Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: A multicentre prospective registry study from the CAP-China Network

European Respiratory Journal

Volumn 54, Issue 2, 2019, Pages

  Zhou, Fei ^a,b,c   Wang, Yimin ^a,b,c   Liu, Yingmei ^a,b,c   Liu, Xuedong ^d   Gu, Li ^b   Zhang, Xiaoju ^e   Pu, Zenghui ^f   Yang, Guoru ^g   Liu, Bo ^h   Nie, Qingrong ⁱ   Xue, Bing ^c   Feng, Jing ^j   Guo, Qiang ^k   Liu, Jianhua ^l   Fan, Hong ^m   Chen, Jin ^b   Zhang, Yongxiang ^b   Xu, Zhenyang ^b   Pang, Min ⁿ   Chen, Yu ^o   Nie, Xiuhong ^b   Cai, Zhigang ^p   Xu, Jinfu ^q   Peng, Kun ^r   Li, Xiangxin ^s   Xiang, Pingchao ^t   Zhang, Zuoqing ^u   Jiang, Shujuan ^v   Su, Xin ^w   Zhang, Jie ^b   Li, Yanming ^x   Jin, Xiuhong ^y   Jiang, Rongmeng ^b   Dong, Jianping ^z   Song, Yuanlin ^aa   Zhou, Hong ^ab   Wang, Chen ^a,b,c   Cao, Bin ^a,b,c   more..

^a CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c TSINGHUA UNIVERSITY   (China)

^d QINGDAO MUNICIPAL HOSPITAL   (China)

^e HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^f YANTAI YUHUANGDING HOSPITAL   (China)

^g Weifang NO 2 People's Hospital   (China)

^h The Affiliated Linzi District People's Hospital of Binzhou Medical University   (China)

ⁱ Beijing Liangxiang Hospital   (China)

^j TIANJIN MEDICAL UNIVERSITY   (China)

^k SOOCHOW UNIVERSITY   (China)

^l UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^m SICHUAN UNIVERSITY   (China)

ⁿ SHANXI MEDICAL UNIVERSITY   (China)

^o CHINA MEDICAL UNIVERSITY   (China)

^p HEBEI MEDICAL UNIVERSITY   (China)

^q SHANGHAI PULMONARY HOSPITAL   (China)

^r Beijing no 6 Hospital   (China)

^s Beijing Changping District Hospital   (China)

^t PEKING UNIVERSITY SHOUGANG HOSPITAL   (China)

^u Peking University Shougang Hospital ^*  (China)

^v SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^w NANJING GENERAL HOSPITAL OF NANJING MILITARY COMMAND   (China)

^x BEIJING HOSPITAL   (China)

^y Capital Medical University Pinggu Teaching Hospital   (China)

^z PEKING UNIVERSITY THIRD HOSPITAL   (China)

^aa FUDAN UNIVERSITY   (China)

^ab BEIJING ELECTRIC POWER HOSPITAL   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRIDAE; ADENOVIRUS INFECTION; ADULT; AGE; AGED; ARTERIAL OXYGEN TENSION; ARTICLE; BREATHING RATE; CHINA; CLINICAL OUTCOME; COHORT ANALYSIS; COMMUNITY ACQUIRED PNEUMONIA; CONFUSION; CORONAVIRIDAE; DIASTOLIC BLOOD PRESSURE; DISEASE REGISTRY; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN METAPNEUMOVIRUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS; HUMAN RHINOVIRUS; HYPOXEMIA; IMMUNOCOMPETENCE; INCIDENCE; INFLUENZA VIRUS; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY RATE; NON INFLUENZA VIRAL INFECTION; PARAINFLUENZA VIRUS INFECTION; PARAMYXOVIRINAE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPSIS; SYSTOLIC BLOOD PRESSURE; VIRUS PNEUMONIA; ADOLESCENT; CLINICAL TRIAL; COMMUNITY ACQUIRED INFECTION; EPIDEMIOLOGY; GEOGRAPHY; HOSPITALIZATION; MIDDLE AGED; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; ODDS RATIO; PROPORTIONAL HAZARDS MODEL; REGISTER; RESPIRATORY TRACT INFECTION; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; VERY ELDERLY; VIROLOGY; VIRUS INFECTION; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHINA; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; GEOGRAPHY; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PNEUMONIA, VIRAL; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; REGISTRIES; RESPIRATORY TRACT INFECTIONS; SEPSIS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; VIRUS DISEASES; YOUNG ADULT;

EID: 85071056573     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/13993003.02406-2018     Document Type: Article

References (69)

1. Mandell LA. Community-acquired pneumonia: An overview. Postgrad Med 2015; 127: 607-615.
2. Burk M, El-Kersh K, Saad M, et al. Viral infection in community-acquired pneumonia: A systematic review and meta-analysis. Eur Respir Rev 2016; 25: 178-188.
3. Cavallazzi R, Ramirez JA. Influenza and viral pneumonia. Clin Chest Med 2018; 39: 703-721.
4. Ruuskanen O, Lahti E, Jennings LC, et al. Viral pneumonia. Lancet 2011; 377: 1264-1275.
5. Haas LE, Thijsen SF, van Elden L, et al. Human metapneumovirus in adults. Viruses 2013; 5: 87-110.
6. Griffiths C, Drews SJ, Marchant DJ. Respiratory syncytial virus: Infection, detection, and new options for prevention and treatment. Clin Microbiol Rev 2017; 30: 277-319.
7. Branche AR, Falsey AR. Parainfluenza virus infection. Semin Respir Crit Care Med 2016; 37: 538-554.
8. Choi SH, Huh JW, Hong SB, et al. Clinical characteristics and outcomes of severe rhinovirus-associated pneumonia identified by bronchoscopic bronchoalveolar lavage in adults: Comparison with severe influenza virus-associated pneumonia. J Clin Virol 2015; 62: 41-47.
9. Vabret A, Mourez T, Gouarin S, et al. An outbreak of coronavirus OC43 respiratory infection in Normandy, France. Clin Infect Dis 2003; 36: 985-989.
10. Liao RS, Appelgate DM, Pelz RK. An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility for the elderly in Oregon. J Clin Virol 2012; 53: 171-173.
11. Jacobs SE, Lamson DM, Soave R, et al. Clinical and molecular epidemiology of human rhinovirus infections in patients with hematologic malignancy. J Clin Virol 2015; 71: 51-58.
12. Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007; 44: Suppl. 2, S27-S72.
13. Weinberg GA, Schnabel KC, Erdman DD, et al. Field evaluation of TaqMan Array Card (TAC) for the simultaneous detection of multiple respiratory viruses in children with acute respiratory infection. J Clin Virol 2013; 57: 254-260.
14. Qu JX, Gu L, Pu ZH, et al. Viral etiology of community-acquired pneumonia among adolescents and adults with mild or moderate severity and its relation to age and severity. BMC Infect Dis 2015; 15: 89.
15. Sanz F, Gimeno C, Lloret T, et al. Relationship between the presence of hypoxemia and the inflammatory response measured by C-reactive protein in bacteremic pneumococcal pneumonia. Eur Respir J 2011; 38: Suppl. 55, 2492.
16. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016; 315: 801-810.
17. Lim WS, Baudouin SV, George RC, et al. BTS guidelines for the management of community acquired pneumonia in adults: Update 2009. Thorax 2009; 64: Suppl. 3, iii1-iii55.
18. Voiriot G, Visseaux B, Cohen J, et al. Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia. Crit Care 2016; 20: 375.
19. Radovanovic D, Sotgiu G, Jankovic M, et al. An international perspective on hospitalized patients with viral community-acquired pneumonia. Eur J Intern Med 2019; 60: 54-70.
20. Jain S, Self WH, Wunderink RG, et al. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med 2015; 373: 415-427.
21. Huang HH, Zhang YY, Xiu QY, et al. Community-acquired pneumonia in Shanghai, China: Microbial etiology and implications for empirical therapy in a prospective study of 389 patients. Eur J Clin Microbiol Infect Dis 2006; 25: 369-374.
22. Liu Y, Chen M, Zhao T, et al. Causative agent distribution and antibiotic therapy assessment among adult patients with community acquired pneumonia in Chinese urban population. BMC Infect Dis 2009; 9: 31.
23. Lui G, Ip M, Lee N, et al. Role of "atypical pathogens" among adult hospitalized patients with community-acquired pneumonia. Respirology 2009; 14: 1098-1105.
24. Ngeow YF, Suwanjutha S, Chantarojanasriri T, et al. An Asian study on the prevalence of atypical respiratory pathogens in community-acquired pneumonia. Int J Infect Dis 2005; 9: 144-153.
25. Song JH, Oh WS, Kang CI, et al. Epidemiology and clinical outcomes of community-acquired pneumonia in adult patients in Asian countries: A prospective study by the Asian network for surveillance of resistant pathogens. Int J Antimicrob Agents 2008; 31: 107-114.
26. Gong C, Zhang T, Luo M, et al. Distribution of the atypical pathogens of community-acquired pneumonia to disease severity. J Thorac Dis 2018; 10: 5991-6001.
27. Tao RJ, Luo XL, Xu W, et al. Viral infection in community acquired pneumonia patients with fever: A prospective observational study. J Thorac Dis 2018; 10: 4387-4395.
28. Luan Y, Sun Y, Duan S, et al. Pathogenic bacterial profile and drug resistance analysis of community-acquired pneumonia in older outpatients with fever. J Int Med Res 2018; 46: 4596-4604.
29. Zhan Y, Yang Z, Chen R, et al. Respiratory virus is a real pathogen in immunocompetent community-acquired pneumonia: Comparing to influenza like illness and volunteer controls. BMC Pulm Med 2014; 14: 144.
30. Musher DM, Abers MS, Bartlett JG. Evolving understanding of the causes of pneumonia in adults, with special attention to the role of pneumococcus. Clin Infect Dis 2017; 65: 1736-1744.
31. Liu YF, Gao Y, Chen MF, et al. Etiological analysis and predictive diagnostic model building of community-acquired pneumonia in adult outpatients in Beijing, China. BMC Infect Dis 2013; 13: 309.
32. Cao B, Ren LL, Zhao F, et al. Viral and Mycoplasma pneumoniae community-acquired pneumonia and novel clinical outcome evaluation in ambulatory adult patients in China. Eur J Clin Microbiol Infect Dis 2010; 29: 1443-1448.
33. Li X, Chen B, Zhang S, et al. Rapid detection of respiratory pathogens for community-acquired pneumonia by capillary electrophoresis-based multiplex PCR. SLAS Technol 2019; 24: 105-116.
34. Chen H, Weng H, Lin M, et al. The clinical significance of FilmArray Respiratory Panel in diagnosing community-acquired pneumonia. Biomed Res Int 2017; 2017: 7320859.
35. Wilkinson TMA, Aris E, Bourne S, et al. A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD. Thorax 2017; 72: 919-927.
36. Jafarinejad H, Moghoofei M, Mostafaei S, et al. Worldwide prevalence of viral infection in AECOPD patients: A meta-analysis. Microb Pathog 2017; 113: 190-196.
37. Jain S. Epidemiology of viral pneumonia. Clin Chest Med 2017; 38: 1-9.
38. Tan D, Zhu H, Fu Y, et al. Severe community-acquired pneumonia caused by human adenovirus in immunocompetent adults: A multicenter case series. PLoS One 2016; 11: E0151199.
39. Cao B, Huang GH, Pu ZH, et al. Emergence of community-acquired adenovirus type 55 as a cause of community-onset pneumonia. Chest 2014; 145: 79-86.
40. Lynch JP. Adenovirus: Epidemiology, global spread of novel serotypes, and advances in treatment and prevention. Semin Respir Crit Care Med 2016; 37: 586-602.
41. Gilca R, Amini R, Douville-Fradet M, et al. Other respiratory viruses are important contributors to adult respiratory hospitalizations and mortality even during peak weeks of the influenza season. Open Forum Infect Dis 2014; 1: Ofu086.
42. Bjarnason A, Westin J, Lindh M, et al. Incidence, etiology, and outcomes of community-acquired pneumonia: A population-based study. Open Forum Infect Dis 2018; 5: Ofy010.
43. Deng JC. Viral-bacterial interactions - therapeutic implications. Influenza Other Respir Viruses 2013; 7: Suppl. 3, 24-35.
44. Shah RD, Wunderink RG. Viral pneumonia and acute respiratory distress syndrome. Clin Chest Med 2017; 38: 113-125.
45. Widmer K, Zhu Y, Williams JV, et al. Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. J Infect Dis 2012; 206: 56-62.
46. Widmer K, Griffin MR, Zhu Y, et al. Respiratory syncytial virus- and human metapneumovirus-associated emergency department and hospital burden in adults. Influenza Other Respir Viruses 2014; 8: 347-352.
47. Ackerson B, Tseng HF, Sy LS, et al. Severe morbidity and mortality associated with respiratory syncytial virus versus influenza infection in hospitalized older adults. Clin Infect Dis 2019; 69: 197-203.
48. van Asten L, van den Wijngaard C, van Pelt W, et al. Mortality attributable to 9 common infections: Significant effect of influenza A, respiratory syncytial virus, influenza B, norovirus, and parainfluenza in elderly persons. J Infect Dis 2012; 206: 628-639.
49. Lee N, Lui GC, Wong KT, et al. High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections. Clin Infect Dis 2013; 57: 1069-1077.
50. Joseph C, Togawa Y, Shindo N. Bacterial and viral infections associated with influenza. Influenza Other Respir Viruses 2013; 7: Suppl. 2, 105-113.
51. Miller JM, Binnicker MJ, Campbell S, et al. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin Infect Dis 2018; 67: E1-e94.
52. Self WH, Balk RA, Grijalva CG, et al. Procalcitonin as a marker of etiology in adults hospitalized with community-acquired pneumonia. Clin Infect Dis 2017; 65: 183-190.
53. Brendish NJ, Malachira AK, Armstrong L, et al. Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): A pragmatic, open-label, randomised controlled trial. Lancet Respir Med 2017; 5: 401-411.
54. Andrews D, Chetty Y, Cooper BS, et al. Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: A quasi-randomised study assessing impact on length of stay and antimicrobial use. BMC Infect Dis 2017; 17: 671.
55. Keske S, Ergonul O, Tutucu F, et al. The rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs. Eur J Clin Microbiol Infect Dis 2018; 37: 779-783.
56. Semret M, Schiller I, Jardin BA, et al. Multiplex respiratory virus testing for antimicrobial stewardship: A prospective assessment of antimicrobial use and clinical outcomes among hospitalized adults. J Infect Dis 2017; 216: 936-944.
57. Afzal Z, Minard CG, Stager CE, et al. Clinical diagnosis, viral PCR, and antibiotic utilization in community-acquired pneumonia. Am J Ther 2016; 23: E766-e772.
58. Hernes SS, Hagen E, Quarsten H, et al. No impact of early real-time PCR screening for respiratory viruses on length of stay and use of antibiotics in elderly patients hospitalized with symptoms of a respiratory tract infection in a single center in Norway. Eur J Clin Microbiol Infect Dis 2014; 33: 359-364.
59. Duan SC, Gu XY, Fan GH, et al. The clinical value of a new molecular point-of-care testing in hospitalized lower respiratory tract infection patients: A randomized controlled study. Am J Respir Crit Care Med 2019; 199: A209.
60. Blatt SP, Yultyev A, Huang M, et al. Impact of respiratory virus molecular testing on antibiotic utilization in community-acquired pneumonia. Am J Infect Control 2017; 45: 1396-1398.
61. Hayden FG, Sugaya N, Hirotsu N, et al. Baloxavir marboxil for uncomplicated influenza in adults and adolescents. N Engl J Med 2018; 379: 913-923.
62. Finberg RW, Lanno R, Anderson D, et al. Phase 2b study of pimodivir ( JNJ-63623872) as monotherapy or in combination with oseltamivir for treatment of acute uncomplicated seasonal influenza A: TOPAZ trial. J Infect Dis 2019; 219: 1026-1034.
63. Koszalka P, Tilmanis D, Hurt AC. Influenza antivirals currently in late-phase clinical trial. Influenza Other Respir Viruses 2017; 11: 240-246.
64. Moss RB, Hansen C, Sanders RL, et al. A phase II study of DAS181, a novel host directed antiviral for the treatment of influenza infection. J Infect Dis 2012; 206: 1844-1851.
65. Thammawat S, Sadlon TA, Adamson P, et al. Effect of sialidase fusion protein (DAS 181) on human metapneumovirus infection of Hep-2 cells. Antivir Chem Chemother 2015; 24: 161-165.
66. Salvatore M, Satlin MJ, Jacobs SE, et al. DAS181 for treatment of parainfluenza virus infections in hematopoietic stem cell transplant recipients at a single center. Biol Blood Marrow Transplant 2016; 22: 965-970.
67. McKimm-Breschkin JL, Jiang S, Hui DS, et al. Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference. Antiviral Res 2018; 149: 118-142.
68. Grimley MS, Chemaly RF, Englund JA, et al. Brincidofovir for asymptomatic adenovirus viremia in pediatric and adult allogeneic hematopoietic cell transplant recipients: A randomized placebo-controlled phase II trial. Biol Blood Marrow Transplant 2017; 23: 512-521.
69. Peto L, Nadjm B, Horby P, et al. The bacterial aetiology of adult community-acquired pneumonia in Asia: A systematic review. Trans R Soc Trop Med Hyg 2014; 108: 326-337.