Salt overload damages the glycocalyx sodium barrier of vascular endothelium

Pflugers Archiv European Journal of Physiology

Volumn 462, Issue 4, 2011, Pages 519-528

  Oberleithner, Hans ^a   Peters, Wladimir ^a   Kusche Vihrog, Kristina ^a   Korte, Stefanie ^a   Schillers, Hermann ^a   Kliche, Katrin ^b   Oberleithner, Kilian ^c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Aldosterone; Endothelium; Sodium; Sodium channel; Vascular dysfunction

Indexed keywords

ALDOSTERONE; HEPARAN SULFATE; PROTEOGLYCAN; SODIUM; SPIRONOLACTONE;

ANIMAL CELL; ARTERIAL STIFFNESS; ARTICLE; ATOMIC FORCE MICROSCOPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; GLYCOCALYX; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; MEMBRANE DAMAGE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STUDY; SODIUM ABSORPTION; SODIUM BALANCE; SODIUM METABOLISM; SODIUM OVERLOAD; UMBILICAL ARTERY; VASCULAR ENDOTHELIUM;

ANIMALS; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GLYCOCALYX; HEPARIN LYASE; HUMANS; MICROSCOPY, ATOMIC FORCE; SODIUM; SODIUM CHLORIDE; SPIRONOLACTONE; UMBILICAL ARTERIES; VASCULAR STIFFNESS;

EID: 80054775017     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-0999-1     Document Type: Article

References (40)

1. HJ Adrogue NE Madias 2007 Sodium and potassium in the pathogenesis of hypertension N Engl J Med 356 1966 1978 17494929 10.1056/NEJMra064486 1:CAS:528:DC%2BD2sXltFait7w%3D (Pubitemid 46740306)
2. JA Bevan 1993 Flow regulation of vascular tone. Its sensitivity to changes in sodium and calcium Hypertension 22 273 281 8349318 1:STN:280:DyaK3szlt1WhsA%3D%3D (Pubitemid 23254073)
3. RA Boon TA Leyen RD Fontijn JO Fledderus JM Baggen OL Volger GP van Nieuw Amerongen AJ Horrevoets 2010 KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium Blood 115 2533 2542 20032497 10.1182/blood-2009-06-228726 1:CAS:528:DC%2BC3cXktlOrsrg%3D
4. C Callies P Schon I Liashkovich C Stock K Kusche-Vihrog J Fels AS Strater H Oberleithner 2009 Simultaneous mechanical stiffness and electrical potential measurements of living vascular endothelial cells using combined atomic force and epifluorescence microscopy Nanotechnology 20 1 8 10.1088/0957-4484/20/17/ 175104
5. P Carl H Schillers 2008 Elasticity measurement of living cells with an atomic force microscope: data acquisition and processing Pflugers Arch 457 551 559 18481081 10.1007/s00424-008-0524-3 1:CAS:528:DC%2BD1cXhtl2mu7%2FP
6. D Chappell M Westphal M Jacob 2009 The impact of the glycocalyx on microcirculatory oxygen distribution in critical illness Curr Opin Anaesthesiol 22 155 162 19307890 10.1097/ACO.0b013e328328d1b6
7. W Chen F Valamanesh T Mirshahi J Soria R Tang MK Agarwal M Mirshahi 2004 Aldosterone signaling modifies capillary formation by human bone marrow endothelial cells Vascul Pharmacol 40 269 277 15063830 10.1016/j.vph.2003.08.003 1:CAS:528:DC%2BD2cXivVCksbo%3D (Pubitemid 38452711)
8. RJ Dekker SS Van RD Fontijn S Salamanca PG de Groot E VanBavel H Pannekoek AJ Horrevoets 2002 Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2) Blood 100 1689 1698 12176889 10.1182/blood-2002-01-0046 1:CAS:528: DC%2BD38Xmslyht78%3D (Pubitemid 34925146)
9. CJ Edgell JE Haizlip CR Bagnell JP Packenham P Harrison B Wilbourn VJ Madden 1990 Endothelium specific Weibel-Palade bodies in a continuous human cell line, EA.hy926 In Vitro Cell Dev Biol 26 1167 1172 2079463 10.1007/BF02623694 1:STN:280:DyaK3M7nslOlsA%3D%3D
10. J Fels C Callies K Kusche-Vihrog H Oberleithner 2010 Nitric oxide release follows endothelial nanomechanics and not vice versa Pflugers Arch 460 915 923 20809399 10.1007/s00424-010-0871-8 1:CAS:528:DC%2BC3cXhtFCgsLrJ
11. J Fels H Oberleithner K Kusche-Vihrog 2010 Menage a trois: aldosterone, sodium and nitric oxide in vascular endothelium Biochim Biophys Acta 1802 1193 1212 20302930 1:CAS:528:DC%2BC3cXhtlKkt73N
12. JA Florian JR Kosky K Ainslie Z Pang RO Dull JM Tarbell 2003 Heparan sulfate proteoglycan is a mechanosensor on endothelial cells Circ Res 93 e136 e142 14563712 10.1161/01.RES.0000101744.47866.D5 1:CAS:528:DC%2BD3sXoslykuro%3D
13. SM Friedman RA McIndoe M Tanaka 1990 The relation of blood sodium concentration to blood pressure in the rat J Hypertens 8 61 66 2157758 10.1097/00004872-199001000-00010 1:STN:280:DyaK3c3hslCrsw%3D%3D (Pubitemid 20186315)
14. L Gao HH Lipowsky 2010 Composition of the endothelial glycocalyx and its relation to its thickness and diffusion of small solutes Microvasc Res 80 394 401 20600162 10.1016/j.mvr.2010.06.005 1:CAS:528:DC%2BC3cXhsVWmtbbM
15. N Golestaneh C Klein F Valamanesh G Suarez MK Agarwal M Mirshahi 2001 Mineralocorticoid receptor-mediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton Biochem Biophys Res Commun 280 1300 1306 11162670 10.1006/bbrc.2001.4275 1:CAS:528:DC%2BD3MXptlCrtQ%3D%3D (Pubitemid 32917785)
16. JB Grinspan SN Mueller EM Levine 1983 Bovine endothelial cells transformed in vitro by benzo(a)pyrene J Cell Physiol 114 328 338 6833405 10.1002/jcp.1041140312 1:CAS:528:DyaL3sXhslCmsLg%3D (Pubitemid 13161554)
17. S Iyer RM Gaikwad V Subba-Rao CD Woodworth I Sokolov 2009 Atomic force microscopy detects differences in the surface brush of normal and cancerous cells Nat Nanotechnol 4 389 393 19498402 10.1038/nnano.2009.77 1:CAS:528:DC%2BD1MXmvVSms7o%3D
18. S Kasas X Wang H Hirling R Marsault B Huni A Yersin R Regazzi G Grenningloh B Riederer L Forro G Dietler S Catsicas 2005 Superficial and deep changes of cellular mechanical properties following cytoskeleton disassembly Cell Motil Cytoskeleton 62 124 132 16145686 10.1002/cm.20086 1:CAS:528:DC%2BD2MXhtF2ntrzE (Pubitemid 41428689)
19. K Kliche P Jeggle H Pavenstadt H Oberleithner 2011 Role of cellular mechanics in the function and life span of vascular endothelium Pflugers Arch 462 209 217 21318292 10.1007/s00424-011-0929-2 1:CAS:528:DC%2BC3MXos1Oht7c%3D
20. K Kusche-Vihrog C Callies J Fels H Oberleithner 2010 The epithelial sodium channel (ENaC): mediator of the aldosterone response in the vascular endothelium? Steroids 75 544 549 19778545 10.1016/j.steroids.2009.09.003 1:CAS:528:DC%2BC3cXntlans70%3D
21. K Kusche-Vihrog K Sobczak N Bangel M Wilhelmi V Nechyporuk-Zloy A Schwab H Schillers H Oberleithner 2008 Aldosterone and amiloride alter ENaC abundance in vascular endothelium Pflugers Arch 455 849 857 17891415 10.1007/s00424-007- 0341-0 1:CAS:528:DC%2BD2sXhsVaqu77O (Pubitemid 350265623)
22. K Kusche-Vihrog K Urbanova A Blanque M Wilhelmi H Schillers K Kliche H Pavenstadt E Brand H Oberleithner 2011 C-reactive protein makes human endothelium stiff and tight Hypertension 57 231 237 21149827 10.1161/HYPERTENSIONAHA.110.163444 1:CAS:528:DC%2BC3MXnvVWnuw%3D%3D
23. +]i and contractile function in Langendorff-perfused rat heart Am J Physiol 273 H1246 H1254 9321813 1:CAS:528:DyaK2sXmtlemu7w%3D
24. P Meneton X Jeunemaitre HE de Wardener GA MacGregor 2005 Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases Physiol Rev 85 679 715 15788708 10.1152/physrev.00056.2003 1:CAS:528:DC%2BD2MXjt12lsLo%3D (Pubitemid 40404639)
25. N Nagy T Freudenberger A Melchior-Becker K Rock BM Ter H Jastrow M Kinzig S Lucke T Suvorava G Kojda AA Weber F Sorgel B Levkau S Ergun JW Fischer 2010 Inhibition of hyaluronan synthesis accelerates murine atherosclerosis: novel insights into the role of hyaluronan synthesis Circulation 122 2313 2322 21098434 10.1161/CIRCULATIONAHA.110.972653 1:CAS:528:DC%2BC3cXhsFSmt77O
26. M Nieuwdorp MC Meuwese H Vink JB Hoekstra JJ Kastelein ES Stroes 2005 The endothelial glycocalyx: a potential barrier between health and vascular disease Curr Opin Lipidol 16 507 511 16148534 10.1097/01.mol.0000181325.08926.9c 1:CAS:528:DC%2BD2MXpslCms7o%3D (Pubitemid 41376899)
27. H Oberleithner 2005 Aldosterone makes human endothelium stiff and vulnerable Kidney Int 67 1680 1682 15840012 10.1111/j.1523-1755.2005.00263.x 1:CAS:528:DC%2BD2MXktlOqtbc%3D (Pubitemid 40577700)
28. H Oberleithner C Callies K Kusche-Vihrog H Schillers V Shahin C Riethmuller GA MacGregor HE de Wardener 2009 Potassium softens vascular endothelium and increases nitric oxide release Proc Natl Acad Sci U S A 106 2829 2834 19202069 10.1073/pnas.0813069106 1:CAS:528:DC%2BD1MXislaht7k%3D
29. H Oberleithner K Kusche-Vihrog H Schillers 2010 Endothelial cells as vascular salt sensors Kidney Int 77 490 494 20054292 10.1038/ki.2009.490 1:CAS:528:DC%2BC3cXisVans7s%3D
30. H Oberleithner C Riethmuller H Schillers GA MacGregor HE de Wardener M Hausberg 2007 Plasma sodium stiffens vascular endothelium and reduces nitric oxide release Proc Natl Acad Sci U S A 104 16281 16286 17911245 10.1073/pnas.0707791104 1:CAS:528:DC%2BD2sXhtF2gsr%2FI (Pubitemid 350099397)
31. D Pesen JH Hoh 2005 Micromechanical architecture of the endothelial cell cortex Biophys J 88 670 679 15489304 10.1529/biophysj.104.049965 1:CAS:528:DC%2BD2MXjtFynu7o%3D (Pubitemid 40070710)
32. M Rehm D Bruegger F Christ P Conzen M Thiel M Jacob D Chappell M Stoeckelhuber U Welsch B Reichart K Peter BF Becker 2007 Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia Circulation 116 1896 1906 17923576 10.1161/ CIRCULATIONAHA.106.684852 1:CAS:528:DC%2BD2sXhtFKmu7fL (Pubitemid 350287085)
33. G Siegel A Walter A Kauschmann M Malmsten E Buddecke 1996 Anionic biopolymers as blood flow sensors Biosens Bioelectron 11 281 294 8562009 10.1016/0956-5663(96)88415-6 1:CAS:528:DyaK28XptVyksw%3D%3D (Pubitemid 26042805)
34. A Singh SC Satchell CR Neal EA McKenzie JE Tooke PW Mathieson 2007 Glomerular endothelial glycocalyx constitutes a barrier to protein permeability J Am Soc Nephrol 18 2885 2893 17942961 10.1681/ASN.2007010119 1:CAS:528:DC%2BD2sXhtlGgsbvN (Pubitemid 350058395)
35. MM Thi JM Tarbell S Weinbaum DC Spray 2004 The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: a "bumper-car" model Proc Natl Acad Sci U S A 101 16483 16488 15545600 10.1073/pnas.0407474101 1:CAS:528:DC%2BD2cXhtVOisbvO (Pubitemid 39557739)
36. J Titze A Machnik 2010 Sodium sensing in the interstitium and relationship to hypertension Curr Opin Nephrol Hypertens 19 385 392 20571401 10.1097/MNH.0b013e32833aeb3b
37. JW VanTeeffelen J Brands C Jansen JA Spaan H Vink 2007 Heparin impairs glycocalyx barrier properties and attenuates shear dependent vasodilation in mice Hypertension 50 261 267 17452501 10.1161/HYPERTENSIONAHA.107.089250 1:CAS:528:DC%2BD2sXmtlKru7k%3D (Pubitemid 46986050)
38. Waanders F, de Vries LV, van GH, Hillebrands JL, Laverman GD, Bakker SJ, Navis G (2011). Aldosterone, from (patho)physiology to treatment in cardiovascular and renal damage. Curr Vasc Pharmacol (in press)
39. S Weinbaum JM Tarbell ER Damiano 2007 The structure and function of the endothelial glycocalyx layer Annu Rev Biomed Eng 9 121 167 17373886 10.1146/annurev.bioeng.9.060906.151959 1:CAS:528:DC%2BD2sXhtVehtLbO (Pubitemid 350246654)
40. S Weinbaum X Zhang Y Han H Vink SC Cowin 2003 Mechanotransduction and flow across the endothelial glycocalyx Proc Natl Acad Sci U S A 100 7988 7995 12810946 10.1073/pnas.1332808100 1:CAS:528:DC%2BD3sXlt1Wqt7c%3D (Pubitemid 36760082)