Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 6, 2016, Pages E762-E771

  Oh, Ji Eun ^a   Kim, Byoung Chan ^b   Chang, Dong Ho ^b   Kwon, Meehyang ^c   Lee, Sun Young ^c   Kang, Dukjin ^c   Kim, Jin Young ^d   Hwang, Inhwa ^e   Yu, Je Wook ^e   Nakae, Susumu ^f,g   Lee, Heung Kyu ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Korea Research Institute of Standards and Science   (South Korea)

^d Korea Basic Science Institute (KBSI)   (South Korea)

^e Yonsei University College of Medicine   (South Korea)

^f UNIVERSITY OF TOKYO   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Commensal microbiota; Dysbiosis; Genital tract; Herpes simplex virus type 2; IL 33

Indexed keywords

ALARMIN; ANTIBIOTIC AGENT; INTERFERON; INTERLEUKIN 33; ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; GAMMA INTERFERON; PEPTIDE HYDROLASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MIGRATION; COMMENSAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DYSBIOSIS; EFFECTOR CELL; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; INNATE IMMUNITY; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE INJURY; VAGINA EPITHELIUM; VAGINA FLORA; VAGINA MUCOSA; VIRAL CLEARANCE; VIRUS IMMUNITY; ANIMAL; BACTERIAL COUNT; BIOSYNTHESIS; C57BL MOUSE; COMPLICATION; DRUG EFFECTS; EOSINOPHIL; GENITAL HERPES; IMMUNOLOGY; METABOLISM; MICROFLORA; MUCOSA; PATHOLOGY; T LYMPHOCYTE; VAGINA; VIROLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIVIRAL AGENTS; COLONY COUNT, MICROBIAL; DYSBIOSIS; EOSINOPHILS; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; IMMUNITY, INNATE; INTERFERON-GAMMA; INTERLEUKIN-33; MICE, INBRED C57BL; MICROBIOTA; MUCOUS MEMBRANE; PEPTIDE HYDROLASES; T-LYMPHOCYTES; VAGINA;

EID: 84957831444     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1518589113     Document Type: Article

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