메뉴 건너뛰기




Volumn 21, Issue 8, 2019, Pages

Duodenal Chemosensing of Short-Chain Fatty Acids: Implications for GI Diseases

Author keywords

Glucagon like peptide 2; Mucosal defense; Nutrition sensing; Serotonin; Short chain fatty acid receptors

Indexed keywords

GLUCAGON LIKE PEPTIDE 2; SEROTONIN; SEROTONIN 3 RECEPTOR; SHORT CHAIN FATTY ACID; NONSTEROID ANTIINFLAMMATORY AGENT; VOLATILE FATTY ACID;

EID: 85068767613     PISSN: 15228037     EISSN: 1534312X     Source Type: Journal    
DOI: 10.1007/s11894-019-0702-9     Document Type: Review
Times cited : (15)

References (64)
  • 2
    • 84964694618 scopus 로고    scopus 로고
    • SCFA transport in rat duodenum
    • COI: 1:CAS:528:DC%2BC2MXjs1Ohur0%3D, This study provides the evidence of rapid, electrogenic SCFA absorption via apical SMCT-1 the duodenal mucosa
    • • Kaji I, Iwanaga T, Watanabe M, Guth PH, Engel E, Kaunitz JD, et al. SCFA transport in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2015;308:G188–97 This study provides the evidence of rapid, electrogenic SCFA absorption via apical SMCT-1 in the duodenal mucosa.
    • (2015) Am J Physiol Gastrointest Liver Physiol , vol.308 , pp. G188-G197
    • Kaji, I.1    Iwanaga, T.2    Watanabe, M.3    Guth, P.H.4    Engel, E.5    Kaunitz, J.D.6    Akiba, Y.7
  • 3
    • 0021709726 scopus 로고
    • Short-chain fatty acids in the proximal gastrointestinal tract of healthy subjects
    • COI: 1:STN:280:DyaL2M7pt1ehtQ%3D%3D
    • Hoverstad T, Bjorneklett A, Midtvedt T, Fausa O, Bohmer T. Short-chain fatty acids in the proximal gastrointestinal tract of healthy subjects. Scand J Gastroenterol. 1984;19:1053–8.
    • (1984) Scand J Gastroenterol , vol.19 , pp. 1053-1058
    • Hoverstad, T.1    Bjorneklett, A.2    Midtvedt, T.3    Fausa, O.4    Bohmer, T.5
  • 4
    • 0022124997 scopus 로고
    • Gas-liquid chromatography of the gingival fluid as an aid in periodontal diagnosis
    • COI: 1:STN:280:DyaL28%2FovVCjtw%3D%3D
    • Botta GA, Radin L, Costa A, Schito G, Blasi G. Gas-liquid chromatography of the gingival fluid as an aid in periodontal diagnosis. J Periodontal Res. 1985;20:450–7.
    • (1985) J Periodontal Res , vol.20 , pp. 450-457
    • Botta, G.A.1    Radin, L.2    Costa, A.3    Schito, G.4    Blasi, G.5
  • 5
    • 84945944451 scopus 로고    scopus 로고
    • Cellular distributions of monocarboxylate transporters: a review
    • COI: 1:CAS:528:DC%2BC28XjvFSjtrc%3D
    • Iwanaga T, Kishimoto A. Cellular distributions of monocarboxylate transporters: a review. Biomed Res. 2015;36:279–301.
    • (2015) Biomed Res , vol.36 , pp. 279-301
    • Iwanaga, T.1    Kishimoto, A.2
  • 6
    • 84921890499 scopus 로고    scopus 로고
    • Short-chain fatty acid sensing in rat duodenum
    • COI: 1:CAS:528:DC%2BC2MXhslagtL8%3D, This study provides for the first time that luminal SCFAs stimulate duodenal mucosa to enhance mucosal defense via distinct 5-HT and GLP-2 pathways via SCFA receptors
    • •• Akiba Y, Inoue T, Kaji I, Higashiyama M, Narimatsu K, Iwamoto K, et al. Short-chain fatty acid sensing in rat duodenum. J Physiol. 2015;593:585–99 This study provides for the first time that luminal SCFAs stimulate duodenal mucosa to enhance mucosal defense via distinct 5-HT and GLP-2 pathways via SCFA receptors.
    • (2015) J Physiol , vol.593 , pp. 585-599
    • Akiba, Y.1    Inoue, T.2    Kaji, I.3    Higashiyama, M.4    Narimatsu, K.5    Iwamoto, K.6    Watanabe, M.7    Guth, P.H.8    Engel, E.9    Kuwahara, A.10    Kaunitz, J.D.11
  • 7
    • 85026812715 scopus 로고    scopus 로고
    • FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats
    • This study links 5-HT release via FFA2 activation to duodenal mucosal injury with indomethacin treatment, implicating 5-HT-related IBS symptom generation
    • •• Akiba Y, Maruta K, Narimatsu K, Said H, Kaji I, Kuri A, et al. FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats. Am J Physiol Gastrointest Liver Physiol. 2017;313:G117–28 This study links 5-HT release via FFA2 activation to duodenal mucosal injury with indomethacin treatment, implicating in 5-HT-related IBS symptom generation.
    • (2017) Am J Physiol Gastrointest Liver Physiol , vol.313 , pp. G117-G128
    • Akiba, Y.1    Maruta, K.2    Narimatsu, K.3    Said, H.4    Kaji, I.5    Kuri, A.6    Iwamoto, K.I.7    Kuwahara, A.8    Kaunitz, J.D.9
  • 8
    • 85019564044 scopus 로고    scopus 로고
    • FFA3 activation stimulates duodenal bicarbonate secretion and prevents NSAID-induced enteropathy via the GLP-2 pathway in rats
    • COI: 1:CAS:528:DC%2BC2sXnvF2htbc%3D
    • Said H, Akiba Y, Narimatsu K, Maruta K, Kuri A, Iwamoto K, et al. FFA3 activation stimulates duodenal bicarbonate secretion and prevents NSAID-induced enteropathy via the GLP-2 pathway in rats. Dig Dis Sci. 2017;62:1944–52.
    • (2017) Dig Dis Sci , vol.62 , pp. 1944-1952
    • Said, H.1    Akiba, Y.2    Narimatsu, K.3    Maruta, K.4    Kuri, A.5    Iwamoto, K.6    Kuwahara, A.7    Kaunitz, J.D.8
  • 9
    • 0022979765 scopus 로고
    • Effects of food restriction and starvation-refeeding on volatile fatty acid concentrations in the rat
    • COI: 1:CAS:528:DyaL28Xmt1Git74%3D
    • Illman RJ, Topping DL, Trimble RP. Effects of food restriction and starvation-refeeding on volatile fatty acid concentrations in the rat. J Nutr. 1986;116:1694–700.
    • (1986) J Nutr , vol.116 , pp. 1694-1700
    • Illman, R.J.1    Topping, D.L.2    Trimble, R.P.3
  • 10
    • 0023276469 scopus 로고
    • Short chain fatty acids in human large intestine, portal, hepatic and venous blood
    • COI: 1:STN:280:DyaL1c%2Fls1CrsA%3D%3D
    • Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut. 1987;28:1221–7.
    • (1987) Gut , vol.28 , pp. 1221-1227
    • Cummings, J.H.1    Pomare, E.W.2    Branch, W.J.3    Naylor, C.P.4    Macfarlane, G.T.5
  • 11
    • 0025321505 scopus 로고
    • Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
    • COI: 1:CAS:528:DyaK3cXlvVymtb0%3D
    • Bergman EN. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol Rev. 1990;70:567–90.
    • (1990) Physiol Rev , vol.70 , pp. 567-590
    • Bergman, E.N.1
  • 13
    • 31044449873 scopus 로고    scopus 로고
    • Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects
    • COI: 1:STN:280:DC%2BD2MvmslKhuw%3D%3D
    • Ostman E, Granfeldt Y, Persson L, Bjorck I. Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects. Eur J Clin Nutr. 2005;59:983–8.
    • (2005) Eur J Clin Nutr , vol.59 , pp. 983-988
    • Ostman, E.1    Granfeldt, Y.2    Persson, L.3    Bjorck, I.4
  • 14
    • 0028926324 scopus 로고
    • Effect of neutralized and native vinegar on blood glucose and acetate responses to a mixed meal in healthy subjects
    • COI: 1:STN:280:DyaK2Mzhslaksw%3D%3D, PID: 7796781
    • Brighenti F, Castellani G, Benini L, Casiraghi MC, Leopardi E, Crovetti R, et al. Effect of neutralized and native vinegar on blood glucose and acetate responses to a mixed meal in healthy subjects. Eur J Clin Nutr. 1995;49:242–7.
    • (1995) Eur J Clin Nutr , vol.49 , pp. 242-247
    • Brighenti, F.1    Castellani, G.2    Benini, L.3    Casiraghi, M.C.4    Leopardi, E.5    Crovetti, R.6    Testolin, G.7
  • 17
    • 0020501561 scopus 로고
    • Endocrine cells in human intestine: an immunocytochemical study
    • PID: 6194039
    • Sjölund K, Sandén G, Håkanson R, Sundler F. Endocrine cells in human intestine: an immunocytochemical study. Gastroenterology. 1983;85:1120–30.
    • (1983) Gastroenterology , vol.85 , pp. 1120-1130
    • Sjölund, K.1    Sandén, G.2    Håkanson, R.3    Sundler, F.4
  • 18
    • 84903720814 scopus 로고    scopus 로고
    • Duodenal luminal chemosensing; acid, ATP, and nutrients
    • Akiba Y, Kaunitz JD. Duodenal luminal chemosensing; acid, ATP, and nutrients. Curr Pharm Des. 2014;20:2760–5.
    • (2014) Curr Pharm Des , vol.20 , pp. 2760-2765
    • Akiba, Y.1    Kaunitz, J.D.2
  • 21
    • 67651114055 scopus 로고    scopus 로고
    • Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum
    • COI: 1:CAS:528:DC%2BD1MXpt1WrsLY%3D
    • Mizumori M, Ham M, Guth PH, Engel E, Kaunitz JD, Akiba Y. Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum. J Physiol. 2009;587:3651–63.
    • (2009) J Physiol , vol.587 , pp. 3651-3663
    • Mizumori, M.1    Ham, M.2    Guth, P.H.3    Engel, E.4    Kaunitz, J.D.5    Akiba, Y.6
  • 22
    • 56749154840 scopus 로고    scopus 로고
    • A gut feeling for obesity: 7TM sensors on enteroendocrine cells
    • COI: 1:CAS:528:DC%2BD1cXhsV2qtbjJ
    • Engelstoft MS, Egerod KL, Holst B, Schwartz TW. A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab. 2008;8:447–9.
    • (2008) Cell Metab , vol.8 , pp. 447-449
    • Engelstoft, M.S.1    Egerod, K.L.2    Holst, B.3    Schwartz, T.W.4
  • 23
    • 70149102106 scopus 로고    scopus 로고
    • Expression of short-chain fatty acid receptor GPR41 in the human colon
    • COI: 1:CAS:528:DC%2BD1MXotlGjtb8%3D
    • Tazoe H, Otomo Y, Karaki S, Kato I, Fukami Y, Terasaki M, et al. Expression of short-chain fatty acid receptor GPR41 in the human colon. BiomedRes. 2009;30:149–56.
    • (2009) BiomedRes , vol.30 , pp. 149-156
    • Tazoe, H.1    Otomo, Y.2    Karaki, S.3    Kato, I.4    Fukami, Y.5    Terasaki, M.6    Kuwahara, A.7
  • 26
    • 85019954519 scopus 로고    scopus 로고
    • Short-chain fatty acids augment rat duodenal mucosal barrier function
    • COI: 1:CAS:528:DC%2BC2sXhtVygu77K, This study provides that luminal SCFAs rather than IV SCFAs enhance duodenal defense mechanisms
    • •• Wan Saudi WS, Sjöblom M. Short-chain fatty acids augment rat duodenal mucosal barrier function. Exp Physiol. 2017;102:791–803 This study provides that luminal SCFAs rather than IV SCFAs enhance duodenal defense mechanisms.
    • (2017) Exp Physiol , vol.102 , pp. 791-803
    • Wan Saudi, W.S.1    Sjöblom, M.2
  • 27
    • 80054787845 scopus 로고    scopus 로고
    • Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats
    • COI: 1:CAS:528:DC%2BC3MXhsFehtb3J
    • Wang JH, Inoue T, Higashiyama M, Guth PH, Engel E, Kaunitz JD, et al. Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats. J Pharmacol Exp Ther. 2011;339:464–73.
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 464-473
    • Wang, J.H.1    Inoue, T.2    Higashiyama, M.3    Guth, P.H.4    Engel, E.5    Kaunitz, J.D.6    Akiba, Y.7
  • 31
    • 79959845565 scopus 로고    scopus 로고
    • The “cryptic” mechanism of action of glucagon-like peptide-2
    • COI: 1:CAS:528:DC%2BC3MXptlSgs78%3D
    • Rowland KJ, Brubaker PL. The “cryptic” mechanism of action of glucagon-like peptide-2. Am J Physiol Gastrointest Liver Physiol. 2011;301:G1–8.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , pp. G1-G8
    • Rowland, K.J.1    Brubaker, P.L.2
  • 32
    • 79958187560 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome
    • COI: 1:CAS:528:DC%2BC3MXpvFWhtb8%3D
    • Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B, O'Keefe SJ. Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome. Gut. 2011;60:902–14.
    • (2011) Gut , vol.60 , pp. 902-914
    • Jeppesen, P.B.1    Gilroy, R.2    Pertkiewicz, M.3    Allard, J.P.4    Messing, B.5    O'Keefe, S.J.6
  • 33
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • COI: 1:CAS:528:DC%2BD28XhtF2gurjM
    • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368:1696–705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 36
    • 84902238872 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats
    • COI: 1:CAS:528:DC%2BC2cXivVOmtg%3D%3D
    • Inoue T, Higashiyama M, Kaji I, Rudenkyy S, Higuchi K, Guth PH, et al. Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats. Dig Dis Sci. 2014;59:1286–95.
    • (2014) Dig Dis Sci , vol.59 , pp. 1286-1295
    • Inoue, T.1    Higashiyama, M.2    Kaji, I.3    Rudenkyy, S.4    Higuchi, K.5    Guth, P.H.6    Engel, E.7    Kaunitz, J.D.8    Akiba, Y.9
  • 38
    • 0030855102 scopus 로고    scopus 로고
    • Immunoelectron microscopic study of the luminal release of serotonin from rat enterochromaffin cells induced by high intraluminal pressure
    • COI: 1:CAS:528:DyaK2sXltlehsLo%3D
    • Fujimiya M, Okumiya K, Kuwahara A. Immunoelectron microscopic study of the luminal release of serotonin from rat enterochromaffin cells induced by high intraluminal pressure. Histochem Cell Biol. 1997;108:105–13.
    • (1997) Histochem Cell Biol , vol.108 , pp. 105-113
    • Fujimiya, M.1    Okumiya, K.2    Kuwahara, A.3
  • 40
    • 34247631654 scopus 로고    scopus 로고
    • Enterochromaffin cells of the human gut: sensors for spices and odorants
    • COI: 1:CAS:528:DC%2BD2sXmsVymsLo%3D
    • Braun T, Voland P, Kunz L, Prinz C, Gratzl M. Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology. 2007;132:1890–901.
    • (2007) Gastroenterology , vol.132 , pp. 1890-1901
    • Braun, T.1    Voland, P.2    Kunz, L.3    Prinz, C.4    Gratzl, M.5
  • 41
    • 0021352890 scopus 로고
    • Acid and isoproterenol cause serotonin release by acting on opposite surfaces of duodenal mucosa
    • COI: 1:CAS:528:DyaL2cXhtlamtrs%3D
    • Kellum JM, Donowitz M, Cerel A, Wu J. Acid and isoproterenol cause serotonin release by acting on opposite surfaces of duodenal mucosa. J Surg Res. 1984;36:172–6.
    • (1984) J Surg Res , vol.36 , pp. 172-176
    • Kellum, J.M.1    Donowitz, M.2    Cerel, A.3    Wu, J.4
  • 43
    • 0033939079 scopus 로고    scopus 로고
    • 3 receptor antagonist, granisetron, in the rat
    • COI: 1:CAS:528:DC%2BD3cXlt1Slu74%3D
    • 3 receptor antagonist, granisetron, in the rat. Br J Pharmacol. 2000;130:1031–6.
    • (2000) Br J Pharmacol , vol.130 , pp. 1031-1036
    • Turvill, J.L.1    Connor, P.2    Farthing, M.J.3
  • 45
    • 0029811856 scopus 로고    scopus 로고
    • Serotonin mechanisms in chemotherapy-induced emesis in cancer patients
    • Cubeddu LX. Serotonin mechanisms in chemotherapy-induced emesis in cancer patients. Oncology. 1996;53(Suppl 1):18–25.
    • (1996) Oncology , vol.53 , pp. 18-25
    • Cubeddu, L.X.1
  • 46
    • 79958829738 scopus 로고    scopus 로고
    • Duodenal implications in the pathophysiology of functional dyspepsia
    • Lee KJ, Tack J. Duodenal implications in the pathophysiology of functional dyspepsia. J Neurogastroenterol Motil. 2010;16:251–7.
    • (2010) J Neurogastroenterol Motil , vol.16 , pp. 251-257
    • Lee, K.J.1    Tack, J.2
  • 47
    • 42449143802 scopus 로고    scopus 로고
    • Serotonin pharmacology in the gastrointestinal tract: a review
    • COI: 1:CAS:528:DC%2BD1cXkvVSitbg%3D
    • Beattie DT, Smith JA. Serotonin pharmacology in the gastrointestinal tract: a review. Naunyn Schmiedeberg's Arch Pharmacol. 2008;377:181–203.
    • (2008) Naunyn Schmiedeberg's Arch Pharmacol , vol.377 , pp. 181-203
    • Beattie, D.T.1    Smith, J.A.2
  • 48
    • 84925224208 scopus 로고    scopus 로고
    • Increased nutrient sensitivity and plasma concentrations of enteral hormones during duodenal nutrient infusion in functional dyspepsia
    • COI: 1:CAS:528:DC%2BC2cXitVCitrvN
    • Bharucha AE, Camilleri M, Burton DD, Thieke SL, Feuerhak KJ, Basu A, et al. Increased nutrient sensitivity and plasma concentrations of enteral hormones during duodenal nutrient infusion in functional dyspepsia. Am J Gastroenterol. 2014;109:1910–20.
    • (2014) Am J Gastroenterol , vol.109 , pp. 1910-1920
    • Bharucha, A.E.1    Camilleri, M.2    Burton, D.D.3    Thieke, S.L.4    Feuerhak, K.J.5    Basu, A.6    Zinsmeister, A.R.7
  • 49
  • 50
    • 33747378241 scopus 로고    scopus 로고
    • Serotonin-producing enterochromaffin (EC) cells of gastrointestinal mucosa in dexamethasone-treated rats
    • COI: 1:CAS:528:DC%2BD28XoslKru78%3D
    • Glisic R, Koko V, Todorovic V, Drndarevic N, Cvijic G. Serotonin-producing enterochromaffin (EC) cells of gastrointestinal mucosa in dexamethasone-treated rats. Regul Pept. 2006;136:30–9.
    • (2006) Regul Pept , vol.136 , pp. 30-39
    • Glisic, R.1    Koko, V.2    Todorovic, V.3    Drndarevic, N.4    Cvijic, G.5
  • 51
    • 84975861217 scopus 로고    scopus 로고
    • Ramosetron reduces symptoms of irritable bowel syndrome with diarrhea and improves quality of life in women
    • COI: 1:CAS:528:DC%2BC28XhsV2jtbY%3D
    • Fukudo S, Kinoshita Y, Okumura T, Ida M, Akiho H, Nakashima Y, et al. Ramosetron reduces symptoms of irritable bowel syndrome with diarrhea and improves quality of life in women. Gastroenterology. 2016;150:358–66.
    • (2016) Gastroenterology , vol.150 , pp. 358-366
    • Fukudo, S.1    Kinoshita, Y.2    Okumura, T.3    Ida, M.4    Akiho, H.5    Nakashima, Y.6    Nishida, A.7    Haruma, K.8
  • 53
    • 84957808210 scopus 로고    scopus 로고
    • A proof-of-concept study showing antibiotics to be more effective in irritable bowel syndrome with than without small-intestinal bacterial overgrowth: a randomized, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC28XitF2ks7g%3D
    • Ghoshal UC, Srivastava D, Misra A, Ghoshal U. A proof-of-concept study showing antibiotics to be more effective in irritable bowel syndrome with than without small-intestinal bacterial overgrowth: a randomized, double-blind, placebo-controlled trial. Eur J Gastroenterol Hepatol. 2016;28:281–9.
    • (2016) Eur J Gastroenterol Hepatol , vol.28 , pp. 281-289
    • Ghoshal, U.C.1    Srivastava, D.2    Misra, A.3    Ghoshal, U.4
  • 54
    • 0033636668 scopus 로고    scopus 로고
    • Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome
    • COI: 1:STN:280:DC%2BD3M%2FpvFSmtA%3D%3D
    • Pimentel M, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol. 2000;95:3503–6.
    • (2000) Am J Gastroenterol , vol.95 , pp. 3503-3506
    • Pimentel, M.1    Chow, E.J.2    Lin, H.C.3
  • 55
    • 84945571052 scopus 로고    scopus 로고
    • Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial
    • Bohn L, Storsrud S, Liljebo T, Collin L, Lindfors P, Tornblom H, et al. Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial. Gastroenterology. 2015;149:1399–407.
    • (2015) Gastroenterology , vol.149 , pp. 1399-1407
    • Bohn, L.1    Storsrud, S.2    Liljebo, T.3    Collin, L.4    Lindfors, P.5    Tornblom, H.6    Simren, M.7
  • 56
    • 0027474771 scopus 로고
    • Protective action of oral N-acetylcysteine against gastric injury: role of hypertonic sodium
    • COI: 1:CAS:528:DyaK3sXktVSlurg%3D, PID: 8460697
    • Barreto JC, Smith GS, Tornwall MS, Miller TA. Protective action of oral N-acetylcysteine against gastric injury: role of hypertonic sodium. Am J Physiol. 1993;264:G422–6.
    • (1993) Am J Physiol , vol.264 , pp. G422-G426
    • Barreto, J.C.1    Smith, G.S.2    Tornwall, M.S.3    Miller, T.A.4
  • 58
    • 0342801753 scopus 로고
    • The effects of 5-hydroxytryptamine on gastric secretion in anaesthetized dogs
    • COI: 1:CAS:528:DyaG1cXhtVKltb0%3D
    • Black JW, Fisher EW, Smith AN. The effects of 5-hydroxytryptamine on gastric secretion in anaesthetized dogs. J Physiol. 1958;141:27–34.
    • (1958) J Physiol , vol.141 , pp. 27-34
    • Black, J.W.1    Fisher, E.W.2    Smith, A.N.3
  • 59
    • 0020670523 scopus 로고
    • The inhibitory effects of 5-hydroxytryptamine on gastric acid secretion by the rat isolated stomach
    • COI: 1:CAS:528:DyaL3sXhtVWkt7s%3D
    • Canfield SP, Spencer JE. The inhibitory effects of 5-hydroxytryptamine on gastric acid secretion by the rat isolated stomach. Br J Pharmacol. 1983;78:123–9.
    • (1983) Br J Pharmacol , vol.78 , pp. 123-129
    • Canfield, S.P.1    Spencer, J.E.2
  • 60
    • 84907188846 scopus 로고    scopus 로고
    • Differential expression of short-chain fatty acid receptor FFA2 and FFA3 in foregut
    • Kaji I, Akiba Y, Kaunitz JD, Karaki S, Kuwahara A. Differential expression of short-chain fatty acid receptor FFA2 and FFA3 in foregut. Gastroenterology. 2012;142:S494.
    • (2012) Gastroenterology , vol.142 , pp. S494
    • Kaji, I.1    Akiba, Y.2    Kaunitz, J.D.3    Karaki, S.4    Kuwahara, A.5
  • 62
    • 74549157189 scopus 로고    scopus 로고
    • Effects of serotonin on acid secretion in isolated rat stomach: the role of 5-HT3 receptors
    • COI: 1:CAS:528:DC%2BD1MXhs1ahs73L
    • Lai YC, Ho Y, Huang KH, Tsai LH. Effects of serotonin on acid secretion in isolated rat stomach: the role of 5-HT3 receptors. Chin J Physiol. 2009;52:395–405.
    • (2009) Chin J Physiol , vol.52 , pp. 395-405
    • Lai, Y.C.1    Ho, Y.2    Huang, K.H.3    Tsai, L.H.4
  • 63
    • 85055275806 scopus 로고    scopus 로고
    • The circadian clock regulates the diurnal levels of microbial short-chain fatty acids and their rhythmic effects on colon contractility in mice
    • This study reports diurnal fluctuation of fecal SCFAs synchronized with colonic myenteric neural FFA3 expression, suggesting that luminal SCFA production regulates SCFA receptor expression
    • • Segers A, Desmet L, Thijs T, Verbeke K, Tack J, Depoortere I. The circadian clock regulates the diurnal levels of microbial short-chain fatty acids and their rhythmic effects on colon contractility in mice. Acta Physiol (Oxf). 2018:e13193 This study reports diurnal fluctuation of fecal SCFAs synchronized with colonic myenteric neural FFA3 expression, suggesting that luminal SCFA production regulates SCFA receptor expression.
    • (2018) Acta Physiol (Oxf)
    • Segers, A.1    Desmet, L.2    Thijs, T.3    Verbeke, K.4    Tack, J.5    Depoortere, I.6
  • 64
    • 85041013509 scopus 로고    scopus 로고
    • Gut microbiota-derived short chain fatty acids induce circadian clock entrainment in mouse peripheral tissue
    • This study provides a new concept that oral SCFA treatment facilitates peripheral clock adjustment, suggesting that the microbiome and host organs are communicating with circadian rhythmicity
    • •• Tahara Y, Yamazaki M, Sukigara H, Motohashi H, Sasaki H, Miyakawa H, et al. Gut microbiota-derived short chain fatty acids induce circadian clock entrainment in mouse peripheral tissue. Sci Rep. 2018;8:1395 This study provides a new concept that oral SCFA treatment facilitates peripheral clock adjustment, suggesting that the microbiome and host organs are communicating with circadian rhythmicity.
    • (2018) Sci Rep , vol.8 , pp. 1395
    • Tahara, Y.1    Yamazaki, M.2    Sukigara, H.3    Motohashi, H.4    Sasaki, H.5    Miyakawa, H.6    Haraguchi, A.7    Ikeda, Y.8    Fukuda, S.9    Shibata, S.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.