메뉴 건너뛰기




Volumn 35, Issue , 2019, Pages 57-62

Nucleoside analogues for the treatment of coronavirus infections

Author keywords

[No Author keywords available]

Indexed keywords

ACYCLOVIR FLEXIMER; ALPHA2A INTERFERON; ALPHA2B INTERFERON; AZAURIDINE; BETA DEXTRO N4 HYDROXYCYTIDINE; BETA1A INTERFERON; FLUOROURACIL; GALIDESIVIR; GEMCITABINE; INTERFERON BETA SERINE; LOPINAVIR PLUS RITONAVIR; MIZORIBINE; NUCLEOSIDE ANALOG; NUCLEOTIDE DERIVATIVE; PLACEBO; REMDESIVIR; RIBAVIRIN; UNCLASSIFIED DRUG; VIRUS RNA; 5'-EXORIBONUCLEASE; ANTIVIRUS AGENT; EXORIBONUCLEASE; NUCLEOSIDE;

EID: 85065835030     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2019.04.002     Document Type: Review
Times cited : (154)

References (51)
  • 2
    • 85065848031 scopus 로고    scopus 로고
    • Revised U.S. Surveillance Case Definition for Severe Acute Respiratory Syndrome (SARS) and Update on SARS Cases — United States and Worldwide, December 2003. [date unknown].
    • Revised U.S. Surveillance Case Definition for Severe Acute Respiratory Syndrome (SARS) and Update on SARS Cases — United States and Worldwide, December 2003. [date unknown].
  • 3
    • 85065833572 scopus 로고    scopus 로고
    • WHO | Middle East respiratory syndrome coronavirus (MERS-CoV). WHO [date unknown.
    • WHO | Middle East respiratory syndrome coronavirus (MERS-CoV). WHO [date unknown.
  • 5
    • 85048464689 scopus 로고    scopus 로고
    • Discovery of novel bat coronaviruses in South China that use the same receptor as middle east respiratory syndrome coronavirus
    • Luo, C.-M., Wang, N., Yang, X.-L., Liu, H.-Z., Zhang, W., Li, B., Hu, B., Peng, C., Geng, Q.-B., Zhu, G.-J., et al. Discovery of novel bat coronaviruses in South China that use the same receptor as middle east respiratory syndrome coronavirus. J Virol, 92, 2018.
    • (2018) J Virol , vol.92
    • Luo, C.-M.1    Wang, N.2    Yang, X.-L.3    Liu, H.-Z.4    Zhang, W.5    Li, B.6    Hu, B.7    Peng, C.8    Geng, Q.-B.9    Zhu, G.-J.10
  • 6
    • 85050779327 scopus 로고    scopus 로고
    • Middle east respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells
    • Chu, H., Chan, C.-M., Zhang, X., Wang, Y., Yuan, S., Zhou, J., Au-Yeung, R.K.-H., Sze, K.-H., Yang, D., Shuai, H., et al. Middle east respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells. J Biol Chem 293 (2018), 11709–11726.
    • (2018) J Biol Chem , vol.293 , pp. 11709-11726
    • Chu, H.1    Chan, C.-M.2    Zhang, X.3    Wang, Y.4    Yuan, S.5    Zhou, J.6    Au-Yeung, R.K.-H.7    Sze, K.-H.8    Yang, D.9    Shuai, H.10
  • 7
    • 84977669592 scopus 로고    scopus 로고
    • A roadmap for MERS-CoV research and product development: report from a world health organization consultation
    • Modjarrad, K., Moorthy, V.S., Ben Embarek, P., Van Kerkhove, M., Kim, J., Kieny, M.-P., A roadmap for MERS-CoV research and product development: report from a world health organization consultation. Nat Med 22 (2016), 701–705.
    • (2016) Nat Med , vol.22 , pp. 701-705
    • Modjarrad, K.1    Moorthy, V.S.2    Ben Embarek, P.3    Van Kerkhove, M.4    Kim, J.5    Kieny, M.-P.6
  • 9
    • 85054087266 scopus 로고    scopus 로고
    • The WHO R&D blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts
    • Mehand, M.S., Al-Shorbaji, F., Millett, P., Murgue, B., The WHO R&D blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts. Antiviral Res, 2018, 63–67.
    • (2018) Antiviral Res , pp. 63-67
    • Mehand, M.S.1    Al-Shorbaji, F.2    Millett, P.3    Murgue, B.4
  • 10
    • 84958086068 scopus 로고    scopus 로고
    • Antiviral strategies based on lethal mutagenesis and error threshold
    • Perales, C., Domingo, E., Antiviral strategies based on lethal mutagenesis and error threshold. Curr Top Microbiol Immunol 392 (2016), 323–339.
    • (2016) Curr Top Microbiol Immunol , vol.392 , pp. 323-339
    • Perales, C.1    Domingo, E.2
  • 11
    • 36048969246 scopus 로고    scopus 로고
    • High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants
    • Eckerle, L.D., Lu, X., Sperry, S.M., Choi, L., Denison, M.R., High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants. J Virol 81 (2007), 12135–12144.
    • (2007) J Virol , vol.81 , pp. 12135-12144
    • Eckerle, L.D.1    Lu, X.2    Sperry, S.M.3    Choi, L.4    Denison, M.R.5
  • 12
    • 84883438898 scopus 로고    scopus 로고
    • Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics
    • Smith, E.C., Blanc, H., Vignuzzi, M., Denison, M.R., Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics. PLoS Pathog, 9, 2013, e1003565.
    • (2013) PLoS Pathog , vol.9
    • Smith, E.C.1    Blanc, H.2    Vignuzzi, M.3    Denison, M.R.4
  • 14
    • 84961670054 scopus 로고    scopus 로고
    • Theories of lethal mutagenesis: from error catastrophe to lethal defection
    • E. Domingo P. Schuster Springer International Publishing
    • Tejero, H., Montero, F., Nuño, J.C., Theories of lethal mutagenesis: from error catastrophe to lethal defection. Domingo, E., Schuster, P., (eds.) Quasispecies: From Theory to Experimental Systems, 2016, Springer International Publishing, 161–179.
    • (2016) Quasispecies: From Theory to Experimental Systems , pp. 161-179
    • Tejero, H.1    Montero, F.2    Nuño, J.C.3
  • 15
    • 34247510980 scopus 로고    scopus 로고
    • Mechanism of action of ribavirin in the treatment of chronic hepatitis C
    • Te, H.S., Randall, G., Jensen, D.M., Mechanism of action of ribavirin in the treatment of chronic hepatitis C. Gastroenterol Hepatol 3 (2007), 218–225.
    • (2007) Gastroenterol Hepatol , vol.3 , pp. 218-225
    • Te, H.S.1    Randall, G.2    Jensen, D.M.3
  • 16
    • 85051395653 scopus 로고    scopus 로고
    • Nucleosides for the treatment of respiratory RNA virus infections
    • Jordan, P.C., Stevens, S.K., Deval, J., Nucleosides for the treatment of respiratory RNA virus infections. Antivir Chem Chemother, 26, 2018, 2040206618764483.
    • (2018) Antivir Chem Chemother , vol.26
    • Jordan, P.C.1    Stevens, S.K.2    Deval, J.3
  • 17
    • 85021671152 scopus 로고    scopus 로고
    • Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
    • Although nucleoside analogs have been shown effective against many RNA viruses, many do not potently inhibit CoVs. This study demonstrates potent activity of nucleoside analogue GS-5734 against a diverse spectrum of human and zoonotic CoV in human airway epithelial cultures and in mouse models of SARS-CoV and MERS-CoV disease. This is the first study to demonstrate activity of GS-5734 against CoVs.
    • Sheahan, T.P., Sims, A.C., Graham, R.L., Menachery, V.D., Gralinski, L.E., Case, J.B., Leist, S.R., Pyrc, K., Feng, J.Y., Trantcheva, I., et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med, 9, 2017, eaal3653 Although nucleoside analogs have been shown effective against many RNA viruses, many do not potently inhibit CoVs. This study demonstrates potent activity of nucleoside analogue GS-5734 against a diverse spectrum of human and zoonotic CoV in human airway epithelial cultures and in mouse models of SARS-CoV and MERS-CoV disease. This is the first study to demonstrate activity of GS-5734 against CoVs.
    • (2017) Sci Transl Med , vol.9
    • Sheahan, T.P.1    Sims, A.C.2    Graham, R.L.3    Menachery, V.D.4    Gralinski, L.E.5    Case, J.B.6    Leist, S.R.7    Pyrc, K.8    Feng, J.Y.9    Trantcheva, I.10
  • 18
    • 19344370471 scopus 로고    scopus 로고
    • Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus
    • Saijo, M., Morikawa, S., Fukushi, S., Mizutani, T., Hasegawa, H., Nagata, N., Iwata, N., Kurane, I., Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus. Antiviral Res 66 (2005), 159–163.
    • (2005) Antiviral Res , vol.66 , pp. 159-163
    • Saijo, M.1    Morikawa, S.2    Fukushi, S.3    Mizutani, T.4    Hasegawa, H.5    Nagata, N.6    Iwata, N.7    Kurane, I.8
  • 19
    • 23944462641 scopus 로고    scopus 로고
    • Mechanism of action of interferon and ribavirin in treatment of hepatitis C
    • Feld, J.J., Hoofnagle, J.H., Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature 436 (2005), 967–972.
    • (2005) Nature , vol.436 , pp. 967-972
    • Feld, J.J.1    Hoofnagle, J.H.2
  • 20
    • 0035208293 scopus 로고    scopus 로고
    • The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase
    • Cameron, C.E., Castro, C., The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase. Curr Opin Infect Dis 14 (2001), 757–764.
    • (2001) Curr Opin Infect Dis , vol.14 , pp. 757-764
    • Cameron, C.E.1    Castro, C.2
  • 24
    • 84952764541 scopus 로고    scopus 로고
    • Oral Ribavirin for the treatment of noninfluenza respiratory viral infections: a systematic review
    • Gross, A.E., Bryson, M.L., Oral Ribavirin for the treatment of noninfluenza respiratory viral infections: a systematic review. Ann Pharmacother 49 (2015), 1125–1135.
    • (2015) Ann Pharmacother , vol.49 , pp. 1125-1135
    • Gross, A.E.1    Bryson, M.L.2
  • 26
    • 84879840922 scopus 로고    scopus 로고
    • Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin
    • Falzarano, D., de Wit, E., Martellaro, C., Callison, J., Munster, V.J., Feldmann, H., Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin. Sci Rep, 3, 2013, 1686.
    • (2013) Sci Rep , vol.3
    • Falzarano, D.1    de Wit, E.2    Martellaro, C.3    Callison, J.4    Munster, V.J.5    Feldmann, H.6
  • 27
    • 84896695450 scopus 로고    scopus 로고
    • Ribavirin and interferon therapy in patients infected with the middle east respiratory syndrome coronavirus: an observational study
    • Al-Tawfiq, J.A., Momattin, H., Dib, J., Memish, Z.A., Ribavirin and interferon therapy in patients infected with the middle east respiratory syndrome coronavirus: an observational study. Int J Infect Dis 20 (2014), 42–46.
    • (2014) Int J Infect Dis , vol.20 , pp. 42-46
    • Al-Tawfiq, J.A.1    Momattin, H.2    Dib, J.3    Memish, Z.A.4
  • 29
    • 84936931504 scopus 로고    scopus 로고
    • IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study
    • Shalhoub, S., Farahat, F., Al-Jiffri, A., Simhairi, R., Shamma, O., Siddiqi, N., Mushtaq, A., IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study. J Antimicrob Chemother 70 (2015), 2129–2132.
    • (2015) J Antimicrob Chemother , vol.70 , pp. 2129-2132
    • Shalhoub, S.1    Farahat, F.2    Al-Jiffri, A.3    Simhairi, R.4    Shamma, O.5    Siddiqi, N.6    Mushtaq, A.7
  • 32
    • 85046493350 scopus 로고    scopus 로고
    • Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease
    • Low level resistance against the potent, broad-spectrum anti-CoV nucleoside analog GS-5734 (remdesivir) was selected by serial passage and is associated with two mutations in the viral RdRP. Remdesivir resistance decreased fitness of MHV and attenuated pathogenesis of SARS-CoV in a mouse model of SARS-CoV disease, supporting further development of remdesivir as a pan-CoV antiviral and raising important questions about the mechanism by which remdesivir overcomes CoV nsp14-ExoN activity.
    • Agostini, M.L., Andres, E.L., Sims, A.C., Graham, R.L., Sheahan, T.P., Lu, X., Smith, E.C., Case, J.B., Feng, J.Y., Jordan, R., et al. Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease. mBio, 9, 2018, e00221-18 Low level resistance against the potent, broad-spectrum anti-CoV nucleoside analog GS-5734 (remdesivir) was selected by serial passage and is associated with two mutations in the viral RdRP. Remdesivir resistance decreased fitness of MHV and attenuated pathogenesis of SARS-CoV in a mouse model of SARS-CoV disease, supporting further development of remdesivir as a pan-CoV antiviral and raising important questions about the mechanism by which remdesivir overcomes CoV nsp14-ExoN activity.
    • (2018) mBio , vol.9
    • Agostini, M.L.1    Andres, E.L.2    Sims, A.C.3    Graham, R.L.4    Sheahan, T.P.5    Lu, X.6    Smith, E.C.7    Case, J.B.8    Feng, J.Y.9    Jordan, R.10
  • 35
    • 85052024066 scopus 로고    scopus 로고
    • Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses
    • This study identifies the modified cytidine ribonucleoside analogue β-D-N4-hydroxycytidine as a potent broad-spectrum inhibitor of respiratory viruses including respiratory syncytial virus, influenza B virus, and influenza A viruses of human, avian, and swine origins and has a high resistance barrier. This compound also is a candidate for the treatment of CoV infection.
    • Yoon, J.-J., Toots, M., Lee, S., Lee, M.-E., Ludeke, B., Luczo, J.M., Ganti, K., Cox, R.M., Sticher, Z.M., Edpuganti, V., et al. Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses. Antimicrob Agents Chemother, 62, 2018, e00766-18 This study identifies the modified cytidine ribonucleoside analogue β-D-N4-hydroxycytidine as a potent broad-spectrum inhibitor of respiratory viruses including respiratory syncytial virus, influenza B virus, and influenza A viruses of human, avian, and swine origins and has a high resistance barrier. This compound also is a candidate for the treatment of CoV infection.
    • (2018) Antimicrob Agents Chemother , vol.62
    • Yoon, J.-J.1    Toots, M.2    Lee, S.3    Lee, M.-E.4    Ludeke, B.5    Luczo, J.M.6    Ganti, K.7    Cox, R.M.8    Sticher, Z.M.9    Edpuganti, V.10
  • 38
    • 2542501662 scopus 로고    scopus 로고
    • Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine
    • Barnard, D.L., Hubbard, V.D., Burton, J., Smee, D.F., Morrey, J.D., Otto, M.J., Sidwell, R.W., Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine. Antivir Chem Chemother 15 (2004), 15–22.
    • (2004) Antivir Chem Chemother , vol.15 , pp. 15-22
    • Barnard, D.L.1    Hubbard, V.D.2    Burton, J.3    Smee, D.F.4    Morrey, J.D.5    Otto, M.J.6    Sidwell, R.W.7
  • 43
    • 85031099670 scopus 로고    scopus 로고
    • Escape of tick-borne flavivirus from 2′-C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness
    • This study demonstrates that the nucleoside analog 7-deaza-2′-C-methyladenosine (7-deaza-2′-CMA) demonstrates potent antiviral activity against tick-borne encephalitis virus. Resistance generated by serial passaging in the presence of 7-deaza-2′-CMA was associated with a single mutation in the polymerase and resulted in resistance against a broad spectrum of derivative compounds. This finding highlights the importance combination therapy to reduce the emergence of resistant virus.
    • Eyer, L., Kondo, H., Zouharova, D., Hirano, M., Valdés, J.J., Muto, M., Kastl, T., Kobayashi, S., Haviernik, J., Igarashi, M., et al. Escape of tick-borne flavivirus from 2′-C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness. J Virol 91, 2017, e01028-17 This study demonstrates that the nucleoside analog 7-deaza-2′-C-methyladenosine (7-deaza-2′-CMA) demonstrates potent antiviral activity against tick-borne encephalitis virus. Resistance generated by serial passaging in the presence of 7-deaza-2′-CMA was associated with a single mutation in the polymerase and resulted in resistance against a broad spectrum of derivative compounds. This finding highlights the importance combination therapy to reduce the emergence of resistant virus.
    • (2017) J Virol 91 , pp. e01028-17
    • Eyer, L.1    Kondo, H.2    Zouharova, D.3    Hirano, M.4    Valdés, J.J.5    Muto, M.6    Kastl, T.7    Kobayashi, S.8    Haviernik, J.9    Igarashi, M.10
  • 44
    • 85051078738 scopus 로고    scopus 로고
    • Prevalence of rilpivirine and etravirine resistance mutations in HIV-1 subtype C-infected patients failing nevirapine or efavirenz-based combination antiretroviral therapy in botswana
    • Diphoko, T., Gaseitsiwe, S., Kasvosve, I., Moyo, S., Okatch, H., Musonda, R., Wainberg, M., Makhema, J., Marlink, R., Novitsky, V., et al. Prevalence of rilpivirine and etravirine resistance mutations in HIV-1 subtype C-infected patients failing nevirapine or efavirenz-based combination antiretroviral therapy in botswana. AIDS Res Hum Retroviruses 34 (2018), 667–671.
    • (2018) AIDS Res Hum Retroviruses , vol.34 , pp. 667-671
    • Diphoko, T.1    Gaseitsiwe, S.2    Kasvosve, I.3    Moyo, S.4    Okatch, H.5    Musonda, R.6    Wainberg, M.7    Makhema, J.8    Marlink, R.9    Novitsky, V.10
  • 45
    • 85015723244 scopus 로고    scopus 로고
    • Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors
    • Valdés, J.J., Butterill, P.T., Růžek, D., Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors. Biochem Biophys Res Commun 492 (2017), 652–658.
    • (2017) Biochem Biophys Res Commun , vol.492 , pp. 652-658
    • Valdés, J.J.1    Butterill, P.T.2    Růžek, D.3
  • 47
    • 85058875739 scopus 로고    scopus 로고
    • Development of small-molecule MERS-CoV inhibitors
    • Comprehensive review of small-molecule inhibitors targeting viral proteins at different stages of the MERS-CoV viral replication cycle. Illustrates chemical structure formulas of inhibitors and summarizes potency, cytotoxicity, and testing model of each inhibitor in a table.
    • Liang, R., Wang, L., Zhang, N., Deng, X., Su, M., Su, Y., Hu, L., He, C., Ying, T., Jiang, S., et al. Development of small-molecule MERS-CoV inhibitors. Viruses, 10, 2018, 721 Comprehensive review of small-molecule inhibitors targeting viral proteins at different stages of the MERS-CoV viral replication cycle. Illustrates chemical structure formulas of inhibitors and summarizes potency, cytotoxicity, and testing model of each inhibitor in a table.
    • (2018) Viruses , vol.10 , pp. 721
    • Liang, R.1    Wang, L.2    Zhang, N.3    Deng, X.4    Su, M.5    Su, Y.6    Hu, L.7    He, C.8    Ying, T.9    Jiang, S.10
  • 48
    • 84986552439 scopus 로고    scopus 로고
    • Identification of inhibitors for the DEDDh family of exonucleases and a unique inhibition mechanism by Crystal structure analysis of CRN-4 bound with 2-Morpholin-4-ylethanesulfonate (MES)
    • Huang, K.-W., Hsu, K.-C., Chu, L.-Y., Yang, J.-M., Yuan, H.S., Hsiao, Y.-Y., Identification of inhibitors for the DEDDh family of exonucleases and a unique inhibition mechanism by Crystal structure analysis of CRN-4 bound with 2-Morpholin-4-ylethanesulfonate (MES). J Med Chem 59 (2016), 8019–8029.
    • (2016) J Med Chem , vol.59 , pp. 8019-8029
    • Huang, K.-W.1    Hsu, K.-C.2    Chu, L.-Y.3    Yang, J.-M.4    Yuan, H.S.5    Hsiao, Y.-Y.6
  • 49
    • 84917707365 scopus 로고    scopus 로고
    • Molecular pathology of emerging coronavirus infections
    • Gralinski, L.E., Baric, R.S., Molecular pathology of emerging coronavirus infections. J Pathol 235 (2015), 185–195.
    • (2015) J Pathol , vol.235 , pp. 185-195
    • Gralinski, L.E.1    Baric, R.S.2
  • 50
    • 85041331786 scopus 로고    scopus 로고
    • Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial
    • Arabi, Y.M., Alothman, A., Balkhy, H.H., Al-Dawood, A., AlJohani, S., Al Harbi, S., Kojan, S., Al Jeraisy, M., Deeb, A.M., Assiri, A.M., et al. Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial. Trials, 19, 2018, 81.
    • (2018) Trials , vol.19 , pp. 81
    • Arabi, Y.M.1    Alothman, A.2    Balkhy, H.H.3    Al-Dawood, A.4    AlJohani, S.5    Al Harbi, S.6    Kojan, S.7    Al Jeraisy, M.8    Deeb, A.M.9    Assiri, A.M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.