메뉴 건너뛰기




Volumn 219, Issue 8, 2019, Pages 1207-1215

Viral load dynamics and clinical disease severity in infants with respiratory syncytial virus infection

Author keywords

Clinical severity; Respiratory syncytial virus; RSV; Viral dynamics; Viral load

Indexed keywords

ARTICLE; COHORT ANALYSIS; DISEASE SEVERITY; FEMALE; HOSPITAL PATIENT; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; INFANT; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OUTPATIENT; PEDIATRIC INTENSIVE CARE UNIT; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY SYNCYTIAL VIRUS INFECTION; SCORING SYSTEM; VIRUS LOAD; PATHOLOGY; PNEUMOVIRUS; REAL TIME POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; VIROLOGY;

EID: 85064516276     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiy655     Document Type: Article
Times cited : (64)

References (28)
  • 1
    • 85021970644 scopus 로고    scopus 로고
    • Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: A systematic review and modelling study
    • Shi T, McAllister DA, O'Brien KL, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: A systematic review and modelling study. Lancet 2017; 390:946-58.
    • (2017) Lancet , vol.390 , pp. 946-958
    • Shi, T.1    McAllister, D.A.2    O'Brien, K.L.3
  • 2
    • 84871036375 scopus 로고    scopus 로고
    • Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380:2095-128.
    • (2012) Lancet , vol.380 , pp. 2095-2128
    • Lozano, R.1    Naghavi, M.2    Foreman, K.3
  • 3
    • 59749095702 scopus 로고    scopus 로고
    • The burden of respiratory syncytial virus infection in young children
    • Hall CB, Weinberg GA, Iwane MK, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009; 360:588-98.
    • (2009) N Engl J Med , vol.360 , pp. 588-598
    • Hall, C.B.1    Weinberg, G.A.2    Iwane, M.K.3
  • 4
    • 85012113486 scopus 로고    scopus 로고
    • The human immune response to respiratory syncytial virus infection
    • Russell CD, Unger SA, Walton M, Schwarze J. The human immune response to respiratory syncytial virus infection. Clin Microbiol Rev 2017; 30:481-502.
    • (2017) Clin Microbiol Rev , vol.30 , pp. 481-502
    • Russell, C.D.1    Unger, S.A.2    Walton, M.3    Schwarze, J.4
  • 5
    • 85014768057 scopus 로고    scopus 로고
    • The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-associated bronchiolitis
    • Piedra FA, Mei M, Avadhanula V, et al. The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-associated bronchiolitis. PLoS One 2017; 12:e0172953.
    • (2017) PLoS One , vol.12 , pp. e0172953
    • Piedra, F.A.1    Mei, M.2    Avadhanula, V.3
  • 6
    • 84888990746 scopus 로고    scopus 로고
    • Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection
    • Mejias A, Dimo B, Suarez NM, et al. Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection. PLoS Med 2013; 10:e1001549.
    • (2013) PLoS Med , vol.10 , pp. e1001549
    • Mejias, A.1    Dimo, B.2    Suarez, N.M.3
  • 7
    • 84876094420 scopus 로고    scopus 로고
    • Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis
    • Mella C, Suarez-Arrabal MC, Lopez S, et al. Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis 2013; 207:564-73.
    • (2013) J Infect Dis , vol.207 , pp. 564-573
    • Mella, C.1    Suarez-Arrabal, M.C.2    Lopez, S.3
  • 8
    • 85044064807 scopus 로고    scopus 로고
    • Respiratory syncytial virus genotypes, host immune profiles, and disease severity in young children hospitalized with bronchiolitis
    • Rodriguez-Fernandez R, Tapia LI, Yang CF, et al. Respiratory syncytial virus genotypes, host immune profiles, and disease severity in young children hospitalized with bronchiolitis. J Infect Dis 2017; 217:24-34.
    • (2017) J Infect Dis , vol.217 , pp. 24-34
    • Rodriguez-Fernandez, R.1    Tapia, L.I.2    Yang, C.F.3
  • 9
    • 85031720410 scopus 로고    scopus 로고
    • Prolonged viral replication and longitudinal viral dynamic differences among respiratory syncytial virus infected infants
    • Brint ME, Hughes JM, Shah A, et al. Prolonged viral replication and longitudinal viral dynamic differences among respiratory syncytial virus infected infants. Pediatr Res 2017; 82:872-80.
    • (2017) Pediatr Res , vol.82 , pp. 872-880
    • Brint, M.E.1    Hughes, J.M.2    Shah, A.3
  • 10
    • 80052422367 scopus 로고    scopus 로고
    • Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children
    • El Saleeby CM, Bush AJ, Harrison LM, Aitken JA, Devincenzo JP. Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J Infect Dis 2011; 204:996-1002.
    • (2011) J Infect Dis , vol.204 , pp. 996-1002
    • El Saleeby, C.M.1    Bush, A.J.2    Harrison, L.M.3    Aitken, J.A.4    DeVincenzo, J.P.5
  • 11
    • 84929658044 scopus 로고    scopus 로고
    • Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: Multicenter cohort studies in the United States and Finland
    • Hasegawa K, Jartti T, Mansbach JM, et al. Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland. J Infect Dis 2015; 211:1550-9.
    • (2015) J Infect Dis , vol.211 , pp. 1550-1559
    • Hasegawa, K.1    Jartti, T.2    Mansbach, J.M.3
  • 12
    • 85015848692 scopus 로고    scopus 로고
    • Severity of respiratory syncytial virus lower respiratory tract infection with viral coinfection in HIV-uninfected children
    • Mazur NI, Bont L, Cohen AL, et al; South African Severe Acute Respiratory Illness (SARI) Surveillance Group. Severity of respiratory syncytial virus lower respiratory tract infection with viral coinfection in HIV-uninfected children. Clin Infect Dis 2017; 64:443-50.
    • (2017) Clin Infect Dis , vol.64 , pp. 443-450
    • Mazur, N.I.1    Bont, L.2    Cohen, A.L.3
  • 13
    • 85066862593 scopus 로고    scopus 로고
    • Multicenter evaluation of the ePlex respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs
    • Babady NE, England MR, Jurcic Smith KL, et al. Multicenter evaluation of the ePlex respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs. J Clin Microbiol 2018; 56:e01658-17.
    • (2018) J Clin Microbiol , vol.56 , pp. e01658-e01717
    • Babady, N.E.1    England, M.R.2    Jurcic Smith, K.L.3
  • 14
    • 84941647372 scopus 로고    scopus 로고
    • Nasopharyngeal bacterial burden and antibiotics: Influence on inflammatory markers and disease severity in infants with respiratory syncytial virus bronchiolitis
    • Suarez-Arrabal MC, Mella C, Lopez SM, et al. Nasopharyngeal bacterial burden and antibiotics: influence on inflammatory markers and disease severity in infants with respiratory syncytial virus bronchiolitis. J Infect 2015; 71:458-69.
    • (2015) J Infect , vol.71 , pp. 458-469
    • Suarez-Arrabal, M.C.1    Mella, C.2    Lopez, S.M.3
  • 15
    • 77956360519 scopus 로고    scopus 로고
    • Breastfeeding is associated with the production of type i interferon in infants infected with influenza virus
    • Melendi GA, Coviello S, Bhat N, Zea-Hernandez J, Ferolla FM, Polack FP. Breastfeeding is associated with the production of type I interferon in infants infected with influenza virus. Acta Paediatr 2010; 99:1517-21.
    • (2010) Acta Paediatr , vol.99 , pp. 1517-1521
    • Melendi, G.A.1    Coviello, S.2    Bhat, N.3    Zea-Hernandez, J.4    Ferolla, F.M.5    Polack, F.P.6
  • 16
    • 84994812757 scopus 로고    scopus 로고
    • Nasopharyngeal microbiota, host transcriptome, and disease severity in children with respiratory syncytial virus infection
    • de Steenhuijsen Piters WA, Heinonen S, Hasrat R, et al. Nasopharyngeal microbiota, host transcriptome, and disease severity in children with respiratory syncytial virus infection. Am J Respir Crit Care Med 2016; 194:1104-15.
    • (2016) Am J Respir Crit Care Med , vol.194 , pp. 1104-1115
    • De Steenhuijsen, P.W.A.1    Heinonen, S.2    Hasrat, R.3
  • 17
    • 84959281741 scopus 로고    scopus 로고
    • Antiviral activity of TMC353121, a respiratory syncytial virus (RSV) fusion inhibitor, in a non-human primate model
    • Ispas G, Koul A, Verbeeck J, et al. Antiviral activity of TMC353121, a respiratory syncytial virus (RSV) fusion inhibitor, in a non-human primate model. PLoS One 2015; 10:e0126959.
    • (2015) PLoS One , vol.10 , pp. e0126959
    • Ispas, G.1    Koul, A.2    Verbeeck, J.3
  • 18
    • 85049989226 scopus 로고    scopus 로고
    • Diagnostic accuracy of digital RNA quantification versus real-time PCR for the detection of respiratory syncytial virus in nasopharyngeal aspirates from children with acute respiratory infection
    • Bouzas ML, Oliveira JR, Queiroz A, et al; Acute Respiratory Infection and Wheeze Study Group Phase I and II. Diagnostic accuracy of digital RNA quantification versus real-time PCR for the detection of respiratory syncytial virus in nasopharyngeal aspirates from children with acute respiratory infection. J Clin Virol 2018; 106:34-40.
    • (2018) J Clin Virol , vol.106 , pp. 34-40
    • Bouzas, M.L.1    Oliveira, J.R.2    Queiroz, A.3
  • 19
    • 0036569233 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of dexamethasone in severe respiratory syncytial virus (RSV) infection: Effects on RSV quantity and clinical outcome
    • Buckingham SC, Jafri HS, Bush AJ, et al. A randomized, double-blind, placebo-controlled trial of dexamethasone in severe respiratory syncytial virus (RSV) infection: effects on RSV quantity and clinical outcome. J Infect Dis 2002; 185:1222-8.
    • (2002) J Infect Dis , vol.185 , pp. 1222-1228
    • Buckingham, S.C.1    Jafri, H.S.2    Bush, A.J.3
  • 20
    • 84988927923 scopus 로고    scopus 로고
    • Robust cytokine and chemokine response in nasopharyngeal secretions: Association with decreased severity in children with physician diagnosed bronchiolitis
    • Nicholson EG, Schlegel C, Garofalo RP, et al. Robust cytokine and chemokine response in nasopharyngeal secretions: Association with decreased severity in children with physician diagnosed bronchiolitis. J Infect Dis 2016; 214:649-55.
    • (2016) J Infect Dis , vol.214 , pp. 649-655
    • Nicholson, E.G.1    Schlegel, C.2    Garofalo, R.P.3
  • 21
    • 18944399906 scopus 로고    scopus 로고
    • Respiratory syncytial virus load predicts disease severity in previously healthy infants
    • DeVincenzo JP, El Saleeby CM, Bush AJ. Respiratory syncytial virus load predicts disease severity in previously healthy infants. J Infect Dis 2005; 191:1861-8.
    • (2005) J Infect Dis , vol.191 , pp. 1861-1868
    • DeVincenzo, J.P.1    El Saleeby, C.M.2    Bush, A.J.3
  • 22
    • 35548960815 scopus 로고    scopus 로고
    • Respiratory syncytial virus infections in hospitalized infants: Association between viral load, virus subgroup, and disease severity
    • Fodha I, Vabret A, Ghedira L, et al. Respiratory syncytial virus infections in hospitalized infants: Association between viral load, virus subgroup, and disease severity. J Med Virol 2007; 79:1951-8.
    • (2007) J Med Virol , vol.79 , pp. 1951-1958
    • Fodha, I.1    Vabret, A.2    Ghedira, L.3
  • 23
    • 77954421312 scopus 로고    scopus 로고
    • Disease severity and viral load are correlated in infants with primary respiratory syncytial virus infection in the community
    • Houben ML, Coenjaerts FE, Rossen JW, et al. Disease severity and viral load are correlated in infants with primary respiratory syncytial virus infection in the community. J Med Virol 2010; 82:1266-71.
    • (2010) J Med Virol , vol.82 , pp. 1266-1271
    • Houben, M.L.1    Coenjaerts, F.E.2    Rossen, J.W.3
  • 24
    • 56049100212 scopus 로고    scopus 로고
    • Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus
    • Martin ET, Kuypers J, Heugel J, Englund JA. Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus. Diagn Microbiol Infect Dis 2008; 62:382-8.
    • (2008) Diagn Microbiol Infect Dis , vol.62 , pp. 382-388
    • Martin, E.T.1    Kuypers, J.2    Heugel, J.3    Englund, J.A.4
  • 25
    • 0037090045 scopus 로고    scopus 로고
    • Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus
    • Wright PF, Gruber WC, Peters M, et al. Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus. J Infect Dis 2002; 185:1011-8.
    • (2002) J Infect Dis , vol.185 , pp. 1011-1018
    • Wright, P.F.1    Gruber, W.C.2    Peters, M.3
  • 26
    • 84930377566 scopus 로고    scopus 로고
    • The impact of viral dynamics on the clinical severity of infants with respiratory syncytial virus bronchiolitis
    • Zhou L, Xiao Q, Zhao Y, Huang A, Ren L, Liu E. The impact of viral dynamics on the clinical severity of infants with respiratory syncytial virus bronchiolitis. J Med Virol 2015; 87:1276-84.
    • (2015) J Med Virol , vol.87 , pp. 1276-1284
    • Zhou, L.1    Xiao, Q.2    Zhao, Y.3    Huang, A.4    Ren, L.5    Liu, E.6
  • 27
    • 85054888822 scopus 로고    scopus 로고
    • Reduced nasal viral load and IFN responses in infants with respiratory syncytial virus bronchiolitis and respiratory failure
    • Thwaites RS, Coates M, Ito K, et al. Reduced nasal viral load and IFN responses in infants with respiratory syncytial virus bronchiolitis and respiratory failure. Am J Respir Crit Care Med 2018; 198:1074-84.
    • (2018) Am J Respir Crit Care Med , vol.198 , pp. 1074-1084
    • Thwaites, R.S.1    Coates, M.2    Ito, K.3
  • 28
    • 0042236473 scopus 로고    scopus 로고
    • Effect of dexamethasone on tracheal viral load and interleukin-8 tracheal concentration in children with respiratory syncytial virus infection
    • van Woensel JB, Lutter R, Biezeveld M, et al. Effect of dexamethasone on tracheal viral load and interleukin-8 tracheal concentration in children with respiratory syncytial virus infection. Pediatr Infect Dis J 2003; 22:721-6.
    • (2003) Pediatr Infect Dis J , vol.22 , pp. 721-726
    • Van Woensel, J.B.1    Lutter, R.2    Biezeveld, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.