Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Cho, Yoonsu ^a   Shin, So Youn ^b   Won, Sungho ^c   Relton, Caroline L ^b,d   Smith, George Davey ^b   Shin, Min Jeong ^a,e  

^a Korea University   (South Korea)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c Seoul National University   (South Korea)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

^e Korea University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ALDH2 PROTEIN, HUMAN; GLUCOSE BLOOD LEVEL; TRIACYLGLYCEROL;

ALLELE; BLOOD; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; DRINKING BEHAVIOR; FEMALE; GENETICS; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; HUMAN; MALE; MIDDLE AGED; PATHOLOGY; RISK FACTOR; SOUTH KOREA; WAIST HIP RATIO;

ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; ALLELES; BLOOD GLUCOSE; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; FEMALE; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; REPUBLIC OF KOREA; RISK FACTORS; TRIGLYCERIDES; WAIST-HIP RATIO;

EID: 84951304932     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18422     Document Type: Article

References (42)

1. Marmot, M. G. Alcohol and coronary heart disease. Int J Epidemiol 13, 160-7 (1984).
2. Bovet, P. & Paccaud, F. Commentary: alcohol, coronary heart disease and public health: which evidence-based policy. Int J Epidemiol 30, 734-7 (2001).
3. Ronksley, P. E., Brien, S. E., Turner, B. J., Mukamal, K. J. & Ghali, W. A. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ 342, d671 (2011).
4. Freiberg, M. S. & Samet, J. H. Alcohol and coronary heart disease: the answer awaits a randomized controlled trial. Circulation 112, 1379-81 (2005).
5. Davey Smith, G. Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health. Genes Nutr 6, 27-43 (2011).
6. Richmond, R. C., Al-Amin, A., Davey Smith, G. & Relton, C. L. Approaches for drawing causal inferences from epidemiological birth cohorts: a review. Early Hum Dev 90, 769-80 (2014).
7. Davey Smith, G. & Ebrahim, S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32, 1-22 (2003).
8. Davey Smith, G. & Ebrahim, S. What can mendelian randomisation tell us about modifiable behavioural and environmental exposures? BMJ 330, 1076-9 (2005).
9. Davey Smith, G. & Hemani, G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23, R89-98 (2014).
10. Holmes, M. V. et al. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ 349, g4164 (2014).
11. Au Yeung, S. L. et al. Moderate alcohol use and cardiovascular disease from Mendelian randomization. PLoS One 8, e68054 (2013).
12. Taylor, A. E. et al. Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis. Sci Rep 5, 14005 (2015).
13. Davey Smith, G. & Ebrahim, S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 33, 30-42 (2004).
14. Au Yeung, S. L. et al. Is aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men? Int J Epidemiol 42, 318-28 (2013).
15. 2 and CYP2E1 gene polymorphisms on drinking behavior and alcoholic liver disease in Japanese male workers. Alcohol Clin Exp Res 25, 19S-23S (2001).
16. 2, ADH1B, and ADH1C genotypes in Asians: a literature review. Alcohol Res Health 30, 22-7 (2007).
17. 2 and ADH1B genotypes with alcohol-related phenotypes in Asian young adults. Alcohol Clin Exp Res 33, 839-47 (2009).
18. Tsuchihashi-Makaya, M. et al. Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. Hypertens Res 32, 207-13 (2009).
19. 2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. Circ J 75, 911-8 (2011).
20. 2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach. Cancer Epidemiol Biomarkers Prev 14, 1967-71 (2005).
21. Chen, L., Davey Smith, G., Harbord, R. M. & Lewis, S. J. Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach. PLoS Med 5, e52 (2008).
22. Kato, N. et al. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet 43, 531-8 (2011).
23. 2 genotype in the Korean population. Int J Epidemiol 40, 1047-55 (2011).
24. 2 rs671 polymorphism and essential hypertension in Asian populations. Herz 40, 203-208 (2015).
25. 2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels. Atherosclerosis 211, 545-50 (2010).
26. 2∗2) is Associated with Coronary Spastic Angina: Possible Roles of Reactive Aldehydes and Implications of Alcohol Flushing Syndrome. Circulation (2015).
27. Do, R. et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 45, 1345-52 (2013).
28. Burgess, S., Freitag, D. F., Khan, H., Gorman, D. N. & Thompson, S. G. Using multivariable Mendelian randomization to disentangle the causal effects of lipid fractions. PLoS One 9, e108891 (2014).
29. Slichter, D. Testing Instrument Validity and Identification with Invalid Instruments. Technical report, Department of Economics, University of Rochester Rochester, USA (2014).
30. Cole, S. R. et al. Illustrating bias due to conditioning on a collider. Int J Epidemiol 39, 417-20 (2010).
31. Davey Smith, G., Timpson, N. & Ebrahim, S. Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization. Annals of Medicine 40, 524-541 (2008).
32. Briel, M. et al. Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis. BMJ 338, b92 (2009).
33. Xu, L. et al. Alcohol Use and Gamma-Glutamyltransferase Using a Mendelian Randomization Design in the Guangzhou Biobank Cohort Study. PLoS One 10, e0137790 (2015).
34. Shin, C., Kwack, K., Cho, N. H., Kim, S. H. & Baik, I. Sex-specific differences in the association of a common aldehyde dehydrogenase 2 gene polymorphism and alcohol consumption with stroke risk in a Korean population: a prospective cohort study. Nutr Res Pract 9, 79-86 (2015).
35. Howie, B. N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 5, e1000529 (2009).
36. Delaneau, O., Zagury, J. F. & Marchini, J. Improved whole-chromosome phasing for disease and population genetic studies. Nat Methods 10, 5-6 (2013).
37. Cho, Y. S. et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 41, 527-34 (2009).
38. Baik, I. & Shin, C. Prospective study of alcohol consumption and metabolic syndrome. Am J Clin Nutr 87, 1455-63 (2008).
39. Friedewald, W. T., Levy, R. I. & Fredrickson, D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499-502 (1972).
40. Rabbee, N. & Speed, T. P. A genotype calling algorithm for affymetrix SNP arrays. Bioinformatics 22, 7-12 (2006).
41. Price, A. L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38, 904-9 (2006).
42. Card, D. Using Geographic Variation in College Proximity to Estimate the Return to Schooling. in Aspects of labour market behaviour: essays in honour of John Vanderkamp (eds. Vanderkamp, J., Christofides, L. N., Grant, E. K. & Swidinsky, R.) (University of Toronto Press, Toronto; Buffalo, 1993).