditure in frontotemporal dementia: a behavioural and imaging study. Brain. 2017;140(1):171-183.
54. Walker KA, Walston J, Gottesman RF, Kucharska-Newton A, Palta P, Windham BG. Midlife systemic inflammation is associated with frailty in later life: The ARIC Study. J Gerontol A Biol Sci Med Sci. 2019;74(3):343-349.
55. Schrack JA, Knuth ND, Simonsick EM, Ferrucci L. "IDEAL" aging is associated with lower resting metabolic rate: the Baltimore Longitudinal Study of Aging. J Am Geriatr Soc. 2014;62(4):667-672.
56. Fabbri E, et al. Energy metabolism and the burden of multimorbidity in older adults: results from the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci. 2015;70(11):1297-1303.
57. Jumpertz R, Hanson RL, Sievers ML, Bennett PH, Nelson RG, Krakoff J. Higher energy expenditure in humans predicts natural mortality. J Clin Endocrinol Metab. 2011;96(6):E972-E976.
58. Brown NJ. Aldosterone and vascular inflammation. Hypertension. 2008;51(2):161-167.
59. Sechi LA, et al. Relationship of plasma renin with a prothrombotic state in hypertension: relevance for organ damage. Am J Hypertens. 2008;21(12):1347-1353.
60. Pacurari M, Kafoury R, Tchounwou PB, Ndebele K. The Renin-Angiotensin-aldosterone system in vascular inflammation and remodeling. Int J Inflam. 2014;2014:689360.
61. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194-1217.
62. Drewnowski A, Rehm CD, Constant F. Water and beverage consumption among adults in the United States: cross-sectional study using data from NHANES 2005-2010. BMC Public Health. 2013;13:1068.
63. Drewnowski A, Rehm CD, Constant F. Water and beverage consumption among children age 4-13y in the United States: analyses of 2005-2010 NHANES data. Nutr J. 2013;12:85.
64. Grandjean AC, Reimers KJ, Buyckx ME. Hydration: issues for the 21st century. Nutr Rev. 2003;61(8):261-271.
65. Cotter JD, Thornton SN, Lee JK, Laursen PB. Are we being drowned in hydration advice? Thirsty for more? Extrem Physiol Med. 2014;3:18.
66. Cheuvront SN, Kenefick RW. Am I drinking enough? Yes, no, and maybe. J Am Coll Nutr. 2016;35(2):185-192.