Global increase and geographic convergence in antibiotic consumption between 2000 and 2015

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 15, 2018, Pages E3463-E3470

  Klein, Eili Y ^a,b,c   Van Boeckel, Thomas P ^d   Martinez, Elena M ^a   Pant, Suraj ^a   Gandra, Sumanth ^a   Levin, Simon A ^e,f   Goossens, Herman ^g   Laxminarayan, Ramanan ^a,e,h  

^a Centre for Disease Dynamics Economics and Policy   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d ETH ZURICH   (Switzerland)

^e PRINCETON UNIVERSITY   (United States)

^f Beijer Institute of Ecological Economics   (Sweden)

^g UNIVERSITY OF ANTWERP   (Belgium)

^h UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Antibiotic stewardship; Antibiotics; Antimicrobial resistance; Defined daily doses; Low income countries

Indexed keywords

ANTIBIOTIC AGENT; CARBAPENEM DERIVATIVE; GLYCYLCYCLINE DERIVATIVE; OXAZOLIDINONE DERIVATIVE; POLYMYXIN DERIVATIVE; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DRUG USE; GEOGRAPHIC DISTRIBUTION; GROSS NATIONAL PRODUCT; HIGH INCOME COUNTRY; HUMAN; LOW INCOME COUNTRY; MIDDLE INCOME COUNTRY; PRESCRIPTION; PRIORITY JOURNAL; DRUG EFFECT; ECONOMICS; HEALTH CARE DELIVERY; SUPPLY AND DISTRIBUTION;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; DRUG RESISTANCE, MICROBIAL; ECONOMICS; HEALTH SERVICES ACCESSIBILITY; HUMANS;

EID: 85045108137     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1717295115     Document Type: Article

References (47)

1. Laxminarayan R, et al. (2016) Access to effective antimicrobials: A worldwide challenge. Lancet 387:168-175.
2. Laxminarayan R, et al. (2013) Antibiotic resistance: The need for global solutions. Lancet Infect Dis 13:1057-1098.
3. Lim C, et al. (2016) Epidemiology and burden of multidrug-resistant bacterial infection in a developing country. Elife 5:e18082.
4. Malhotra-Kumar S, Lammens C, Coenen S, Van Herck K, Goossens H (2007) Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: A randomised, double-blind, placebo-controlled study. Lancet 369:482-490.
5. Fridkin SK, et al.; Intensive Care Antimicrobial Resistance Epidemiology (ICARE) Project and the National Nosocomial Infections Surveillance (NNIS) System Hospitals (2001) The effect of vancomycin and third-generation cephalosporins on prevalence of vancomycin-resistant enterococci in 126 U.S. adult intensive care units. Ann Intern Med 135:175-183.
6. Daneman N, et al. (2015) Variability in antibiotic use across nursing homes and the risk of antibiotic-related adverse outcomes for individual residents. JAMA Intern Med 175: 1331-1339.
7. Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD (2010) Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: Systematic review and meta-analysis. BMJ 340:c2096.
8. Steinke D, Davey P (2001) Association between antibiotic resistance and community prescribing: A critical review of bias and confounding in published studies. Clin Infect Dis 33(Suppl 3):S193-S205.
9. Goossens H, Ferech M, Vander Stichele R, Elseviers M; ESAC Project Group (2005) Outpatient antibiotic use in Europe and association with resistance: A cross-national database study. Lancet 365:579-587.
10. United Nations (2016) Draft political declaration of the high-level meeting of the General Assembly on antimicrobial resistance. Available at https://www.un.org/pga/71/wp-content/uploads/sites/40/2016/09/DGACM_GAEAD_ESCAB-AMR-Draft-Politi-cal-Declaration-1616108E.pdf. Accessed June 27, 2017.
11. World Health Organization (2015) Global action plan on antimicrobial resistance. Available at www.who.int/antimicrobial-resistance/publications/global-action-plan/en/. Accessed May 31, 2017.
12. World Health Organization (2013) Integrated surveillance of antimicrobial resistance. Available at apps.who.int/iris/bitstream/10665/91778/1/9789241506311_eng.pdf. Accessed September 13, 2016.
13. Collineau L, et al. (2017) Guidance on the selection of appropriate indicators for quantification of antimicrobial usage in humans and animals. Zoonoses Public Health 64:165-184.
14. Versporten A, et al.; WHO/Europe-ESAC Project Group (2014) Antibiotic use in Eastern Europe: A cross-national database study in coordination with the WHO Regional Office for Europe. Lancet Infect Dis 14:381-387.
15. Van Boeckel TP, et al. (2014) Global antibiotic consumption 2000 to 2010: An analysis of national pharmaceutical sales data. Lancet Infect Dis 14:742-750.
16. Högberg LD, Muller A, Zorzet A, Monnet DL, Cars O (2014) Antibiotic use worldwide. Lancet Infect Dis 14:1179-1180.
17. Col NF, O'Connor RW (1987) Estimating worldwide current antibiotic usage: Report of Task Force 1. Rev Infect Dis 9(Suppl 3):S232-S243.
18. World Bank (2017) World DataBank: World Development Indicators. Available at databank.worldbank.org/data/reports.aspx?source=world-development-indicators. Accessed May 31, 2017.
19. Drukker DM, et al. (2003) Testing for serial correlation in linear panel-data models. Stata J 3:168-177.
20. Sabuncu E, et al. (2009) Significant reduction of antibiotic use in the community after a nationwide campaign in France, 2002-2007. PLoS Med 6:e1000084.
21. Institut de veille sanitaire (InVS) et Agence nationale de sécurité du médicament et des produits de santé (ANSM) (2015) Consommation d'antibiotiques et résistance aux antibiotiques en France: Nécessité d'une mobilisation déterminée et durable. Bilan des Données de Surveillance. [Antibiotic consumption and antibiotic resistance in France: The need for a determined and sustainable mobilization. Review of Surveillance Data] (Institut de veille sanitaire, Saint-Maurice, France), pp 1-16. French.
22. Shekarchian S, Schwartz BS, Teherani A, Irby D, Chin-Hong PV (2016) Is it time for a coordinated and longitudinal approach to antibiotic stewardship education? Clin Infect Dis 63:848-849.
23. Alirol E, Getaz L, Stoll B, Chappuis F, Loutan L (2011) Urbanisation and infectious diseases in a globalised world. Lancet Infect Dis 11:131-141.
24. Steele AD, Hay Burgess DC, Diaz Z, Carey ME, Zaidi AKM (2016) Challenges and opportunities for typhoid fever control: A call for coordinated action. Clin Infect Dis 62(Suppl 1):S4-S8.
25. Gubler DJ (2011) Dengue, urbanization and globalization: The unholy trinity of the 21(st) century. Trop Med Health 39(Suppl):3-11.
26. Weaver SC (2013) Urbanization and geographic expansion of zoonotic arboviral diseases: Mechanisms and potential strategies for prevention. Trends Microbiol 21: 360-363.
27. Neiderud C-J (2015) How urbanization affects the epidemiology of emerging infectious diseases. Infect Ecol Epidemiol 5:27060.
28. Brugha R, Grigg J (2014) Urban air pollution and respiratory infections. Paediatr Respir Rev 15:194-199.
29. Blommaert A, et al. (2014) Determinants of between-country differences in ambulatory antibiotic use and antibiotic resistance in Europe: A longitudinal observational study. J Antimicrob Chemother 69:535-547.
30. Paterson DL, Bonomo RA (2005) Extended-spectrum β-lactamases: A clinical update. Clin Microbiol Rev 18:657-686.
31. Kotwani A, Holloway K (2014) Antibiotic prescribing practice for acute, uncomplicated respiratory tract infections in primary care settings in New Delhi, India. Trop Med Int Health 19:761-768.
32. Gandra S, et al. (2016) Trends in antibiotic resistance among major bacterial pathogens isolated from blood cultures tested at a large private laboratory network in India, 2008-2014. Int J Infect Dis 50:75-82.
33. Capoor MR, Nair D (2010) Quinolone and cephalosporin resistance in enteric fever. J Glob Infect Dis 2:258-262.
34. Johnson AP, Woodford N (2013) Global spread of antibiotic resistance: The example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance. J Med Microbiol 62:499-513.
35. Liu Y-Y, et al. (2016) Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study. Lancet Infect Dis 16:161-168.
36. Food and Drug Administration (2013) FDA Drug Safety Communication: FDA warns of increased risk of death with IV antibacterial Tygacil (tigecycline) and approves new boxed warning. Available at https://www.fda.gov/drugs/drugsafety/ucm369580.htm. Accessed September 8, 2017.
37. Senior K (2007) FDA issue linezolid warning. Lancet Infect Dis 7:310.
38. Laxminarayan R (2014) Antibiotic effectiveness: Balancing conservation against innovation. Science 345:1299-1301.
39. Laxminarayan RP, Malani AP, Howard DP, Smith DLP (2007) Extending the Cure: Policy Responses to the Growing Threat of Antibiotic Resistance (Resources for the Future, Washington, DC).
40. Nandi A, Megiddo I, Ashok A, Verma A, Laxminarayan R (2017) Reduced burden of childhood diarrheal diseases through increased access to water and sanitation in India: A modeling analysis. Soc Sci Med 180:181-192.
41. Lawes T, et al. (2015) Effects of national antibiotic stewardship and infection control strategies on hospital-associated and community-associated meticillin-resistant Staphylococcus aureus infections across a region of Scotland: A non-linear time-series study. Lancet Infect Dis 15:1438-1449.
42. Do NTT, et al. (2016) Point-of-care C-reactive protein testing to reduce inappropriate use of antibiotics for non-severe acute respiratory infections in Vietnamese primary health care: A randomised controlled trial. Lancet Glob Health 4:e633-e641.
43. Lee GC, et al. (2014) Outpatient antibiotic prescribing in the United States: 2000 to 2010. BMC Med 12:96.
44. Poehling KA, et al. (2004) Population-based impact of pneumococcal conjugate vaccine in young children. Pediatrics 114:755-761.
45. Bruyndonckx R, et al. (2014) Measuring trends of outpatient antibiotic use in Europe: Jointly modelling longitudinal data in defined daily doses and packages. J Antimicrob Chemother 69:1981-1986.
46. Laxminarayan R, et al. (2016) UN high-level meeting on antimicrobials: What do we need? Lancet 388:218-220.
47. Lenton TM, et al. (2008) Tipping elements in the Earth's climate system. Proc Natl Acad Sci USA 105:1786-1793.