Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection

Cell Reports

Volumn 28, Issue 1, 2019, Pages 245-256.e4

  Bradley, Konrad C ^a   Finsterbusch, Katja ^a   Schnepf, Daniel ^b,c   Crotta, Stefania ^a   Llorian, Miriam ^a   Davidson, Sophia ^a   Fuchs, Serge Y ^d   Staeheli, Peter ^b,e   Wack, Andreas ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

anti viral protection; antibiotics; gut; influenza; lung; microbiota; tonic IFN signaling; type I interferon (IFN)

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; INTERFERON; ANTIINFECTIVE AGENT; PTPRC PROTEIN, MOUSE; RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASE C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL RESISTANCE; ARTICLE; C57BL 6 MOUSE; CELL INTERACTION; CELL PROTECTION; CHIMERA; CONTROLLED STUDY; DRUG USE; FECAL MICROBIOTA TRANSPLANTATION; FEMALE; HEMATOPOIETIC CELL; INFECTION PREVENTION; INFLUENZA; LUNG PARENCHYMA; MICROBIAL INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION LEVEL; STEADY STATE; STROMA CELL; VIRUS IMMUNITY; VIRUS REPLICATION; WILD TYPE; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL LINE; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOLOGY; INFLUENZA A VIRUS; KNOCKOUT MOUSE; LUNG; METABOLISM; MICROBIOLOGY; MICROFLORA; PATHOLOGY; VIROLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; BONE MARROW CELLS; CELL LINE; CHIMERA; EPITHELIAL CELLS; FECAL MICROBIOTA TRANSPLANTATION; GENE EXPRESSION REGULATION, VIRAL; HEMATOPOIETIC STEM CELLS; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; INTERFERON TYPE I; LEUKOCYTE COMMON ANTIGENS; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROBIOTA; RECEPTOR, INTERFERON ALPHA-BETA; RNA-SEQ; STROMAL CELLS;

EID: 85067889389     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2019.05.105     Document Type: Article

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