Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly

Cell Host and Microbe

Volumn 10, Issue 3, 2011, Pages 237-247

  Sun, Shihu ^a,b   Suresh, Swetha ^c   Liu, Huisheng ^a,b   Tepp, William H ^d   Johnson, Eric A ^d   Edwardson, J Michael ^c   Chapman, Edwin R ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITOXIN; BOTULINUM TOXIN B; GANGLIOSIDE GT 1B; MEMBRANE PROTEIN; TOOSENDANIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATOMIC FORCE MICROSCOPY; BACTERIAL TRANSLOCATION; CHANNEL GATING; CONTROLLED STUDY; ENDOSOME; HYDROPHOBICITY; LIPID BILAYER; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; PH; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN SECONDARY STRUCTURE; RAT; RECEPTOR BINDING;

ANIMALS; BINDING SITES; BOTULINUM TOXINS; BOTULISM; CELL MEMBRANE; CLOSTRIDIUM BOTULINUM; GANGLIOSIDES; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MICE, KNOCKOUT; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; RECEPTORS, CELL SURFACE;

CLOSTRIDIUM BOTULINUM;

EID: 80052994116     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2011.06.012     Document Type: Article

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