Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China

The Lancet

Volumn 393, Issue 10183, 2019, Pages 1831-1842

  Millwood, Iona Y ^a   Walters, Robin G ^a   Mei, Xue W ^a   Guo, Yu ^b   Yang, Ling ^a   Bian, Zheng ^b   Bennett, Derrick A ^a   Chen, Yiping ^a   Dong, Caixia ^c   Hu, Ruying ^d   Zhou, Gang ^e   Yu, Bo ^f   Jia, Weifang ^g   Parish, Sarah ^a   Clarke, Robert ^a   Davey Smith, George ^h   Collins, Rory ^a   Holmes, Michael V ^a   Li, Liming ⁱ   Peto, Richard ^a   Chen, Zhengming ^a   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c GANSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^d ZHEJIANG PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^e CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^f Chinese Center of Disease Control and Prevention   (China)

^g Disease Control and Prevention Center   (China)

^h UNIVERSITY OF BRISTOL   (United Kingdom)

ⁱ PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; ALDEHYDE DEHYDROGENASE ISOENZYME 1B; ALDEHYDE DEHYDROGENASE ISOENZYME 2; UNCLASSIFIED DRUG; ADH1B PROTEIN, HUMAN; ALCOHOL DEHYDROGENASE; ALDH2 PROTEIN, HUMAN;

ADH1B GENE; ADULT; ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ALDH2 GENE; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHINA; CONTROLLED STUDY; DISEASE ASSOCIATION; DRINKING BEHAVIOR; ELECTRONIC MEDICAL RECORD; FEMALE; GENETIC ASSOCIATION; GENETIC EPIDEMIOLOGY; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MORBIDITY; MORTALITY; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SELF REPORT; SEX DIFFERENCE; VASCULAR DISEASE; AGED; BLOOD PRESSURE; CEREBROVASCULAR ACCIDENT; FAR EAST; GENETICS; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGED; ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CEREBRAL HEMORRHAGE; CHINA; FAR EAST; FEMALE; GENOTYPE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PROSPECTIVE STUDIES; STROKE;

EID: 85064901783     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(18)31772-0     Document Type: Article

References (29)

1. Zaridze, D, Lewington, S, Boroda, A, et al. Alcohol and mortality in Russia: prospective observational study of 151 000 adults. Lancet 383 (2014), 1465–1473.
2. Ronksley, PE, Brien, SE, Turner, BJ, Mukamal, KJ, Ghali, WA, Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ, 342, 2011, d671.
3. Roerecke, M, Rehm, J, The cardioprotective association of average alcohol consumption and ischaemic heart disease: a systematic review and meta-analysis. Addiction 107 (2012), 1246–1260.
4. Larsson, SC, Wallin, A, Wolk, A, Markus, HS, Differing association of alcohol consumption with different stroke types: a systematic review and meta-analysis. BMC Med, 14, 2016, 178.
5. Bell, S, Daskalopoulou, M, Rapsomaniki, E, et al. Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records. BMJ, 356, 2017, j909.
6. Wood, AM, Kaptoge, S, Butterworth, AS, et al. Risk thresholds for alcohol consumption: combined analysis of individual participant data for 599 912 current drinkers in 83 prospective studies. Lancet 391 (2018), 1513–1523.
7. Emberson, JR, Bennett, DA, Effect of alcohol on risk of coronary heart disease and stroke: causality, bias, or a bit of both?. Vasc Health Risk Manag 2 (2006), 239–249.
8. Zhao, J, Stockwell, T, Roemer, A, Naimi, T, Chikritzhs, T, Alcohol consumption and mortality from coronary heart disease: an updated meta-analysis of cohort studies. J Stud Alcohol Drugs 78 (2017), 375–386.
9. Rimm, EB, Williams, P, Fosher, K, Criqui, M, Stampfer, MJ, Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ 319 (1999), 1523–1528.
10. Brien, SE, Ronksley, PE, Turner, BJ, Mukamal, KJ, Ghali, WA, Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies. BMJ, 342, 2011, d636.
11. Roerecke, M, Kaczorowski, J, Tobe, SW, Gmel, G, Hasan, OSM, Rehm, J, The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis. Lancet Public Health 2 (2017), e108–e120.
12. Davey Smith, G, Hemani, G, Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23 (2014), R89–R98.
13. Holmes, MV, Dale, CE, Zuccolo, L, et al. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ, 349, 2014, g4164.
14. Edenberg, HJ, Foroud, T, Genetics and alcoholism. Nat Rev Gastroenterol Hepatol 10 (2013), 487–494.
15. Chen, L, Davey Smith, G, Harbord, RM, Lewis, SJ, Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach. PLoS Med, 5, 2008, e52.
16. Cho, Y, Shin, SY, Won, S, Relton, CL, Davey Smith, G, Shin, MJ, Alcohol intake and cardiovascular risk factors: a Mendelian randomisation study. Sci Rep, 5, 2015, 18422.
17. Taylor, AE, Lu, F, Carslake, D, et al. Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis. Sci Rep, 5, 2015, 14005.
18. Chen, Z, Chen, J, Collins, R, et al. China Kadoorie Biobank of 0·5 million people: survey methods, baseline characteristics and long-term follow-up. Int J Epidemiol 40 (2011), 1652–1666.
19. Millwood, IY, Li, L, Smith, M, et al. Alcohol consumption in 0·5 million people from 10 diverse regions of China: prevalence, patterns and socio-demographic and health-related correlates. Int J Epidemiol 42 (2013), 816–827.
20. Plummer, M, Improved estimates of floating absolute risk. Stat Med 23 (2004), 93–104.
21. MacMahon, S, Peto, R, Cutler, J, et al. Blood pressure, stroke, and coronary heart disease. Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 335 (1990), 765–774.
22. Christensen, AI, Nordestgaard, BG, Tolstrup, JS, Alcohol intake and risk of ischemic and haemorrhagic stroke: results from a Mendelian randomisation study. J Stroke 20 (2018), 218–227.
23. Lacey, B, Lewington, S, Clarke, R, et al. Age-specific association between blood pressure and vascular and non-vascular chronic diseases in 0·5 million adults in China: a prospective cohort study. Lancet Glob Health 6 (2018), e641–e649.
24. Takeuchi, F, Yokota, M, Yamamoto, K, et al. Genome-wide association study of coronary artery disease in the Japanese. Eur J Hum Genet 20 (2012), 333–340.
25. Lu, X, Peloso, GM, Liu, DJ, et al. Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet 49 (2017), 1722–1730.
26. Bowman, L, Hopewell, JC, Chen, F, et al. Effects of anacetrapib in patients with atherosclerotic vascular disease. N Engl J Med 377 (2017), 1217–1227.
27. Millwood, IY, Bennett, DA, Holmes, MV, et al. Association of CETP gene variants with risk for vascular and nonvascular diseases among Chinese adults. JAMA Cardiol 3 (2018), 34–43.
28. Chen, CH, Ferreira, JC, Gross, ER, Mochly-Rosen, D, Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. Physiol Rev 94 (2014), 1–34.
29. Polimanti, R, Gelernter, J, ADH1B: from alcoholism, natural selection, and cancer to the human phenome. Am J Med Genet B Neuropsychiatr Genet 177 (2018), 113–125.